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Jiyun Chen
Life Science
Xiamen University
Fujian
Language: English, Chinese
Rna Helicases
Gene Expression
Regulation
Structural Biology
Molecular Biology
Biophysics
Protein Structure
Genomics
Biochemistry
Cell Biology
Areas of Focus
- Structural studies of RNA helicases mediated gene expression and regulation
Work Experience
- 2017-2020 - Peking University Health Science Center - Postdoctoral Fellow
- 2020-Present - Xiamen University, School of Life Sciences - Assistant Professor
Academic Background & Achievements
- 2014 - Bachelor's Degree in Basic Medical Sciences: Peking University
- 2017 - Ph.D. in Biophysics: Peking University
Publications
- NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction, Wang J, Chen J, Wu G, Zhang H, Du X, Chen S, Zhang L, Wang K, Wu X, Gao S, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y, Li J, Yun C, Cheng H, 2019
- Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase, Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH, 2016
- Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function, Liu L, Chen JY, Yang B, Wang FH, Wang YH, Yun CH, 2015
- Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045, Zhao P, Yao MY, Zhu SJ, Chen JY, Yun CH, 2018
- FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission, Shi Y, Fan S, Wang D, Huyan T, Chen J, Chen J, Su J, Li X, Wang Z, Xie S, Yun C, Li X, Tie L, 2018
- Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML), Liu F, Wang B, Wang Q, Qi Z, Chen C, Kong LL, Chen JY, Liu X, Wang A, Hu C, Wang W, Wang H, Wu F, Ruan Y, Qi S, Liu J, Zou F, Hu Z, Wang W, Wang L, Zhang S, Yun CH, Zhai Z, Liu J, Liu Q, 2016
- Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins, Liu L, Chen J, Yang B, Wang Y, 2015
- Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions, Liu L, Chen J, Yang B, Wang Y, 2015
