Bachelor's and Master's: China Pharmaceutical University
Ph.D.: University of Marburg, Germany
Postdoctoral Research: University of Marburg
Humboldt Scholar: University of Giessen
Published over 90 papers in renowned journals
11 authorized Chinese invention patents
1 PCT patent application
2013 - Present: Zhejiang University, College of Pharmaceutical Sciences
2021: Shihua Yu Young Teacher Award
2018: Excellent 'New Student Friend' of Zhejiang University
2017: 'Li Guanghua Teaching Award' for Teaching Innovation
2016: Excellent Instructor for Summer Social Practice Activities of Zhejiang University
2016: Second Prize in Young Teacher Teaching Skills Competition of the College of Pharmaceutical Sciences
2016: Excellent Class Advisor of Lantian Academy
2015: Excellent Class Advisor of Zhejiang University
2014: Excellent Class Advisor of Lantian Academy
Research
Innovative design, efficient screening, and mechanism research of drugs for major diseases such as cancer Nuclear receptor-targeted drugs Antibacterial drugs
Small-Molecule Inhibition of AR Dimerization as a Strategy Against Prostate Cancer, Fu WT, Yang H, Hu CX, Liao JN, Gong Z, Zhang MK, Yang S, Ye SX, Lei YX, Sheng R, Zhang ZG, Yao XJ, Tang C, Li D, Hou TJ, 2023
Computationally Guided Discovery of Novel Non-steroidal AR-GR Dual Antagonists Demonstrating Potency Against Antiandrogen Resistance, Chai X, Hu XP, Wang XY, Wang HT, Pang JP, Zhou WF, Liao JN, Shan LH, Xu XH, Xia HG, Hou TJ, Li D, 2023
Discovery and Optimization of N-acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-steroidal Selective Glucocorticoid Receptor Modulators, Li D, Bao XD, Pang JP, Hu XP, Wang LL, Wang JJ, Yang ZX, Xu L, Wang SY, Weng QJ, Cui SL, Hou TJ, 2022
PROTAC-DB 2.0: an Updated Database of PROTACs, Weng GQ, Cai XY, Cao DS, Du HY, Shen C, Deng YF, He QJ, Yang B, Li D, Hou TJ, 2023
Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1H-pyrazol-3-yl) acetamides as Potent, Selective, and Orally Available Antagonists Targeting the Androgen Receptor, Chen CW, Chai X, Hu XP, Lou SY, Li D, Hou TJ, Cui SL, 2022
A Loosened Gating Mechanism of RIG-I Leads to Autoimmune Disorders, Lei YX, Fei PY, Song B, Shi WJ, Luo C, Luo DH, Li D, Chen W, Zheng J, 2022
Discovery of Novel DprE1 Inhibitors via Computational Bioactivity Fingerprints and Structure-based Virtual Screening, Hu XP, Yang L, Chai X, Lei YX, Alam MS, Liu L, Shen C, Jiang DJ, Wang Z, Liu ZY, Xu L, Wan KL, Zhang TY, Yin YL, Li D, Cao DS, Hou TJ, 2022
Discovery of Novel Non-steroidal Selective Glucocorticoid Receptor Modulators by Structure- and IGN-based Virtual Screening, Structural Optimization, and Biological Evaluation, Hu XP, Pang JP, Chen CW, Jiang DJ, Shen C, Chai X, Yang L, Zhang XJ, Xu L, Cui SL, Hou TJ, Li D, 2022
Discovery of N-(4-(benzyloxy)-phenyl)-sulfonamide Derivatives as Novel Antagonists of Human Androgen Receptor Targeting the Activation Function 2, Chai X, Sun HY, Zhou WF, Chen CW, Shan LH, Yang YH, He JZ, Pang JP, Yang L, Wang XY, Cui SL, Fu YQ, Xu XH, Xu L, Yao XJ, Li D, Hou TJ, 2022
