Professor | Genze Shao | Asia Growth Partners

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Name	Genze Shao
Contact Information	gzshao@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Genze Shao

Contact Information

gzshao@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2000-2003: PhD in Cell Biology, Peking University 1993-1996: Master's in Tumor Biochemistry, Shantou University Medical College 1986-1990: Bachelor's in Biology, East China Normal University
Work Experience	2010-present: Professor, Department of Cell Biology, Peking University 2006-2010: Postdoctoral Fellow, University of Pennsylvania School of Medicine 2004-2006: Postdoctoral Fellow, Columbia University Radiation Research Center 1996-2000: Assistant Lecturer, Lecturer, Shantou University Medical College 1990-1993: Assistant Lecturer, Jiangxi Normal University
Awards	2015: Outstanding Doctoral Dissertation Advisor, Peking University

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2000-2003: PhD in Cell Biology, Peking University
1993-1996: Master's in Tumor Biochemistry, Shantou University Medical College
1986-1990: Bachelor's in Biology, East China Normal University

Work Experience

2010-present: Professor, Department of Cell Biology, Peking University
2006-2010: Postdoctoral Fellow, University of Pennsylvania School of Medicine
2004-2006: Postdoctoral Fellow, Columbia University Radiation Research Center
1996-2000: Assistant Lecturer, Lecturer, Shantou University Medical College
1990-1993: Assistant Lecturer, Jiangxi Normal University

Awards

2015: Outstanding Doctoral Dissertation Advisor, Peking University

Areas of Focus	BRCA1 tumor suppressor network Mechanisms of breast cancer metastasis Tumor biomarker discovery and application K63-linked protein ubiquitination and cell mitosis
Publications	RNF8 promotes epithelial-mesenchymal transition of breast cancer cells, Kuang J, Li L, Guo L, Su Y, Wang Y, Xu Y, Wang X, Meng S, Lei L, Xu L, Shao G, 2016 The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells, Yan K, Li L, Wang X, Hong R, Zhang Y, Yang H, Lin M, Zhang S, He Q, Zheng D, Tang J, Yin Y, Shao G, 2015 DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation, Yi J, Lu G, Li L, Wang X, Cao L, Lin M, Zhang S, Shao G, 2015 K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks, Zhu B, Yan K, Li L, Lin M, Zhang S, He Q, Zheng D, Yang H, Shao G, 2015 HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway, Wang X, Lu G, Li L, Yi J, Yan K, Wang Y, Zhu B, Kuang J, Lin M, Zhang S, Shao G, 2014 Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex, Patterson-Fortin J, Shao G, Bretscher H, Messick TE, Greenberg RA, 2010 Merit 40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double strand breaks, Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, Greenberg RA, 2009 The Rap80-BRCC36 Deubiquitinating Complex Antagonizes RNF8-Ubc13 Dependent Ubiquitination Events at DNA Double Strand Breaks, Shao G, Lilli DR, Patterson-Fortin J, Coleman KA, Morrissey DE, Greenberg RA, 2009 Rap80 targets BRCA1 to specific ubiquitin structures at DNA damage sites, Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA, 2007 Epigenetic inactivation of Betaig-h3 gene in human cancer cells, Shao G, Berenguer J, Borczuk AC, Powell CA, Hei TK, Zhao Y, 2006 TGFBIDeficiency Predisposes Mice to Spontaneous Tumor Development, Zhang Y, Wen G, Shao G, Wang C, Lin C, Fang H, Balajee AS, Bhagat G, Hei TK, Zhao Y, 2009 p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase, Shao G, Balajee AS, Hei TK, Zhao Y, 2008 Methylation screening of the TGFBI promoter in human lung and prostate cancer by methylation-specific PCR, Shah JN, Shao G, Hei TK, Zhao Y, 2008 Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma, Shao GZ, Zhou RL, Zhang QY, Zhang Y, Liu JJ, Rui JA, Wei X, Ye DX, 2003

Areas of Focus

BRCA1 tumor suppressor network
Mechanisms of breast cancer metastasis
Tumor biomarker discovery and application
K63-linked protein ubiquitination and cell mitosis

Publications

RNF8 promotes epithelial-mesenchymal transition of breast cancer cells, Kuang J, Li L, Guo L, Su Y, Wang Y, Xu Y, Wang X, Meng S, Lei L, Xu L, Shao G, 2016
The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells, Yan K, Li L, Wang X, Hong R, Zhang Y, Yang H, Lin M, Zhang S, He Q, Zheng D, Tang J, Yin Y, Shao G, 2015
DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation, Yi J, Lu G, Li L, Wang X, Cao L, Lin M, Zhang S, Shao G, 2015
K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks, Zhu B, Yan K, Li L, Lin M, Zhang S, He Q, Zheng D, Yang H, Shao G, 2015
HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway, Wang X, Lu G, Li L, Yi J, Yan K, Wang Y, Zhu B, Kuang J, Lin M, Zhang S, Shao G, 2014
Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex, Patterson-Fortin J, Shao G, Bretscher H, Messick TE, Greenberg RA, 2010
Merit 40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double strand breaks, Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, Greenberg RA, 2009
The Rap80-BRCC36 Deubiquitinating Complex Antagonizes RNF8-Ubc13 Dependent Ubiquitination Events at DNA Double Strand Breaks, Shao G, Lilli DR, Patterson-Fortin J, Coleman KA, Morrissey DE, Greenberg RA, 2009
Rap80 targets BRCA1 to specific ubiquitin structures at DNA damage sites, Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA, 2007
Epigenetic inactivation of Betaig-h3 gene in human cancer cells, Shao G, Berenguer J, Borczuk AC, Powell CA, Hei TK, Zhao Y, 2006
TGFBIDeficiency Predisposes Mice to Spontaneous Tumor Development, Zhang Y, Wen G, Shao G, Wang C, Lin C, Fang H, Balajee AS, Bhagat G, Hei TK, Zhao Y, 2009
p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase, Shao G, Balajee AS, Hei TK, Zhao Y, 2008
Methylation screening of the TGFBI promoter in human lung and prostate cancer by methylation-specific PCR, Shah JN, Shao G, Hei TK, Zhao Y, 2008
Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma, Shao GZ, Zhou RL, Zhang QY, Zhang Y, Liu JJ, Rui JA, Wei X, Ye DX, 2003

Brca1 Tumor Suppressor Gene Breast Cancer Ovarian Cancer Dna Damage Cell Cycle Molecular Mechanisms Protein Degradation Cancer Research Metastasis K63 Ubiquitination Chromatin Remodeling Epigenetics Rnf8 Tumor Progression Molecular Biology Cancer Therapy Protein Interactions Biomarkers Early Diagnosis Therapeutic Evaluation Prognosis Serum Markers Tumor Specific Sensitive Markers Cancer Detection Clinical Applications Molecular Diagnostics Cell Division Mitosis Spindle Assembly Checkpoint Mechanisms Protein Ubiquitination Deubiquitinating Enzymes Genetic Stability

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