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Language ability	Chinese, English
Province	Shanghai

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Name

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2006-09--2011-07 Ph.D. in Cell Biology: Peking University 2001-09--2005-07 Bachelor's in Biotechnology: Northeast Forestry University Received National Outstanding Youth Science Fund Supported by the Youth Project of the National High-level Talents Program Supported by the CAS Innovation Cross Team Shanghai Outstanding Youth Academic Leader
Work Experience	2016-08 - Present - CAS Center for Excellence in Molecular Cell Science - Researcher, Group Leader, Doctoral Supervisor 2011 - 2016 - The Johns Hopkins University and Memorial Sloan Kettering Cancer Center - Postdoctoral Training in Tumor Biology
Awards	National Outstanding Youth Science Fund Youth Project of the National High-level Talents Program CAS Innovation Cross Team Shanghai Outstanding Youth Academic Leader

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2006-09--2011-07 Ph.D. in Cell Biology: Peking University
2001-09--2005-07 Bachelor's in Biotechnology: Northeast Forestry University
Received National Outstanding Youth Science Fund
Supported by the Youth Project of the National High-level Talents Program
Supported by the CAS Innovation Cross Team
Shanghai Outstanding Youth Academic Leader

Work Experience

2016-08 - Present - CAS Center for Excellence in Molecular Cell Science - Researcher, Group Leader, Doctoral Supervisor
2011 - 2016 - The Johns Hopkins University and Memorial Sloan Kettering Cancer Center - Postdoctoral Training in Tumor Biology

Awards

National Outstanding Youth Science Fund
Youth Project of the National High-level Talents Program
CAS Innovation Cross Team
Shanghai Outstanding Youth Academic Leader

