Professor | 石杨 | 数字化转型顾问

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Name	石杨
Contact Information	{'en': 'shiyang(at)cibr.ac.cn', 'zh': 'shiyang(at)cibr.ac.cn', 'de': 'shiyang(at)cibr.ac.cn'}
Language ability	英语, 中文
Province	北京

Upload Avatar (500 x 500)

Name

石杨

Contact Information

{'en': 'shiyang(at)cibr.ac.cn', 'zh': 'shiyang(at)cibr.ac.cn', 'de': 'shiyang(at)cibr.ac.cn'}

Language ability

英语, 中文

Province

北京

University/Lab Affiliation and Title	北京脑科学与类脑研究所
Faculty	Brain Science and Anthropology
Academic Background & Achievements	2012-2018 神经科学博士: 美国华盛顿圣路易斯大学 2007-2011 生物科学学士: 中国农业大学
Work Experience	2022至今 - 北京脑科学与类脑研究所 - 研究员 2019.1-2022.6 - 美国华盛顿圣路易斯大学 - 博士后
Awards	2021: 美国 Rainwater 基金会tau研究领导力奖 2020: 美国神经化学学会Marian Kies 奖 2019: 华盛顿圣路易斯大学神经系Tom Thach 奖 2019: 第144届美国神经疾病学协会会议旅行奖 2018: 华盛顿圣路易斯大学生物医学研究奖 2017: 美国 Rainwater 基金会Tau研究协会奖学金

University/Lab Affiliation and Title

北京脑科学与类脑研究所

Faculty

Brain Science and Anthropology

Academic Background & Achievements

2012-2018 神经科学博士: 美国华盛顿圣路易斯大学
2007-2011 生物科学学士: 中国农业大学

Work Experience

2022至今 - 北京脑科学与类脑研究所 - 研究员
2019.1-2022.6 - 美国华盛顿圣路易斯大学 - 博士后

Awards

2021: 美国 Rainwater 基金会tau研究领导力奖
2020: 美国神经化学学会Marian Kies 奖
2019: 华盛顿圣路易斯大学神经系Tom Thach 奖
2019: 第144届美国神经疾病学协会会议旅行奖
2018: 华盛顿圣路易斯大学生物医学研究奖
2017: 美国 Rainwater 基金会Tau研究协会奖学金

Areas of Focus	APOE的免疫调控机制周围免疫系统对AD病理与神经退行的影响靶向小胶质细胞及周围免疫系统的治疗方案神经免疫互作
Publications	Cholesterol and matrisome pathways dysregulated in APOE ε4 human microglia and astrocytes., TCW, J., Qian, L., Pipalia, N., Chao, M., Liang, S., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., Goate, A. M., 2022 Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms., Shi, Y., Andhey, P.S., Ising, C., Wang K., Snipes, L.L., Boyer, K., Lawson. S., Yamada, K., Qin, W., Manis, M., Remolina J., Benitez, B.A., Schmidt, R.E., Artyomov, M., Ulrich, J., Holtzman, D.M., 2021 Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia., Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P.S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J., Holtzman, D.M., 2021 ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model., Litvinchuk, A., Huynh, T., Shi, Y., Jackson, R., Finn, M.B., Manis, M., Francis, C.M., Tran, A., Sullivan, P/M., Ulrich, J., Hyman, B.T., Cole, T., Holtzman, D.M., 2021 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner., Wong, M., Lewis, M., Doherty, J. J., Shi, Y, Sullivan, P. M., Covey, D. F., Petsko1, G. A., Holtzman, D. M., Paul, S. M., Luo, W., 2020 Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model., Shi, Y., Manis, M., Long, J., Wang, K., Remolina, J., Hoyle, R., Holtzman, D. M., 2019 Interplay between innate immunity and Alzheimer’s disease: APOE and TREM2 in the spotlight., Shi, Y & Holtzman, D. M., 2018 ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy., Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., Rojas, J. C., Gallardo, G., Wang, K., Roh, J., Robinson, G., Finn, M. B., Jiang H., Sullivan, P. M., Baufeld, C., Wood, M. W., Sutphen, C., McCue, L., Xiong, C., Del-Aguila, J. L., Morris, J. C., Cruchaga, C., Fagan, A. M., Miller, B. L., Boxer, A. L., Seeley, W. W., Butovsky, O., Barres, B. A., Paul, S. M., Holtzman, D. M., 2017 TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques., Wang, Y., Ulland, T., Ulrich, J., Song, E., Tzaferis, J., Hole, J., Yuan, P., Mahan, T., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R., Cirrito, J., Holtzman, D., Colonna, M., 2016 Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice., Jia, S., Liu, Y., Shi, Y., Ma, Y., Hu, Y., Wang M., Li, X., 2016 Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation., Achariyar, T., Li, B., Peng, W., Verghese, P., Shi, Y., McConnell, E., Benraiss, A., Kasper, T., Song, W., Takano, T., Holtzman, D., Nedergaard, M., Deane, R., 2016 An in vitro assay to study induction of the regenerative state in sensory neurons., Frey, E., Valakh, V., Karney-Grobe, S., Shi, Y., Milbrandt, J., DiAntonio, A., 2015

