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Yong Chen
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Epigenetics
Structural Biology
Histone
Methylation
Chromatin
Gene Regulation
Protein Complexes
Dna Binding
Telomeres
Nucleosomes
Areas of Focus
- Structural Biology of Epigenetics
Work Experience
- 2012-08~Present - Shanghai Institute of Biochemistry and Cell Biology - Researcher
- 2005-05~2012-08 - University of Michigan - Postdoctoral Fellow
Academic Background & Achievements
- 1999-09--2005-01 PhD: Tsinghua University
- 1995-09--1999-07 Bachelor's Degree: Tsinghua University
Publications
- Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2(B) and RAP1, Rai, Rekha, Biju, Kevin, Sun, Wenqi, Sodeinde, Tori, AlHiysat, Amer, Morgan, Jaida, Ye, Xianwen, Li, Xueqing, Chen, Yong, Chang, Sandy, 2023
- Structural basis for product specificities of MLL family methyltransferases, Li, Yanjing, Zhao, Lijie, Zhang, Yuebin, Wu, Ping, Xu, Ying, Mencius, Jun, Zheng, Yongxin, Wang, Xiaoman, Xu, Wancheng, Huang, Naizhe, Ye, Xianwen, Lei, Ming, Shi, Pan, Tian, Changlin, Peng, Chao, Li, Guohui, Liu, Zhijun, Quan, Shu, Chen, Yong, 2022
- The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications, Li, Yanjing, Ge, Kexue, Li, Tingting, Cai, Run, Chen, Yong, 2022
- Global profiling of regulatory elements in the histone benzoylation pathway, Wang, Duo, Yan, Fuxiang, Wu, Ping, Ge, Kexue, Li, Muchun, Li, Tingting, Gao, Ying, Peng, Chao, Chen, Yong, 2022
- DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates, Lijie Zhao, Naizhe Huang, Jun Mencius, Yanjing Li, Ying Xu, Yongxin Zheng, Wei He, Na Li, Jun Zheng, Min Zhuang, Shu Quan, Yong Chen, 2022
- Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres, Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M Tesmer, Jayakrishnan Nandakumar, Yong Chen, Sandy Chang, 2021
- Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes, Zheng, Yongxin, Huang, Yinping, Mencius, Jun, Li, Yanjing, Zhao, Lijie, Luo, Wanting, Chen, Yong, Quan, Shu, 2021
- Dri1 mediates heterochromatin assembly via RNAi and histone deacetylation, Ban, Hyoju, Sun, Wenqi, Chen, YuHang, Chen, Yong, Li, Fei, 2021
- Development and optimization of a cascade of screening assays for inhibitors of TRF2, Guo, Tianyue, Dong, Yao, Chen, Yong, Liu, Liu, Sun, Haiying, 2020
- The Structural Basis for Specific Recognition of H3K14 Acetylation by Sth1 in the RSC Chromatin Remodeling Complex, Chen, Guochao, Li, Wei, Yan, Fuxiang, Wang, Duo, Chen, Yong, 2020
- Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases, Li, Yanjing, Zhao, Lijie, Tian, Xiaoxu, Peng, Chao, Gong, Fan, Chen, Yong, 2020
- N-terminal modified cyclopeptidic mimetics of Apollo(TBM) as inhibitors of TRF2, Chen, Xia, Dong, Yao, Guo, Tianyue, Yang, ChaoYie, Chen, Yong, Sun, Haiying, 2020
- Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly, Alessandro Cicconi, Rekha Rai, Xuexue Xiong, Cayla Broton, Amer AlHiyasat, Chunyi Hu, Siying Dong, Wenqi Sun, Jennifer Garbarino, Ranjit S Bindra, Carl Schildkraut, Yong Chen, Sandy Chang, 2020
- Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation, Guochao Chen, Duo Wang, Bin Wu, Fuxiang Yan, Hongjuan Xue, Quanmeng Wang, Shu Quan, Yong Chen, 2020
- The structural biology of the shelterin complex, Chen, Yong, 2019
- Structural basis of nucleosome recognition and modification by MLL methyltransferases, Xue, Han, Yao, Tonghui, Cao, Mi, Zhu, Guanjun, Li, Yan, Yuan, Guiyong, Chen, Yong, Lei, Ming, Huang, Jing, 2019
