Professor | Jun He | Asia Growth Partners

Name	Jun He
Contact Information	he_jun@gibh.ac.cn
Language ability	English, Chinese
Province	Guangdong

Name

Jun He

Contact Information

he_jun@gibh.ac.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2008-10 to 2012-11 PhD: University of London Cancer Research Institute 2002-09 to 2006-07 Bachelor's: Tsinghua University
Work Experience	2018-11 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2016-08 to 2018-11 - UCB Pharma - Senior Researcher 2013-11 to 2016-08 - Francis Crick Institute - Postdoctoral Researcher 2012-11 to 2013-11 - University of London Cancer Research Institute - Postdoctoral Researcher
Awards	National Outstanding Self-financed Student Scholarship (2013): National Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2008-10 to 2012-11 PhD: University of London Cancer Research Institute
2002-09 to 2006-07 Bachelor's: Tsinghua University

Work Experience

2018-11 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2016-08 to 2018-11 - UCB Pharma - Senior Researcher
2013-11 to 2016-08 - Francis Crick Institute - Postdoctoral Researcher
2012-11 to 2013-11 - University of London Cancer Research Institute - Postdoctoral Researcher

Awards

National Outstanding Self-financed Student Scholarship (2013): National Level

Areas of Focus	Structure and function of key macromolecular complexes in the cell cycle and structure-based drug design Structure and function of membrane protein complexes in signal transduction and structure-based drug design In situ structural study techniques of biological macromolecular complexes in tissue cells
Publications	Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes, Jun He, 2023 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex, Jun He, 2023 Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants, Jun He, 2023 Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike, Jun He, 2022 SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope, Jun He, 2022 Diversity Among Cyanobacterial Photosystem I Oligomers, Jun He, 2022 Structure Insights Into Photosystem I Octamer From Cyanobacteria, Jun He, 2022 A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD, Jun He, 2022 Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP, Jun He, 2022 Nonstructural protein 7 and 8 complexes of SARS‐CoV‐2, Jun He, 2021 Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2, Jun He, 2020 Cdt1 stabilizes an open MCM ring for helicase loading, Jun He, 2017 Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex, Jun He, 2013 The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric alpha-Helical Rings, Jun He, 2012 Molecular Model of the Human 26S Proteasome, Jun He, 2012

Areas of Focus

Structure and function of key macromolecular complexes in the cell cycle and structure-based drug design
Structure and function of membrane protein complexes in signal transduction and structure-based drug design
In situ structural study techniques of biological macromolecular complexes in tissue cells

Publications

Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes, Jun He, 2023
Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex, Jun He, 2023
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants, Jun He, 2023
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike, Jun He, 2022
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope, Jun He, 2022
Diversity Among Cyanobacterial Photosystem I Oligomers, Jun He, 2022
Structure Insights Into Photosystem I Octamer From Cyanobacteria, Jun He, 2022
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD, Jun He, 2022
Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP, Jun He, 2022
Nonstructural protein 7 and 8 complexes of SARS‐CoV‐2, Jun He, 2021
Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2, Jun He, 2020
Cdt1 stabilizes an open MCM ring for helicase loading, Jun He, 2017
Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex, Jun He, 2013
The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric alpha-Helical Rings, Jun He, 2012
Molecular Model of the Human 26S Proteasome, Jun He, 2012

Macromolecular Complexes Cell Cycle Structure-Based Drug Design Membrane Protein Complexes Signal Transduction In Situ Structural Study Biological Macromolecules Tissue Cells Chromatin Epigenetic Regulation

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