Professor | Yang Shi | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Yang Shi
Contact Information	{'en': 'shiyang(at)cibr.ac.cn', 'zh': 'shiyang(at)cibr.ac.cn', 'de': 'shiyang(at)cibr.ac.cn'}
Language ability	English, Chinese
Province	Beijing

Upload Avatar (500 x 500)

Name

Yang Shi

Contact Information

{'en': 'shiyang(at)cibr.ac.cn', 'zh': 'shiyang(at)cibr.ac.cn', 'de': 'shiyang(at)cibr.ac.cn'}

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Chinese Institute for Brain Research, Beijing
Faculty	Brain Science and Anthropology
Academic Background & Achievements	2012-2018 Ph.D. in Neuroscience: Washington University in St. Louis 2007-2011 Bachelor's in Biological Sciences: China Agricultural University
Work Experience	2022-present - Beijing Institute for Brain Sciences and Brain-like Research - Researcher 2019.1-2022.6 - Washington University in St. Louis - Postdoctoral Researcher
Awards	2021: Rainwater Foundation Tau Leadership Award 2020: Marian Kies Award of American Society for Neurochemistry 2019: Tom Thach Award, Washington University in St. Louis 2019: The 144th Annual Meeting of the American Neurological Association Travel Award 2018: David M. Kipnis Award in Biomedical Sciences, Washington University in St. Louis 2017: Rainwater Foundation Tau consortium fellowship

University/Lab Affiliation and Title

Chinese Institute for Brain Research, Beijing

Faculty

Brain Science and Anthropology

Academic Background & Achievements

2012-2018 Ph.D. in Neuroscience: Washington University in St. Louis
2007-2011 Bachelor's in Biological Sciences: China Agricultural University

Work Experience

2022-present - Beijing Institute for Brain Sciences and Brain-like Research - Researcher
2019.1-2022.6 - Washington University in St. Louis - Postdoctoral Researcher

Awards

2021: Rainwater Foundation Tau Leadership Award
2020: Marian Kies Award of American Society for Neurochemistry
2019: Tom Thach Award, Washington University in St. Louis
2019: The 144th Annual Meeting of the American Neurological Association Travel Award
2018: David M. Kipnis Award in Biomedical Sciences, Washington University in St. Louis
2017: Rainwater Foundation Tau consortium fellowship

Areas of Focus	APOE's immune regulatory mechanism Impact of peripheral immune system on AD pathology and neurodegeneration Therapeutic strategies targeting microglia and peripheral immune system Neuro-immune interactions
Publications	Cholesterol and matrisome pathways dysregulated in APOE ε4 human microglia and astrocytes., TCW, J., Qian, L., Pipalia, N., Chao, M., Liang, S., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., Goate, A. M., 2022 Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms., Shi, Y., Andhey, P.S., Ising, C., Wang K., Snipes, L.L., Boyer, K., Lawson. S., Yamada, K., Qin, W., Manis, M., Remolina J., Benitez, B.A., Schmidt, R.E., Artyomov, M., Ulrich, J., Holtzman, D.M., 2021 Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia., Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P.S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J., Holtzman, D.M., 2021 ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model., Litvinchuk, A., Huynh, T., Shi, Y., Jackson, R., Finn, M.B., Manis, M., Francis, C.M., Tran, A., Sullivan, P/M., Ulrich, J., Hyman, B.T., Cole, T., Holtzman, D.M., 2021 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner., Wong, M., Lewis, M., Doherty, J. J., Shi, Y, Sullivan, P. M., Covey, D. F., Petsko1, G. A., Holtzman, D. M., Paul, S. M., Luo, W., 2020 Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model., Shi, Y., Manis, M., Long, J., Wang, K., Remolina, J., Hoyle, R., Holtzman, D. M., 2019 Interplay between innate immunity and Alzheimer’s disease: APOE and TREM2 in the spotlight., Shi, Y & Holtzman, D. M., 2018 ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy., Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., Rojas, J. C., Gallardo, G., Wang, K., Roh, J., Robinson, G., Finn, M. B., Jiang H., Sullivan, P. M., Baufeld, C., Wood, M. W., Sutphen, C., McCue, L., Xiong, C., Del-Aguila, J. L., Morris, J. C., Cruchaga, C., Fagan, A. M., Miller, B. L., Boxer, A. L., Seeley, W. W., Butovsky, O., Barres, B. A., Paul, S. M., Holtzman, D. M., 2017 TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques., Wang, Y., Ulland, T., Ulrich, J., Song, E., Tzaferis, J., Hole, J., Yuan, P., Mahan, T., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R., Cirrito, J., Holtzman, D., Colonna, M., 2016 Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice., Jia, S., Liu, Y., Shi, Y., Ma, Y., Hu, Y., Wang M., Li, X., 2016 Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation., Achariyar, T., Li, B., Peng, W., Verghese, P., Shi, Y., McConnell, E., Benraiss, A., Kasper, T., Song, W., Takano, T., Holtzman, D., Nedergaard, M., Deane, R., 2016 An in vitro assay to study induction of the regenerative state in sensory neurons., Frey, E., Valakh, V., Karney-Grobe, S., Shi, Y., Milbrandt, J., DiAntonio, A., 2015