- Developmental ROS individualizes organismal stress resistance and lifespan, Bazopoulou, Daphne, Knoefler, Daniela, Zheng, Yongxin, Ulrich, Kathrin, Oleson, Bryndon J, Xie, Lihan, Kim, Minwook, Kaufmann, Anke, Lee, YoungTae, Dou, Yali, Chen, Yong, Quan, Shu, Jakob, Ursula, 2019
- The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope, Hu, Chunyi, Inoue, Haruna, Sun, Wenqi, Takeshita, Yumiko, Huang, Yaoguang, Xu, Ying, Kanoh, Junko, Chen, Yong, 2019
- The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex, Han, Jianming, Li, Tingting, Li, Yanjing, Li, Muchun, Wang, Xiaoman, Peng, Chao, Su, Chen, Li, Na, Li, Yiwen, Xu, Ying, Chen, Yong, 2019
- Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast, Hu, Chunyi, Inoue, Haruna, Sun, Wenqi, Takeshita, Yumiko, Huang, Yaoguang, Xu, Ying, Kanoh, Junko, Chen, Yong, 2019
- CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development, Li, Qing, Li, Yanjing, Yang, Suming, Huang, Shuo, Yan, Meng, Ding, Yifu, Tang, Wei, Lou, Xiwen, Yin, Qi, Sun, Zhanfei, Lu, Lei, Shi, Huijuan, Wang, Hongyan, Chen, Yong, Li, Jinsong, 2018
- Structural and functional analysis of the mammalian TIN2-TPP1-TRF2 telomeric complex, Chen Yong, 2017
- Structural basis for DAXX interaction with ATRX, Wang, Xiaoman, Zhao, Yiyue, Zhang, Jian, Chen, Yong, 2017
- NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres, Rai, Rekha, Hu, Chunyi, Broton, Cayla, Chen, Yong, Lei, Ming, Chang, Sandy, 2017
- Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction, Karatas, Hacer, Li, Yangbing, Liu, Liu, Ji, Jiao, Lee, Shirley, Chen, Yong, Yang, Jiuling, Huang, Liyue, Bernard, Denzil, Xu, Jing, Townsend, Elizabeth C, Cao, Fang, Ran, Xu, Li, Xiaoqin, Wen, Bo, Sun, Duxin, Stuckey, Jeanne A, Lei, Ming, Dou, Yali, Wang, Shaomeng, 2017
- Structure of the fission yeast S. pombe telomeric Poz1-Tpz1-Rap1 complex, Chen Yong, 2017
- TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions, Rekha Rai, Yong Chen, Ming Lei, Sandy Chang, 2016
- Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex, Ran, Xu, Liu, Liu, Yang, ChaoYie, Lu, Jianfeng, Chen, Yong, Lei, Ming, Wang, Shaomeng, 2016
- Structural basis for activity regulation of MLL family methyltransferases, Li, Yanjing, Han, Jianming, Zhang, Yuebin, Cao, Fang, Liu, Zhijun, Li, Shuai, Wu, Jian, Hu, Chunyi, Wang, Yan, Shuai, Jin, Chen, Juan, Cao, Liaoran, Li, Dangsheng, Shi, Pan, Tian, Changlin, Zhang, Jian, Dou, Yali, Li, Guohui, Chen, Yong, Lei, Ming, 2016
- Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex, Yin, Jinhu, Wan, Bingbing, Sarkar, Jaya, Horvath, Kent, Wu, Jian, Chen, Yong, Cheng, Guangjuan, Wan, Ke, Chin, Peiju, Lei, Ming, Liu, Yie, 2016
- Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency, Yang, Yul W, Flynn, Ryan A, Chen, Yong, Qu, Kun, Wan, Bingbing, Wang, Kevin C, Lei, Ming, Chang, Howard Y, 2014
- Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30, Chen, Yong, Cao, Fang, Wan, Bingbing, Dou, Yali, Lei, Ming, 2012
- Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding, Chen, Yong, Wan, Bingbing, Wang, Kevin C, Cao, Fang, Yang, Yuting, Protacio, Angeline, Dou, Yali, Chang, Howard Y, Lei, Ming, 2011
- A Conserved Motif within RAP1 Plays Diversified Roles in Telomere Protection and Regulation in Different Organisms, Yong Chen, Rekha Rai, ZiRen Zhou, Junko Kanoh, Cyril Ribeyre, Yuting Yang, Hong Zheng, Pascal Damay, Feng Wang, Hisayo Tsujii, Yasushi Hiraoka, David Shore, HongYu Hu, Sandy Chang, Ming Lei, 2011
- An Ash2L/RbBP5
Awards
- Chinese Academy of Sciences Excellent Graduate Advisor Award (2016)
