Professor | Meiyu Geng | Asia Growth Partners

Name	Meiyu Geng
Contact Information	mygeng@mail.shcnc.ac.cn
Language ability	English, Chinese, Japanese
Province	Shanghai

Name

Meiyu Geng

Contact Information

mygeng@mail.shcnc.ac.cn

Language ability

English, Chinese, Japanese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1993-10 to 1997-08 Ph.D. in Pharmacy: University of Tokyo 1986-09 to 1989-07 Master's in Medicine: Shandong Medical University 1980-09 to 1986-07 Bachelor's in Medicine: Shandong Medical University
Work Experience	2014-03 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Party Secretary 2011-08 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Deputy Director 2006-06 to 2011-08 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher 1999-12 to 2006-05 - Ocean University of China - Doctoral Supervisor 1997-12 to 2006-05 - Ocean University of China - Professor 1991-12 to 1997-11 - Ocean University of China - Lecturer 1989-07 to 1991-11 - Ocean University of China - Assistant
Awards	Shanghai Women's Civilization Post, City Level, 2014 National Hundred, Thousand, and Ten Thousand Talent Project - 'Outstanding Contribution Young and Middle-aged Expert' Title, First Prize, National Level, 2013 Shanghai Leading Talent, First Prize, Provincial Level, 2011 Shanghai Excellent Discipline Leader, First Prize, Provincial Level, 2010 Preparation Technology of Marine Characteristic Oligosaccharides, First Prize, National Level, 2009

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1993-10 to 1997-08 Ph.D. in Pharmacy: University of Tokyo
1986-09 to 1989-07 Master's in Medicine: Shandong Medical University
1980-09 to 1986-07 Bachelor's in Medicine: Shandong Medical University

Work Experience

2014-03 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Party Secretary
2011-08 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Deputy Director
2006-06 to 2011-08 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher
1999-12 to 2006-05 - Ocean University of China - Doctoral Supervisor
1997-12 to 2006-05 - Ocean University of China - Professor
1991-12 to 1997-11 - Ocean University of China - Lecturer
1989-07 to 1991-11 - Ocean University of China - Assistant

Awards

Shanghai Women's Civilization Post, City Level, 2014
National Hundred, Thousand, and Ten Thousand Talent Project - 'Outstanding Contribution Young and Middle-aged Expert' Title, First Prize, National Level, 2013
Shanghai Leading Talent, First Prize, Provincial Level, 2011
Shanghai Excellent Discipline Leader, First Prize, Provincial Level, 2010
Preparation Technology of Marine Characteristic Oligosaccharides, First Prize, National Level, 2009

