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Huahua Du
Animal Sciences
Zhejiang University
Zhejiang
Language: English, Chinese
Animal Nutrition
Immunity
Iron Nutrition
Anti-Infection
Endogenous Peptides
Antimicrobial
Regulation
Animal Health
Feed Science
Research
Areas of Focus
- Animal Nutrition and Immunity
- Iron Nutrition and Anti-infection Immunity
- Regulation of Endogenous Antimicrobial Peptides
Work Experience
- 2020-present: Professor, Doctoral Supervisor, College of Animal Sciences, Zhejiang University
- 2014-2020: Associate Researcher, Doctoral Supervisor, College of Animal Sciences, Zhejiang University
- 2012-2014: Visiting Scholar, Harvard Medical School, USA
- 2010-2012: Associate Researcher, Master's Supervisor, College of Animal Sciences, Zhejiang University
- 2009-2010: Visiting Scholar, Purdue University, USA
- 2008-2009: Assistant Researcher, College of Animal Sciences, Zhejiang University
- 2006-2008: Postdoctoral Researcher, Feed Science Research Institute, Zhejiang University
Academic Background & Achievements
- 2006: Ph.D. in Animal Nutrition and Feed Science, Zhejiang University
- 2001: Bachelor's in Veterinary Medicine, Zhejiang University
- Zhejiang Province Outstanding Youth Fund Recipient
- Deputy Director, Feed Science Research Institute, Zhejiang University
- Deputy Director, National Engineering Research Center for Green Feed and Healthy Breeding
- Deputy Director, Key Laboratory of Animal Nutrition and Feed in East China, Ministry of Agriculture and Rural Affairs
Publications
- Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis, Jing Zhao, Wan Ma, Sisi Wang, Kang Zhang, Qingqing Xiong, Yunqin Li, Hong Yu, Huahua Du, 2024
- Specifically targeted antimicrobial peptides synergize with bacterial-entrapping peptide against systemic MRSA infections, Bocheng Xu, Lin Wang, Chen Yang, Rong Yan, Pan Zhang, Mingliang Jin, Huahua Du, Yizhen Wang, 2024
- Sex-specific appetite regulation of lipocalin-2 in high fat diet-induced obese mice, Linfeng Miao, Chenying Tian, Qingqing Xiong, Jing Zhao, Yunfei Feng, Hong Yu, Huahua Du, 2024
- Lcn2 deficiency accelerates the infection of Escherichia coli O157:H7 by disrupting the intestinal barrier function, Kang Zhang, Jianjun Chen, Li Liang, Zhenjie Wang, Qingqing Xiong, Hong Yu, Huahua Du, 2023
- Heme oxygenase-1 increases intracellular iron storage and suppresses inflammatory response of macrophages by inhibiting M1 polarization, Xueyou Tang, Yunqin Li, Jing Zhao, Li Liang, Kang Zhang, Xiaofeng Zhang, Hong Yu, Huahua Du, 2023
- Maternal folic acid supplementation improves the intestinal health of offspring porcine by promoting the proliferation and differentiation of intestinal stem cells, Yuhui Zhang, Xiaofeng Zhang, Jianjun Chen, Shouchuan Jiang, Yu Han, Huahua Du, 2023
- Iron chelator deferoxamine alleviates progression of diabetic nephropathy by relieving inflammation and fibrosis in rats, Yunfei Feng, Li Jia, Wan Ma, Chenying Tian, Huahua Du, 2023
- Secondary iron overload induces chronic pancreatitis and ferroptosis of acinar cells in mice, Chenying Tian, Jing Zhao, Qingqing Xiong, Hong Yu, Huahua Du, 2023
- Regulation of a high-iron diet on lipid metabolism and gut microbiota in mice, Qingqing Xiong, Jing Zhao, Chenying Tian, Wan Ma, Linfeng Miao, Li Liang, Kang Zhang, Huahua Du, 2022
- Dietary iron modulates hepatic glucose homeostasis via regulating gluconeogenesis, Jiahui Li, Li Jia, Wan Ma, Yunfei Feng, Hong Yu, Huahua Du, 2022
- Intraperitoneal supplementation of iron alleviates dextran sodium sulfate-induced colitis by enhancing intestinal barrier function, Li Liang, Qingqing Xiong, Jingxia Kong, Chenying Tian, Linfeng Miao, Xiaofeng Zhang, Huahua Du, 2021
- Lipocalin-2 alleviates LPS-induced inflammation through alteration of macrophage properties, Huahua Du, Li Liang, Jiahui Li, Qingqing Xiong, Xin Yu, Hong Yu, 2021
