Professor | Ji-Yan Ma | Asia Growth Partners

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Name	Ji-Yan Ma
Contact Information	{'en': 'majiyan(at)cibr.ac.cn', 'zh': 'majiyan(at)cibr.ac.cn', 'de': 'majiyan(at)cibr.ac.cn'}
Language ability	English, Chinese
Province	Beijing

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Name

Ji-Yan Ma

Contact Information

{'en': 'majiyan(at)cibr.ac.cn', 'zh': 'majiyan(at)cibr.ac.cn', 'de': 'majiyan(at)cibr.ac.cn'}

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Chinese Institute for Brain Research, Beijing
Faculty	Brain Science and Anthropology
Academic Background & Achievements	Ph.D.: University of Illinois at Chicago, Biochemistry and Molecular Biology Master's Degree: Shanghai Medical University (now Fudan University Shanghai Medical College), Medicine Bachelor's Degree: Shanghai Medical University (now Fudan University Shanghai Medical College), Medicine
Work Experience	Current - Beijing Institute for Brain Science and Brain-like Research - Senior Researcher Previous - Van Andel Institute, USA - Professor Previous - Ohio State University, USA - Tenured Associate Professor Previous - Ohio State University, USA - Assistant Professor Previous - University of Chicago/Howard Hughes Medical Institute, USA - Postdoctoral Researcher
Awards	Graduate School Fellowship: University of Illinois at Chicago Young Scientist Award: Swiss International Conference on Protein Translocation, Glycosylation and Health Young Scholar Award: Ellison Medical Foundation Outstanding Teaching Award: Ohio State University College of Medicine

University/Lab Affiliation and Title

Chinese Institute for Brain Research, Beijing

Faculty

Brain Science and Anthropology

Academic Background & Achievements

Ph.D.: University of Illinois at Chicago, Biochemistry and Molecular Biology
Master's Degree: Shanghai Medical University (now Fudan University Shanghai Medical College), Medicine
Bachelor's Degree: Shanghai Medical University (now Fudan University Shanghai Medical College), Medicine

Work Experience

Current - Beijing Institute for Brain Science and Brain-like Research - Senior Researcher
Previous - Van Andel Institute, USA - Professor
Previous - Ohio State University, USA - Tenured Associate Professor
Previous - Ohio State University, USA - Assistant Professor
Previous - University of Chicago/Howard Hughes Medical Institute, USA - Postdoctoral Researcher

Awards

Graduate School Fellowship: University of Illinois at Chicago
Young Scientist Award: Swiss International Conference on Protein Translocation, Glycosylation and Health
Young Scholar Award: Ellison Medical Foundation
Outstanding Teaching Award: Ohio State University College of Medicine

Areas of Focus	Protein Misfolding and Neurodegenerative Diseases α-Synuclein and Neurodegenerative Diseases Prion Protein and Transmissible Spongiform Encephalopathies
Publications	Immunotherapy against prion disease, Ma Y and Ma J, 2020 Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity, Wang F, Wang X, Orrú C.D., Groveman B. R., Surewicz K., Abskharon R., Imamura M., Yokoyama T., Kim Y.S., Vander Stel K.J., Sinniah K., Priola S.A., Surewicz W.K., Caughey B., Ma J, 2017 Intraperitoneal infection of wild-type mice with synthetically generated mammalian prion, Wang X, McGovern G, Zhang Y, Wang F, Zha L, Jeffrey M, Ma J, 2015 The role of cofactors in prion propagation and infectivity, Ma J, 2012 Generating a prion with bacterially expressed recombinant prion protein, Wang, F., Wang, X., Yuan, C., Ma, J, 2010 Lipid interaction converts prion protein to a PrPSc-like proteinase K resistant conformation under physiological conditions, Wang, F., Yang, F., Hu, Y., Wang, X., Wang, X., Jin, C., Ma, J, 2007 Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol, Ma, J., Wollmann, R., Lindquist, S, 2002 Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol, Ma, J. and Lindquist, S, 2002 Wild-type and mutant PrP accumulate in the cytoplasm upon proteasome inhibition, Ma, J. and Lindquist, S, 2001 De novo generation of a PrPSc-like conformation in living cells, Ma. J. and Lindquist, S, 1999 Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy Bodies, Bargar C, Wang W, Gunzler SA, LeFevre A, Wang Z, Lerner AJ, Singh N, Tatsuoka C, Appleby B, Zhu X, Xu R, Haroutunian V, Zou W, Ma J, Chen SG, 2021 Skin α-synuclein aggregation seeding activity as a novel biomarker for Parkinson’s disease, Wang Z, Becker K, Donadio V, Siedlak S, Yuan J, Rezaee M, Incensi A, Kuzkina A, Orrú CD, Tatsuoka C, Liguori R, Gunzler SA, Caughey B, Jimenez-Capdeville ME, Zhu X, Doppler K, Cui L, Chen SG, Ma J, Zou W, 2020 Modeling α-synucleinopathy in organotypic brain slice culture with preformed α-synuclein amyloid fibrils, Roux A, Wang X, Becker K, Ma J, 2020 Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective, Marshall LL, Killinger BA, Ensink E, Li P, Li KX, Cui W, Lubben N, Weiland M, Wang X, Gordevicius J, Goetzee GA, Ma J, Jovinge S, Labrie V, 2020 Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration, Wang X, Becker K, Levine N, Zhang M, Lieberman AP, Moore DJ, Ma J, 2019 Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration, Chen X, Kordich JK, Williams ET, Levine N, Cole-Strauss A, Marshall L, Labrie V, Ma J, Lipton JW, Moore DJ, 2019 Metabolomic profiling of bile acids in an experimental model of prodromal Parkinson’s disease, Graham SF, Rey NL, Ugur Z, Yilmaz A, Sherman E, Maddens M, Bahado-Singh RO, Becker K, Schulz E, Meyerdirk LK, Steiner JA, Ma J, Brundin P, 2018 14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic alpha-synuclein, Wang B, Underwood R, Kamath A, Britain C, McFerrin MB, McLean PJ, Volpicelli-Daley LA, Whitaker RH, Placzek WJ, Becker K, Ma J, Yacoubian TA, 2018 Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinson’s disease reveal distinct metabolic profiles, Graham SF, Rey NL, Yilmaz A, Kumar P, Madaj Z, Maddens M, Bahado-Singh RO, Becker K, Schulz E, Meyerdirk LK, Steiner JA, Ma J, Brundin P, 2018 Detecting alpha synuclein seeding activity in formaldehyde-fixed MSA patient tissue by PMCA, Becker K, Wang X, Vander Stel K, Chu Y, Kordower J, Ma J, 2018

