Professor | Shuai Liu | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Shuai Liu
Contact Information	shuailiu@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Shuai Liu

Contact Information

shuailiu@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2008.09-2012.06 Bachelor: Nankai University, School of Chemistry 2012.09-2017.06 PhD: Nankai University, School of Chemistry MIT Technology Review Asia-Pacific '35 Innovators Under 35'
Work Experience	2022.01-present - Zhejiang University, College of Pharmaceutical Sciences - Researcher 2017.12-2021.11 - University of Texas Southwestern Medical Center - Postdoctoral Researcher
Awards	MIT Technology Review Asia-Pacific '35 Innovators Under 35'

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2008.09-2012.06 Bachelor: Nankai University, School of Chemistry
2012.09-2017.06 PhD: Nankai University, School of Chemistry
MIT Technology Review Asia-Pacific '35 Innovators Under 35'

Work Experience

2022.01-present - Zhejiang University, College of Pharmaceutical Sciences - Researcher
2017.12-2021.11 - University of Texas Southwestern Medical Center - Postdoctoral Researcher

Awards

MIT Technology Review Asia-Pacific '35 Innovators Under 35'

Areas of Focus	Development of lipid nanoparticles and mRNA delivery applications Organ-specific gene therapy/editing Preparation and application of multifunctional biomaterials
Publications	Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation, Su, K., Shi, L., Sheng, T., Yan, X., Lin, L., Meng, C., Wu, S., Chen Y., Zhang, Y., Wang, C., Wang, Z., Qiu, J., Zhao, J., Xu, T., Ping, Y., Gu, Z., Liu, S., 2024 An overview of lipid constituents in lipid nanoparticle mRNA delivery systems, Wu, S., Lin, L., Shi, L., Liu, S., 2024 One-Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells, Zhang, X.†, Su, K.†, Wu, S.†, Lin, L., He, S., Yan, X., Shi, L., Liu, S., 2024 Zwitterionic materials for nucleic acid delivery and therapeutic applications, He, S., Liu, S., 2024 Enzymatically Activatable Polymers for Disease Diagnosis and Treatment, Ma, B., Shi, J., Zhang, Y., Li, Z., Yong, H., Zhou, Y., Liu, S., A, S., Zhou, D., 2023 Engineering siRNA therapeutics: challenges and strategies, Ali Zaidi, S., Fatima, F., Ali Zaidi, S., Zhou, D., Deng, W., Liu, S., 2023 Targeting materials and strategies for RNA delivery, Lin, L.†, Su, K.†, Cheng, Q., Liu, S., 2023 Branched hydrophobic tails in lipid nanoparticles enhance mRNA delivery for cancer immunotherapy, Yan, Y., Liu, X., Wang, L., Wu, C., Shuai, Q., Zhang, Y., Liu, S., 2023 Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery, Wang, X., Liu, S., Sun, Y., Yu, X., Lee, S.M., Cheng, Q., Wei, T., Gong, J., Robinson, J., Zhang, D., Lian, X., Basak, P., Siegwart D.J., 2023 Genetic Engineering of Adipose-Derived Stem Cells Using Biodegradable and Lipid-Like Highly Branched Poly(β-amino ester)s, Li, Q.†, Sun, L.†, Huang, X.†, Liu, S., Yong, H., Wang, C., Li, J., Zhou, D., 2022 Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model, Johnson, L.T., Zhang, D., Zhou, K., Lee, S.M., Liu, S., Dilliard, S.A., Farbiak, L., Chatterjee, S., Lin, Y.H., Siegwart, D.J., 2022 Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes, Liu, S., Wang, X., Yu X., Cheng, Q., Johnson, L.T., Chatterjee, S., Zhang, D., Lee, S.M., Sun, Y., Lin, T., Liu, J.L., Siegwart D.J., 2021 Membrane-destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR-Cas gene editing, Liu, S.†, Cheng, Q.