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Linghui Qian
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Biomarkers
Fluorescent Probes
Organic Molecules
Biomacromolecules
Pathological Regulation
Drug Targets
Mechanisms Of Action
Disease Mechanisms
Early Diagnosis
Pharmacy
Areas of Focus
- Exploring disease-related biomarkers and constructing high-performance fluorescent probes for detection
- Developing new organic small molecule/biomacromolecule formulations to regulate pathological states
- Studying drug/active compound targets and mechanisms of action
- Revealing disease mechanisms and optimizing early disease diagnosis
Work Experience
- 2018.11-present: Researcher, Doctoral Supervisor, Zhejiang University
- 2017.9-2018.9: Postdoctoral Researcher, Institute of Molecular and Cell Biology, A*STAR, Singapore
- 2017.1-2017.8: Research Assistant, Department of Chemistry, National University of Singapore
Academic Background & Achievements
- 2013-2017: Ph.D. in Chemical Biology, National University of Singapore
- 2008-2012: Bachelor's in Pharmacy, Zhejiang University
Publications
- Targeted Degradation of Cell-Surface Proteins via Chaperone-Mediated Autophagy by Using Peptide-Conjugated Antibodies, Shao, J.; Lin, X.; Wang, H.; Zhao, C.; Yao, S. Q.; Ge, J.; Zeng, S.; Qian, L., 2024
- Atroposelective synthesis of eight-membered lactam-bridged N-arylindoles via stepwise cut-and-sew strategy, Tao, L.-F.; Huang, F.; Zhao, X.; Qian, L.; Liao, J.-Y., 2023
- Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins, Zhang, B.; Brahma, R. K.; Zhu, L. Feng, J.; Hu, S.; Qian, L.; Du, S.; Yao, S. Q.; Ge, J., 2023
- A Dual-Modal Graph Learning Framework for Identifying Interaction Events among Chemical and Biotech Drugs, Ru, Z.; Wu, Y.; Shao, J.; Yin, J.; Qian, L.; Miao, X., 2023
- 化学成像技术及其在药物分析中的应用, 郑伊; 林雪芬; 徐昕怡; 曾苏; 钱玲慧, 2023
- Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality, Huang, F.; Tao, L.-F.; Liu, J.; Qian, L.; Liao J.-Y., 2023
- The Dawn of a New Era: Targeting the ‘Undruggables’ with Antibody-Based Therapeutics, Qian, L.; Lin, X.; Gao, X.; Khan, R. U.; Liao, J.-Y.; Du, S.; Ge, J.; Zeng, S.; Yao, S. Q., 2023
- Quantitative analysis of mitochondrial RNA in living cells with a dual-color imaging system, Chen, Z; Zeng, S.; Qian, L., 2023
- pH-Triggered cancer-targeting strategies: from extracellular accumulation to intracellular release, Khan, R. U.; Shao, J.; Liao, J.-Y. Qian, L., 2023
- PKM2-mediated neuronal hyperglycolysis enhances risk of Parkinson's disease in diabetic rats, Zhao, Y.; Wang, Y.; Wu, Y.; Tao, C.; Xu, R.; Chen, Y.; Qian, L.; Xu, T.; Lian, X., 2023
- Sensitive Imaging of Cellular RNA via Cascaded Proximity-Induced Fluorogenic Reactions, Chen, Z; Wang, W.; Wang, W.; Huang, J.; Liao, J.-Y.; Zeng, S.; Qian, L., 2022
- Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers, Luo, Z.-H.; Wang, W.-T.; Tang, T.-Y.; Zhang, S.; Huang, F.; Hu, D.; Tao, L.-F.; Qian, L.; Liao, J.-Y., 2022
- Catalytic Asymmetric [3+3] Cycloaddition of Activated Isocyanides with Azomethine Imines, Tao, L.-F.; Qian, L.; Liao, J.-Y., 2022
- Simultaneous Construction of C−N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3 + 2] Cycloaddition of Prochiral N‑Aryl Maleimides with Activated Isocyanides, Zhang, S.; Luo, Z.-H.; Wang, W.-T.; Qian, L.; Liao, J.-Y., 2022
