Professor | Linghui Qian | Asia Growth Partners

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Name	Linghui Qian
Contact Information	lhqian@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Linghui Qian

Contact Information

lhqian@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2013-2017: Ph.D. in Chemical Biology, National University of Singapore 2008-2012: Bachelor's in Pharmacy, Zhejiang University
Work Experience	2018.11-present: Researcher, Doctoral Supervisor, Zhejiang University 2017.9-2018.9: Postdoctoral Researcher, Institute of Molecular and Cell Biology, A*STAR, Singapore 2017.1-2017.8: Research Assistant, Department of Chemistry, National University of Singapore

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2013-2017: Ph.D. in Chemical Biology, National University of Singapore
2008-2012: Bachelor's in Pharmacy, Zhejiang University

Work Experience

2018.11-present: Researcher, Doctoral Supervisor, Zhejiang University
2017.9-2018.9: Postdoctoral Researcher, Institute of Molecular and Cell Biology, A*STAR, Singapore
2017.1-2017.8: Research Assistant, Department of Chemistry, National University of Singapore

Areas of Focus	Exploring disease-related biomarkers and constructing high-performance fluorescent probes for detection Developing new organic small molecule/biomacromolecule formulations to regulate pathological states Studying drug/active compound targets and mechanisms of action Revealing disease mechanisms and optimizing early disease diagnosis
Publications	Targeted Degradation of Cell-Surface Proteins via Chaperone-Mediated Autophagy by Using Peptide-Conjugated Antibodies, Shao, J.; Lin, X.; Wang, H.; Zhao, C.; Yao, S. Q.; Ge, J.; Zeng, S.; Qian, L., 2024 Atroposelective synthesis of eight-membered lactam-bridged N-arylindoles via stepwise cut-and-sew strategy, Tao, L.-F.; Huang, F.; Zhao, X.; Qian, L.; Liao, J.-Y., 2023 Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins, Zhang, B.; Brahma, R. K.; Zhu, L. Feng, J.; Hu, S.; Qian, L.; Du, S.; Yao, S. Q.; Ge, J., 2023 A Dual-Modal Graph Learning Framework for Identifying Interaction Events among Chemical and Biotech Drugs, Ru, Z.; Wu, Y.; Shao, J.; Yin, J.; Qian, L.; Miao, X., 2023 化学成像技术及其在药物分析中的应用, 郑伊; 林雪芬; 徐昕怡; 曾苏; 钱玲慧, 2023 Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality, Huang, F.; Tao, L.-F.; Liu, J.; Qian, L.; Liao J.-Y., 2023 The Dawn of a New Era: Targeting the ‘Undruggables’ with Antibody-Based Therapeutics, Qian, L.; Lin, X.; Gao, X.; Khan, R. U.; Liao, J.-Y.; Du, S.; Ge, J.; Zeng, S.; Yao, S. Q., 2023 Quantitative analysis of mitochondrial RNA in living cells with a dual-color imaging system, Chen, Z; Zeng, S.; Qian, L., 2023 pH-Triggered cancer-targeting strategies: from extracellular accumulation to intracellular release, Khan, R. U.; Shao, J.; Liao, J.-Y. Qian, L., 2023 PKM2-mediated neuronal hyperglycolysis enhances risk of Parkinson's disease in diabetic rats, Zhao, Y.; Wang, Y.; Wu, Y.; Tao, C.; Xu, R.; Chen, Y.; Qian, L.; Xu, T.; Lian, X., 2023 Sensitive Imaging of Cellular RNA via Cascaded Proximity-Induced Fluorogenic Reactions, Chen, Z; Wang, W.; Wang, W.; Huang, J.; Liao, J.-Y.; Zeng, S.; Qian, L., 2022 Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers, Luo, Z.-H.; Wang, W.-T.; Tang, T.-Y.; Zhang, S.; Huang, F.; Hu, D.; Tao, L.-F.; Qian, L.; Liao, J.-Y., 2022 Catalytic Asymmetric [3+3] Cycloaddition of Activated Isocyanides with Azomethine Imines, Tao, L.-F.; Qian, L.; Liao, J.