Discovery of a Novel Nonsteroidal Selective Glucocorticoid Receptor Modulator by Virtual Screening and Bioassays, Pang JP, Hu XP, Wang YX, Liao JN, Chai X, Wang XW, Shen C, Wang JJ, Zhang LL, Wang XY, Zhu F, Weng QJ, Xu L, Hou TJ, Li D, 2022
Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis, Hu XP, Pang JP, Zhang JT, Shen C, Chai X, Wang EC, Chen HY, Wang XW, Duan MJ, Fu WT, Xu L, Kang Y, Li D, Xia HG, Hou TJ, 2022
Opportunities for Overcoming Tuberculosis: Emerging Targets and Their Inhibitors, Yang L, Hu XP, Chai X, Ye Q, Pang JP, Li D, Hou TJ, 2022
Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers, Fu WT, Zhang MK, Liao JN, Tang Q, Lei YX, Gong Z, Shan LH, Duan MJ, Chai X, Pang JP, Tang C, Wang XW, Xu XH, Li D, Sheng R, Hou TJ, 2021
Identification of Active Molecules against Mycobacterium Tuberculosis through Machine Learning, Ye Q, Chai X, Jiang DJ, Yang L, Shen C, Zhang XJ, Li D, Cao DS, Hou TJ, 2021
Discovery of Novel Antagonists Targeting the DNA Binding Domain of Androgen Receptor by Integrated Docking-Based Virtual Screening and Bioassays, Pang JP, Shen C, Zhou WF, Wang YX, Shan LH, Chai X, Shao Y, Hu XP, Zhu F, Zhu DY, Xiao L, Xu L, Xu XH, Li D, Hou TJ, 2022
PROTAC-DB: an Online Database of PROTACs, Weng GQ, Shen C, Cao DS, Gao J, Dong X, He QJ, Yang B, Li D, Wu J, Hou TJ, 2021
Novel Androgen Receptor Antagonist Identified by Structure-based Virtual Screening, Structural Optimization, and Biological Evaluation, Tang Q, Fu WT, Zhang MK, Wang EC, Shan LH, Chai X, Pang JP, Wang XW, Xu XH, Xu L, Li D, Sheng R, Hou TJ, 2020
Advances in the Computational Development of Androgen Receptor Antagonists, Hu XP, Chai X, Wang XW, Duan MJ, Pang JP, Fu WT, Li D, Hou TJ, 2020
Importance of Incorporating Protein Flexibility in Molecule Modeling: A Theoretical Study on Type I1/2 NIK Inhibitors, Shen C, Liu H, Wang XW, Lei TL, Wang EC, Xu L, Yu HD, Li D, Yao XJ, 2019
A Magic Drug Target: Androgen Receptor, Li D, Zhou WF, Pang JP, Tang Q, Zhong BL, Shen C, Xiao L, Hou TJ, 2019
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays, Zhou WF, Duan MJ, Fu WT, Pang JP, Tang Q, Sun HY, Xu L, Chang S, Li D, Hou TJ, 2018
Importance of Protein Flexibility on Molecular Recognition: Modeling Binding Mechanisms of Aminopyrazine Inhibitors to Nek2, Tang XY, Wang Z, Lei TL, Zhou WF, Chang S, Li D, 2018
Prediction of Luciferase Inhibitors by the High-performance MIEC-GBDT Approach Based on Interaction Energetic Patterns, Chen F, Sun HY, Liu H, Li D, Li YY, Hou TJ, 2017
Recent Advances in Protein-Protein Docking, Zhang Q, Feng T, Xu L, Sun HY, Pan PC, Li YY, Li D, Hou TJ, 2016
Exploring Resistance Mechanisms of HCV NS3/4A Protease Mutations to MK5172: Insight from Molecular Dynamics Simulations and Free Energy Calculations, Guan Y, Sun HY, Pan PC, Li YY, Li D, Hou TJ, 2015
ADMET Evaluation in Drug Discovery. 13. Development of in Silico Prediction Models for P-glycoprotein Substrates, Li D, Chen L, Li YY, Tian S, Sun HY, Hou TJ, 2014
