Areas of Focus
- c-Met and ALK Inhibitors
- Tumor Metabolism and Its Inhibitors
- EMT and Tumor Metastasis
- Biomarkers
Work Experience
- 2014-03 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Party Secretary
- 2011-08 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Deputy Director
- 2006-06 to 2011-08 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher
- 1999-12 to 2006-05 - Ocean University of China - Doctoral Supervisor
- 1997-12 to 2006-05 - Ocean University of China - Professor
- 1991-12 to 1997-11 - Ocean University of China - Lecturer
- 1989-07 to 1991-11 - Ocean University of China - Assistant
Academic Background & Achievements
- 1993-10 to 1997-08 Ph.D. in Pharmacy: University of Tokyo
- 1986-09 to 1989-07 Master's in Medicine: Shandong Medical University
- 1980-09 to 1986-07 Bachelor's in Medicine: Shandong Medical University
Publications
- SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer, Ji Zhou, XuChao Zhang, Shan Xue, Mengdi Dai, Yueliang Wang, Xia Peng, Jianjiao Chen, Xinyi Wang, Yanyan Shen, Hui Qin, Bi Chen, Yu Zheng, Xiwen Gao, Zuoquan Xie, Jian Ding, Handong Jiang, YiLong Wu, Meiyu Geng, Jing Ai, 2023
- Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase, Sun, Yaoliang, Zhang, Ying, Chen, Xiaoai, Yu, Aisong, Du, Wenhao, Huang, Yuting, Wu, Feifei, Yu, Lei, Li, Jiayi, Wen, Cuiyun, Yang, Hong, Shi, Qiongyu, Geng, Meiyu, Huang, Xun, Xu, Shilin, 2022
- Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis, Xie, Zuoquan, Tong, Siyu, Chu, Xingkun, Feng, Teng, Geng, Meiyu, 2022
- SAF-248,a novel PI3Kδ-selective inhibitor,potently suppresses the growth of diffuse large B-cell lymphoma, Zhang Xi, Duan Yuting, Wang Yi, Zhao Xingdong, Sun Yiming, Lin Dongze, Chen Yi, Wang Yuxiang, Zhou Zuwen, Liu Yanxin, Jiang Lihua, Geng Meiyu, Ding Jian, Meng Linghua, 2022
- Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, Xie, Zuoquan, Wang, Zhen, Fan, Fengying, Zhou, Jinpei, Hu, Zhaoxue, Wang, Qingxia, Wang, Xiyuan, Zeng, Qingzhong, Zhang, Yan, Qiu, Jiaxuan, Zhou, Xiaoqian, Xu, Hui, Bai, Hudagula, Zhan, Zhengsheng, Ding, Jian, Zhang, Huibin, Duan, Wenhu, Yu, Xuekui, Geng, Meiyu, 2022
- A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia, Xiao, Shifu, Chan, Piu, Wang, Tao, Hong, Zhen, Wang, Shuzhen, Kuang, Weihong, He, Jincai, Pan, Xiaoping, Zhou, Yuying, Ji, Yong, Wang, Luning, Cheng, Yan, Peng, Ying, Ye, Qinyong, Wang, Xiaoping, Wu, Yuncheng, Qu, Qiumin, Chen, Shengdi, Li, Shuhua, Chen, Wei, Xu, Jun, Peng, Dantao, Zhao, Zhongxin, Li, Yansheng, Zhang, Junjian, Du, Yifeng, Chen, Weixian, Fan, Dongsheng, Yan, Yong, Liu, Xiaowei, Zhang, Wei, Luo, Benyan, Wu, Wenyuan, Shen, Lu, Liu, Chunfeng, Mao, Peixian, Wang, Qiumei, Zhao, Qianhua, Guo, Qihao, Zhou, Yongtao, Li, Yi, Jiang, Lijun, Ren, Wenwei, Ouyang, Yingjun, Wang, Yan, Liu, Shuai, Jia, Jianjun, Zhang, Nan, Liu, Zhonglin, He, Raoli, Feng, Tingyi, Lu, Wenhui, Tang, Huidong, Gao, Ping, Zhang, Yingchun, Chen, Lanlan, Wang, Lei, Yin, You, Xu, Qun, Xiao, Jinsong, Cong, Lin, Cheng, Xi, Zhang, Hui, Gao, Dan, Xia, Minghua, Lian, Tenghong, Peng, Guoping, Zhang, Xu, Jiao, Bin, Hu, Hua, Chen, Xueyan, Guan, Yihui, Cui, Ruixue, Huang, Qiu, Xin, Xianliang, Chen, Hongjian, Ding, Yu, Z, 2021
- Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy, Zhang, Zhuqing, Guo, Zuhao, Xu, Xiaowei, Cao, Danyan, Yang, Hong, Li, Yanlian, Shi, Qiongyu, Du, Zhiyan, Guo, Xiaobin, Wang, Xin, Chen, Danqi, Zhang, Ying, Chen, Lin, Zhou, Kaixin, Li, Jian, Geng, Meiyu, Huang, Xun, Xiong, Bing, 2021
- A phase II randomized trial of sodium oligomannate in Alzheimer's dementia, Wang, Tao, Kuang, Weihong, Chen, Wei, Xu, Wenwei, Zhang, Liming, Li, Yingjie, Li, Hailin, Peng, Ying, Chen, Yangmei, Wang, Baojun, Xiao, Jinsong, Li, Honghua, Yan, Chuanzhu, Du, Yifeng, Tang, Mouni, He, Zhiyi, Chen, Haibo, Li, Wei, Lin, Hong, Shi, Shugui, Bi, Jianzhong, Zhou, Huadong, Cheng, Yan, Gao, Xiaoping, Guan, Yihui, Huang, Qiu, Chen, Kewei, Xin, Xianliang, Ding, Jian, Geng, Meiyu, Xiao, Shifu, 2020
- The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors, Wang, Xinyi, Ai, Jing, Liu, Hongyan, Peng, Xia, Chen, Hui, Chen, Yi, Su, Yi, Shen, Aijun, Huang, Xun, Ding, Jian, Geng, Meiyu, 2019
- CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression, Fu Xuhong, Zhang Xiong, Yang Hong, Xu Xiaowei, Hu Zonglong, Yan Juan, Zheng Xingling, Wei Rongrui, Zhang Zhuqing, Tang Shirui, Geng Meiyu, Huang Xun, 2019
Awards
- Shanghai Women's Civilization Post, City Level, 2014
- National Hundred, Thousand, and Ten Thousand Talent Project - 'Outstanding Contribution Young and Middle-aged Expert' Title, First Prize, National Level, 2013
- Shanghai Leading Talent, First Prize, Provincial Level, 2011
- Shanghai Excellent Discipline Leader, First Prize, Provincial Level, 2010
- Preparation Technology of Marine Characteristic Oligosaccharides, First Prize, National Level, 2009
