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Rong Sheng
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Drug Design
Drug Discovery
Green Synthesis
Ai
Medicinal Chemistry
Target-Based
Clinical Development
Computational Drug Design
Tumor
Virus
Areas of Focus
- New Drug Design and Discovery
- Green Synthesis Process of Drugs
- AI + Medicinal Chemistry
Work Experience
- 1997.8-present: Teaching at Zhejiang University School of Pharmacy
Academic Background & Achievements
- 1990.9-1994.7: Bachelor's in Chemistry, Hangzhou University (now Zhejiang University)
- 1994.9-1997.7: Master's in Science, Shanghai Institute of Applied Physics, Chinese Academy of Sciences
- 2001.2-2005.6: Ph.D. in Medicinal Chemistry, Zhejiang University
- 2009.6-2010.11: Postdoctoral Research, University of Michigan
Publications
- Discovery of novel HBV capsid assembly modulators by structure-based virtual screening and bioassays, Yuan Wang, Zhe Wang, Jiacheng Liu, Yunwen Wang, Rui Wu, Rong Sheng, Tingjun Hou, 2021
- Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors, Xiao-bing Chen, Hai-ying Zhu, Kun Bao, Li Jiang, Hong Zhu, Mei-dan Ying, Qiao-jun He, Bo Yang, Rong Sheng, Ji Cao, 2021
- Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K α inhibitors via docking-based virtual screening, Dongyan Gu, Gang Cheng, Mengmeng Zhang, Yu-Bo Zhou, Jia Li, Rong Sheng, 2021
- Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H3 receptor antagonists and b-amyloid aggregation inhibitors for the treatment of Alzheimer’s disease, Minkui Zhang, Li Tang, Liu Jiang, Jun Wei, Yongzhou Hu, Rong Sheng, 2021
- Visible-light promoted three-component tandem reaction to synthesize difluoromethylated oxazolidin-2-imine, Kun Bao, Jun Wei, Huihui Yan, Rong Sheng, 2020
- Microenvironment-triggered dual-activation of a photosensitizer fluorophore conjugate for tumor specific imaging and photodynamic therapy, Chang Wang, Shengdan Wang, Yuan Wang, Honghai Wu, Kun Bao, Rong Sheng, Xin Li, 2020
- Novel usage of 2-BTSO2CF2H for metal-free electrophilic difluoroalkanethiolation of indoles, Jun Wei, Kun Bao, Yuan Wang, Rong Sheng, Jinbo Hu, 2020
- Transition-Metal-Free Electrophilic Fluoroalkanesulfinylation of Electron-Rich (Het)Arenes with Fluoroalkyl Heteroaryl Sulfones via C(Het) S and S=O Bond Cleavage, Jun Wei, Kun Bao, Chengcheng Qi, Yao Liu, Chuanfa Ni, Rong Sheng, Jinbo Hu, 2019
- Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kd-selective inhibitors for treating B-cell mediated malignancies, Xiaodong Ma, Jun Wei, Chang Wang, Dongyan Gu, Yongzhou Hu, Rong Sheng, 2019
- Transition-Metal-Free Desulfinative Cross-Coupling of Heteroaryl Sulfinates with Grignard Reagents, Jun Wei, Huamin Liang, Chuanfa Ni, Rong Sheng, Jinbo Hu, 2019
- Visible-light-mediated radical arylthiodifluoromethylation of isocyanides with fluorinated 2-pyridyl sulfones, Jun Wei, Dongyan Gu, Shengdan Wang, Jinbo Hu, Xiaowu Dong, Rong Sheng, 2018
- A Copper-Catalyzed Tandem Cyclization Reaction of Aminoalkynes with Alkynes for the Construction of Tetrahydropyrrolo[1,2-a]quinolines Scaffold, Can-Liang Ma, Jin-Hao Zhao, Yong Yang, Min-Kui Zhang, Chao Shen, Rong Sheng, Xiao-Wu Dong, Yong-Zhou Hu, 2017
- One-pot Synthesis of 6-Azachromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization, Gang Cheng, Yingbei Qi, Xiaoqian Zhou, Rong Sheng, Yong-Zhou Hu, Youhong Hu, 2017
- The stability and reactivity of tri-, di-, and monofluoromethyl/methoxy/methylthio groups on arenes under acidic and basic conditions, Lingfei Wang, Jun Wei, Ranran Wu, Gang Cheng, Xinjin Li, Jinbo Hu, Yongzhou Hu, Rong Sheng, 2017
- Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation, Shan Li, Penghui Wan, Jing Ai, Rong Sheng, Yongzhou Hu, youhong Hu, 2017
- Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease, Rong Sheng, Li Tang, Liu Jiang, Lingjuan Hong, Ying Shi, Naiming Zhou, Yongzhou Hu, 2016
- Identification of 2-subsituted Benzothiazole Derivatives as Triple-functional agents with potential for AD Therapy, Liu Jiang, Minkui Zhang, Li Tang, Qinjie Weng, Yanhong Shen, Yongzhou Hu, Rong Sheng, 2016
Awards
- 2011: Third Prize, Zhejiang Provincial Science and Technology Progress Award for the design and development of innovative anti-Alzheimer's drugs
- 2010: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the design and discovery of targeted anti-tumor drugs
- 2011: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the discovery and development of anti-tumor drugs targeting topoisomerase II
- 2008: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the establishment and application of anti-tumor drug activity evaluation methods based on action targets
- 2003: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the research and development of the national second-class new drug exemestane
