Expanded the scope of drug analysis from active ingredients to drug effect molecules, creating analytical pharmacology
Constructed humanized drug enzyme and transporter models, discovering drug targets/biomarkers based on epigenetic regulation mechanisms
Proposed a strategy to increase drug concentration in tumor cells by inducing uptake transporter expression to reverse drug resistance
National Outstanding Youth Fund
National Excellent Teacher Award
Special Government Allowance from the State Council
Selected for the National 'Hundred, Thousand, and Ten Thousand Talents Project'
Research
Drug Metabolism Drug Analysis
The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma, Chen L, Wang Z, Xu Q, Liu Y, Chen L, Guo S, Wang H, Zeng K, Liu J, Zeng S, Yu L, 2020
VARIDT 1.0: variability of drug transporter database, Yin J, Sun W, Li F, Hong J, Li X, Zhou Y, Lu Y, Liu M, Zhang X, Chen N, Jin X, Xue J, Zeng S, Yu L, Zhu F, 2020
Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma, Zhu Q, Yu L, Qin Z, Chen L, Hu H, Zheng X, Zeng S, 2019
A novel human lncRNA SANT1 cis-regulates the expression of SLC47A2 by altering SFPQ/E2F1/HDAC1 binding to the promoter region in renal cell carcinoma, Gao Z, Chen M, Tian X, Chen L, Chen L, Zheng X, Wang H, Chen J, Zhao A, Yao Q, Zhu Q, Jin S, Hu H, Zeng S, Yu L, 2019
Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin, Liu Y, Zheng X, Yu Q, Wang H, Tan F, Zhu Q, Yuan L, Jiang H, Yu L, Zeng S, 2016
Oestrogen sulfotransferase ablation sensitizes mice to sepsis, Chai X, Guo Y, Jiang M, Hu B, Li Z, Fan J, Deng M, Billiar TR, Kucera HR, Gaikwad NW, Xu M, Lu P, Yan J, Fu H, Liu Y, Yu L, Huang M, Zeng S, Xie W, 2015
Research advances in the detection of miRNA, Ye J, Xu M, Tian X, Cai S, Zeng S, 2019
Ultrasensitive detection of miRNA via one-step rolling circle-quantitative PCR (RC-qPCR), Xu M, Ye J, Yang D, Abdullah Al-Maskri AA, Hu H, Jung C, Cai S, Zeng S, 2019
Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma, Yu Q, Liu Y, Zheng X, Zhu Q, Shen Z, Wang H, He H, Lin N, Jiang H, Yu L, Zeng S, 2017
Mechanism for ginkgolic acid (15 : 1)-induced MDCK cell necrosis: Mitochondria and lysosomes damages and cell cycle arrest, Yao QQ, Liu ZH, Xu MC, Hu HH, Zhou H, Jiang HD, Yu LS, Zeng S, 2017
The regioselective glucuronidation of morphine by dimerized human UGT2B7, 1A1, 1A9 and their allelic variants, Yang ZZ, Li L, Wang L, Yuan LM, Xu MC, Gu JK, Jiang HD, Yu LS, Zeng S, 2017
Response to Comment on 'Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin', Zheng X, Liu Y, Yu Q, Wang H, Tan F, Zhu Q, Yuan L, Jiang H, Zeng S, Yu L, 2017
Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor, Yang ZZ, Li L, Xu MC, Ju HX, Hao M, Gu JK, Jim Wang ZJ, Jiang HD, Yu LS, Zeng S, 2017
Chiral detection of entecavir stereoisomeric impurities through coordination with R-besivance and ZnII using mass spectrometry, Wang Y, Wang L, Chen X, Sun C, Zhu Y, Kang Y, Zeng S, 2018
Dimerization of human uridine diphosphate glucuronosyltransferase allozymes 1A1 and 1A9 alters their quercetin glucuronidation activities, Liu YQ, Yuan LM, Gao ZZ, Xiao YS, Sun HY, Yu LS, Zeng S, 2016
siRNA capsulated brain-targeted nanoparticles specifically knock down OATP2B1 in mice: a mechanism for acute morphine tolerance suppression, Yang ZZ, Li L, Wang L, Xu MC, An S, Jiang C, Gu JK, Wang ZJ, Yu LS, Zeng S, 2016
