Professor | Xiangbao Meng | Asia Growth Partners

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Name	Xiangbao Meng
Contact Information	xbmeng@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Xiangbao Meng

Contact Information

xbmeng@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1997 - Bachelor's Degree: Beijing Medical University, School of Pharmacy 2002 - Ph.D.: Peking University, School of Pharmaceutical Sciences Published over 100 research papers First inventor of 7 authorized Chinese patents and 7 international patents
Work Experience	2002-09 - Shanghai WuXi AppTec New Drug Development Co., Ltd. - Role not specified 2003-08 - Postdoctoral Research: École Normale Supérieure, Paris, Chemistry Department, Professor Pierre Sinay's Group 2005-Present - Peking University, School of Pharmaceutical Sciences - Professor, Doctoral Supervisor

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1997 - Bachelor's Degree: Beijing Medical University, School of Pharmacy
2002 - Ph.D.: Peking University, School of Pharmaceutical Sciences
Published over 100 research papers
First inventor of 7 authorized Chinese patents and 7 international patents

Work Experience

2002-09 - Shanghai WuXi AppTec New Drug Development Co., Ltd. - Role not specified
2003-08 - Postdoctoral Research: École Normale Supérieure, Paris, Chemistry Department, Professor Pierre Sinay's Group
2005-Present - Peking University, School of Pharmaceutical Sciences - Professor, Doctoral Supervisor

Areas of Focus	Small Molecule Immunomodulators Discovery and Optimization of Novel Anti-inflammatory Drugs Multi-target Drug Research for Advanced Drug-resistant Tumors
Publications	Design, Synthesis, and Biological Evaluation of Proteolysis-targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-regulated Kinase 5, Pengming Pan, Tongtong Geng, Zhongtang Li, Xuyang Ding, Mengyuan Shi, Yang Li, Yashuai Wang, Yuanyuan Shi, Jiaojiao Wu, Liang Zhong, Dengbo Ji, Zhongjun Li, and Xiangbao Meng, 2023 Design, Synthesis and Antitumor Activity Evaluation of ERK1/2 PROTAC Degraders, Pengming Pan, Yichao He, Tongtong Geng, Zhongtang Li, Zhongjun Li and Xiangbao Meng, 2023 Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation, Pengming Pan, Dengbo Ji, Zhongjun Li, and Xiangbao Meng, 2024 SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade, Mingxia Zhao, Wenjie Guo, Yuanyuan Wu, Chenxi Yang, Liang Zhong, Guoliang Deng, Yuyu Zhu, Wen Liu, Yanhong Gu, Yin Lu, Lingdong Kong, Xiangbao Meng, Qiang Xu, Yang Sun, 2019 Nano-encapsulated tryptanthrin derivative for combined anticancer therapy via inhibiting indoleamine 2,3-dioxygenase and inducing immunogenic cell death, Canyu Yang, Bing He, Qiang Zheng, Dakuan Wang, Mengmeng Qin, Hua Zhang, Qiang Zhang, Xiangbao Meng, Xueqing Wang, 2019 Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors, Liangkun Pan, Qiang Zheng, Yu Chen, Rui Yang, Yanyan Yang, Zhongjun Li, Xiangbao Meng, 2018 Targeting peroxiredoxin 1 by a curcumin analogue, AI-44, inhibits NLRP3 inflammasome activation and attenuates Lipopolysaccharide-induced sepsis in mice, Wen Liu, Wenjie Guo, Yongcheng Zhu, Shuang Peng, Wei Zhang, Chao Zhang, Fenli Shao, Yuyu Zhu, Nan Hang, Lingdong Kong, Xiangbao Meng, Qiang Xu, Yang Sun, 2018 A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells, Wan Fu, Xue Li, Xiaopeng Lu, Ran Li, Nan Zhang, Shan Liu, Yue Wang, Ying Zhao, Xiangbao Meng, and Wei-Guo Zhu, 2017 A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes, Liyan Ji, Simin Yang, Shasha Li, Shan Liu, Shunan Tang, Zhongqiu Liu, Xiangbao Meng, and Siwang Yu, 2017 Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents, Jun Yang, Simin Yang, Shanshan Zhou, Dongbo Lu, Liyan Ji, Zhongjun Li, Siwang Yu, Xiangbao Meng, 2016

Areas of Focus

Small Molecule Immunomodulators
Discovery and Optimization of Novel Anti-inflammatory Drugs
Multi-target Drug Research for Advanced Drug-resistant Tumors

Publications

Design, Synthesis, and Biological Evaluation of Proteolysis-targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-regulated Kinase 5, Pengming Pan, Tongtong Geng, Zhongtang Li, Xuyang Ding, Mengyuan Shi, Yang Li, Yashuai Wang, Yuanyuan Shi, Jiaojiao Wu, Liang Zhong, Dengbo Ji, Zhongjun Li, and Xiangbao Meng, 2023
Design, Synthesis and Antitumor Activity Evaluation of ERK1/2 PROTAC Degraders, Pengming Pan, Yichao He, Tongtong Geng, Zhongtang Li, Zhongjun Li and Xiangbao Meng, 2023
Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation, Pengming Pan, Dengbo Ji, Zhongjun Li, and Xiangbao Meng, 2024
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade, Mingxia Zhao, Wenjie Guo, Yuanyuan Wu, Chenxi Yang, Liang Zhong, Guoliang Deng, Yuyu Zhu, Wen Liu, Yanhong Gu, Yin Lu, Lingdong Kong, Xiangbao Meng, Qiang Xu, Yang Sun, 2019
Nano-encapsulated tryptanthrin derivative for combined anticancer therapy via inhibiting indoleamine 2,3-dioxygenase and inducing immunogenic cell death, Canyu Yang, Bing He, Qiang Zheng, Dakuan Wang, Mengmeng Qin, Hua Zhang, Qiang Zhang, Xiangbao Meng, Xueqing Wang, 2019
Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors, Liangkun Pan, Qiang Zheng, Yu Chen, Rui Yang, Yanyan Yang, Zhongjun Li, Xiangbao Meng, 2018
Targeting peroxiredoxin 1 by a curcumin analogue, AI-44, inhibits NLRP3 inflammasome activation and attenuates Lipopolysaccharide-induced sepsis in mice, Wen Liu, Wenjie Guo, Yongcheng Zhu, Shuang Peng, Wei Zhang, Chao Zhang, Fenli Shao, Yuyu Zhu, Nan Hang, Lingdong Kong, Xiangbao Meng, Qiang Xu, Yang Sun, 2018
A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells, Wan Fu, Xue Li, Xiaopeng Lu, Ran Li, Nan Zhang, Shan Liu, Yue Wang, Ying Zhao, Xiangbao Meng, and Wei-Guo Zhu, 2017
A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes, Liyan Ji, Simin Yang, Shasha Li, Shan Liu, Shunan Tang, Zhongqiu Liu, Xiangbao Meng, and Siwang Yu, 2017
Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents, Jun Yang, Simin Yang, Shanshan Zhou, Dongbo Lu, Liyan Ji, Zhongjun Li, Siwang Yu, Xiangbao Meng, 2016

Immunomodulators Small Molecules Anti-Inflammatory Drug Discovery Optimization Multi-Target Drug-Resistant Tumors Cancer Inflammation Immune Regulation

Ke Yu - Fudan University

Zhiruo Zhou - Fudan University

Hong Liang - Peking University

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