†, Wei, T., Yu, X., Johnson, L.T., Farbiak, L., Siegwart, D.J., 2021 Zinc(II)-Cyclen Multifunctional Complex Module-Mediated Polycation-Based High-Performance pDNA Vectors, Chen, Z., Liu, S., Liu, W., Jiang, P., Wang, L., Li, J., Zhou, H., Guo, T., 2021 Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration, Yu, X., Liu, S., Cheng, Q., Lee, S.M., Wei, T., Zhang, D., Farbiak, L., Johnson, L.T., Wang, X., Siegwart, D.J., 2021 Ag(I) Pyridine-Amidoxime Complex as the Catalysis Activity Domain for the Rapid Hydrolysis of Organothiophosphate-Based Nerve Agents: Mechanistic Evaluation and Application, Zheng, S., Pan, J., Wang, J., Liu, S., Zhou, T., Wang, L., Jia, H., Chen, Z., Peng, Q., Guo, T., 2021 Zinc(II)‐Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process, Jia, H., Wang, X., Chen, Z., Liu, S., Zhou, T., Zhou, H., Guo, T., 2021 Zn(II)-Dipicolylamine analogues with amphiphilic side chains endow low molecular weight PEI with high transfection performance, Chen, Z., Wang, X., Liu, S., Li, Y., Zhou, H., Guo, T., 2021 A Systematic study of unsaturation in lipid nanoparticles leads to improved mRNA transfection in vivo, Lee, S., Cheng, Q., Yu, X., Liu, S., Johnson, L., Siegwart, D.J., 2021 Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo, Xiong, H., Liu, S., Wei, T., Cheng, Q., Siegwart, D.J., 2020 Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver, Yu, X., Liu, S., Cheng, Q., Wei, T., Lee, S., Zhang, D., Siegwart, D.J., 2020 Highly branched poly (β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells, Liu, S.†, Gao, Y.†, Zhou, D.†, Zeng, M., Alshehri, F., Newland, B., Lyu, J., O’Keeffe-Ahern, J., Greiser, U., Guo, T., Zhang, F., Wang, W., 2019 Rapid hydrolysis of nerve agent simulants by molecularly imprinted porous crosslinked polymer incorporating mononuclear zinc (II)-picolinamine-amidoxime module, Pan, J., Liu, S., Jia, H., Yang, J., Qin, M., Zhou, T., Chen, Z., Jia, X., Guo, T., 2019 Multifunctional oligomer immobilized on quartz crystal microbalance: a facile and stabilized molecular imprinting strategy for glycoprotein detection, Zhang, X., Liu, S., Pan, J., Jia, H., Chen, Z., Guo, T., 2019 Zinc coordinated cationic polymers break up the paradox between low molecular weight and high transfection efficacy, Liu, S., Jia, H., Yang, J., Pan, J., Liang, H., Zeng, L., Zhou, H., Chen, J., Guo, T., 2018 Zinc coordination substitute amine: A non-cationic platform for efficient and safe gene delivery, Liu, S., Jia, H., Yang, J., Pan, J., Liang, H., Zeng, L., Zhou, H., Chen, J., Guo, T., 2018 Virus spike and membrane-lytic mimicking nanoparticles for high cell binding and superior endosomal escape, Liu, S., Jia, H., Yang, J., Zhou, H., Chen, J., Guo, T., 2018 Facile fabrication of superhydrophobic nanocomposite coatings based on water-based emulsion latex, Yang, J., Liang, H., Zeng, L., Liu, S., Guo, T., 2018 Alkylated branched poly(β-amino esters) demonstrate strong DNA encapsulation, high nanoparticle stability and robust gene transfection efficacy, Liu, S.†, Sun, Z.†, Zhou, D., Guo, T., 2017 Bioreducible zinc(II) coordinative polyethylenimine with low molecular weight for robust gene delivery of primary and stem cells, Liu, S.†, Zhou, D.†, Yang, J., Zhou, H., Chen, J., Guo, T., 2017 Biodegradable highly branched poly(β-Amino ester)s for targeted cancer cell gene transfection, Liu, S., Gao, Y., A, S., Zhou, D., Greiser, U., Guo, T., Guo, R., Wang W., 2017 Multifunctional oligomer incorporation: a potent strategy to enhance the transfection activity of poly(l-lysine), Liu, S., Yang, J., Ren, H., O’Keeffe-Ahern, J., Zhou, D., Zhou, H., Chen, J., Guo, T., 2016 N,N,N-trimethylchitosan modified with well defined multifunctional polymer modules used as pDNA delivery vector, Ren, H., Liu, S., Yang, J., Zhang, X., Zhou, H., Chen, J., Guo, T., 2016 Polycation-based ternary gene delivery system, Liu, S., Guo, T., 2015 Fluorescently labeled degradable thermoplastic polyurethane elastomers: Visual evaluation for the degradation behavior, Liu, Z., Liu, S., Shi, H., Ren, H., Wang, R., Yang, J., Guo, T., 2015 Novel imprinted nanocapsule with highly enhanced hydrolytic activity for organophosphorus pesticide degradation and elimination, Shi, H., Wang, R., Yang, J., Ren, H., Liu, S., Guo, T.