Areas of Focus	Adult Stem Cells Organoids and Tissue Reconstruction Prostate Cancer Pancreatic Cancer Cell Plasticity and Tumor Drug Resistance Tumor Organoid Model Library
Publications	Engineering CpG-ASO-Pt-loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy, Wang YQ, Zhang LP, Liu Y, Tang LL, He J, Sun XQ, Younis MH, Cui DX, Xiao HH, Gao D, Kong XY, Cai WB, Song J, 2022 Hepatobiliary tumor organoids reveal HLA I neoantigen landscape and antitumoral activity of neoantigen peptide enhanced with ICIs, Wang WW#, Yuan TG#, Ma LL#, Zhu YJ#, Bao JX, Zhao XF, Zhao Y, Zong YL, Zhang YN, Yang S, Qiu XY, Shen SY, Wu R, Wu T, Wang HY, Gao D, Wang P, Chen L, 2022 Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targe, Tang FY#, Xu D#, Wang SQ#, Wong CK#, Fundichely AM, Lee CJ, Cohen S, Park J, Hill CE, Eng K, Bareja R, Han T, Liu EM, Palladino A, Di W, Gao D, Abida W, Beg S, Puca L, Meneses M, Stanchina E, Berger MF, Gopalan A, Dow L, Mosquera JM, Beltran H, Sternberg CN, Chi P, Scher HI, Sboner A, Chen Y, Ekta Khurana E, 2022 Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility to drug sensitivity networks, Shi XH#, Li YG#, Yuan QY#, Tang SJ#, Guo SW#, Zhang YH, He J, Zhang XY, Han M, Liu Z, Zhu YQ, Gao SZ, Wang H, Xu XF, Zheng KL, Jing W, Chen LN, Wang Y, Jin G, Gao D, 2022 Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2, Gu YQ#, Cao J#, Zhang XY#, Gao H#, Wang YY#, Wang J#, He J#, Jiang XY#, Zhang JL, Shen GH, Yang J, Zheng XC, Hu GW, Zhu YF, Du SJ, Zhu YK, Zhang R, Xu JQ, Zhang CC, Lan F, Qu D, Xu GL, Zhao Y, Gao D, Xie YH, Luo M, Lu ZG, 2022 Recent advances in tissue stem cells, Fu X#, He Q#, Tao Y#, Wang DM#, Wang W#, Wang YL#, Yu QC#, Zhang F#, Zhang XY#, Chen YG, Gao D, Hu P, Hui LJ, Wang XQ, Zeng YA, 2021 Loss of Hilnc prevents the development of diet-induced hepatic steatosis through IGF2BP2, Jiang YA#, Peng JY#, Song JW, Jiang M, Wang J, Ma LY, Wang YA, Zhang Z, Wu HL, Gao D, Zhao Y, 2021 Single cell transcriptome analysis uncovers intra-tumoral heterogeneity and underlying mechanisms for drug resistance in hepatobiliary tumor organoids, Zhao Y#, Li ZX#, Zhu YJ#, Fu J#, Zhao XF, Zhang YN, Wang S, Wu JM, Wang KT, Wu R, Sui CJ, Shen SY, Wu X, Wang HY, Gao D, Chen L, 2021 Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide, Li F#, Han M#, Dai PF#, Xu W#, He J#, Tao XT#, Wu Y#, Tong XY, Xia XY, Guo WX, Zhou YJ, Li YG, Zhu YQ, Zhang XY, Liu Z, Aji R, Cai X, Li YT, Qu D, Chen Y, Jiang SB, Wang Q, Ji HB, Xie YH, Sun YH, Lu L, Gao D, 2021 An embryonic diapause-like state with suppressed Myc activity enables tumor treatment persistence, Dhimolea E, de Matos Simoes R, Kansara D, Al'Khafaji A, Bouyssou J, Weng X, Sharma S, Raja J, Awate P, Shirasaki R, Tang H, Glassner BJ, Liu ZY, Gao D, Bryan J, Bender S, Roth J, Scheffer M, Jeselsohn R, Gray NS, Georgakoudi I, Vazquez F, Tsherniak A, Chen Y, Welm A, Duy C, Melnick A, Bartholdy B, Brown M, Culhane AC, Mitsiades CS, 2021 ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming, Li F#, Yuan QY#, Di W#, Xia XY#, Liu Z, Mao NH, Li L, Li CF, He J, Li YG, Guo WX, Zhang XY, Zhu YQ, Aji R, Wang SQ, Chi P, Carver B, Wang Y, Chen Y, Gao D, 2020 Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips, Guo WX#, Li L#, He J, Liu Z, Han M, Li F, Xia XY, Zhang XY, Zhu Y, Wei Y, Li YG, Aji R, Dai H, Wei H, Li CF, Chen Y, Chen LN, Gao D, 2020 Organoid technology for tissue engineering, He J, Zhang X, Xia XY, Han M, Li F, Li CF, Li YG, Gao D, 2020 Sca1+ Vascular Stem Cells Contribute to Smooth Muscle for Artery Repair and Regeneration, Tang J#, Wang HX#, Huang XZ#, Li F#, Zhu H, Li Y, He LJ, Zhang H, Pu WJ, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Zhang L, Gao D, Zhou B, 2020 Organoid technology in cancer precision medicine, Xia XY, Li F, He J, Aji R, Gao D, 2019 Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer, Ding YF#, Li N#, Dong BJ#, Guo WX, Wei H, Chen QL, Yuan HR, Han Y, Chang HW, Kan S, Wang XG, Pan Q, Wu P, Peng C, Qiu T, Li QT, Gao D, Xue W, Qin J, 2019 In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity, Zhang K#, Zhang L#,, Liu W#, Ma X, Cen J, Sun Z, Wang C, Feng S, Zhang Z, Yue L, Sun L, Zhu Z, Chen X, Feng A, Wu J, Jiang Z, Li P, Cheng X, Gao D, Peng L, Hui L, 2018 PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells, Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL, 2018 Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway, Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Andrew J. Aguirre AJ, Viswanathan SR, Tamayo P, Yang WS, Rees MG, Chen SX, Boskovic ZV, Javaid S, Huang C, Wu XY, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Daniel A. Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR & Schreiber SL, 2017 The potential of organoids in urological cancer research, Wang SQ, Gao D, Chen Y, 2017 SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling, Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA, Barbieri CE, 2017 SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer, Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL, 2017 N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer, Dardenne E#, Beltran H#, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA, Francesca Demichelis F and Rickman DS, 2016 Organoid culture systems for prostate epithelial tissue and prostate cancer tissue, Drost J#, Karthaus WR#, Gao D, Driehuis E, Sawyers CL, Chen Y and Clevers H, 2016 Alternative transcription initiation leads to expression of a novel ALK isoform in cancer, Wiesner T, Lee W, Obenauf A, Ran L,

