Professor | Yalin Wu | Asia Growth Partners

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Name	Yalin Wu
Contact Information	yalinw@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Yalin Wu

Contact Information

yalinw@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	1998-2002 Bachelor of Engineering: Nanjing University of Technology, Biochemical Engineering 2002-2007 Doctor of Science: Zhejiang University, Chemistry
Work Experience	2007-2011 - Columbia University, USA - Postdoctoral Researcher in Chemistry/Ophthalmology 2011-2015 - Zhejiang University, Institute of Pharmacology and Toxicology - Distinguished Researcher/Doctoral Supervisor 2012-2015 - Zhejiang University, Second Affiliated Hospital, Ophthalmology Center - Distinguished Professor (Concurrent) 2015-Present - Xiamen University, School of Medicine, Institute of Ophthalmology - Professor/Doctoral Supervisor
Awards	Chinese Ophthalmological Society Award (2018) Xiamen Key Talent (2017) Youth Committee Member of the Chinese Medical Association Ophthalmology Branch (2016) First Batch of High-Level Talents Introduced in Fujian Province (2016)

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

1998-2002 Bachelor of Engineering: Nanjing University of Technology, Biochemical Engineering
2002-2007 Doctor of Science: Zhejiang University, Chemistry

Work Experience

2007-2011 - Columbia University, USA - Postdoctoral Researcher in Chemistry/Ophthalmology
2011-2015 - Zhejiang University, Institute of Pharmacology and Toxicology - Distinguished Researcher/Doctoral Supervisor
2012-2015 - Zhejiang University, Second Affiliated Hospital, Ophthalmology Center - Distinguished Professor (Concurrent)
2015-Present - Xiamen University, School of Medicine, Institute of Ophthalmology - Professor/Doctoral Supervisor

Awards

Chinese Ophthalmological Society Award (2018)
Xiamen Key Talent (2017)
Youth Committee Member of the Chinese Medical Association Ophthalmology Branch (2016)
First Batch of High-Level Talents Introduced in Fujian Province (2016)

Areas of Focus	Retinal Diseases Age-related Macular Degeneration (AMD) Stargardt Disease (STGD)
Publications	eIF2α incites photoreceptor cell and retina damage by all-trans-retinal., He D, Tao L, Cai B, Chen X, Wang Y, Li S, Liao C, Chen Y, Chen J, Liu Z, and Wu Y., 2023 Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal., Chen C, Yang K, He D, Yang B, Tao L, Chen J, and Wu Y., 2023 Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina., Cai B, Liao C, He D, Chen J, Han J, Lu J, Qin K, Liang W, Wu X, Liu Z, and Wu Y., 2022 Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance., Chen C, Chen J, Wang Y, Liu Z, and Wu Y., 2021 Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice., Liao C, Cai B, Feng Y, Chen J, Wu YP, Zhuang J, Liu Z, and Wu Y., 2020 Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal., Liao Y#, Zhang H#, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, and Wu Y., 2019 Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina., Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y., 2018 Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium., Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y., 2017 Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids., Liu X, Chen J, Liu Z, Li J, Yao K, and Wu Y., 2016 Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration., Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y., 2015 Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin., Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y., 2014 Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'., Wu Y, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X., 2014 Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells., Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*., 2013 Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid., Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR., 2011 Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration., Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR., 2010 Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease., Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR., 2009

Areas of Focus

Retinal Diseases
Age-related Macular Degeneration (AMD)
Stargardt Disease (STGD)

Publications

eIF2α incites photoreceptor cell and retina damage by all-trans-retinal., He D, Tao L, Cai B, Chen X, Wang Y, Li S, Liao C, Chen Y, Chen J, Liu Z*, and Wu Y*., 2023
Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal., Chen C, Yang K, He D, Yang B, Tao L, Chen J, and Wu Y*., 2023
Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina., Cai B, Liao C, He D, Chen J, Han J, Lu J, Qin K, Liang W, Wu X, Liu Z, and Wu Y*., 2022
Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance., Chen C, Chen J, Wang Y, Liu Z, and Wu Y*., 2021
Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice., Liao C, Cai B, Feng Y, Chen J, Wu YP, Zhuang J, Liu Z, and Wu Y*., 2020
Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal., Liao Y#, Zhang H#, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, and Wu Y*., 2019
Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina., Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y*., 2018
Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium., Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y*., 2017
Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids., Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*., 2016
Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration., Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*., 2015
Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin., Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*., 2014
Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'., Wu Y*, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X., 2014
Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells., Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*., 2013
Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid., Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR., 2011
Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration., Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR., 2010
Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease., Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR., 2009

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