Areas of Focus	c-Met and ALK Inhibitors Tumor Metabolism and Its Inhibitors EMT and Tumor Metastasis Biomarkers
Publications	SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer, Ji Zhou, XuChao Zhang, Shan Xue, Mengdi Dai, Yueliang Wang, Xia Peng, Jianjiao Chen, Xinyi Wang, Yanyan Shen, Hui Qin, Bi Chen, Yu Zheng, Xiwen Gao, Zuoquan Xie, Jian Ding, Handong Jiang, YiLong Wu, Meiyu Geng, Jing Ai, 2023 Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase, Sun, Yaoliang, Zhang, Ying, Chen, Xiaoai, Yu, Aisong, Du, Wenhao, Huang, Yuting, Wu, Feifei, Yu, Lei, Li, Jiayi, Wen, Cuiyun, Yang, Hong, Shi, Qiongyu, Geng, Meiyu, Huang, Xun, Xu, Shilin, 2022 Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis, Xie, Zuoquan, Tong, Siyu, Chu, Xingkun, Feng, Teng, Geng, Meiyu, 2022 SAF-248,a novel PI3Kδ-selective inhibitor,potently suppresses the growth of diffuse large B-cell lymphoma, Zhang Xi, Duan Yuting, Wang Yi, Zhao Xingdong, Sun Yiming, Lin Dongze, Chen Yi, Wang Yuxiang, Zhou Zuwen, Liu Yanxin, Jiang Lihua, Geng Meiyu, Ding Jian, Meng Linghua, 2022 Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, Xie, Zuoquan, Wang, Zhen, Fan, Fengying, Zhou, Jinpei, Hu, Zhaoxue, Wang, Qingxia, Wang, Xiyuan, Zeng, Qingzhong, Zhang, Yan, Qiu, Jiaxuan, Zhou, Xiaoqian, Xu, Hui, Bai, Hudagula, Zhan, Zhengsheng, Ding, Jian, Zhang, Huibin, Duan, Wenhu, Yu, Xuekui, Geng, Meiyu, 2022 A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia, Xiao, Shifu, Chan, Piu, Wang, Tao, Hong, Zhen, Wang, Shuzhen, Kuang, Weihong, He, Jincai, Pan, Xiaoping, Zhou, Yuying, Ji, Yong, Wang, Luning, Cheng, Yan, Peng, Ying, Ye, Qinyong, Wang, Xiaoping, Wu, Yuncheng, Qu, Qiumin, Chen, Shengdi, Li, Shuhua, Chen, Wei, Xu, Jun, Peng, Dantao, Zhao, Zhongxin, Li, Yansheng, Zhang, Junjian, Du, Yifeng, Chen, Weixian, Fan, Dongsheng, Yan, Yong, Liu, Xiaowei, Zhang, Wei, Luo, Benyan, Wu, Wenyuan, Shen, Lu, Liu, Chunfeng, Mao, Peixian, Wang, Qiumei, Zhao, Qianhua, Guo, Qihao, Zhou, Yongtao, Li, Yi, Jiang, Lijun, Ren, Wenwei, Ouyang, Yingjun, Wang, Yan, Liu, Shuai, Jia, Jianjun, Zhang, Nan, Liu, Zhonglin, He, Raoli, Feng, Tingyi, Lu, Wenhui, Tang, Huidong, Gao, Ping, Zhang, Yingchun, Chen, Lanlan, Wang, Lei, Yin, You, Xu, Qun, Xiao, Jinsong, Cong, Lin, Cheng, Xi, Zhang, Hui, Gao, Dan, Xia, Minghua, Lian, Tenghong, Peng, Guoping, Zhang, Xu, Jiao, Bin, Hu, Hua, Chen, Xueyan, Guan, Yihui, Cui, Ruixue, Huang, Qiu, Xin, Xianliang, Chen, Hongjian, Ding, Yu, Z, 2021 Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy, Zhang, Zhuqing, Guo, Zuhao, Xu, Xiaowei, Cao, Danyan, Yang, Hong, Li, Yanlian, Shi, Qiongyu, Du, Zhiyan, Guo, Xiaobin, Wang, Xin, Chen, Danqi, Zhang, Ying, Chen, Lin, Zhou, Kaixin, Li, Jian, Geng, Meiyu, Huang, Xun, Xiong, Bing, 2021 A phase II randomized trial of sodium oligomannate in Alzheimer's dementia, Wang, Tao, Kuang, Weihong, Chen, Wei, Xu, Wenwei, Zhang, Liming, Li, Yingjie, Li, Hailin, Peng, Ying, Chen, Yangmei, Wang, Baojun, Xiao, Jinsong, Li, Honghua, Yan, Chuanzhu, Du, Yifeng, Tang, Mouni, He, Zhiyi, Chen, Haibo, Li, Wei, Lin, Hong, Shi, Shugui, Bi, Jianzhong, Zhou, Huadong, Cheng, Yan, Gao, Xiaoping, Guan, Yihui, Huang, Qiu, Chen, Kewei, Xin, Xianliang, Ding, Jian, Geng, Meiyu, Xiao, Shifu, 2020 The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors, Wang, Xinyi, Ai, Jing, Liu, Hongyan, Peng, Xia, Chen, Hui, Chen, Yi, Su, Yi, Shen, Aijun, Huang, Xun, Ding, Jian, Geng, Meiyu, 2019 CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression, Fu Xuhong, Zhang Xiong, Yang Hong, Xu Xiaowei, Hu Zonglong, Yan Juan, Zheng Xingling, Wei Rongrui, Zhang Zhuqing, Tang Shirui, Geng Meiyu, Huang Xun, 2019

Areas of Focus

c-Met and ALK Inhibitors
Tumor Metabolism and Its Inhibitors
EMT and Tumor Metastasis
Biomarkers