Reverse of acute and chronic morphine tolerance by lithocholic acid via down-regulating UGT2B7, Yang ZZ, Li L, Hu HH, Xu MC, Gu JK, Wang ZJ, Yu LS, Zeng S, 2016
Inter-isoform Hetero-dimerization of Human UGTs 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity, Yuan LM, Gao ZZ, Sun HY, Qian SN, Xiao YS, Sun LL, Zeng S, 2016
Screening and verifying potential NTCP inhibitors from herbal medicinal ingredients using the LLC-PK1 cell model stably expressing human NTCP, Shen ZW, Luo MY, Hu HH, Zhou H, Jiang HD, Yu LS, Zeng S, 2016
Construction of HEK293 cells stably expressing wild-type organic anion transporting polypeptide 1B1 (OATP1B1*1a) and variant OATP1B1*1b and OATP1B1*15, Chen M, Qu BX, Chen XL, Hu HH, Jiang HD, Yu LS, Zhou Q, Zeng S, 2016
Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines, Qin Z, Zhao L, Hu H, Jiang H, Yu LS, Zeng S, 2016
Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor, Yu LS, Wang ZT, Huang MM, Li YY, Zeng K, Lei JX, Hu HH, Chen BA, Lu J, Xie W, Zeng S, 2016
Simultaneous analysis of gemfibrozil, morphine, and its two active metabolites in different mouse brain structures using solid-phase extraction with ultra-high performance liquid chromatography and tandem mass spectrometry with a deuterated internal standard, Yang ZZ, Wang L, Xu MC, Gu JK, Yu LS, Zeng S, 2016
Significance and challenges of stereoselectivity assessing methods in drug metabolism, Shen ZW, Lv C, Zeng S, 2016
Aristolochic acid I is a substrate of BCRP but not P-glycoprotein or MRP2, Ma L, Qin Y, Shen Z, Bi H, Hu H, Huang M, Zhou H, Yu L, Jiang H, Zeng S, 2015
Time-Dependent Inhibition of hOAT1 and hOAT3 by Anthraquinones, Ma L, Qin Y, Shen Z, Hu H, Zhou H, Yu L, Jiang H, Zeng S, 2015
Inhibitory effects of neochamaejasmin B on P-glycoprotein in MDCK-hMDR1 cells and molecular docking of NCB binding in P-glycoprotein, Pan L, Hu H, Wang X, Yu L, Jiang H, Chen J, Lou Y, Zeng S, 2015
Application of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to identify curcumin metabolites produced by human intestinal bacteria, Lou Y, Zheng J, Hu H, Lee J, Zeng S, 2015
Oestrogen sulfotransferase ablation sensitizes mice to sepsis, Chai X, Guo Y, Jiang M, Hu B, Li Z, Fan J, Deng M, Billiar TR, Kucera HR, Gaikwad NW, Xu M, Lu P, Yan J, Fu H, Liu Y, Yu L, Huang M, Zeng S, Xie W, 2015
Platinum(II)-Oligonucleotide Coordination Based Aptasensor for Simple and Selective Detection of Platinum Compounds, Cai S, Tian X, Sun L, Hu H, Zheng S, Jiang H, Yu L, Zeng S, 2015
Homo-and hetero-dimerization of human UGT2B7 wild type and its allelic variants affect zidovudineglucuronidation activity, Yuan L, Qian S, Xiao Y, Sun H, Zeng S, 2015
Expression of Bama Minipig and Human CYP3A Enzymes Comparison of the Catalytic Characteristics with Each Other and Their Liver Microsomes, Bian Y, Yao Q, Shang H, Lei J, Hu H, Guo K, Jiang H, Yu L, Wei H, Zeng S, 2015
Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients fromherbal medicines, Xu C, Luo M, Jiang H, Yu L, Zeng S, 2015
Interplay of Breast Cancer Resistance Protein (BCRP) and Metabolizing Enzymes, Tian Y, Bian Y, Jiang Y, Qian S, Yu A, Zeng S, 2015
Keywords
Drug MetabolismPharmacokineticsDrug TransportersEpigeneticsBiomarkersDrug ResistanceTumor CellsHumanized ModelsAnalytical PharmacologyDrug Enzymes
Area of Focus
Single-Cell | Multi-Omics | Traditional Chinese Medicine | Pharmacology | Toxicology | Nanotoxicology | Exosomes | Epigenetics | Hepatotoxicity | Biomarkers