Areas of Focus

Adult Stem Cells
Organoids and Tissue Reconstruction
Prostate Cancer
Pancreatic Cancer
Cell Plasticity and Tumor Drug Resistance
Tumor Organoid Model Library

Publications

Engineering CpG-ASO-Pt-loaded Macrophages (CAP@M) For Synergistic Chemo-/Gene-/Immuno-Therapy, Wang YQ, Zhang LP, Liu Y, Tang LL, He J, Sun XQ, Younis MH, Cui DX, Xiao HH, Gao D*, Kong XY*, Cai WB*, Song J*, 2022
Hepatobiliary tumor organoids reveal HLA I neoantigen landscape and antitumoral activity of neoantigen peptide enhanced with ICIs, Wang WW#, Yuan TG#, Ma LL#, Zhu YJ#, Bao JX, Zhao XF, Zhao Y, Zong YL, Zhang YN, Yang S, Qiu XY, Shen SY, Wu R, Wu T, Wang HY*, Gao D*, Wang P*, Chen L*, 2022
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targe, Tang FY#, Xu D#, Wang SQ#, Wong CK#, Fundichely AM, Lee CJ, Cohen S, Park J, Hill CE, Eng K, Bareja R, Han T, Liu EM, Palladino A, Di W, Gao D, Abida W, Beg S, Puca L, Meneses M, Stanchina E, Berger MF, Gopalan A, Dow L, Mosquera JM, Beltran H, Sternberg CN, Chi P, Scher HI, Sboner A, Chen Y*, Ekta Khurana E*, 2022
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility to drug sensitivity networks, Shi XH#, Li YG#, Yuan QY#, Tang SJ#, Guo SW#, Zhang YH, He J, Zhang XY, Han M, Liu Z, Zhu YQ, Gao SZ, Wang H, Xu XF, Zheng KL, Jing W, Chen LN*, Wang Y*, Jin G*, Gao D*, 2022
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2, Gu YQ#, Cao J#, Zhang XY#, Gao H#, Wang YY#, Wang J#, He J#, Jiang XY#, Zhang JL, Shen GH, Yang J, Zheng XC, Hu GW, Zhu YF, Du SJ, Zhu YK, Zhang R, Xu JQ, Zhang CC, Lan F, Qu D, Xu GL, Zhao Y*, Gao D*, Xie YH*, Luo M*, Lu ZG*, 2022
Recent advances in tissue stem cells, Fu X#, He Q#, Tao Y#, Wang DM#, Wang W#, Wang YL#, Yu QC#, Zhang F#, Zhang XY#, Chen YG*, Gao D*, Hu P*, Hui LJ*, Wang XQ*, Zeng YA*, 2021
Loss of Hilnc prevents the development of diet-induced hepatic steatosis through IGF2BP2, Jiang YA#, Peng JY#, Song JW, Jiang M, Wang J, Ma LY, Wang YA, Zhang Z, Wu HL, Gao D, Zhao Y*, 2021
Single cell transcriptome analysis uncovers intra-tumoral heterogeneity and underlying mechanisms for drug resistance in hepatobiliary tumor organoids, Zhao Y#, Li ZX#, Zhu YJ#, Fu J#, Zhao XF, Zhang YN, Wang S, Wu JM, Wang KT, Wu R, Sui CJ, Shen SY, Wu X, Wang HY*, Gao D*, Chen L*, 2021
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide, Li F#, Han M#, Dai PF#, Xu W#, He J#, Tao XT#, Wu Y#, Tong XY, Xia XY, Guo WX, Zhou YJ, Li YG, Zhu YQ, Zhang XY, Liu Z, Aji R, Cai X, Li YT, Qu D, Chen Y, Jiang SB, Wang Q, Ji HB, Xie YH*, Sun YH*, Lu L*, Gao D*, 2021
An embryonic diapause-like state with suppressed Myc activity enables tumor treatment persistence, Dhimolea E*, de Matos Simoes R, Kansara D, Al'Khafaji A, Bouyssou J, Weng X, Sharma S, Raja J, Awate P, Shirasaki R, Tang H, Glassner BJ, Liu ZY, Gao D, Bryan J, Bender S, Roth J, Scheffer M, Jeselsohn R, Gray NS, Georgakoudi I, Vazquez F, Tsherniak A, Chen Y, Welm A, Duy C, Melnick A, Bartholdy B, Brown M, Culhane AC, Mitsiades CS*, 2021
ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming, Li F#, Yuan QY#, Di W#, Xia XY#, Liu Z, Mao NH, Li L, Li CF, He J, Li YG, Guo WX, Zhang XY, Zhu YQ, Aji R, Wang SQ, Chi P, Carver B, Wang Y*, Chen Y*, Gao D*, 2020
Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips, Guo WX#, Li L#, He J, Liu Z, Han M, Li F, Xia XY, Zhang XY, Zhu Y, Wei Y, Li YG, Aji R, Dai H, Wei H, Li CF, Chen Y*, Chen LN*, Gao D*, 2020
Organoid technology for tissue engineering, He J, Zhang X, Xia XY, Han M, Li F, Li CF, Li YG, Gao D*, 2020
Sca1+ Vascular Stem Cells Contribute to Smooth Muscle for Artery Repair and Regeneration, Tang J#, Wang HX#, Huang XZ#, Li F#, Zhu H, Li Y, He LJ, Zhang H, Pu WJ, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Zhang L*, Gao D*, Zhou B*, 2020
Organoid technology in cancer precision medicine, Xia XY, Li F, He J, Aji R, Gao D*, 2019
Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer, Ding YF#, Li N#, Dong BJ#, Guo WX, Wei H, Chen QL, Yuan HR, Han Y, Chang HW, Kan S, Wang XG, Pan Q, Wu P, Peng C, Qiu T, Li QT, Gao D*, Xue W*, Qin J*, 2019
In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity, Zhang K#, Zhang L#,*, Liu W#, Ma X, Cen J, Sun Z, Wang C, Feng S, Zhang Z, Yue L, Sun L, Zhu Z, Chen X, Feng A, Wu J, Jiang Z, Li P, Cheng X, Gao D, Peng L*, Hui L*, 2018
PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells, Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL*, 2018
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway, Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Andrew J. Aguirre AJ, Viswanathan SR, Tamayo P, Yang WS, Rees MG, Chen SX, Boskovic ZV, Javaid S, Huang C, Wu XY, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Daniel A. Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR & Schreiber SL*, 2017
The potential of organoids in urological cancer research, Wang SQ, Gao D, Chen Y*, 2017
SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling, Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA*, Barbieri CE*, 2017
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer, Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL*, 2017
N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer, Dardenne E#, Beltran H#, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C, Gao D, Chen Y, Eilers M, Mosquera JM, Robinson BD, Elemento O, Rubin MA, Francesca Demichelis F and Rickman DS*, 2016
Organoid culture systems for prostate epithelial tissue and prostate cancer tissue, Drost J#, Karthaus WR#, Gao D, Driehuis E, Sawyers CL, Chen Y and Clevers H*, 2016
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer, Wiesner T, Lee W, Obenauf A, Ran L,

Stem Cells Organoids Tissue Reconstruction Prostate Cancer Pancreatic Cancer Cell Plasticity Drug Resistance Tumor Models Biotechnology Cancer Research

Xiaolei Yin - Tongji University

Yuan Baozhu - Tongji University

Chunhua Zhao - Shanghai University

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