-Y., 2022 Simultaneous Construction of C−N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3 + 2] Cycloaddition of Prochiral N‑Aryl Maleimides with Activated Isocyanides, Zhang, S.; Luo, Z.-H.; Wang, W.-T.; Qian, L.; Liao, J.-Y., 2022 Cooperative Catalysis-Enabled C-N Bond Cleavage of Biaryl Lactams with Activated Isocyanides, Wang, W.-T.; Zhang, S.; Tao, L.-F.; Pan, Z.-Q.; Qian, L.; Liao, J.-Y., 2022 Diastereo- and Enantioselective Silver-Catalyzed [3+3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides, Tao, L.-F.; Zhang, S.; Huang, F.; Wang, W.-T.; Luo, Z.-H.; Qian, L.; Liao, J.-Y., 2022 Prediction of Maximum Absorption Wavelength Using Deep Neural Networks, Shao, J.; Liu, Y.; Yan, J.; Yan, Z.-Y.; Wu, Y.; Ru, Z.; Liao, J.-Y.; Miao, X.; Qian, L., 2022 In Vivo Targeted Delivery of Antibodies into Cancer Cells with pH-Responsive Cell-Penetrating Poly(disulfide)s, Kong, Y.; Zeng, K.; Zhang, Y.; Shao, J.; Yan, J.; Liao, J.-Y.; Wang, W.; Dai, X.; Weng, Q.; Yao, S. Q.; Zeng, S.; Qian, L., 2022 Real-Time Imaging of Cell-Surface Proteins with Antibody-Based Fluorogenic Probes, Wang, W.; Zhang, Y.; Zhao, H.; Zhuang, X.; Wang, H.; He, K.; Xu, W.; Kang, Y.; Chen, S.; Zeng, S.; Qian, L., 2021 Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides, Qian, L.; Tao, L.-F.; Wang, W.-T.; Jameel, E.; Luo, Z.-H.; Zhang, T.; Zhao, Y.; Liao, J.-Y., 2021 Isocyanides: Promising Functionalities in Bioorthogonal Labeling of Biomolecules, Zhu, Y.; Liao, J.-Y.; Qian, L., 2021 Recent Progress in the Molecular Imaging of Therapeutic Monoclonal Antibodies, He, K.; Zeng, S.; Qian, L., 2020 国家自然科学基金批准资助药物分析项目分析, 钱玲慧; 蔡圣; 余露山; 曾苏, 2020 Recent Advances in Construction of Small Molecule-Based Fluorophore-Drug Conjugates, Lang, W.; Yuan, C.; Zhu, L.; Du, S.; Qian, L.; Ge, J.; Yao, S. Q., 2020 Differently Tagged Probes for Protein Profiling of Mitochondria, Dong, J.; Hong, D.; Lang, W.; Huang, J.; Qian, L.; Zhu, Q.; Li, L.; Ge, J., 2019 Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases, Shi, R.; Wu, Q.; Xin, C.; Yu, H.; Lim, K.-L.; Li, X.; Shi, Z.; Zhang, C.-W.; Qian, L.; Li, L.; Huang, W., 2019 Live-cell Imaging and Profiling of c-Jun N-terminal Kinases Using Covalent Inhibitor-derived Probes, Qian, L.; Pan, S.; Lee, J.-S.; Ge, J.; Li, L.; Yao, S. Q., 2019 Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s, Qian, L.; Fu, J.; Yuan, P.; Du, S.; Huang, W.; Li, L.; Yao, S. Q., 2018 Fused Bicyclic Caspase-1 Inhibitors Assembled by Copper-Free Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC), Qian, L.; Zhang, C.-J.; Wu, J.; Yao, S. Q., 2017 Two-Photon Small Molecule Enzymatic Probes, Qian, L.; Li, L.; Yao, S. Q., 2016 Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models, Qian, L.; Zhang, C.-W.; Mao, Y.; Li, L.; Gao, N.; Lim, K.-L.; Xu, Q.-H.; Yao, S. Q., 2016 Intracellular Delivery of Functional Native Antibodies under Hypoxic Conditions by Using a Biodegradable Silica Nanoquencher, Yuan, P.; Zhang, H.; Qian, L.; Mao, X.; Du, S.; Yu, C.; Peng, B.; Yao, S. Q., 2017 Cell-Penetrating Poly(disulfide) Assisted Intracellular Delivery of Mesoporous Silica Nanoparticles for Inhibition of miR-21 Function and Detection of Subsequent Therapeutic Effects, Yu, C.; Qian, L.; Ge, J.; Fu, J.; Yuan, P.; Yao, S. C. L.; Yao, S. Q., 2016 Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications, Li, Z.; Qian, L.; Li, L.; Bernhammer, J. C.; Huynh, H. V.; Lee, J.-S.; Yao, S. Q., 2016 Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit mi

