1988: Graduated from Beijing Medical University, School of Pharmacy
2008: Advanced studies in Japan
Research on HIV/AIDS drugs since 2000
1988 - Present: Beijing University School of Pharmacy - Various roles including Assistant, Lecturer, and Associate Professor
2013: Second Prize, Chinese Preventive Medicine Association Science and Technology Award for the establishment and promotion of the HIV drug resistance testing platform in China
Research
Design, synthesis, and activity evaluation of single-target and dual-target inhibitors for HIV-1 Research on host STING protein agonists for new anti-HIV strategies Design, synthesis, and activity evaluation of anti-HBV drugs
Novel Pyridinone Derivatives As Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) with High Potency against NNRTI-Resistant HIV-1 Strains, Amin Li, Yabo Ouyang, Ziyun Wang, Yuanyuan Cao, Xiangyi Liu, Li Ran, Chao Li, Li Li, Liang Zhang, Kang Qiao, Weisi Xu, Yang Huang, Zhili Zhang, Chao Tian, Zhenming Liu, Shibo Jiang, Yiming Shao, Yansheng Du, Liyang Ma, Xiaowei Wang, Junyi Liu, 2013
Design, Synthesis and Biological Evaluation of 1-[(2-benzyloxyl/alkoxyl) methyl]-5-halo-6–aryl uracils as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Drug Resistance Profile, Xiaowei Wang, Jianfang Zhang, Yang Huang, Ruiping Wang, Liang Zhang, Kang Qiao, Li Li, Chang Liu, Yabo Ouyang, Weisi Xu, Zhili Zhang, Liangren Zhang, Shibo Jiang, Yimin Shao, Liying Ma, Junyi Liu, 2012
Design, Synthesis, and Biological Evaluation of (E)-3,4-Dihydroxystyryl Aralkyl Sulfones and Sulfoxides as Novel Multifunctional Neuroprotective Agents, Xianling Ning, Ying Guo, Xiaowei Wang, Xiaoyan Ma, Chao Tian, Xueqi Shi, Renzong Zhu, Can Cheng, Yansheng Du, Zhizhong Ma, Zhili Zhang, Junyi Liu, 2014
Mechanism-based Design, Synthesis and Biological Studies of N5-Substituted Tetrahydrofolate Analogues as Inhibitors of Cobalamin-dependent Methionine Synthase and Potential Anticancer Agents, Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Bernard T. Golding, Roger J. Griff, Yansheng Du, Junyi Liu, 2012
A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2 (2H)-ones as potency inhibitors of HIV-1 variants, Shaotong Wu, Qianqian Yin, Liang Zhao, Ningning Fan, Xiaowan Tang, Jianxiong Zhao, Tao Sheng, Ying Guo, Chao Tian, Zhili Zhang, Weisi Xu, Zhenming Liu, Shibo Jiang, Liying Ma, Junyi Liu, Xiaowei Wang, 2015
The HEPT analogue, 1-((benzyloxy) methyl)-6-(3, 5-dimethylbenzyl)-5- iodopyrimidine-2, 4(1H, 3H)-dione (WPR-6), is active against a broad spectrum of HIV-1 strains of different subtypes with drug-resistance, Weisi Xu, Jianxiong Zhao, Jianping Sun, Qianqian Yin, Yan Wang, Yang Jiao, Junyi Liu, Shibo Jiang, Yiming Shao, Xiaowei Wang, Liying Ma, 2015
An approach to synthesis of pyrimido[b]azepines via Ruthenium-catalyzed ring-closing metathesis, Tong-Bo Zhang, Yuan-Yuan Cao, Shao-Tong Wu, Yu Zhang, Ying Guo, Jian-Xiong Zhao, Xue-Feng Sun, Quan-Zhi Yang, Zhi-Li Zhang, Chao Tian, Jun-Yi Liu, Xiao-Wei Wang, 2015
Rapid Access to 10-(Cyclohexylimino)-7,9-diazaspiro[4.5]decane-6,8-dione Derivatives for HIV-1 Reverse Transcriptase Inhibition via Ruthenium-Catalyzed Ring-Closing Metathesis, Zhang Tongbo, Wu Shaotong, Cao Yuanyuan, Fu Yuhong, Guo Ying, Zhang Liang, Li Li, Zhou Han, Liu Xiangyi, Li Chao, Tang Xiaowan, Zhang Zhili, Tian Chao, Wang Xiaowei, Liu Junyi, 2013
Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors, Yang Huang, Xiaowei Wang, Xiaoling Yu, Lin Yuan, Ying Guo, Weisi Xu, Tiejun Liu, Junyi Liu, Yiming Shao, Liying Ma, 2011
Rapid access to multi-substituted pyrimido[4,5-b][1,4] diazepine-2,4,6-trione and pyrimido[4,5-b][1,4]diazepine-2,4-dione as novel and versatile scaffolds for drug discovery, Gong Li, Xiaowei Wang, Chao Tian, Tongbo Zhang, Zhili Zhang, Junyi Liu, 2012
The Design and Synthesis of N-1 alkylated 5-aminoaryalkyl substituted 6-methyluracils as potential non-nucleoside HIV-1 RT Inhibitors, Xiao Lu, Yanli Chen, Ying Guo, Zhenming Liu, Yawei Shi, Yang Xu, Xiaowei Wang, Junyi Liu, 2007
The design and synthesis of 9-phenylcyclohepta[d] pyrimidine-2, 4-dione derivatives as potent non- nucleoside inhibitors of HIV reverse transcriptase, Xiaowei Wang, Qinghua Lou, Ying Guo, Yang Xu, Zhili Zhang, Junyi Liu, 2006
New efficient and flexible synthetic route to Emivirine and its analogs, Li Li, Liying Ma, Xiaowei Wang, Junyi Liu, 2013
Area of Focus
Molecular Targeted Drug Design | New Theories | New Methods | Molecular Simulation | Biological Macromolecules | Active Small Molecules | Mechanisms Of Action | Lead Compounds | New Targets | Innovative Drugs
