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Haibin Qu
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Pharmaceutical Process Analytical Technology (Pat)
Quality By Design (Qbd) In Pharmaceuticals
Big Data Analysis In Pharmaceutical Industry
Traditional Chinese Medicine
Pharmaceutical Informatics
Near-Infrared Spectroscopy
Chemometrics
Bioprocess Development
Monoclonal Antibody Production
Pharmaceutical Engineering
Areas of Focus
- Pharmaceutical Process Analytical Technology (PAT)
- Quality by Design (QbD) in Pharmaceuticals
- Big Data Analysis in Pharmaceutical Industry
Work Experience
- 2004.12-present - Zhejiang University, College of Pharmaceutical Sciences - Professor
- 2003.1-2004.11 - Zhejiang University, College of Pharmaceutical Sciences - Associate Professor
- 2001.1-2002.12 - Zhejiang University, College of Materials and Chemical Engineering - Associate Professor
- 1997.6-2000.12 - Zhejiang University, Department of Information and Electronic Engineering - Lecturer
- 1990.7-1992.8 - Baosteel Chemical Company, Shanghai - Assistant Engineer
Academic Background & Achievements
- 1986-1990 Bachelor's Degree: Zhejiang University, Department of Chemical Engineering
- 1992-1997 Doctoral Degree: Zhejiang University, National Key Laboratory of Industrial Control Technology
- 2004 Promoted to Professor and Doctoral Supervisor
- Director of the Institute of Pharmaceutical Informatics, Zhejiang University
- Director of the Department of Traditional Chinese Medicine Science and Engineering, Zhejiang University
- Director of the Key Laboratory of Traditional Chinese Medicine (TCM) Pharmaceutical Engineering, Zhejiang Province
- Selected for the Ministry of Education's New Century Excellent Talents Support Program
- Key support from Zhejiang Province's 'New Century 151 Talent Project'
Publications
- Combining Convolutional Neural Networks and In‐line Near‐infrared Spectroscopy for Real‐time Monitoring of the Chromatographic Elution Process in Commercial Production of Notoginseng Total Saponins, Yan, X., Fu, H., Zhang, S., & Qu, H., 2019
- Development of an on‐line Raman spectral analytical method for monitoring and endpoint determination of the Cornu Caprae Hircus hydrolysis process, Yan, X., Li, W., Zhang, X., Liu, S., & Qu, H., 2019
- Application of definitive screening design to quantify the effects of process parameters on key granule characteristics and optimize operating parameters in pulsed-spray fluid-bed granulation, Zhao, J., Li, W., Qu, H., Tian, G., & Wei, Y., 2019
- Pharmacological and transcriptome profiling analyses of Fufang E'jiao Jiang during chemotherapy-induced myelosuppression in mice, Zhang, Y., Ye, T., Hong, Z., Gong, S., Zhou, X., Liu, H., ... & Qu, H., 2019
- RNA-sequencing based bone marrow cell transcriptome analysis reveals the potential mechanisms of E'jiao against blood-deficiency in mice, Zhang, Y., Ye, T., Gong, S., Hong, Z., Zhou, X., Liu, H., ... & Qian, J., 2019
- Chemometric identification of canonical metabolites linking critical process parameters to monoclonal antibody production during bioprocess development, Shen, L., Yan, X., Nie, L., Xu, W., Miao, S., Wang, H., ... & Qu, H., 2019
- Rapid analysis of the Tanreqing injection by near-infrared spectroscopy combined with least squares support vector machine and Gaussian process modeling techniques, Li, W., Yan, X., Pan, J., Liu, S., Xue, D., & Qu, H., 2019
- Development and validation of in-line near-infrared spectroscopy based analytical method for commercial production of a botanical drug product, Zhang, S., Xiong, H., Zhou, L., Ju, W., Yang, Z., Yan, K., ... & Qu, H., 2019
- Development and Qualification of a Scale-Down Mammalian Cell Culture Model and Application in Design Space Development by Definitive Screening Design, Nie, L., Gao, D., Jiang, H., Gou, J., Li, L., Hu, F., ... & Qu, H., 2019
