Professor | Guo Ao | Asia Growth Partners

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Name	Guo Ao
Contact Information	guoao@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Guo Ao

Contact Information

guoao@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	2010 - Bachelor's Degree: University of Science and Technology of China 2017 - PhD: University of Science and Technology of China Postdoctoral Research: St. Jude Children's Research Hospital under Douglas R. Green
Work Experience	2023 - Present: University of Science and Technology of China, Department of Life Sciences and Medicine

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

2010 - Bachelor's Degree: University of Science and Technology of China
2017 - PhD: University of Science and Technology of China
Postdoctoral Research: St. Jude Children's Research Hospital under Douglas R. Green

Work Experience

2023 - Present: University of Science and Technology of China, Department of Life Sciences and Medicine

Areas of Focus	Asymmetric division of CD8 T cells and memory T cell formation Epigenetic and molecular mechanisms of T cell fate decisions such as aging and exhaustion Interactions between T cells and other cells in tumor and infection environments and their impact on T cell fate In vitro differentiation of stem cells into T cells and optimization of related CAR-T immunotherapies
Publications	cBAF complex components and MYC cooperate early in CD8+ T cell fate, Guo A, Huang H, Zhu Z, Chen M, Shi H, Sharma P, Liedmann S, Haydar D, Yang M, Beere H, Krenciute G, Roberts C.W.M, Chi H, and Green D.R., 2022 Mitotic bookmarking by SWI/SNF subunits, Zhu Z, Chen X, Guo A, Manzano T, Walsh P, Wills K, Halliburton R, Radko-Juettner S, Carter R, Partridge J, Green D.R., Zhang J, Roberts C.W.M., 2023 Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate, Liedmann S, Liu X, Guy C, Crawford JC, Rodrigues D.A., Kuzuoglu-Ozturk D, Guo A, Verbist K.C., Temirov J, Chen M.J., Ruggero D, Zhang H, Thomas P.G., Green D.R., 2022 NF-κB directly regulates β-arrestin-1 expression and forms a negative feedback circuit in TNF-α-induced cell death, Li J, Guo A, Wang Q, Li Y, Zhao J, Lu J, Pei G., 2018 Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization, Guo A, Huang S, Yu J, Wang H, Li H, Pei G, Shen L., 2017 Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation, Li H, Guo A, Xie Z, Tu W, Yu J, Wang H, Zhao J, Zhong C, Kang J, Li J, Huang S, Shen L., 2017 Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells, Xu H, Yue C, Zhang T, Li Y, Guo A, Liao J, Pei G, Li J, Jing N., 2017 Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents, Guo A, He D, Xu H, Geng C, Zhao J., 2015 Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation, Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G., 2013 Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells, Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G., 2011

Areas of Focus

Asymmetric division of CD8 T cells and memory T cell formation
Epigenetic and molecular mechanisms of T cell fate decisions such as aging and exhaustion
Interactions between T cells and other cells in tumor and infection environments and their impact on T cell fate
In vitro differentiation of stem cells into T cells and optimization of related CAR-T immunotherapies

Publications

cBAF complex components and MYC cooperate early in CD8+ T cell fate, Guo A, Huang H, Zhu Z, Chen M, Shi H, Sharma P, Liedmann S, Haydar D, Yang M, Beere H, Krenciute G, Roberts C.W.M, Chi H, and Green D.R., 2022
Mitotic bookmarking by SWI/SNF subunits, Zhu Z, Chen X, Guo A, Manzano T, Walsh P, Wills K, Halliburton R, Radko-Juettner S, Carter R, Partridge J, Green D.R., Zhang J, Roberts C.W.M., 2023
Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate, Liedmann S, Liu X, Guy C, Crawford JC, Rodrigues D.A., Kuzuoglu-Ozturk D, Guo A, Verbist K.C., Temirov J, Chen M.J., Ruggero D, Zhang H, Thomas P.G., Green D.R., 2022
NF-κB directly regulates β-arrestin-1 expression and forms a negative feedback circuit in TNF-α-induced cell death, Li J*, Guo A*, Wang Q, Li Y, Zhao J, Lu J, Pei G., 2018
Single-Cell Dynamic Analysis of Mitosis in Haploid Embryonic Stem Cells Shows the Prolonged Metaphase and Its Association with Self-diploidization, Guo A, Huang S, Yu J, Wang H, Li H, Pei G, Shen L., 2017
Stabilization of mouse haploid embryonic stem cells with combined kinase and signal modulation, Li H*, Guo A*, Xie Z, Tu W, Yu J, Wang H, Zhao J, Zhong C, Kang J, Li J, Huang S, Shen L., 2017
Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells, Xu H, Yue C, Zhang T, Li Y, Guo A, Liao J, Pei G, Li J, Jing N., 2017
Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents, Guo A, He D, Xu H, Geng C, Zhao J., 2015
Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation, Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G., 2013
Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells, Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G., 2011

Cd8 T Cells Asymmetric Division Memory T Cells Epigenetics Molecular Mechanisms T Cell Aging T Cell Exhaustion Tumor Environment Infection Environment Car-T Therapy

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