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Chao Tian
Pharmaceutical Sciences
Peking University
Beijing
Language: Chinese, English
Chk1
Checkpoint Kinase 1
Anti-Tumor
Sensitizers
Vascular Disrupting Agents
Kras
Mutant Tumors
Dual-Target Inhibitors
Mk2
Cancer Research
Areas of Focus
- Research on anti-tumor sensitizers targeting CHK1 (Checkpoint Kinase 1)
- Research on novel tumor vascular disrupting agents
- Research on CHK1/MK2 dual-target inhibitors for KRAS mutant tumors
Work Experience
- 2011-present - Peking University School of Pharmaceutical Sciences - Lecturer
Academic Background & Achievements
- 2002-2006 Bachelor: Peking University School of Pharmaceutical Sciences
- 2006-2008 Master: Peking University School of Pharmaceutical Sciences
- 2008-2011 PhD: Peking University School of Pharmaceutical Sciences
- 2019 Peking University Health Science Center Youth Post Expert
- 2018 Peking University Health Science Center Excellent Teacher
- 2014 Peking University Health Science Center Excellent Teacher
Publications
- Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl) methanone analogues as potent anti-tubulin polymerization agents, Chao Tian, Xuanzhen Chen, Zhili Zhang, Xiaowei Wang, Junyi Liu, 2019
- Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstituted-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d] pyrimidine analogues as novel CHK1 inhibitors, Chao Tian, Zifei Han, Yuanxin Li, Meng Wang, Jiajia Yang, Xiaowei Wang, Zhili Zhang, Junyi Liu, 2018
- Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents, Chao Tian, Meng Wang, Zifei Han, Fang Fang, Zhili Zhang, Xiaowei Wang, Junyi Liu, 2017
- Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase, Meng Wang, Jiajia Yang, Mengmeng Yuan, Liangmin Xue, Hao Li, Chao Tian, Xiaowei Wang, Junyi Liu, Zhili Zhang, 2017
- Synthesis, antifolate and anticancer activities of n5-substituted 8,10-dideazatetrahydrofolate analogues, Chao Tian, Zhili Zhang, Shouxin Zhou, Mengmeng Yuan, Xiaowei Wang, Junyi Liu, 2016
- Design, Synthesis, and biological evaluation of (E)-3, 4-dihydroxystyryl aralkyl sulfones and sulfoxides as novel multifunctional neuroprotective agents, Xianling Ning, Ying Guo, Xiaowei Wang, Xiaoyan Ma, Chao Tian, Xueqi Shi, Renzong Zhu, Can Cheng, Yansheng Du, Zhizhong Ma, Junyi Liu, 2014
Awards
- 2019: Peking University Health Science Center Youth Post Expert
- 2018: Peking University Health Science Center Excellent Teacher
- 2014: Peking University Health Science Center Excellent Teacher