Areas of Focus

Exploring disease-related biomarkers and constructing high-performance fluorescent probes for detection
Developing new organic small molecule/biomacromolecule formulations to regulate pathological states
Studying drug/active compound targets and mechanisms of action
Revealing disease mechanisms and optimizing early disease diagnosis

Publications

Targeted Degradation of Cell-Surface Proteins via Chaperone-Mediated Autophagy by Using Peptide-Conjugated Antibodies, Shao, J.; Lin, X.; Wang, H.; Zhao, C.; Yao, S. Q.; Ge, J.; Zeng, S.; Qian, L., 2024
Atroposelective synthesis of eight-membered lactam-bridged N-arylindoles via stepwise cut-and-sew strategy, Tao, L.-F.; Huang, F.; Zhao, X.; Qian, L.; Liao, J.-Y., 2023
Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins, Zhang, B.; Brahma, R. K.; Zhu, L. Feng, J.; Hu, S.; Qian, L.; Du, S.; Yao, S. Q.; Ge, J., 2023
A Dual-Modal Graph Learning Framework for Identifying Interaction Events among Chemical and Biotech Drugs, Ru, Z.; Wu, Y.; Shao, J.; Yin, J.; Qian, L.; Miao, X., 2023
化学成像技术及其在药物分析中的应用, 郑伊; 林雪芬; 徐昕怡; 曾苏; 钱玲慧, 2023
Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality, Huang, F.; Tao, L.-F.; Liu, J.; Qian, L.; Liao J.-Y., 2023
The Dawn of a New Era: Targeting the ‘Undruggables’ with Antibody-Based Therapeutics, Qian, L.; Lin, X.; Gao, X.; Khan, R. U.; Liao, J.-Y.; Du, S.; Ge, J.; Zeng, S.; Yao, S. Q., 2023
Quantitative analysis of mitochondrial RNA in living cells with a dual-color imaging system, Chen, Z; Zeng, S.; Qian, L., 2023
pH-Triggered cancer-targeting strategies: from extracellular accumulation to intracellular release, Khan, R. U.; Shao, J.; Liao, J.-Y. Qian, L., 2023
PKM2-mediated neuronal hyperglycolysis enhances risk of Parkinson's disease in diabetic rats, Zhao, Y.; Wang, Y.; Wu, Y.; Tao, C.; Xu, R.; Chen, Y.; Qian, L.; Xu, T.; Lian, X., 2023
Sensitive Imaging of Cellular RNA via Cascaded Proximity-Induced Fluorogenic Reactions, Chen, Z; Wang, W.; Wang, W.; Huang, J.; Liao, J.-Y.; Zeng, S.; Qian, L., 2022
Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers, Luo, Z.-H.; Wang, W.-T.; Tang, T.-Y.; Zhang, S.; Huang, F.; Hu, D.; Tao, L.-F.; Qian, L.; Liao, J.-Y., 2022
Catalytic Asymmetric [3+3] Cycloaddition of Activated Isocyanides with Azomethine Imines, Tao, L.-F.; Qian, L.; Liao, J.-Y., 2022
Simultaneous Construction of C−N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3 + 2] Cycloaddition of Prochiral N‑Aryl Maleimides with Activated Isocyanides, Zhang, S.; Luo, Z.-H.; Wang, W.-T.; Qian, L.; Liao, J.-Y., 2022
Cooperative Catalysis-Enabled C-N Bond Cleavage of Biaryl Lactams with Activated Isocyanides, Wang, W.-T.; Zhang, S.; Tao, L.-F.; Pan, Z.-Q.; Qian, L.; Liao, J.-Y., 2022
Diastereo- and Enantioselective Silver-Catalyzed [3+3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides, Tao, L.-F.; Zhang, S.; Huang, F.; Wang, W.-T.; Luo, Z.-H.; Qian, L.; Liao, J.-Y., 2022
Prediction of Maximum Absorption Wavelength Using Deep Neural Networks, Shao, J.; Liu, Y.; Yan, J.; Yan, Z.-Y.; Wu, Y.; Ru, Z.; Liao, J.-Y.; Miao, X.; Qian, L., 2022
