Professor | Rong Sheng | Asia Growth Partners

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Name	Rong Sheng
Contact Information	shengr@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Rong Sheng

Contact Information

shengr@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1990.9-1994.7: Bachelor's in Chemistry, Hangzhou University (now Zhejiang University) 1994.9-1997.7: Master's in Science, Shanghai Institute of Applied Physics, Chinese Academy of Sciences 2001.2-2005.6: Ph.D. in Medicinal Chemistry, Zhejiang University 2009.6-2010.11: Postdoctoral Research, University of Michigan
Work Experience	1997.8-present: Teaching at Zhejiang University School of Pharmacy
Awards	2011: Third Prize, Zhejiang Provincial Science and Technology Progress Award for the design and development of innovative anti-Alzheimer's drugs 2010: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the design and discovery of targeted anti-tumor drugs 2011: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the discovery and development of anti-tumor drugs targeting topoisomerase II 2008: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the establishment and application of anti-tumor drug activity evaluation methods based on action targets 2003: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the research and development of the national second-class new drug exemestane

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1990.9-1994.7: Bachelor's in Chemistry, Hangzhou University (now Zhejiang University)
1994.9-1997.7: Master's in Science, Shanghai Institute of Applied Physics, Chinese Academy of Sciences
2001.2-2005.6: Ph.D. in Medicinal Chemistry, Zhejiang University
2009.6-2010.11: Postdoctoral Research, University of Michigan

Work Experience

1997.8-present: Teaching at Zhejiang University School of Pharmacy

Awards

2011: Third Prize, Zhejiang Provincial Science and Technology Progress Award for the design and development of innovative anti-Alzheimer's drugs
2010: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the design and discovery of targeted anti-tumor drugs
2011: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the discovery and development of anti-tumor drugs targeting topoisomerase II
2008: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the establishment and application of anti-tumor drug activity evaluation methods based on action targets
2003: Second Prize, Zhejiang Provincial Science and Technology Progress Award for the research and development of the national second-class new drug exemestane

Areas of Focus	New Drug Design and Discovery Green Synthesis Process of Drugs AI + Medicinal Chemistry
Publications	Discovery of novel HBV capsid assembly modulators by structure-based virtual screening and bioassays, Yuan Wang, Zhe Wang, Jiacheng Liu, Yunwen Wang, Rui Wu, Rong Sheng, Tingjun Hou, 2021 Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors, Xiao-bing Chen, Hai-ying Zhu, Kun Bao, Li Jiang, Hong Zhu, Mei-dan Ying, Qiao-jun He, Bo Yang, Rong Sheng, Ji Cao, 2021 Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K α inhibitors via docking-based virtual screening, Dongyan Gu, Gang Cheng, Mengmeng Zhang, Yu-Bo Zhou, Jia Li, Rong Sheng, 2021 Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H3 receptor antagonists and b-amyloid aggregation inhibitors for the treatment of Alzheimer’s disease, Minkui Zhang, Li Tang, Liu Jiang, Jun Wei, Yongzhou Hu, Rong Sheng, 2021 Visible-light promoted three-component tandem reaction to synthesize diﬂuoromethylated oxazolidin-2-imine, Kun Bao, Jun Wei, Huihui Yan, Rong Sheng, 2020 Microenvironment-triggered dual-activation of a photosensitizer fluorophore conjugate for tumor specific imaging and photodynamic therapy, Chang Wang, Shengdan Wang, Yuan Wang, Honghai Wu, Kun Bao, Rong Sheng, Xin Li, 2020 Novel usage of 2-BTSO2CF2H for metal-free electrophilic diﬂuoroalkanethiolation of indoles, Jun Wei, Kun Bao, Yuan Wang, Rong Sheng, Jinbo Hu, 2020 Transition-Metal-Free Electrophilic Fluoroalkanesulfinylation of Electron-Rich (Het)Arenes with Fluoroalkyl Heteroaryl Sulfones via C(Het) S and S=O Bond Cleavage, Jun Wei, Kun Bao, Chengcheng Qi, Yao Liu, Chuanfa Ni, Rong Sheng, Jinbo Hu, 2019 Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kd-selective inhibitors for treating B-cell mediated malignancies, Xiaodong Ma, Jun Wei, Chang Wang, Dongyan Gu, Yongzhou Hu, Rong Sheng, 2019 Transition-Metal-Free Desulﬁnative Cross-Coupling of Heteroaryl Sulﬁnates with Grignard Reagents, Jun Wei, Huamin Liang, Chuanfa Ni, Rong Sheng, Jinbo Hu, 2019 Visible-light-mediated radical arylthiodifluoromethylation of isocyanides with fluorinated 2-pyridyl sulfones, Jun Wei, Dongyan Gu, Shengdan Wang, Jinbo Hu, Xiaowu Dong, Rong Sheng, 2018 A Copper-Catalyzed Tandem Cyclization Reaction of Aminoalkynes with Alkynes for the Construction of Tetrahydropyrrolo[1,2-a]quinolines Scaffold, Can-Liang Ma, Jin-Hao Zhao, Yong Yang, Min-Kui Zhang, Chao Shen, Rong Sheng, Xiao-Wu Dong, Yong-Zhou Hu, 2017 One-pot Synthesis of 6-Azachromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization, Gang Cheng, Yingbei Qi, Xiaoqian Zhou, Rong Sheng, Yong-Zhou Hu, Youhong Hu, 2017 The stability and reactivity of tri-, di-, and monofluoromethyl/methoxy/methylthio groups on arenes under acidic and basic conditions, Lingfei Wang, Jun Wei, Ranran Wu, Gang Cheng, Xinjin Li, Jinbo Hu, Yongzhou Hu, Rong Sheng, 2017 Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation, Shan Li, Penghui Wan, Jing Ai, Rong Sheng, Yongzhou Hu, youhong Hu, 2017 Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease, Rong Sheng, Li Tang, Liu Jiang, Lingjuan Hong, Ying Shi, Naiming Zhou, Yongzhou Hu, 2016 Identification of 2-subsituted Benzothiazole Derivatives as Triple-functional agents with potential for AD Therapy, Liu Jiang, Minkui Zhang, Li Tang, Qinjie Weng, Yanhong Shen, Yongzhou Hu, Rong Sheng, 2016