- Erastin-induced ferroptosis causes physiological and pathological changes in healthy tissues of mice, Jing Zhao, Ben Xu, Qingqing Xiong, Yunfei Feng, Huahua Du, 2021
- Iron overload protects from obesity by ferroptosis, Wan Ma, Li Jia, Qingqing Xiong, Huahua Du, 2021
- The role of iron homeostasis in adipocyte metabolism, Wan Ma, Li Jia, Qingqing Xiong, Yunfei Feng, Huahua Du, 2021
- Distribution of lactoferrin is related with dynamics of neutrophils in bacterial infected mice intestine, Li Liang, Zhen-Jie Wang, Guang Ye, Xue-You Tang, Yuan-Yuan Zhang, Jing-Xia Kong, Hua-Hua Du, 2020
- Dynamics of the physicochemical characteristics, microbiota, and metabolic functions of soybean meal and corn mixed substrates during two-stage solid-state fermentation, Cheng Wang, Changyou Shi, Weifa Su, Mingliang Jin, Bocheng Xu, Lihong Hao, Yu Zhang, Zeqing Lu, Fengqin Wang, Yizhen Wang, Huahua Du, 2020
- Lipocalin 2 protects against Escherichia coli infection by modulating neutrophil and macrophage function, Qianqian Wang, Shuhui Li, Xueyou Tang, Li Liang, Fengqin Wang, Huahua Du, 2019
- Split iron supplementation is beneficial for newborn piglets, Xiaoyun Chen, Xiaofeng Zhang, Jing Zhao, Xueyou Tang, Fengqin Wang, Huahua Du, 2019
- Increased iron availability aggravates the infection of Escherichia coli O157:H7 in mice, Xin Yu, Zhenshun Gan, Zhenjie Wang, Xueyou Tang, Bingxiu Guo, Huahua Du, 2019
- Dietary iron modulates glucose and lipid homeostasis in diabetic mice, Wan Ma, Yunfei Feng, Li Jia, Shuhui Li, Jiahui Li, Zhenjie Wang, Xiaoyun Chen, Huahua Du, 2019
- Iron promotes intestinal development in neonatal piglets, Yutian Pu, Shuhui Li, Haitao Xiong, Xiaofeng Zhang, Yizhen Wang, Huahua Du, 2018
- Synthetic porcine hepcidin exerts opposite roles in Escherichia coli and Salmonella infections, Dan Liu, Zhen-Shun Gan, Wan Ma, Hai-Tao Xiong, Yun-Qing Li, Yi-Zhen Wang, Hua-Hua Du, 2017
- Lipocalin 2 regulates intestine bacterial survival by interplaying with siderophore in a weaned piglet model of Escherichia coli infection, Bing-Xiu Guo, Qian-Qian Wang, Jia-Hui Li, Zhen-Shun Gan, Xiao-Feng Zhang, Yi-Zhen Wang, Hua-Hua Du, 2017
- Iron reduces M1 macrophage polarization in RAW264.7 macrophages associated with inhibition of STAT1, Zhen-Shun Gan, Qian-Qian Wang, Jia-Hui, Li, Xu-Liang Wang, Yi-Zhen Wang, Hua-Hua Du, 2017
- Butyrate upregulates endogenous host defense peptides to enhance disease resistance in piglets via histone deacetylase inhibition, Haitao Xiong, Bingxiu Guo, Zhenshun Gan, Deguang Song, Zeqing Lu, Hongbo Yi, Yueming Wu, Yizhen Wang, Huahua Du, 2016
- High therapeutic efficacy of Cathelicidin-WA against postweaning diarrhea via inhibiting inflammation and enhancing epithelial barrier in the intestine, Hongbo Yi, Lin Zhang, Zhenshun Gan, Haitao Xiong, Caihua Yu, Huahua Du, Yizhen Wang, 2016
- Iron supplementation attenuates the inflammatory status of anemic piglets by regulating hepcidin, Yutian Pu, Bingxiu Guo, Dan Liu, Haitao Xiong, Yizhen Wang, Huahua Du, 2015
- Porcine hepcidin exerts an iron-independent bacteriostatic activity against pathogenic bacteria, Dan Liu, Yutian Pu, Haitao Xiong, Yizhen Wang, Huahua Du, 2015
- Immunomodulatory effects of hyperthermia on resisting WSSV infection in Procambarus clarkii, Xiaoguo Wu, Haitao Xiong, Yizhen Wang, Huahua Du, 2015
- High level of hepcidin mRNA expression is associated with high production of immune factors in Tibetan pigs, Hai-tao Xiong, Yan-hua Gao, Dan Liu, Yi-zhen Wang, Hua-hua Du, 2015
- Antigenic and immunogenic properties of truncated VP28 protein of white spot syndrome virus in Procambarus clarkii, Hua-Hua Du, Chong-Lin Hou, Xiao-Guo
Awards
- 2019: Second Prize, National Science and Technology Progress Award
- 2017: First Prize, Zhejiang Province Science and Technology Progress Award
- 2015: Second Prize, Da Bei Nong Science and Technology Award
- 2013: Second Prize, Ministry of Education Science and Technology Progress Award
