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Pengpeng Zhang
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Natural Products
Total Synthesis
Synthetic Methodologies
Target-Oriented
Machine Learning
Artificial Intelligence
Pharmacy
Medicinal Chemistry
Molecular Manufacturing
Bioactive Compounds
Areas of Focus
- Total Synthesis of Bioactive Natural Products
- Development of Target-Oriented Novel Synthetic Methodologies
- Machine Learning-Assisted Synthetic Chemistry and Medicinal Chemistry
- Artificial Intelligence in Pharmacy and Molecular 'Intelligent' Manufacturing
Work Experience
- 2023.8–Present: Zhejiang University, College of Pharmaceutical Sciences, Hundred Talents Program Researcher, Doctoral Supervisor
- 2018.7–2023.7: Yale University, Department of Chemistry, Postdoctoral Researcher (Co-supervisor: Timothy R. Newhouse)
Academic Background & Achievements
- 2023.8–Present: Zhejiang University, College of Pharmaceutical Sciences, Hundred Talents Program Researcher, Doctoral Supervisor
- 2018.7–2023.7: Yale University, Department of Chemistry, Postdoctoral Researcher (Co-supervisor: Timothy R. Newhouse)
- 2013.9–2018.7: Peking University, Ph.D. in Chemistry (Chemical Genomics) (Supervisors: Zhen Yang, Jianxian Gong)
- 2009.9–2013.6: Lanzhou University, B.Sc. in Chemistry (Basic Theory Class) (Supervisors: Xingguo Chen, Xiaoping Cao)
Publications
- Carbonylative difunctionalization of unactivated alkenes initiated by unstabilized enolates, Zhang, P.; Newhouse, T. R., 2023
- A neural network model informs the total synthesis of clovane sesquiterpenoids, Zhang, P.; Eun, J.; Elkin, M.; Zhao, Y. Z.; Cantrell, R. L.; Newhouse, T. R., 2023
- Coordination-controlled nickel-catalyzed benzylic allylation of unactivated electron-deficient heterocycles, Zhang, P.; Wang, J.; Robertson, Z. R.; Newhouse, T. R., 2022
- Aryl-nickel-catalyzed benzylic dehydrogenation of electron-deficient heteroarenes, Zhang, P.; Huang, D.; Newhouse, T. R., 2020
- Oxidation stepping-stones: α-oxytriflation enables asymmetric arylation of amides, Zhang, P.; Newhouse, T. R., 2019
- Enantioselective total synthesis of (–)-pavidolide B, Zhang, P.-P.; Yan, Z.-M.; Li, Y.-H.; Gong, J.; Yang Z., 2017
- Role of benzylic deprotonation in Ni-catalyzed benzylic dehydrogenation, Zhang, P.; Cantrell, R. L.; Newhouse, T. R., 2021
- Thiophene, 2-bromo-5-methyl-, Zhang, P.; Newhouse, T. R., 2021
- Asymmetric total synthesis of (–)-pavidolide B via a thiyl-radical-mediated [3+2] annulation reaction, Zhang, P.; Li, Y.; Yan, Z.; Gong, J.; Yang Z., 2019
- Diastereoselective synthesis of diquinanes and triquinanes bearing vicinal quaternary carbon stereocenters from acyclic allene-based precursors via a cascade reaction, Li, S.; Zhang, P.-P.; Li, Y.-H.; Lu, S.-M.; Gong, J.; Yang Z., 2017
- Nickel-catalyzed difunctionalization of unactivated alkenes initiated by unstabilized enolates, Huang, D.; Olivieri, D.; Yang, S.; Zhang, P.; Newhouse, T. R., 2019
- Allyl-nickel catalysis enables carbonyl dehydrogenation and oxidative cycloalkenylation of ketones, Huang, D.; Szewczyk, S. M.; Zhang, P.; Newhouse, T. R., 2019
- Feed Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction, Cuomo, A. E.; Ibarraran, S.; Sreekumar, S.; Li, H.; Eun, J.; Menzel, J. P.; Zhang, P.; Helbrault, D.; Buono, F.; Crabtree, R. H.; Batista, V. S.; Newhouse, T. R., 2023
- A chiral pool approach for asymmetric syntheses of (-)-antrocin, (+)-asperolide C and (-)-trans-ozic acid, Li, F.-Z.; Li, S.; Zhang, P.-P.; Huang, Z.-H.; Zhang, W.-B.; Gong, J.; Yang Z., 2016
- Regio- and stereoselective syntheses of 7-oxabicyclo[2.2.1]heptanes via a gold (I)-catalyzed cycloisomerization of alkynediols: asymmetric total synthesis of farnesiferol C, Gu, Y.-Q.; Zhang, P.-P.; Fu, J.-K.; Liu, S.; Lan, Y.; Gong, J.; Yang Z., 2016
- Synthesis of the macrocyclic core of rhizopodin, Song, L.; Liu, J.; Gui, H.; Hui, C.; Zhou, J.; Guo, Y.; Zhang, P.; Xu, Z.; Ye, T., 2013
Awards
- 2024: Project Leader, Major Project of the Ministry of Science and Technology, Science and Technology Innovation 2030—'New Generation Artificial Intelligence'
- 2023: Participant, Zhejiang University 'Huahai Young Scholars Innovation Fund'
- 2023: National Natural Science Foundation of China Excellent Youth Fund (Overseas)
- 2023: Zhejiang University 'New Hundred Talents Program' Special Start-up Fund (Category I)
- 2021: The 3rd Merck Compound Challenge
- 2020: Postdoctoral Fellowship of Genentech, Inc.
- 2018: Rudolph J. Anderson Postdoc Fellowship of Yale University
- 2018: 'Outstanding Graduate' of Beijing Higher Education Institutions
- 2018: 'Outstanding Graduate' of Peking University
- 2017: WuXi AppTec Poster Presentation Excellence Award
- 2017: Morningside Excellent Paper Scholarship
- 2017: ACS Shanghai Chapter Outstanding Graduate Student Research Award
- 2017: National Scholarship for Doctoral Students of Peking University
- 2013: 'Outstanding Graduate' of Lanzhou University
- 2012: 'Three Good Students' of Gansu Higher Education Institutions
- 2012: 'Outstanding Student Model' of Lanzhou University