- Cooperative Catalysis-Enabled C-N Bond Cleavage of Biaryl Lactams with Activated Isocyanides, Wang, W.-T.; Zhang, S.; Tao, L.-F.; Pan, Z.-Q.; Qian, L.; Liao, J.-Y., 2022
- Diastereo- and Enantioselective Silver-Catalyzed [3+3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides, Tao, L.-F.; Zhang, S.; Huang, F.; Wang, W.-T.; Luo, Z.-H.; Qian, L.; Liao, J.-Y., 2022
- Prediction of Maximum Absorption Wavelength Using Deep Neural Networks, Shao, J.; Liu, Y.; Yan, J.; Yan, Z.-Y.; Wu, Y.; Ru, Z.; Liao, J.-Y.; Miao, X.; Qian, L., 2022
- In Vivo Targeted Delivery of Antibodies into Cancer Cells with pH-Responsive Cell-Penetrating Poly(disulfide)s, Kong, Y.; Zeng, K.; Zhang, Y.; Shao, J.; Yan, J.; Liao, J.-Y.; Wang, W.; Dai, X.; Weng, Q.; Yao, S. Q.; Zeng, S.; Qian, L., 2022
- Real-Time Imaging of Cell-Surface Proteins with Antibody-Based Fluorogenic Probes, Wang, W.; Zhang, Y.; Zhao, H.; Zhuang, X.; Wang, H.; He, K.; Xu, W.; Kang, Y.; Chen, S.; Zeng, S.; Qian, L., 2021
- Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides, Qian, L.; Tao, L.-F.; Wang, W.-T.; Jameel, E.; Luo, Z.-H.; Zhang, T.; Zhao, Y.; Liao, J.-Y., 2021
- Isocyanides: Promising Functionalities in Bioorthogonal Labeling of Biomolecules, Zhu, Y.; Liao, J.-Y.; Qian, L., 2021
- Recent Progress in the Molecular Imaging of Therapeutic Monoclonal Antibodies, He, K.; Zeng, S.; Qian, L., 2020
- 国家自然科学基金批准资助药物分析项目分析, 钱玲慧; 蔡圣; 余露山; 曾苏, 2020
- Recent Advances in Construction of Small Molecule-Based Fluorophore-Drug Conjugates, Lang, W.; Yuan, C.; Zhu, L.; Du, S.; Qian, L.; Ge, J.; Yao, S. Q., 2020
- Differently Tagged Probes for Protein Profiling of Mitochondria, Dong, J.; Hong, D.; Lang, W.; Huang, J.; Qian, L.; Zhu, Q.; Li, L.; Ge, J., 2019
- Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases, Shi, R.; Wu, Q.; Xin, C.; Yu, H.; Lim, K.-L.; Li, X.; Shi, Z.; Zhang, C.-W.; Qian, L.; Li, L.; Huang, W., 2019
- Live-cell Imaging and Profiling of c-Jun N-terminal Kinases Using Covalent Inhibitor-derived Probes, Qian, L.; Pan, S.; Lee, J.-S.; Ge, J.; Li, L.; Yao, S. Q., 2019
- Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s, Qian, L.; Fu, J.; Yuan, P.; Du, S.; Huang, W.; Li, L.; Yao, S. Q., 2018
- Fused Bicyclic Caspase-1 Inhibitors Assembled by Copper-Free Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC), Qian, L.; Zhang, C.-J.; Wu, J.; Yao, S. Q., 2017
- Two-Photon Small Molecule Enzymatic Probes, Qian, L.; Li, L.; Yao, S. Q., 2016
- Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models, Qian, L.; Zhang, C.-W.; Mao, Y.; Li, L.; Gao, N.; Lim, K.-L.; Xu, Q.-H.; Yao, S. Q., 2016
- Intracellular Delivery of Functional Native Antibodies under Hypoxic Conditions by Using a Biodegradable Silica Nanoquencher, Yuan, P.; Zhang, H.; Qian, L.; Mao, X.; Du, S.; Yu, C.; Peng, B.; Yao, S. Q., 2017
- Cell-Penetrating Poly(disulfide) Assisted Intracellular Delivery of Mesoporous Silica Nanoparticles for Inhibition of miR-21 Function and Detection of Subsequent Therapeutic Effects, Yu, C.; Qian, L.; Ge, J.; Fu, J.; Yuan, P.; Yao, S. C. L.; Yao, S. Q., 2016
- Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications, Li, Z.; Qian, L.; Li, L.; Bernhammer, J. C.; Huynh, H. V.; Lee, J.-S.; Yao, S. Q., 2016
- Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit mi