Areas of Focus

New Drug Design and Discovery
Green Synthesis Process of Drugs
AI + Medicinal Chemistry

Publications

Discovery of novel HBV capsid assembly modulators by structure-based virtual screening and bioassays, Yuan Wang, Zhe Wang, Jiacheng Liu, Yunwen Wang, Rui Wu, Rong Sheng, Tingjun Hou, 2021
Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors, Xiao-bing Chen, Hai-ying Zhu, Kun Bao, Li Jiang, Hong Zhu, Mei-dan Ying, Qiao-jun He, Bo Yang, Rong Sheng, Ji Cao, 2021
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K α inhibitors via docking-based virtual screening, Dongyan Gu, Gang Cheng, Mengmeng Zhang, Yu-Bo Zhou, Jia Li, Rong Sheng, 2021
Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H3 receptor antagonists and b-amyloid aggregation inhibitors for the treatment of Alzheimer’s disease, Minkui Zhang, Li Tang, Liu Jiang, Jun Wei, Yongzhou Hu, Rong Sheng, 2021
Visible-light promoted three-component tandem reaction to synthesize diﬂuoromethylated oxazolidin-2-imine, Kun Bao, Jun Wei, Huihui Yan, Rong Sheng, 2020
Microenvironment-triggered dual-activation of a photosensitizer fluorophore conjugate for tumor specific imaging and photodynamic therapy, Chang Wang, Shengdan Wang, Yuan Wang, Honghai Wu, Kun Bao, Rong Sheng, Xin Li, 2020
Novel usage of 2-BTSO2CF2H for metal-free electrophilic diﬂuoroalkanethiolation of indoles, Jun Wei, Kun Bao, Yuan Wang, Rong Sheng, Jinbo Hu, 2020
Transition-Metal-Free Electrophilic Fluoroalkanesulfinylation of Electron-Rich (Het)Arenes with Fluoroalkyl Heteroaryl Sulfones via C(Het) S and S=O Bond Cleavage, Jun Wei, Kun Bao, Chengcheng Qi, Yao Liu, Chuanfa Ni, Rong Sheng, Jinbo Hu, 2019
Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kd-selective inhibitors for treating B-cell mediated malignancies, Xiaodong Ma, Jun Wei, Chang Wang, Dongyan Gu, Yongzhou Hu, Rong Sheng, 2019
Transition-Metal-Free Desulﬁnative Cross-Coupling of Heteroaryl Sulﬁnates with Grignard Reagents, Jun Wei, Huamin Liang, Chuanfa Ni, Rong Sheng, Jinbo Hu, 2019
Visible-light-mediated radical arylthiodifluoromethylation of isocyanides with fluorinated 2-pyridyl sulfones, Jun Wei, Dongyan Gu, Shengdan Wang, Jinbo Hu, Xiaowu Dong, Rong Sheng, 2018
A Copper-Catalyzed Tandem Cyclization Reaction of Aminoalkynes with Alkynes for the Construction of Tetrahydropyrrolo[1,2-a]quinolines Scaffold, Can-Liang Ma, Jin-Hao Zhao, Yong Yang, Min-Kui Zhang, Chao Shen, Rong Sheng, Xiao-Wu Dong, Yong-Zhou Hu, 2017
One-pot Synthesis of 6-Azachromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization, Gang Cheng, Yingbei Qi, Xiaoqian Zhou, Rong Sheng, Yong-Zhou Hu, Youhong Hu, 2017
The stability and reactivity of tri-, di-, and monofluoromethyl/methoxy/methylthio groups on arenes under acidic and basic conditions, Lingfei Wang, Jun Wei, Ranran Wu, Gang Cheng, Xinjin Li, Jinbo Hu, Yongzhou Hu, Rong Sheng, 2017
Palladium-Catalyzed, Silver-Assisted Direct C-5–H Arylation of 3-Substituted 1,2,4-Oxadiazoles under Microwave Irradiation, Shan Li, Penghui Wan, Jing Ai, Rong Sheng, Yongzhou Hu, youhong Hu, 2017
Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer’s Disease, Rong Sheng, Li Tang, Liu Jiang, Lingjuan Hong, Ying Shi, Naiming Zhou, Yongzhou Hu, 2016
Identification of 2-subsituted Benzothiazole Derivatives as Triple-functional agents with potential for AD Therapy, Liu Jiang, Minkui Zhang, Li Tang, Qinjie Weng, Yanhong Shen, Yongzhou Hu, Rong Sheng, 2016

Drug Design Drug Discovery Green Synthesis Ai Medicinal Chemistry Target-Based Clinical Development Computational Drug Design Tumor Virus

Xian Zeng - Fudan University

Yi-Fei Qi - Fudan University

Xiaowu Dong - Zhejiang University

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