1996-2000 Bachelor of Science: Beijing Medical University, School of Pharmaceutical Sciences, Major in Medicinal Chemistry
2000-2005 Doctor of Science: Peking University, College of Chemistry and Molecular Engineering, Major in Physical Chemistry (Doctoral Supervisor: Luhua Lai)
2011-present Researcher, Associate Researcher, Peking University School of Pharmaceutical Sciences
2005-2011 Lecturer, Peking University School of Pharmaceutical Sciences
2007-2009 Office of Major New Drug Creation Science and Technology Major Project Implementation Management
Research
Medicinal Chemistry and Drug Design
CMNPD: a comprehensive marine natural products database towards facilitating drug discovery from the ocean, Chuanyu Lyu, Tong Chen, Bo Qiang, Ningfeng Liu, Heyu Wang, Liangren Zhang, Zhenming Liu, 2020
Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists, Zhang H, He X, Wang X, Yu B, Zhao S, Jiao P, Jin H, Liu Z, Wang K, Zhang L, Zhang L, 2020
Discovery of 2-(2-aminobenzo[d]thiazol-6-yl) benzo[d]oxazol-5-amine derivatives that regulated HPV relevant cellular pathway and prevented cervical cancer from abnormal proliferation, Jiao P, Wang Y, Mao B, Wang B, Zhong Y, Jin H, Zhang L, Zhang L, Liu Z, 2020
Privileged Scaffold Analysis of Natural Products with Deep Learning-based Indication Prediction Model, Lai J, Hu J, Wang Y, Zhou X, Li Y, Zhang L, Liu Z, 2020
TF3P: Three-Dimensional Force Fields Fingerprint Learned by Deep Capsular Network, Wang Y, Hu J, Lai J, Li Y, Jin H, Zhang L, Zhang LR, Liu ZM, 2020
Comprehensive analysis of human IgG Fc N-glycopeptides and construction of a screening model for colorectal cancer, Zou Y, Hu J, Jie J, Lai J, Li M, Liu Z, Zou X, 2020
DeepScaffold: A Comprehensive Tool for Scaffold-Based De Novo Drug Discovery Using Deep Learning, Li Y, Hu J, Wang Y, Zhou J, Zhang L, Liu Z, 2020
ETCM: an encyclopaedia of traditional Chinese medicine, Xu HY, Zhang YQ, Liu ZM, Chen T, Lv CY, Tang SH, Zhang XB, Zhang W, Li ZY, Zhou RR, Yang HJ, Wang XJ, Huang LQ, 2019
Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket, Yu P, Liu Z, Yu X, Ye P, Liu H, Xue X, Yang L, Li Z, Wu Y, Fang C, Zhao YJ, Yang F, Luo JH, Jiang LH, Zhang L, Zhang L, Yang W, 2019
Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL, Yang L, Liu Y, Fan M, Zhu G, Jin H, Liang J, Liu Z, Huang Z, Zhang L, 2019
Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation, Xue Y, He X, Yang T, Wang Y, Liu Z, Zhang G, Wang Y, Wang K, Zhang L, Zhang L, 2019
Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases, Dou X, Huang H, Li Y, Jiang L, Wang Y, Jin H, Jiao N, Zhang L, Zhang L, Liu Z, 2019
Rational Design and Identification of Small-Molecule Allosteric Inhibitors of CD38, Yang L, Li T, Li S, Wu Y, Shi X, Jin H, Liu Z, Zhao Y, Zhang L, Lee HC, Zhang L, 2019
Discovery of novel glycogen synthase kinase-3α inhibitors: Structure-based virtual screening, preliminary SAR and biological evaluation for treatment of acute myeloid leukemia, Wang Y, Dou X, Jiang L, Jin H, Zhang L, Zhang L, Liu Z, 2019
Multi-objective de novo drug design with conditional graph generative model, Li Y, Zhang L, Liu Z, 2018
Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors, Zhang H, Liu H, Luo X, Wang Y, Liu Y, Jin H, Liu Z, Yang W, Yu P, Zhang L, Zhang L, 2018
Discovery of N-(Naphtho[1,2-b]Furan-5-Yl) Benzenesulfonamides as Novel Selective Inhibitors of Triple-Negative Breast Cancer (TNBC), Chen Y, Tang Y, Mao B, Li W, Jin H, Zhang L, Liu Z, 2018
Discovery of new GSK-3β inhibitors through structure-based virtual screening, Dou X, Jiang L, Wang Y, Jin H, Liu Z, Zhang L, 2018
Calcium-Mobilizing Behaviors of Neutral Cyclic ADP-Ribose Mimics that Integrate Modifications to the Nucleobase, Northern Ribose and Pyrophosphate, Wang X, Zhang X, Zhang K, Hu J, Liu Z, Jin H, Zhang L, Zhang L, 2018