Publications

SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer, Ji Zhou, XuChao Zhang, Shan Xue, Mengdi Dai, Yueliang Wang, Xia Peng, Jianjiao Chen, Xinyi Wang, Yanyan Shen, Hui Qin, Bi Chen, Yu Zheng, Xiwen Gao, Zuoquan Xie, Jian Ding, Handong Jiang, YiLong Wu, Meiyu Geng, Jing Ai, 2023
Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase, Sun, Yaoliang, Zhang, Ying, Chen, Xiaoai, Yu, Aisong, Du, Wenhao, Huang, Yuting, Wu, Feifei, Yu, Lei, Li, Jiayi, Wen, Cuiyun, Yang, Hong, Shi, Qiongyu, Geng, Meiyu, Huang, Xun, Xu, Shilin, 2022
Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis, Xie, Zuoquan, Tong, Siyu, Chu, Xingkun, Feng, Teng, Geng, Meiyu, 2022
SAF-248,a novel PI3Kδ-selective inhibitor,potently suppresses the growth of diffuse large B-cell lymphoma, Zhang Xi, Duan Yuting, Wang Yi, Zhao Xingdong, Sun Yiming, Lin Dongze, Chen Yi, Wang Yuxiang, Zhou Zuwen, Liu Yanxin, Jiang Lihua, Geng Meiyu, Ding Jian, Meng Linghua, 2022
Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation, Xie, Zuoquan, Wang, Zhen, Fan, Fengying, Zhou, Jinpei, Hu, Zhaoxue, Wang, Qingxia, Wang, Xiyuan, Zeng, Qingzhong, Zhang, Yan, Qiu, Jiaxuan, Zhou, Xiaoqian, Xu, Hui, Bai, Hudagula, Zhan, Zhengsheng, Ding, Jian, Zhang, Huibin, Duan, Wenhu, Yu, Xuekui, Geng, Meiyu, 2022
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer's dementia, Xiao, Shifu, Chan, Piu, Wang, Tao, Hong, Zhen, Wang, Shuzhen, Kuang, Weihong, He, Jincai, Pan, Xiaoping, Zhou, Yuying, Ji, Yong, Wang, Luning, Cheng, Yan, Peng, Ying, Ye, Qinyong, Wang, Xiaoping, Wu, Yuncheng, Qu, Qiumin, Chen, Shengdi, Li, Shuhua, Chen, Wei, Xu, Jun, Peng, Dantao, Zhao, Zhongxin, Li, Yansheng, Zhang, Junjian, Du, Yifeng, Chen, Weixian, Fan, Dongsheng, Yan, Yong, Liu, Xiaowei, Zhang, Wei, Luo, Benyan, Wu, Wenyuan, Shen, Lu, Liu, Chunfeng, Mao, Peixian, Wang, Qiumei, Zhao, Qianhua, Guo, Qihao, Zhou, Yongtao, Li, Yi, Jiang, Lijun, Ren, Wenwei, Ouyang, Yingjun, Wang, Yan, Liu, Shuai, Jia, Jianjun, Zhang, Nan, Liu, Zhonglin, He, Raoli, Feng, Tingyi, Lu, Wenhui, Tang, Huidong, Gao, Ping, Zhang, Yingchun, Chen, Lanlan, Wang, Lei, Yin, You, Xu, Qun, Xiao, Jinsong, Cong, Lin, Cheng, Xi, Zhang, Hui, Gao, Dan, Xia, Minghua, Lian, Tenghong, Peng, Guoping, Zhang, Xu, Jiao, Bin, Hu, Hua, Chen, Xueyan, Guan, Yihui, Cui, Ruixue, Huang, Qiu, Xin, Xianliang, Chen, Hongjian, Ding, Yu, Z, 2021
Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy, Zhang, Zhuqing, Guo, Zuhao, Xu, Xiaowei, Cao, Danyan, Yang, Hong, Li, Yanlian, Shi, Qiongyu, Du, Zhiyan, Guo, Xiaobin, Wang, Xin, Chen, Danqi, Zhang, Ying, Chen, Lin, Zhou, Kaixin, Li, Jian, Geng, Meiyu, Huang, Xun, Xiong, Bing, 2021
A phase II randomized trial of sodium oligomannate in Alzheimer's dementia, Wang, Tao, Kuang, Weihong, Chen, Wei, Xu, Wenwei, Zhang, Liming, Li, Yingjie, Li, Hailin, Peng, Ying, Chen, Yangmei, Wang, Baojun, Xiao, Jinsong, Li, Honghua, Yan, Chuanzhu, Du, Yifeng, Tang, Mouni, He, Zhiyi, Chen, Haibo, Li, Wei, Lin, Hong, Shi, Shugui, Bi, Jianzhong, Zhou, Huadong, Cheng, Yan, Gao, Xiaoping, Guan, Yihui, Huang, Qiu, Chen, Kewei, Xin, Xianliang, Ding, Jian, Geng, Meiyu, Xiao, Shifu, 2020
The Secretome Engages STAT3 to Favor a Cytokine-rich Microenvironment in Mediating Acquired Resistance to FGFR Inhibitors, Wang, Xinyi, Ai, Jing, Liu, Hongyan, Peng, Xia, Chen, Hui, Chen, Yi, Su, Yi, Shen, Aijun, Huang, Xun, Ding, Jian, Geng, Meiyu, 2019
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression, Fu Xuhong, Zhang Xiong, Yang Hong, Xu Xiaowei, Hu Zonglong, Yan Juan, Zheng Xingling, Wei Rongrui, Zhang Zhuqing, Tang Shirui, Geng Meiyu, Huang Xun, 2019

C-Met Alk Inhibitors Tumor Metabolism Emt Metastasis Biomarkers Cancer Therapy

Yi Lu - Southern University of Science and Technology

Jialing Liu - Southern University of Science and Technology

Tang Yueting - Wuhan University

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