Professor | Xuan Zhang | Asia Growth Partners

Name	Xuan Zhang
Contact Information	xuanzhang@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

Name

Xuan Zhang

Contact Information

xuanzhang@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1990, 1993, 1999 - Bachelor's, Master's, and Doctorate in Pharmaceutics: China Pharmaceutical University 2003, 2008, 2015 - Peking University Health Science Center Outstanding Teacher Award 1996 - Third Prize for Scientific and Technological Progress by the National Medical Products Administration (2nd contributor) 2003 - Second Prize for Scientific and Technological Progress by the Ministry of Education (2nd contributor) 2008 - First Prize for Scientific and Technological Progress by the Chinese Pharmaceutical Association (2nd contributor) 2009 - First Prize for Natural Science by the Ministry of Education (4th contributor)
Work Experience	1993-1996 - Lecturer at the Department of Pharmaceutics, China Pharmaceutical University 1999-2001 - Postdoctoral Researcher at the School of Pharmaceutical Sciences, Peking University 2001-present - Professor and Doctoral Supervisor at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University 2004-2005 - Visiting Researcher at Stockholm University, Sweden April 2006 - Visiting Researcher at Kyushu University, Japan
Awards	2003, 2008, 2015 - Peking University Health Science Center Outstanding Teacher Award 1996 - Third Prize for Scientific and Technological Progress by the National Medical Products Administration (2nd contributor) 2003 - Second Prize for Scientific and Technological Progress by the Ministry of Education (2nd contributor) 2008 - First Prize for Scientific and Technological Progress by the Chinese Pharmaceutical Association (2nd contributor) 2009 - First Prize for Natural Science by the Ministry of Education (4th contributor)

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1990, 1993, 1999 - Bachelor's, Master's, and Doctorate in Pharmaceutics: China Pharmaceutical University
2003, 2008, 2015 - Peking University Health Science Center Outstanding Teacher Award
1996 - Third Prize for Scientific and Technological Progress by the National Medical Products Administration (2nd contributor)
2003 - Second Prize for Scientific and Technological Progress by the Ministry of Education (2nd contributor)
2008 - First Prize for Scientific and Technological Progress by the Chinese Pharmaceutical Association (2nd contributor)
2009 - First Prize for Natural Science by the Ministry of Education (4th contributor)

Work Experience

1993-1996 - Lecturer at the Department of Pharmaceutics, China Pharmaceutical University
1999-2001 - Postdoctoral Researcher at the School of Pharmaceutical Sciences, Peking University
2001-present - Professor and Doctoral Supervisor at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University
2004-2005 - Visiting Researcher at Stockholm University, Sweden
April 2006 - Visiting Researcher at Kyushu University, Japan

Awards

2003, 2008, 2015 - Peking University Health Science Center Outstanding Teacher Award
1996 - Third Prize for Scientific and Technological Progress by the National Medical Products Administration (2nd contributor)
2003 - Second Prize for Scientific and Technological Progress by the Ministry of Education (2nd contributor)
2008 - First Prize for Scientific and Technological Progress by the Chinese Pharmaceutical Association (2nd contributor)
2009 - First Prize for Natural Science by the Ministry of Education (4th contributor)

