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Yuan Ping
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Drug Delivery: Drug Delivery
Therapeutic Efficacy
Biocompatibility
Pharmacology
Nanomedicine
Targeted Therapy
Controlled Release
Drug Carriers
Bioavailability
Disease Treatment
Biomaterials: Biomaterials
Tissue Engineering
Regenerative Medicine
Polymers
Nanomaterials
Scaffolds
Biomedical Applications
Material Science
Drug Delivery
Gene Editing: Gene Editing
Crispr/Cas9
Genome Editing
Genetic Therapy
Non-Viral Vectors
Precision Medicine
Genetic Disorders
Molecular Biology
Therapeutic Applications
Biotechnology
Areas of Focus
- Drug Delivery
- Biomaterials
- Gene Editing
Work Experience
- 2017 - Present: Zhejiang University - Researcher, Associate Professor, Professor
- Dean of the School of Pharmacy at Zunyi Medical University
Academic Background & Achievements
- 2017: Joined Zhejiang University as a researcher under the 'Hundred Talents Program'
- 2020: Promoted to Tenured Associate Professor at Zhejiang University
- 2023: Promoted to Tenured Professor at Zhejiang University
- Published over 80 papers in international SCI journals, with over 40 as corresponding author in journals like Nature Nanotechnology, PNAS, Science Advances
- Received funding from National Natural Science Foundation, Ministry of Science and Technology, National Biopharmaceutical Technology Innovation Center, Zhejiang Provincial Outstanding Youth Project
Publications
- Proinflammatory polarization of engineered heat-inducible macrophages reprogram the tumor immune microenvironment during cancer immunotherapy, Y. Xue, X. Yan, D. Li, S. Dong, Y. Ping, 2024
- Supramolecular Genome Editing: Targeted Delivery and Endogenous Activation of CRISPR/Cas9 by Dynamic Host-Guest Recognition, B. Li, Q. Li, Z. Qi, Z. Li, X. Yan, Y. Chen, X. Xu, Q. Pan, Y. Chen, F. Huang, Y. Ping, 2024
- An oncolytic virus–T cell chimera for cancer immunotherapy, Y. Chen, X. Chen, W. Bao, G. Liu, W. Wei, Y. Ping, 2024
- Development of CRISPR/Cas Delivery Systems for In Vivo Precision Genome Editing, Y. Chen, Y. Ping, 2023
- Targeted Delivery of PROTAC-based Prodrug Activated by Bond-Cleavage Bioorthogonal Chemistry for Microneedle-Assisted Cancer Therapy, J. Huang, Z. Yao, B. Li, Y. Ping, 2023
- Non-Invasive Activation of Intratumoural Gene Editing for Improved Adoptive T-Cell Therapy in Solid Tumours, X. Chen, S. Wang, Y. Chen, H. Xin, S. Zhang, D. Wu, Y. Xue, M. Zha, H. Li, K. Li, Z. Gu, W. Wei, Y. Ping, 2023
- A Dual-Specific CRISPR-Cas Nanosystem for Precision Therapeutic Editing of Liver Disorders, X. Xu, H. Tang, J. Guo, H. Xin, Y. Ping, 2022
- Peptides as Molecular Trojan Horses, Y. Ping, 2022
- A Duplex CRISPR-Cas9 Ribonucleoprotein Nanomedicine for Colorectal Cancer Gene Therapy, T. Wan, Q. Pan, C. Liu, J. Guo, B. Li, X. Yan, Y. Cheng, Y. Ping, 2021
- Genome-Editing Prodrug: Targeted Delivery and Conditional Stabilization of CRISPR/Cas9 for Precision Therapy of Inflammatory Disease, X. Yan, Q. Pan, H. Xin, Y. Chen, Y. Ping, 2021
- Rational Design of Poly(disulfide)s as a Universal Platform for Delivery of CRISPR/Cas9 Machineries toward Therapeutic Genome Editing, J. Guo, T. Wan, B. Li, Q. Pan, H. Xin, Y. Qiu, Y. Ping, 2021
- Microneedle-Assisted Genome Editing: A Transdermal Strategy of Targeting NLRP3 by CRISPR/Cas9 for Synergistic Therapy of Inflammatory Skin Disorders, T. Wan, P. Qi, Y. Ping, 2021
