1987 - Bachelor of Clinical Medicine, Lanzhou University Medical College
1990 - Master of Medical Genetics, Lanzhou University Medical College
1994 - PhD in Medical and Science, Peking Union Medical College & Chinese Academy of Medical Sciences, Cancer Institute
1990-1995 - Research Assistant, Lecturer at Peking Union Medical College, Chinese Academy of Medical Sciences, National Laboratory of Oncology
1995-2000 - Visiting Scholar, Postdoctoral Researcher at NIH, NCI, USA
2000-2010 - Senior Staff Scientist at CDC, NIOSH, USA
2010-2011 - Director, Professor at Capital Medical University, Century Altar Hospital Cancer Center
2011-2020 - Director, Professor at National Food and Drug Supervision and Administration, China Food and Drug Testing Institute, Cell Resource Conservation and Research Center
2020-Present - Professor, Director of Stem Cell Quality Control Center, Chief Scientist at Tongji University Affiliated Shanghai East Hospital
Research
Quality standards research for therapeutic cell products Process and pharmaceutical research for therapeutic cell products Regulatory science research for therapeutic cell products
Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells., Han X, Na T, Wu T, Yuan BZ, 2020
The DLC-1 tumor suppressor is involved in regulating immunomodulation of human mesenchymal stem cells through interacting with the Notch1 protein., Na T, Zhang KH, Yuan BZ, 2020
DLC-1 tumor suppressor regulates CD105 expression on human non-small cell lung carcinoma cells through inhibiting TGF-1 signaling., Zhang K, Na T, Ge F, Yuan BZ, 2020
Human epithelial ovarian cancer cells expressing CD105, CD44 and CD106 surface markers exhibit increased invasive capacity and drug resistance., Zhang J, Yuan BZ, Zhang H, Li HX, 2019
Report of the international conference on manufacturing and testing of pluripotent stem cells., Abbot S, Agbanyo F, Yuan BZ, Zoon K, et al., 2018
Report of the international stem cell banking initiative workshop activity: current hurdles and progress in seed-stock banking of human pluripotent stem cells., Kim JH, Kurtz A, Yuan BZ, Koo SK, Stacey GN, 2017
The hUC-MSCs cell line CCRC-1 represents a novel, safe and high-yielding HDCs for the production of human viral vaccines., Chen P, Zhang K, Na T, Wang L, Yin WD, Wang JZ, Yuan BZ, 2017
RIG-1 and IL-6 are negative-feedback regulators of STING induced by double-strand DNA., Wu X, Yang J, Na T, Zhang K, Davidoff AM, Wang Y, Yuan BZ, 2017
Points to consider in the development of seed stocks of pluripotent stem cells., Glyn Stacey, Yuan BZ, et al., 2015
Notch signaling regulates immunomodulation of human umbilical cord-derived mesenchymal stem cells through promoting IDO1 transcription., Na T, Liu J, Zhang KH, He XQ, Yuan BZ, 2015
Establishing a quality control system for stem cell-based medicinal products in China., Yuan BZ, 2015
Human diploid MRC-5 cells exhibit several critical properties of human umbilical cord-derived mesenchymal cells., Zhang KH, Na T, Wang L, Gao Q, Yin W, Wang J, Yuan BZ, 2014
The regulatory sciences for stem cell-based medicinal products., Yuan BZ, Wang JZ, 2014
Immunobiology of mesenchymal stem cells., Ma S, Xie N, Li W, Yuan BZ, Shi YF, Wang Y, 2014
TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein Cleavages., Yuan BZ, Chapman J, Ding M, Wang J, Jiang BH, Rojanasakul Y, Reynolds SH, 2013
The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers., Wang JS, Xu KY, Wu J, Luo CH, Li YC, Wu XB, Gao H, Feng GS, Yuan BZ, 2012
Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage., Yuan BZ, Chapman JC, Reynolds SH, 2009
Proteasome inhibitor MG132 induces apoptosis and inhibits invasion of human mesothelioma cells., Yuan BZ, Jefferson AM, Millecchia L, Popescu NC, Reynolds SH, 2008
Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells., Yuan BZ, Jefferson AM, Baldwin KT, Thorgeirsson SS, Popescu NC, Reynolds SH, 2007
DLC-1: a Rho GTP-activating protein and tumor suppressor., Durkin ME, Yuan BZ, Zhou X, Zimonjic DB, Lowy DR, Thorgeirsson SS, Popescu NC, 2007
DLC-1, a RhoGTPase-activating protein with tumor suppressor function, is essential for embryonic development., Durkin ME, Avner MR, Huh C-G, Yuan BZ, Thorgeirsson SS, Popescu NC, 2005
The human mineral dust-induced gene, mdig, is a novel cell growth regulating gene associated with lung cancer., Zhang YD, Lu YJ, Yuan BZ, Castranova V, Shi XL, Stauffer JL, Demers LM, Fei Chen, 2005
Recurrent gene alterations identified during the transition of DNA methylation status in human non-small cell lung carcinoma cells., Yuan BZ, Jefferson AM, Popescu NC, Reynolds SH, 2004
Expression profile of eukaryotic translation factors in human cancer tissues and cell lines., Joseph P, O’Kernick CM, Othumpangat S, Lei YX, Yuan BZ, Ong TM, 2004
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas., Yuan BZ, Jefferson AM, Baldwin KT, Thorgeirsson SS, Popescu NC, Reynolds SH, 2004
CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer., Zhang P, Wang J, Gao W, Yuan BZ, Rogers JS, Reed E, 2004
Amplification and overexpression of the EMS-1 oncogene, a possible prognostic marker, in human hepatocellular carcinoma., Yuan BZ, Zhou X, Zimonjic DB, Keck-Waggoner CL, Durkin ME, Popescu NC, 2003
DLC-1 gene inhibits human breast cancer cell growth and in vitro tumorigenicity., Yuan BZ, Zhou X, Durkin ME, Zimonjic DB, Gumundsdottir K, Eyfjord JE, Thorgeirsson SS, Popescu NC, 2003
Gene structure, tissue expression and linkage mapping of the mouse DLC-1 gene (Arhgap7)., Durkin ME, Yuan BZ, Thorgeirsson SS, Popescu NC, 2002
Profile of genetic alterations and tumorigenicity of human breast cancer cells., Zimonjic DB, Keck-Waggoner CL, Yuan BZ, Kraus MH, Popescu NC, 2000
Alteration of FHIT gene in human hepatocellular carcinoma., Yuan BZ, Keck-Waggoner CL, Zimonjic DB, Thorgeirsson SS, Popescu NC, 2000
Cloning and assignment of mouse DLC-1 gene to Chromosome 8A4-B 2, a conserved syntenic region of human Chromosome 8p21-22., Yuan BZ, Yang Y, Keck-Waggoner CL
