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Yan Li
Animal Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Hematopoietic Stem Cell
Immune Cell
Development
Viral Infection
Immune Suppression
Inflammatory Response
Immune Pathology
Anti-Infective Substances
Screening
Mechanism
Areas of Focus
- Hematopoietic Stem Cell and Immune Cell Development
- Viral Infection and Immune Suppression
- Inflammatory Response and Immune Pathology
- Screening and Mechanism of Anti-Infective Substances
Work Experience
- 2017.10-present - Zhejiang University, College of Animal Sciences - Researcher
- 2016.1-2017.9 - University of Pennsylvania - Assistant Researcher
- 2011.2-2016.1 - University of Pennsylvania - Postdoctoral Researcher
- 2009.2-2011.1 - Wadsworth Center, New York State Department of Health - Joint Ph.D. Student
Academic Background & Achievements
- 2005.9-2010.6 Ph.D.: Wuhan Institute of Virology, Chinese Academy of Sciences
- 2001.9-2005.6 Bachelor's: Nanjing Agricultural University, College of Veterinary Medicine
- Received funding from the Leukemia & Lymphoma Society of America
- Published over 20 SCI papers with a total impact factor exceeding 150
- Cited over 1300 times
- Received multiple NIH R01 and R21 project grants
Publications
- Fast and sensitive differential diagnosis of pseudorabies virus-infected versus pseudorabies virus-vaccinated swine using CRISPR-Cas12a, Wang H, Li H, Tang B, Ye C, Han M, Teng L, Yue M, Li Y, 2024
- Influenza A virus inhibits TET2 expression by endoribonuclease PA-X to attenuate type I interferon signaling and promote viral replication, Hu Y, Chen X, Ling Y, Zhou K, Han M, Wang X, Yue M, Li Y, 2023
- Infant food production environments: A potential reservoir for vancomycin-resistant enterococci non-nosocomial infections, Wang Z, Liao S, Huang G, Feng M, Yin R, Teng L, Jia C, Yao Y, Yue M, Li Y, 2023
- Nucleoporin 85 interacts with influenza A virus PB1 and PB2 to promote its replication by facilitating nuclear import of ribonucleoprotein, Ling YH, Wang H, Han MQ, Wang D, Hu YX, Zhou K, Li Y, 2022
- Paving the way for precise diagnostics of antimicrobial resistant bacteria, Wang H, Jia C, Li H, Yin R, Chen J, Li Y, Yue M, 2022
- RUNX1 inhibits the antiviral immune response against influenza A virus through attenuating type I interferon signaling, Hu Y, Pan Q, Zhou K, Ling Y, Wang H, Li Y, 2022
- MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo, Bennett LF, Mumau MD, Li Y, Speck NA, 2022
- ONE Health Approach to Address Zoonotic Brucellosis: A Spatiotemporal Associations Study between Animals and Humans, Zhou K, Wu B, Pan H, Paudyal N, Jiang J, Zhang L, Li Y, Yue M, 2020
- CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation, Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA, Zon LI, 2020
- Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells, Gao P, Chen C, Howell ED, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann AF, Speck NA, Tan K, 2020
- Developmental trajectory of prehematopoietic stem cell formation from endothelium, Zhu Q, Gao P, Tober J, Bennett L, Chen C, Uzun Y, Li Y, Howell ED, Mumau M, Yu W, He B, Speck NA, Tan K, 2020
- Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis, Yzaguirre AD, Howell ED, Li Y, Liu Z, Speck NA, 2018
- Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by upregulation of PD-L1, Tober J, Maijenburg M, Li Y, Gao L, Hadland BK, Gao P, Minoura K, Bernstein ID, Tan K, Speck NA, 2018
- CD27 marks murine embryonic hematopoietic stem cells and type II pre-hematopoietic stem cells, Li Y, Gao L, Hadland B, Tan K, Speck NA, 2017
- Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production, Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, Speck NA, 2014
- PB2 residue 158 is a pathogenic determinant of pandemic-H1N1 and H5 influenza A viruses in mice, Zhou B, Li Y, Halpin R, Hine E, Spiro DJ, Wentworth DE, 2011
- Host range, prevalence, and genetic diversity of adenoviruses in bats, Li Y, Ge X, Zhang H, Zhou P, Zhu Y, Zhang Y, Yuan J, Wang LF, Shi Z, 2010
- Prevalence and genetic diversity of adeno-associated viruses in bats, China, Li Y, Ge X, Hon CC, Zhang H, Zhou P, Zhang Y, Wu Y, Wang LF, Shi Z, 2010
- Antibodies to Nipah or Nipah-like viruses in bats, China, Li Y, Wang J, Hickey AC, Zhang Y, Li Y, Wu Y, Zhang H, Yuan J, Han Z, McEachern J, Broder CC, Wang LF, Shi Z, 2008
- Engineering temperature sensitive live attenuated influenza vaccines from emerging viruses, Zhou B, Li Y, Speer SD, Subba A, Lin X, Wentworth DE, 2012
- NS-based Live Attenuated H1N1 Pandemic Vaccines Protect Mice and Ferrets, Zhou B, Li Y, Belser JA, Pearce MB, Schmolke M, Subba AX, Shi Z, Zaki SR, Blau DM, García-Sastre A, Tumpey TM, Wentworth DE, 2010
- Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells, Chen MJ, Li Y, De Obaldia ME, Yang Q, Yzaguirre AD, Yamada-Inagawa T, Vink CS, Bhandoola A, Dzierzak E, Speck NA, 2011
- Metagenomic Analysis of Viruses from Bat Fecal Samples Reveals Many Novel Viruses in Insectivorous Bats in China, Ge X, Li Y, Yang X, Zhang H, Zhou P, Zhang Y, Shi Z, 2012
- Asparagine Substitution at PB2 Residue 701 Enhances the Replication, Pathogenicity, and Transmission of the 2009 Pandemic H1N1 Influenza A Virus, Zhou B, Pearce MB, Li Y, Wang J, Mason RJ, Tumpey TM, Wentworth DE, 2013
- Isolation and characterization of a novel alphanodavirus, Bai H, Wang Y, Li X, Mao H, Li Y, Han S, Shi Z, Chen X, 2011
- Reverse genetics plasmid for cloning unstable Influenza A virus gene segments, Zhou B, Jerzak G, Scholes DT, Donnelly ME, Li Y, Wentworth DE, 2011
- In
Awards
- 2018: Second Prize of National Natural Science Award
- 2017: Selected for Zhejiang University's 'Hundred Talents Program'
- 2014: Best Paper Abstract Award at the 56th Annual Meeting of the American Society of Hematology
- 2012: Leukemia & Lymphoma Society of America Research Grant
- 2012: Third Prize of the 14th Hubei Province Natural Science Excellent Academic Paper Award
- 2010: Excellent Award of the President's Scholarship of the Chinese Academy of Sciences
- 2010: Special Award of the Changhua Scholarship of the Wuhan Education Base of the Chinese Academy of Sciences
- 2010: Excellent Graduate of the Chinese Academy of Sciences
- 2010: Director's Special Scholarship of the Wuhan Institute of Virology, Chinese Academy of Sciences
- 2009: Director's Special Scholarship of the Wuhan Institute of Virology, Chinese Academy of Sciences