In Vivo Targeted Delivery of Antibodies into Cancer Cells with pH-Responsive Cell-Penetrating Poly(disulfide)s, Kong, Y.; Zeng, K.; Zhang, Y.; Shao, J.; Yan, J.; Liao, J.-Y.; Wang, W.; Dai, X.; Weng, Q.; Yao, S. Q.; Zeng, S.; Qian, L., 2022
Real-Time Imaging of Cell-Surface Proteins with Antibody-Based Fluorogenic Probes, Wang, W.; Zhang, Y.; Zhao, H.; Zhuang, X.; Wang, H.; He, K.; Xu, W.; Kang, Y.; Chen, S.; Zeng, S.; Qian, L., 2021
Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides, Qian, L.; Tao, L.-F.; Wang, W.-T.; Jameel, E.; Luo, Z.-H.; Zhang, T.; Zhao, Y.; Liao, J.-Y., 2021
Isocyanides: Promising Functionalities in Bioorthogonal Labeling of Biomolecules, Zhu, Y.; Liao, J.-Y.; Qian, L., 2021
Recent Progress in the Molecular Imaging of Therapeutic Monoclonal Antibodies, He, K.; Zeng, S.; Qian, L., 2020
国家自然科学基金批准资助药物分析项目分析, 钱玲慧; 蔡圣; 余露山; 曾苏, 2020
Recent Advances in Construction of Small Molecule-Based Fluorophore-Drug Conjugates, Lang, W.; Yuan, C.; Zhu, L.; Du, S.; Qian, L.; Ge, J.; Yao, S. Q., 2020
Differently Tagged Probes for Protein Profiling of Mitochondria, Dong, J.; Hong, D.; Lang, W.; Huang, J.; Qian, L.; Zhu, Q.; Li, L.; Ge, J., 2019
Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases, Shi, R.; Wu, Q.; Xin, C.; Yu, H.; Lim, K.-L.; Li, X.; Shi, Z.; Zhang, C.-W.; Qian, L.; Li, L.; Huang, W., 2019
Live-cell Imaging and Profiling of c-Jun N-terminal Kinases Using Covalent Inhibitor-derived Probes, Qian, L.; Pan, S.; Lee, J.-S.; Ge, J.; Li, L.; Yao, S. Q., 2019
Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s, Qian, L.; Fu, J.; Yuan, P.; Du, S.; Huang, W.; Li, L.; Yao, S. Q., 2018
Fused Bicyclic Caspase-1 Inhibitors Assembled by Copper-Free Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC), Qian, L.; Zhang, C.-J.; Wu, J.; Yao, S. Q., 2017
Two-Photon Small Molecule Enzymatic Probes, Qian, L.; Li, L.; Yao, S. Q., 2016
Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models, Qian, L.; Zhang, C.-W.; Mao, Y.; Li, L.; Gao, N.; Lim, K.-L.; Xu, Q.-H.; Yao, S. Q., 2016
Intracellular Delivery of Functional Native Antibodies under Hypoxic Conditions by Using a Biodegradable Silica Nanoquencher, Yuan, P.; Zhang, H.; Qian, L.; Mao, X.; Du, S.; Yu, C.; Peng, B.; Yao, S. Q., 2017
Cell-Penetrating Poly(disulfide) Assisted Intracellular Delivery of Mesoporous Silica Nanoparticles for Inhibition of miR-21 Function and Detection of Subsequent Therapeutic Effects, Yu, C.; Qian, L.; Ge, J.; Fu, J.; Yuan, P.; Yao, S. C. L.; Yao, S. Q., 2016
Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications, Li, Z.; Qian, L.; Li, L.; Bernhammer, J. C.; Huynh, H. V.; Lee, J.-S.; Yao, S. Q., 2016
Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit mi

Biomarkers Fluorescent Probes Organic Molecules Biomacromolecules Pathological Regulation Drug Targets Mechanisms Of Action Disease Mechanisms Early Diagnosis Pharmacy

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