Professor | 吴亚林 | 数字化转型顾问

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Name	吴亚林
Contact Information	yalinw@xmu.edu.cn
Language ability	中文, 英语
Province	福建

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Name

吴亚林

Contact Information

yalinw@xmu.edu.cn

Language ability

中文, 英语

Province

福建

University/Lab Affiliation and Title	厦门大学
Faculty	Medical
Academic Background & Achievements	1998-2002 工学学士: 南京工业大学, 生物化工专业 2002-2007 理学博士: 浙江大学, 化学专业
Work Experience	2007-2011 - 美国哥伦比亚大学 - 化学系/眼科系博士后 2011-2015 - 浙江大学药学院药理毒理研究所 - 特聘研究员/博导 2012-2015 - 浙江大学医学院附属第二医院眼科中心 - 特聘教授（兼） 2015-至今 - 厦门大学医学院眼科研究所 - 教授/博导
Awards	中华眼科学会奖（2018）厦门市重点人才（2017）中华医学会眼科分会青年委员（2016）福建省首批高层次引进人才（2016）

University/Lab Affiliation and Title

厦门大学

Faculty

Medical

Academic Background & Achievements

1998-2002 工学学士: 南京工业大学, 生物化工专业
2002-2007 理学博士: 浙江大学, 化学专业

Work Experience

2007-2011 - 美国哥伦比亚大学 - 化学系/眼科系博士后
2011-2015 - 浙江大学药学院药理毒理研究所 - 特聘研究员/博导
2012-2015 - 浙江大学医学院附属第二医院眼科中心 - 特聘教授（兼）
2015-至今 - 厦门大学医学院眼科研究所 - 教授/博导

Awards

中华眼科学会奖（2018）
厦门市重点人才（2017）
中华医学会眼科分会青年委员（2016）
福建省首批高层次引进人才（2016）

Areas of Focus	视网膜疾病年龄相关性黄斑变性（AMD） Stargardt病（STGD）
Publications	eIF2α incites photoreceptor cell and retina damage by all-trans-retinal., He D, Tao L, Cai B, Chen X, Wang Y, Li S, Liao C, Chen Y, Chen J, Liu Z, and Wu Y., 2023 Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal., Chen C, Yang K, He D, Yang B, Tao L, Chen J, and Wu Y., 2023 Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina., Cai B, Liao C, He D, Chen J, Han J, Lu J, Qin K, Liang W, Wu X, Liu Z, and Wu Y., 2022 Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance., Chen C, Chen J, Wang Y, Liu Z, and Wu Y., 2021 Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice., Liao C, Cai B, Feng Y, Chen J, Wu YP, Zhuang J, Liu Z, and Wu Y., 2020 Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal., Liao Y#, Zhang H#, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, and Wu Y., 2019 Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina., Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y., 2018 Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium., Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y., 2017 Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids., Liu X, Chen J, Liu Z, Li J, Yao K, and Wu Y., 2016 Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration., Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y., 2015 Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin., Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y., 2014 Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'., Wu Y, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X., 2014 Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells., Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*., 2013 Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid., Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR., 2011 Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration., Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR., 2010 Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease., Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR., 2009

Areas of Focus

视网膜疾病
年龄相关性黄斑变性（AMD）
Stargardt病（STGD）

Publications

eIF2α incites photoreceptor cell and retina damage by all-trans-retinal., He D, Tao L, Cai B, Chen X, Wang Y, Li S, Liao C, Chen Y, Chen J, Liu Z*, and Wu Y*., 2023
Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal., Chen C, Yang K, He D, Yang B, Tao L, Chen J, and Wu Y*., 2023
Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina., Cai B, Liao C, He D, Chen J, Han J, Lu J, Qin K, Liang W, Wu X, Liu Z, and Wu Y*., 2022
Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance., Chen C, Chen J, Wang Y, Liu Z, and Wu Y*., 2021
Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice., Liao C, Cai B, Feng Y, Chen J, Wu YP, Zhuang J, Liu Z, and Wu Y*., 2020
Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal., Liao Y#, Zhang H#, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, and Wu Y*., 2019
Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina., Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y*., 2018
Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium., Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y*., 2017
Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids., Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*., 2016
Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration., Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*., 2015
Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin., Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*., 2014
Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'., Wu Y*, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X., 2014
Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells., Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*., 2013
Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid., Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR., 2011
Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration., Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR., 2010
Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease., Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR., 2009

视网膜黄斑变性 Amd Stgd 光感受器基因突变失明药物开发机制

骆严 - 浙江大学

Area of Focus
肿瘤 | 生物化学 | 代谢 | 干细胞 | 伤口愈合 | 抗癌 | 药物开发 | 研究 | 机制 | 平台

金鑫 - 厦门大学

邱彦 - 厦门大学

Area of Focus
脂质代谢 | Naaa | 药物开发 | 药效学 | 脂肪酰基乙醇胺 | 脂质微环境 | 炎症 | 癌症 | 调控 | 机制

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