- Reprogramming Tumor Microenvironment through Second Near-Infrared Photothermal Genome Editing of PD-L1 mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy, H. Tang, X. Xu, Y. Chen, H. Xin, T. Wan, B. Li, H. Pan, D. Li, Y. Ping, 2021
- Delivery of CRISPR/Cas9 Plasmids by Cationic Gold Nanorods: Impact of Aspect Ratio for Genome Editing and Treatment of Hepatic Fibrosis, Y. Chen, X. Chen, D. Wu, H. Xin, D. Chen, D. Li, H. Pan, C. Zhou, Y. Ping, 2021
- Delivery of genome-editing biomacromolecules for treatment of lung genetic disorders, T. Wan, Y. Ping, 2021
- Near-Infrared Engineering of Photothermal NanoCRISPR for Programmable Genome Editing, X. Chen, Y. Chen, H. Xin, T. Wan, Y. Ping, 2020
- A synergistic optical strategy for enhanced deep-tumor penetration and therapy in the second near-infrared window, D. Wu, X. Chen, J. Zhou, Y. Chen, T. Wan, Y. Wang, A. Lin, Y. Ruan, Z. Chen, X. Song, W. Fang, H. Duan, Y. Ping, 2020
- Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy, T. Wan, Y. Chen, Q. Pan, X. Xu, Y. Kang, X. Gao, F. Huang, C. Wu, Y. Ping, 2020
- Bioengineering Bacterial Vesicle-Coated Polymeric Nanomedicine for Enhanced Cancer Immunotherapy and Metastasis Prevention, Q. Chen, M. Wu, G. Huang, G. Tang, Y. Ping, 2020
- Off-Targeting of Base Editors: BE3 but not ABE induces substantial off-target single nucleotide variants, H. Xin, T. Wan, Y. Ping, 2019
- A boronic acid-rich dendrimer with robust and unprecedented efficiency for cytosolic protein delivery and CRISPR/Cas9 gene editing, C. Liu, T. Wan, H. Wang, S. Zhang, Y. Ping, Y. Cheng, 2019
- Material Solutions for Delivery of CRISPR/Cas-Based Genome Editing Tools: Current Status and Future Outlook, T. Wan, D. Niu, C. Wu, F-J Xu, G. Church, Y. Ping, 2019
- Cationic Polymer‐Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing, Z. Zhang, T. Wan, Y. Chen, Y. Chen, H. Sun, T. Cao, Z. Songyang, G. Tang, C. Wu, Y. Ping, F. J. Xu, J. Huang, 2018
- Reactive Oxygen Species (ROS)-Responsive Nanomedicine for RNAi-Based Cancer Therapy, Y. Li, H. Bai, H. Wang, Y. Shen, G. Tang, Y. Ping, 2018
- A Cooperative Dimensional Strategy for Enhanced Nuclear-Targeted Delivery of Anticancer Drug, H. Wang, Y. Li, H. Bai, J. Shen, X. Chen, Y. Ping, Guping Tang, 2017
- Targeting ETS1 with RNAi-based Supramolecular Nanoassemblies for Multidrug-Resistant Breast Cancer Therapy, M. Wu, X. Liu, W. Jin, Y. Li, Y. Li, Q. Hu, P. Chu, G. Tang, Y. Ping, 2017
- Multiple Regulation of Cancer Multidrug Resistance through Lanthanide-Functionalized Supramolecular Polymeric Nanoparticles, W. Jin, Q. Wang, M. Wu, Y. Li, G. Tang, Y. Ping, P. K. Chu, 2017
- Redox-Activatable ATP-Depleting Micelles with Dual Modulation Characteristics for Multidrug-Resistant Cancer Therapy, H. Wang, Y. Li, M. Zhang, D. Wu, Y. Shen, G. Tang, Y. Ping, 2017
- A Redox-activated Light-up Nanomicelle for Precise Imaging-guided Cancer Therapy and Real-time Pharmacokinetic Monitoring, X. Liu, M. Wu, Q. Hu, H. Bai, S. Zhang, Y. Shen, G. Tang, Y. Ping, 2016
- Structure-Invertible Nanoparticles for Triggered Co-Delivery of Nucleic Acids and Hydrophobic Drugs for Combination Cancer Therapy, K. Wang, Q. Hu, W. Zhu, M. Zhao, Y. Ping, G. Tang, 2015
- Engineering Nanoparticle-Coated Bacteria as Oral DNA Vaccines for Cancer Immunotherapy, Q. Hu, M. Wu, C. Fang, C. Cheng, M. Zhao, W. Fang, P. K. Chu, Y. Ping, G. Tang, 2015
Awards
- JCR (Journal of Controlled Release) Emerging Leader Award
- International Association of Advanced Materials Scientist Medal
- Zhejiang University 2020 Top Ten Academic Progress Nomination