Areas of Focus

Development of lipid nanoparticles and mRNA delivery applications
Organ-specific gene therapy/editing
Preparation and application of multifunctional biomaterials

Publications

Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation, Su, K., Shi, L., Sheng, T., Yan, X., Lin, L., Meng, C., Wu, S., Chen Y., Zhang, Y., Wang, C., Wang, Z., Qiu, J., Zhao, J., Xu, T., Ping, Y.*, Gu, Z.*, Liu, S.*, 2024
An overview of lipid constituents in lipid nanoparticle mRNA delivery systems, Wu, S., Lin, L., Shi, L., Liu, S.*, 2024
One-Component Cationic Lipids for Systemic mRNA Delivery to Splenic T Cells, Zhang, X.†, Su, K.†, Wu, S.†, Lin, L., He, S., Yan, X., Shi, L., Liu, S.*, 2024
Zwitterionic materials for nucleic acid delivery and therapeutic applications, He, S., Liu, S.*, 2024
Enzymatically Activatable Polymers for Disease Diagnosis and Treatment, Ma, B., Shi, J., Zhang, Y., Li, Z., Yong, H., Zhou, Y.*, Liu, S.*, A, S.*, Zhou, D.*, 2023
Engineering siRNA therapeutics: challenges and strategies, Ali Zaidi, S., Fatima, F., Ali Zaidi, S., Zhou, D.*, Deng, W.*, Liu, S.*, 2023
Targeting materials and strategies for RNA delivery, Lin, L.†, Su, K.†, Cheng, Q., Liu, S.*, 2023
Branched hydrophobic tails in lipid nanoparticles enhance mRNA delivery for cancer immunotherapy, Yan, Y.*, Liu, X., Wang, L., Wu, C., Shuai, Q., Zhang, Y., Liu, S., 2023
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery, Wang, X., Liu, S., Sun, Y., Yu, X., Lee, S.M., Cheng, Q., Wei, T., Gong, J., Robinson, J., Zhang, D., Lian, X., Basak, P., Siegwart D.J.*, 2023
Genetic Engineering of Adipose-Derived Stem Cells Using Biodegradable and Lipid-Like Highly Branched Poly(β-amino ester)s, Li, Q.†, Sun, L.†, Huang, X.†, Liu, S.*, Yong, H., Wang, C., Li, J.*, Zhou, D.*, 2022
Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model, Johnson, L.T., Zhang, D., Zhou, K., Lee, S.M., Liu, S., Dilliard, S.A., Farbiak, L., Chatterjee, S., Lin, Y.H., Siegwart, D.J.*, 2022
Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes, Liu, S., Wang, X., Yu X., Cheng, Q., Johnson, L.T., Chatterjee, S., Zhang, D., Lee, S.M., Sun, Y., Lin, T., Liu, J.L., Siegwart D.J.*, 2021
Membrane-destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR-Cas gene editing, Liu, S.†, Cheng, Q.†, Wei, T., Yu, X., Johnson, L.T., Farbiak, L., Siegwart, D.J.*, 2021
Zinc(II)-Cyclen Multifunctional Complex Module-Mediated Polycation-Based High-Performance pDNA Vectors, Chen, Z., Liu, S., Liu, W., Jiang, P., Wang, L., Li, J., Zhou, H.*, Guo, T.*, 2021
Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration, Yu, X., Liu, S., Cheng, Q., Lee, S.M., Wei, T., Zhang, D., Farbiak, L., Johnson, L.T., Wang, X., Siegwart, D.J.*, 2021
Ag(I) Pyridine-Amidoxime Complex as the Catalysis Activity Domain for the Rapid Hydrolysis of Organothiophosphate-Based Nerve Agents: Mechanistic Evaluation and Application, Zheng, S., Pan, J., Wang, J., Liu, S., Zhou, T., Wang, L., Jia, H., Chen, Z., Peng, Q.*, Guo, T.*, 2021
Zinc(II)‐Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process, Jia, H., Wang, X., Chen, Z., Liu, S., Zhou, T., Zhou, H., Guo, T.*, 2021
Zn(II)-Dipicolylamine analogues with amphiphilic side chains endow low molecular weight PEI with high transfection performance, Chen, Z., Wang, X., Liu, S., Li, Y., Zhou, H., Guo, T.*, 2021
A Systematic study of unsaturation in lipid nanoparticles leads to improved mRNA transfection in vivo, Lee, S., Cheng, Q., Yu, X., Liu, S., Johnson, L., Siegwart, D.J.*, 2021
Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo, Xiong, H.*, Liu, S., Wei, T., Cheng, Q., Siegwart, D.J.*, 2020
Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver, Yu, X., Liu, S., Cheng, Q., Wei, T., Lee, S., Zhang, D., Siegwart, D.J.*, 2020
Highly branched poly (β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells, Liu, S.†, Gao, Y.†, Zhou, D.†*, Zeng, M., Alshehri, F., Newland, B., Lyu, J., O’Keeffe-Ahern, J., Greiser, U., Guo, T.*, Zhang, F., Wang, W.*, 2019
Rapid hydrolysis of nerve agent simulants by molecularly imprinted porous crosslinked polymer incorporating mononuclear zinc (II)-picolinamine-amidoxime module, Pan, J., Liu, S., Jia, H., Yang, J., Qin, M., Zhou, T., Chen, Z., Jia, X., Guo, T.*, 2019
Multifunctional oligomer immobilized on quartz crystal microbalance: a facile and stabilized molecular imprinting strategy for glycoprotein detection, Zhang, X., Liu, S., Pan, J., Jia, H., Chen, Z., Guo, T.*, 2019
Zinc coordinated cationic polymers break up the paradox between low molecular weight and high transfection efficacy, Liu, S.*, Jia, H., Yang, J., Pan, J., Liang, H., Zeng, L., Zhou, H., Chen, J., Guo, T.*, 2018
Zinc coordination substitute amine: A non-cationic platform for efficient and safe gene delivery, Liu, S., Jia, H., Yang, J., Pan, J., Liang, H., Zeng, L., Zhou, H., Chen, J., Guo, T.*, 2018
Virus spike and membrane-lytic mimicking nanoparticles for high cell binding and superior endosomal escape, Liu, S.*, Jia, H., Yang, J., Zhou, H., Chen, J., Guo, T.*, 2018
Facile fabrication of superhydrophobic nanocomposite coatings based on water-based emulsion latex, Yang, J., Liang, H., Zeng, L., Liu, S., Guo, T.*, 2018
Alkylated branched poly(β-amino esters) demonstrate strong DNA encapsulation, high nanoparticle stability and robust gene transfection efficacy, Liu, S.†, Sun, Z.†, Zhou, D.*, Guo, T.*, 2017
Bioreducible zinc(II) coordinative polyethylenimine with low molecular weight for robust gene delivery of primary and stem cells, Liu, S.†, Zhou, D.†, Yang, J., Zhou, H., Chen, J., Guo, T.*, 2017
Biodegradable highly branched poly(β-Amino ester)s for targeted cancer cell gene transfection, Liu, S., Gao, Y., A, S., Zhou, D.*, Greiser, U., Guo, T.*, Guo, R., Wang W.*, 2017
Multifunctional oligomer incorporation: a potent strategy to enhance the transfection activity of poly(l-lysine), Liu, S., Yang, J., Ren, H., O’Keeffe-Ahern, J., Zhou, D.*, Zhou, H., Chen, J., Guo, T.*, 2016
N,N,N-trimethylchitosan modified with well defined multifunctional polymer modules used as pDNA delivery vector, Ren, H., Liu, S., Yang, J., Zhang, X., Zhou, H., Chen, J., Guo, T.*, 2016
Polycation-based ternary gene delivery system, Liu, S., Guo, T.*, 2015
Fluorescently labeled degradable thermoplastic polyurethane elastomers: Visual evaluation for the degradation behavior, Liu, Z., Liu, S., Shi, H., Ren, H., Wang, R., Yang, J., Guo, T.*, 2015
Novel imprinted nanocapsule with highly enhanced hydrolytic activity for organophosphorus pesticide degradation and elimination, Shi, H., Wang, R., Yang, J., Ren, H., Liu, S., Guo, T.*

Lipid Nanoparticles Mrna Delivery Gene Therapy Gene Editing Biomaterials Cancer Treatment Genetic Diseases Crispr/Cas Nanotechnology Biomedical Engineering

Yongzhong Du - Zhejiang University

Yuqi Zhang - Zhejiang University

Jicheng Yu - Zhejiang University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us