Areas of Focus

APOE's immune regulatory mechanism
Impact of peripheral immune system on AD pathology and neurodegeneration
Therapeutic strategies targeting microglia and peripheral immune system
Neuro-immune interactions

Publications

Cholesterol and matrisome pathways dysregulated in APOE ε4 human microglia and astrocytes., TCW, J., Qian, L., Pipalia, N., Chao, M., Liang, S., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., Goate, A. M., 2022
Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms., Shi, Y., Andhey, P.S., Ising, C., Wang K., Snipes, L.L., Boyer, K., Lawson. S., Yamada, K., Qin, W., Manis, M., Remolina J., Benitez, B.A., Schmidt, R.E., Artyomov, M., Ulrich, J., Holtzman, D.M., 2021
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia., Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P.S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J., Holtzman, D.M., 2021
ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model., Litvinchuk, A., Huynh, T., Shi, Y., Jackson, R., Finn, M.B., Manis, M., Francis, C.M., Tran, A., Sullivan, P/M., Ulrich, J., Hyman, B.T., Cole, T., Holtzman, D.M., 2021
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner., Wong, M., Lewis, M., Doherty, J. J., Shi, Y, Sullivan, P. M., Covey, D. F., Petsko1, G. A., Holtzman, D. M., Paul, S. M., Luo, W., 2020
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model., Shi, Y., Manis, M., Long, J., Wang, K., Remolina, J., Hoyle, R., Holtzman, D. M., 2019
Interplay between innate immunity and Alzheimer’s disease: APOE and TREM2 in the spotlight., Shi, Y & Holtzman, D. M., 2018
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy., Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., Rojas, J. C., Gallardo, G., Wang, K., Roh, J., Robinson, G., Finn, M. B., Jiang H., Sullivan, P. M., Baufeld, C., Wood, M. W., Sutphen, C., McCue, L., Xiong, C., Del-Aguila, J. L., Morris, J. C., Cruchaga, C., Fagan, A. M., Miller, B. L., Boxer, A. L., Seeley, W. W., Butovsky, O., Barres, B. A., Paul, S. M., Holtzman, D. M., 2017
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques., Wang, Y., Ulland, T., Ulrich, J., Song, E., Tzaferis, J., Hole, J., Yuan, P., Mahan, T., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R., Cirrito, J., Holtzman, D., Colonna, M., 2016
Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice., Jia, S., Liu, Y., Shi, Y., Ma, Y., Hu, Y., Wang M., Li, X., 2016
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation., Achariyar, T., Li, B., Peng, W., Verghese, P., Shi, Y., McConnell, E., Benraiss, A., Kasper, T., Song, W., Takano, T., Holtzman, D., Nedergaard, M., Deane, R., 2016
An in vitro assay to study induction of the regenerative state in sensory neurons., Frey, E., Valakh, V., Karney-Grobe, S., Shi, Y., Milbrandt, J., DiAntonio, A., 2015

Apoe Immune Regulation Peripheral Immune System Ad Pathology Neurodegeneration Microglia Therapeutic Strategies Neuro-Immune Interactions Alzheimer'S Disease Tau Protein

Ji-Yan Ma - Chinese Institute for Brain Research, Beijing

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us