Professor | Donghui Yang | Asia Growth Partners

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Name	Donghui Yang
Contact Information	ydhui@bjmu.edu.cn
Language ability	Chinese, English, Japanese
Province	Beijing

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Name

Donghui Yang

Contact Information

ydhui@bjmu.edu.cn

Language ability

Chinese, English, Japanese

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1998 - Medical Doctorate: Beijing University of Chinese Medicine 1998-2000 - Postdoctoral Research: Peking University School of Pharmaceutical Sciences Published over 40 papers in journals such as Angew. Chem. Int. Ed., J. Am. Chem. Soc., Commun. Chem., ACS Catal., Org. Lett., J. Nat. Prod. Granted 5 patents
Work Experience	2000-present - Peking University School of Pharmaceutical Sciences - Faculty Member 2001-2002 - Eisai Co., Ltd., Tsukuba Research Laboratories, Japan - Visiting Researcher 2008 - Nagasaki International University, Faculty of Pharmaceutical Sciences, Japan - Visiting Researcher 2013-2014 - The Scripps Research Institute, USA - Visiting Researcher

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1998 - Medical Doctorate: Beijing University of Chinese Medicine
1998-2000 - Postdoctoral Research: Peking University School of Pharmaceutical Sciences
Published over 40 papers in journals such as Angew. Chem. Int. Ed., J. Am. Chem. Soc., Commun. Chem., ACS Catal., Org. Lett., J. Nat. Prod.
Granted 5 patents

Work Experience

2000-present - Peking University School of Pharmaceutical Sciences - Faculty Member
2001-2002 - Eisai Co., Ltd., Tsukuba Research Laboratories, Japan - Visiting Researcher
2008 - Nagasaki International University, Faculty of Pharmaceutical Sciences, Japan - Visiting Researcher
2013-2014 - The Scripps Research Institute, USA - Visiting Researcher

Areas of Focus	Discovery of natural products Biosynthesis Biotransformation
Publications	Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis, Tingting Lou, Annan Li, Houchao Xu, Jingfeng Pan, Baiying Xing, Ruibo Wu, Jeroen S. Dickschat, Donghui Yang, Ming Ma, 2023 Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes, Baiying Xing, Houchao Xu, Annan Li, Tingting Lou, Meng Xu, Kaibiao Wang, Zhengren Xu, Jeroen S. Dickschat, Donghui Yang, Ming Ma, 2022 Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis, Baiying Xing, Jiahui Yu, Changbiao Chi, Xueyang Ma, Qingxia Xu, Annan Li, Yuanjie Ge, Zhengdong Wang, Tan Liu, Hongli Jia, Fuling Yin, Juan Guo, Luqi Huang, Donghui Yang, Ming Ma, 2021 Functional characterization and crystal structure of the bifunctional thioesterase catalyzing epimerization and cyclization in skyllamycin biosynthesis, Jiahui Yu, Juan Song, Changbiao Chi, Tan Liu, Tongtong Geng, Zonghui Cai, Weidong Dong, Cheng Shi, Xueyang Ma, Zhongyi Zhang, Xiaojie Ma, Baiying Xing, Hongwei Jin, Liangren Zhang, Suwei Dong, Donghui Yang, Ming Ma, 2021 Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications, Tan Liu, Xiaojie Ma, Jiahui Yu, Wensheng Yang, guiyang wang, Zhengdong Wang, Yuanjie Ge, Juan Song, Hua Han, Wen Zhang, Donghui Yang, Xuehui Liu, Ming Ma, 2021 Generation of Unusual Aromatic Polyketides by Incorporation of Phenylamine Analogues into a C-Ring-Cleaved Angucyclinone, Hua Xiao, Guiyang Wang, Zhengdong Wang, Yi Kuang, Juan Song, Jing Jin, Min Ye, Donghui Yang, Ming Ma, 2021 Discovery and Biosyntheses of Pepticinnamins G-M Featuring Three Enzyme-Catalyzed Nonproteinogenic Amino Acid Formation, Yuanjie Ge, Guiyang Wang, Jing Jin, Tan Liu, Xueyang Ma, Zhongyi Zhang, Tongtong Geng, Juan Song, Xiaojie Ma, Yingtao Zhang, Donghui Yang, Ming Ma, 2020 Strepimidazoles A-G from the Plant Endophytic Streptomyces sp. PKU-EA00015 with Inhibitory Activities against a Plant Pathogenic Fungus, Xiaoxu Sun, Guiyang Wang, Hua Xiao, Jingyi Jiang, Dongliang Xiao, Baiying Xing, Annan Li, Yingtao Zhang, Kai Sun, Yuquan Xu, Lanping Guo, Donghui Yang, Ming Ma, 2020 Discovery of a Phenylamine-Incorporated Angucyclinone from Marine Streptomyces sp. PKU-MA00218 and Generation of Derivatives with Phenylamine Analogues, Tan Liu, Jing Jin, Xiaoyan Yang, Juan Song, Jiahui Yu, Tongtong Geng, Zhongyi Zhang, Xueyang Ma, Guiyang Wang, Hua Xiao, Yuanjie Ge, Xiaoxu Sun, Baiying Xing, Xiaojie Ma, Changbiao Chi, Yi Kuang, Min Ye, Hailong Wang, Youming Zhang, Donghui Yang, Ming Ma, 2019 Fluostatins M-Q featuring a 6-5-6-6 ring skeleton and high oxidized A-rings from marine Streptomyces sp. PKU-MA00045, Jing Jin, Xiaoyan Yang, Tan Liu, Hua Xiao, Guiyang Wang, Mengjie Zhou, Fawang Liu, Yingtao Zhang, Dong Liu, Minghua Chen, Wei Cheng, Donghui Yang, Ming Ma, 2018 Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092, Mengjie Zhou, Fawang Liu, Xiaoyan Yang, Jing Jin, Xin Dong, Ke-Wu Zeng, Dong Liu, Yingtao Zhang, Ming Ma, Donghui Yang, 2018 Cloning, expression, and characterization of a four-component O-demethylase from human intestinal bacterium Eubacterium limosum ZL-II, Jia-Xing Chen, Chao-Yin Deng, Ying-Tao Zhang, Zhen-Ming Liu, Ping-Zhang Wang, Shu-Lin Liu, Wei Qian, Donghui Yang, 2016