Areas of Focus

APOE的免疫调控机制
周围免疫系统对AD病理与神经退行的影响
靶向小胶质细胞及周围免疫系统的治疗方案
神经免疫互作

Publications

Cholesterol and matrisome pathways dysregulated in APOE ε4 human microglia and astrocytes., TCW, J., Qian, L., Pipalia, N., Chao, M., Liang, S., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., Sikora, E., Andrews, E. J., Martini, A. C., Karch, C. M., Head, E., Holtzman, D. M., Zhang, B., Wang, M., Maxfield, F. R., Poon, W. W., Goate, A. M., 2022
Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms., Shi, Y., Andhey, P.S., Ising, C., Wang K., Snipes, L.L., Boyer, K., Lawson. S., Yamada, K., Qin, W., Manis, M., Remolina J., Benitez, B.A., Schmidt, R.E., Artyomov, M., Ulrich, J., Holtzman, D.M., 2021
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia., Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P.S., Manis, M., Schroeder, C., Yin, Z., Madore, C., Butovsky, O., Artyomov, M., Ulrich, J., Holtzman, D.M., 2021
ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model., Litvinchuk, A., Huynh, T., Shi, Y., Jackson, R., Finn, M.B., Manis, M., Francis, C.M., Tran, A., Sullivan, P/M., Ulrich, J., Hyman, B.T., Cole, T., Holtzman, D.M., 2021
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner., Wong, M., Lewis, M., Doherty, J. J., Shi, Y, Sullivan, P. M., Covey, D. F., Petsko1, G. A., Holtzman, D. M., Paul, S. M., Luo, W., 2020
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model., Shi, Y., Manis, M., Long, J., Wang, K., Remolina, J., Hoyle, R., Holtzman, D. M., 2019
Interplay between innate immunity and Alzheimer’s disease: APOE and TREM2 in the spotlight., Shi, Y & Holtzman, D. M., 2018
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy., Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., Rojas, J. C., Gallardo, G., Wang, K., Roh, J., Robinson, G., Finn, M. B., Jiang H., Sullivan, P. M., Baufeld, C., Wood, M. W., Sutphen, C., McCue, L., Xiong, C., Del-Aguila, J. L., Morris, J. C., Cruchaga, C., Fagan, A. M., Miller, B. L., Boxer, A. L., Seeley, W. W., Butovsky, O., Barres, B. A., Paul, S. M., Holtzman, D. M., 2017
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques., Wang, Y., Ulland, T., Ulrich, J., Song, E., Tzaferis, J., Hole, J., Yuan, P., Mahan, T., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R., Cirrito, J., Holtzman, D., Colonna, M., 2016
Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice., Jia, S., Liu, Y., Shi, Y., Ma, Y., Hu, Y., Wang M., Li, X., 2016
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation., Achariyar, T., Li, B., Peng, W., Verghese, P., Shi, Y., McConnell, E., Benraiss, A., Kasper, T., Song, W., Takano, T., Holtzman, D., Nedergaard, M., Deane, R., 2016
An in vitro assay to study induction of the regenerative state in sensory neurons., Frey, E., Valakh, V., Karney-Grobe, S., Shi, Y., Milbrandt, J., DiAntonio, A., 2015

Apoe 免疫调控周围免疫系统 Ad病理神经退行小胶质细胞治疗策略神经免疫互作阿尔兹海默症 Tau蛋白

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