- Preparation of Salvianolic Acid B Disodium Salt Considering the Water Extract Quality Standard, Ye, T., Qu, H., & Gong, X., 2019
- Combining convolutional neural networks and on-line Raman spectroscopy for monitoring the Cornu Caprae Hircus hydrolysis process, Yan, X., Zhang, S., Fu, H., & Qu, H., 2019
- Critical process parameter identification of manufacturing processes of Astragali Radix extract with a weighted determination coefficient method, Sun, M. F., Yang, J. Y., Cao, W., Shao, J. Y., Wang, G. X., Qu, H. B., ... & Gong, X. C., 2019
- Application of near-infrared spectroscopy combined with design of experiments for process development of the pulsed spray fluid bed granulation process, Tian, G., Wei, Y., Zhao, J., Li, W., & Qu, H., 2018
- In-situ monitoring of saccharides removal of alcohol precipitation using near-infrared spectroscopy, Huang, H., & Qu, H., 2018
- In-line Vis-NIR spectral analysis for the column chromatographic processes of Ginkgo biloba part I: End-point determination of the elution process, Li, W., Yan, X., Chen, H., & Qu, H., 2018
- Optimization of a Coupling Process for Insulin Degludec According to a Quality by Design (QbD) Paradigm, Nie, L., Hu, M., Yan, X., Guo, T., Wang, H., Zhang, S., & Qu, H., 2018
- A novel quality by design approach for developing an HPLC method to analyze herbal extracts: A case study of sugar content analysis, Shao, J., Cao, W., Qu, H., Pan, J., & Gong, X., 2018
- Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values, Gong, X., Huang, S., Pan, J., & Qu, H., 2017
- Rapid quantification of multi-components in alcohol precipitation liquid of Codonopsis Radix using near infrared spectroscopy (NIRS), Luo, Y., Li, W., Huang, W. H., Liu, X. H., Song, Y. G., & Qu, H. B., 2017
- Measurement and Correlation of Liquid–Liquid Equilibria for the Ternary Systems of Water+ d-Fructose+ 1-Butanol, Water+ d-Glucose+ 1-Butanol, and Water+ d-Galactose+ 1-Butanol at (288.2, 303.2 and 318.2) K, Ye, T., Qu, H., & Gong, X., 2017
- A feasibility research on the monitoring of traditional Chinese medicine production process using NIR-based multivariate process trajectories, Li, W., Han, H., Cheng, Z., Zhang, Y., Liu, S., & Qu, H., 2016
- Chromatographic elution process design space development for the purification of saponins in Panax notoginseng extract using a probability‐based approach, Chen, T., Gong, X., Chen, H., Zhang, Y., & Qu, H., 2016
- Development of an analytical method by defining a design space: a case study of saponin determination for Panax notoginseng extracts, Gong, X., Zhang, Y., Chen, H., Chen, T., Pan, J., Wang, X., & Qu, H., 2016
- Determination of total organic carbon and soluble solids contents in Tanreqing injection intermediates with NIR spectroscopy and chemometrics, Li, W., & Qu, H., 2016
- Identification of bioactive ingredients with immuno-enhancement and anti-oxidative effects from Fufang-Ejiao-Syrup by LC–MSn combined with bioassays, Shen, L., Chen, H., Zhu, Q., Wang, Y., Wang, S., Qian, J., ... & Qu, H., 2016
- Monitoring of the hydrolysis process of bear bile powder using near infrared spectroscopy and chemometrics, Li, W., Cheng, Z., & Qu, H., 2016
- The determination of dissociation constants for active ingredients from herbal extracts using a liquid–liquid equilibrium method, Gong, X., Huang, S., Jiao, R., Pan, J., Li, Y., & Qu, H., 2016
- Degradation Kinetics and Mechanism of Lithospermic Acid under Low Oxygen Condition Using Quantitative 1H N
Awards
- National Science and Technology Progress Award First Prize (2014)
- National Science and Technology Progress Award Second Prize (2004)
- Provincial and Ministerial Science and Technology Award Special Prize
- Provincial and Ministerial Science and Technology Award First Prize
- Provincial and Ministerial Science and Technology Award Second Prize (7 times)
- Provincial and Ministerial Science and Technology Award Third Prize (2 times)
- 8th Zhejiang Youth Science and Technology Award