Areas of Focus

Discovery of natural products
Biosynthesis
Biotransformation

Publications

Structural Insights into Three Sesquiterpene Synthases for the Biosynthesis of Tricyclic Sesquiterpenes and Chemical Space Expansion by Structure-Based Mutagenesis, Tingting Lou, Annan Li, Houchao Xu, Jingfeng Pan, Baiying Xing, Ruibo Wu, Jeroen S. Dickschat, Donghui Yang, Ming Ma, 2023
Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes, Baiying Xing, Houchao Xu, Annan Li, Tingting Lou, Meng Xu, Kaibiao Wang, Zhengren Xu, Jeroen S. Dickschat, Donghui Yang, Ming Ma, 2022
Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis, Baiying Xing, Jiahui Yu, Changbiao Chi, Xueyang Ma, Qingxia Xu, Annan Li, Yuanjie Ge, Zhengdong Wang, Tan Liu, Hongli Jia, Fuling Yin, Juan Guo, Luqi Huang, Donghui Yang, Ming Ma, 2021
Functional characterization and crystal structure of the bifunctional thioesterase catalyzing epimerization and cyclization in skyllamycin biosynthesis, Jiahui Yu, Juan Song, Changbiao Chi, Tan Liu, Tongtong Geng, Zonghui Cai, Weidong Dong, Cheng Shi, Xueyang Ma, Zhongyi Zhang, Xiaojie Ma, Baiying Xing, Hongwei Jin, Liangren Zhang, Suwei Dong, Donghui Yang, Ming Ma, 2021
Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications, Tan Liu, Xiaojie Ma, Jiahui Yu, Wensheng Yang, guiyang wang, Zhengdong Wang, Yuanjie Ge, Juan Song, Hua Han, Wen Zhang, Donghui Yang, Xuehui Liu, Ming Ma, 2021
Generation of Unusual Aromatic Polyketides by Incorporation of Phenylamine Analogues into a C-Ring-Cleaved Angucyclinone, Hua Xiao, Guiyang Wang, Zhengdong Wang, Yi Kuang, Juan Song, Jing Jin, Min Ye, Donghui Yang, Ming Ma, 2021
Discovery and Biosyntheses of Pepticinnamins G-M Featuring Three Enzyme-Catalyzed Nonproteinogenic Amino Acid Formation, Yuanjie Ge, Guiyang Wang, Jing Jin, Tan Liu, Xueyang Ma, Zhongyi Zhang, Tongtong Geng, Juan Song, Xiaojie Ma, Yingtao Zhang, Donghui Yang, Ming Ma, 2020
Strepimidazoles A-G from the Plant Endophytic Streptomyces sp. PKU-EA00015 with Inhibitory Activities against a Plant Pathogenic Fungus, Xiaoxu Sun, Guiyang Wang, Hua Xiao, Jingyi Jiang, Dongliang Xiao, Baiying Xing, Annan Li, Yingtao Zhang, Kai Sun, Yuquan Xu, Lanping Guo, Donghui Yang, Ming Ma, 2020
Discovery of a Phenylamine-Incorporated Angucyclinone from Marine Streptomyces sp. PKU-MA00218 and Generation of Derivatives with Phenylamine Analogues, Tan Liu, Jing Jin, Xiaoyan Yang, Juan Song, Jiahui Yu, Tongtong Geng, Zhongyi Zhang, Xueyang Ma, Guiyang Wang, Hua Xiao, Yuanjie Ge, Xiaoxu Sun, Baiying Xing, Xiaojie Ma, Changbiao Chi, Yi Kuang, Min Ye, Hailong Wang, Youming Zhang, Donghui Yang, Ming Ma, 2019
Fluostatins M-Q featuring a 6-5-6-6 ring skeleton and high oxidized A-rings from marine Streptomyces sp. PKU-MA00045, Jing Jin, Xiaoyan Yang, Tan Liu, Hua Xiao, Guiyang Wang, Mengjie Zhou, Fawang Liu, Yingtao Zhang, Dong Liu, Minghua Chen, Wei Cheng, Donghui Yang, Ming Ma, 2018
Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092, Mengjie Zhou, Fawang Liu, Xiaoyan Yang, Jing Jin, Xin Dong, Ke-Wu Zeng, Dong Liu, Yingtao Zhang, Ming Ma, Donghui Yang, 2018
Cloning, expression, and characterization of a four-component O-demethylase from human intestinal bacterium Eubacterium limosum ZL-II, Jia-Xing Chen, Chao-Yin Deng, Ying-Tao Zhang, Zhen-Ming Liu, Ping-Zhang Wang, Shu-Lin Liu, Wei Qian, Donghui Yang, 2016

Natural Products Biosynthesis Biotransformation Terpene Synthase Gut Microbiota Enzymes Bioactive Molecules Chemical Space Expansion Mutagenesis Patents

Zhang Wei - Fudan University

Huang Hai - Fudan University

Jiyang Li - Fudan University

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