Areas of Focus

Protein Misfolding and Neurodegenerative Diseases
α-Synuclein and Neurodegenerative Diseases
Prion Protein and Transmissible Spongiform Encephalopathies

Publications

Immunotherapy against prion disease, Ma Y and Ma J, 2020
Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity, Wang F, Wang X, Orrú C.D., Groveman B. R., Surewicz K., Abskharon R., Imamura M., Yokoyama T., Kim Y.S., Vander Stel K.J., Sinniah K., Priola S.A., Surewicz W.K., Caughey B., Ma J, 2017
Intraperitoneal infection of wild-type mice with synthetically generated mammalian prion, Wang X, McGovern G, Zhang Y, Wang F, Zha L, Jeffrey M, Ma J, 2015
The role of cofactors in prion propagation and infectivity, Ma J, 2012
Generating a prion with bacterially expressed recombinant prion protein, Wang, F.*, Wang, X.*, Yuan, C., Ma, J, 2010
Lipid interaction converts prion protein to a PrPSc-like proteinase K resistant conformation under physiological conditions, Wang, F., Yang, F., Hu, Y., Wang, X., Wang, X., Jin, C., Ma, J, 2007
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol, Ma, J., Wollmann, R., Lindquist, S, 2002
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol, Ma, J. and Lindquist, S, 2002
Wild-type and mutant PrP accumulate in the cytoplasm upon proteasome inhibition, Ma, J. and Lindquist, S, 2001
De novo generation of a PrPSc-like conformation in living cells, Ma. J. and Lindquist, S, 1999
Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy Bodies, Bargar C, Wang W, Gunzler SA, LeFevre A, Wang Z, Lerner AJ, Singh N, Tatsuoka C, Appleby B, Zhu X, Xu R, Haroutunian V, Zou W*, Ma J*, Chen SG*, 2021
Skin α-synuclein aggregation seeding activity as a novel biomarker for Parkinson’s disease, Wang Z, Becker K, Donadio V, Siedlak S, Yuan J, Rezaee M, Incensi A, Kuzkina A, Orrú CD, Tatsuoka C, Liguori R, Gunzler SA, Caughey B, Jimenez-Capdeville ME, Zhu X, Doppler K, Cui L, Chen SG*, Ma J*, Zou W*, 2020
Modeling α-synucleinopathy in organotypic brain slice culture with preformed α-synuclein amyloid fibrils, Roux A, Wang X, Becker K, Ma J, 2020
Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective, Marshall LL, Killinger BA, Ensink E, Li P, Li KX, Cui W, Lubben N, Weiland M, Wang X, Gordevicius J, Goetzee GA, Ma J, Jovinge S, Labrie V, 2020
Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration, Wang X, Becker K, Levine N, Zhang M, Lieberman AP, Moore DJ, Ma J, 2019
Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration, Chen X, Kordich JK, Williams ET, Levine N, Cole-Strauss A, Marshall L, Labrie V, Ma J, Lipton JW, Moore DJ, 2019
Metabolomic profiling of bile acids in an experimental model of prodromal Parkinson’s disease, Graham SF, Rey NL, Ugur Z, Yilmaz A, Sherman E, Maddens M, Bahado-Singh RO, Becker K, Schulz E, Meyerdirk LK, Steiner JA, Ma J, Brundin P, 2018
14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic alpha-synuclein, Wang B, Underwood R, Kamath A, Britain C, McFerrin MB, McLean PJ, Volpicelli-Daley LA, Whitaker RH, Placzek WJ, Becker K, Ma J, Yacoubian TA, 2018
Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinson’s disease reveal distinct metabolic profiles, Graham SF, Rey NL, Yilmaz A, Kumar P, Madaj Z, Maddens M, Bahado-Singh RO, Becker K, Schulz E, Meyerdirk LK, Steiner JA, Ma J, Brundin P, 2018
Detecting alpha synuclein seeding activity in formaldehyde-fixed MSA patient tissue by PMCA, Becker K, Wang X, Vander Stel K, Chu Y, Kordower J, Ma J, 2018

Protein Misfolding Neurodegeneration Alzheimer'S Disease Parkinson'S Disease Α-Synuclein Prion Transmissible Spongiform Encephalopathies Neurotoxicity Molecular Biology Biomarkers

Yang Shi - Chinese Institute for Brain Research, Beijing

Guang Chen - Chinese Institute for Brain Research, Beijing

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