Docking Field-based QSAR and pharmacophore studies on the substituted pyrimidine derivatives targeting HIV-1 reverse transcriptase, Fan N, Zhang S, Sheng T, Zhao L, Liu Z, Liu J, Wang X, 2017
The scoring bias in reverse docking and the score normalization strategy to improve success rate of target fishing, Luo Q, Zhao L, Hu J, Jin H, Liu Z, Zhang L, 2017
Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage, Yang R, Zhang Y, Huang D, Luo X, Zhang L, Zhu X, Zhang X, Liu Z, Han JY, Xiong JW, 2017
Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2, Yu P, Xue X, Zhang J, Hu X, Wu Y, Jiang LH, Jin H, Luo J, Zhang L, Liu Z, Yang W, 2017
Comparative studies of three cholesteryl ester transfer proteins and their interactions with known inhibitors, Wang Z, Niimi M, Ding Q, Liu Z, Wang L, Zhang J, Xu J, Fan J, 2017
Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation, Wang Y, Wu X, Du M, Chen X, Ning X, Chen H, Wang S, Liu J, Liu Z, Li R, Fu G, Wang C, McNutt MA, Zhou D, Yin Y, 2017
Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-β-benzyl ester derivatives as potent topoisomerase IIα inhibitors, Han X, Zhong Y, Zhou G, Qi H, Li S, Ding Q, Liu Z, Song Y, Qiao X, 2017
Using Support Vector Machine (SVM) for Classification of Selectivity of H1N1 Neuraminidase Inhibitors, Li Y, Kong Y, Zhang M, Yan A, Liu Z, 2016
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones, Guo J, Ma X, Cai Y, Ma Y, Zhan Z, Zhou YJ, Liu W, Guan M, Yang J, Cui G, Kang L, Yang L, Shen Y, Tang J, Lin H, Ma X, Jin B, Liu Z, Peters RJ, Zhao ZK, Huang L, 2016
A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(2H)-ones as potency inhibitors of HIV-1 variants, Wu S, Yin Q, Zhao L, Fan N, Tang X, Zhao J, Sheng T, Guo Y, Tian C, Zhang Z, Xu W, Liu Z, Jiang S, Ma L, Liu J, Wang X, 2016
New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compounds, Zhang Y, Liu B, Wu X, Li R, Ning X, Liu Y, Liu Z, Ge Z, Li R, Yin Y, 2015
Comparative Analysis of Pharmacophore Features and Quantitative Structure–Activity Relationships for CD38 Covalent and Non-covalent Inhibitors, Zhang S, Xue X, Zhang L, Zhang L, Liu Z, 2015
Integrating Pharmacophore into Membrane Molecular Dynamics Simulations to Improve Homology Modeling of G Protein-coupled Receptors with Ligand Selectivity: A2A Adenosine Receptor as an Example, Zeng L, Guan M, Jin H, Liu Z, Zhang L, 2015
Enrichment Assessment of Multiple Virtual Screening Strategies for Toll-Like Receptor 8 Agonists Based on a Maximal Unbiased Benchmarking Data Set, Pei F, Jin H, Zhou X, Xia J, Sun L, Liu Z, Zhang L, 2015
Antimalarial drug artemisinin depletes erythrocytes by activating apoptotic pathways in zebrafish, Yang R, Yan S, Zhu X, Li CY, Liu Z, Xiong JW, 2015
An Unbiased Method To Build Benchmarking Sets for Ligand-Based Virtual Screening and its Application To GPCRs, Xia J, Jin H, Liu Z, Zhang L, Wang XS, 2014
Unfolding and Conformational Variations of ThrombinBinding DNA Aptamers: Synthesis, Circular Dichroism and Molecular Dynamics Simulations, Sun L, Jin H, Zhao X, Liu Z, Guan Y, Yang Z, Zhang L, Zhang L, 2014
Area of Focus
Natural Products | Drug Research | Active Compounds | Pharmacology | Biochemistry | Drug Design | Medicinal Chemistry | Bioactive Molecules | Therapeutics | Pharmaceuticals
Area of Focus
Synthesis | Drug Development | Chemical Reactions | Organic Compounds | Pharmaceuticals | Laboratory Techniques | Chemical Analysis | Molecular Chemistry | Chemical Engineering | Medicinal Chemistry
Area of Focus
Gpcr | Nuclear Receptors | Neuropsychiatric Diseases | Autoimmune Diseases | Metabolic Diseases | Lead Compounds | Dynamic Virtual Screening | Drug Design | Pain Relief | Ai In Drug Design