Areas of Focus	Drug Delivery Systems
Publications	In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions, Liu XR, Wu KC, Huang Y, Sun JB, Ke XY, Wang JC, Lu WL, Zhang X, Zhang Q, 2008 Antiangiogenic Activity of Sterically Stabilized Liposomes Containing Paclitaxel (SSL-PTX): In Vitro and In Vivo, Huang Y, Chen XM, Zhao BX, Ke XY, Zhao BJ, Zhao X, Wang Y, Zhang X, Zhang Q, 2010 The therapeutic efficacy of conjugated linoleic acid - paclitaxel on glioma in the rat, Ke XY, Zhao BJ, Zhao X, Wang Y, Huang Y, Chen XM, Zhao BX, Zhao SS, Zhang X, Zhang Q, 2010 Dual functions of the human antimicrobial peptide LL-37-Target membrane perturbation and host cell cargo delivery, Zhang X, Ogl？cka K, Sandgren S, Belting M, Esbj？rner EK, Nordén B, Gr？slund A, 2010 The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats, Zhao BJ, Ke XY, Huang Y, Chen XM, Zhao X, Zhao BX, Lu WL, Lou JN, Zhang X, Zhang Q, 2011 A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate, Jia Z, Lin P, Xiang Y, Wang X, Wang J, Zhang X, Zhang Q, 2011 A novel paclitaxel microemulsion containing a reduced amount of Cremophor EL: pharmacokinetics, biodistribution, in vivo anti-tumor efficacy and safety, Wang Y, Wu KC, Zhao BX, Zhao X, Wang X, Chen S, Nie SF, Pan WS, Zhang X, Zhang Q, 2011 The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel, Zhao BX, Zhao Y, Huang Y, Luo LM, Song P, Wang X, Chen S, Yu KF, Zhang X, Zhang Q, 2012 Monitoring the transport of polymeric micelles across MDCK cell monolayer and exploring related mechanisms, Zhao S, Dai W, He B, Wang J, He Z, Zhang X, Zhang Q, 2012 Pharmacokinetics, tissue distribution and anti-tumour efficacy of paclitaxel delivered by polyvinylpyrrolidone solid dispersion, Liu X, Sun J, Chen X, Wang S, Scott H, Zhang X, Zhang Q, 2012 Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel, Luo LM, Huang Y, Zhao BX, Zhao X, Duan Y, Du R, Yu KF, Song P, Zhao Y, Zhang X, Zhang Q, 2013 Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings, Li D, Yang K, Li JS, Ke XY, Duan Y, Du R, Song P, Yu KF, Ren W, Huang D, Li XH, Hu X, Zhang X, Zhang Q, 2012 Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation, Duan Y, Zhao X, Ren W, Wang X, Yu KF, Li D, Zhang X, Zhang Q, 2013 The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation, Yu KF, Zhang WQ, Luo LM, Song P, Li D, Du R, Ren W, Huang D, Lu WL, Zhang X, Zhang Q, 2013 Antitumor effect of iRGD-modified liposomes containing conjugated linoleic acid-paclitaxel (CLA-PTX) on B16-F10 melanoma, Du R Zhong T, Zhang WQ, Song P, Song WD, Zhao Y, Wang C, Tang YQ, Zhang X, Zhang Q, 2014 The antitumor activity of tumor-homing peptide-modified thermosensitive liposomes containing doxorubicin on MCF-7/ADR: in vitro and in vivo, Wang C, Wang X, Zhong T, Zhao Y, Zhang WQ, Ren W, Huang D, Zhang S, Guo Y, Yao X, Tang YQ, Zhang X, Zhang Q, 2015 Does ligand-receptor mediated competitive effect or penetrating effect of iRGD peptide when co-administration with iRGD-modified SSL?, Zhang WQ, Yu KF, Zhong T, Luo LM, Du R, Ren W, Huang D, Song P, Li D, Zhao Y, Wang C, Zhang X, 2015 Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity, Zhao Y, Ren W, Zhong T, Zhang S, Huang D, Guo Y, Yao X, Wang C, Zhang WQ, Zhang X, Zhang Q, 2016 Multi-targeting NGR-modified liposomes recognizing glioma tumor cells and vasculogenic mimicry for improving anti-glioma therapy, Huang D, Zhang S, Zhong T, Ren W, Yao X, Guo Y, Duan XC, Yin YF, Zhang SS, Zhang X, 2016 The anti-tumor efficacy of 3-(2-Nitrophenyl) propionic acid-paclitaxel (NPPA-PTX): a novel paclitaxel bioreductive prodrug, Song P, Yao X, Zhong T, Zhang S, Guo Y, Ren W, Huang D, Duan XC, Yin YF, Zhang SS, Zhang X, 2016 A self-assembling nanomedicine of conjugated linoleic acid-paclitaxel conjugate (CLA-PTX) with higher drug loading and carrier-free characteristic, Zhong T, Yao X, Zhang S, Guo Y, Duan XC, Ren W, Dan Huang, Yin YF, Zhang X, 2016 Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix, Guo Y, Zhong T, Duan XC, Zhang S, Yao X, Yin YF, Huang D, Ren W, Zhang Q, Zhang X, 2017 Improving Solubility and Oral Bioavailability of Febuxostat by Polymer-Coated Nanomatrix, Yin YF, Guo Y, Song WD, Duan XC, Zheng XC, Zhong T, Zhang S, Yao X, Xu MQ, Zhang Q, Zhang X, 2017 The effect of XlogP and Hansen solubility parameters on small molecule modified paclitaxel anti-cancer drug conjugates self-assembled into nanoparticles, Zhong T, Hao YL, Yao X, Zhang S, Duan XC, Yin YF, Xu MQ, Guo Y, Li ZT, Zheng XC, Li H, Zhang X*, 2018

Areas of Focus

Drug Delivery Systems

Publications

In vitro and in vivo studies on plasma-to-blood ratio of paclitaxel in human, rabbit and rat blood fractions, Liu XR, Wu KC, Huang Y, Sun JB, Ke XY, Wang JC, Lu WL, Zhang X*, Zhang Q, 2008
Antiangiogenic Activity of Sterically Stabilized Liposomes Containing Paclitaxel (SSL-PTX): In Vitro and In Vivo, Huang Y, Chen XM, Zhao BX, Ke XY, Zhao BJ, Zhao X, Wang Y, Zhang X*, Zhang Q, 2010
The therapeutic efficacy of conjugated linoleic acid - paclitaxel on glioma in the rat, Ke XY, Zhao BJ, Zhao X, Wang Y, Huang Y, Chen XM, Zhao BX, Zhao SS, Zhang X*, Zhang Q, 2010
Dual functions of the human antimicrobial peptide LL-37-Target membrane perturbation and host cell cargo delivery, Zhang X, Ogl？cka K, Sandgren S, Belting M, Esbj？rner EK, Nordén B, Gr？slund A, 2010
The antiangiogenic efficacy of NGR-modified PEG-DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats, Zhao BJ, Ke XY, Huang Y, Chen XM, Zhao X, Zhao BX, Lu WL, Lou JN, Zhang X*, Zhang Q, 2011
A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate, Jia Z, Lin P, Xiang Y, Wang X, Wang J, Zhang X*, Zhang Q*, 2011
A novel paclitaxel microemulsion containing a reduced amount of Cremophor EL: pharmacokinetics, biodistribution, in vivo anti-tumor efficacy and safety, Wang Y, Wu KC, Zhao BX, Zhao X, Wang X, Chen S, Nie SF, Pan WS, Zhang X*, Zhang Q, 2011
The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel, Zhao BX, Zhao Y, Huang Y, Luo LM, Song P, Wang X, Chen S, Yu KF, Zhang X*, Zhang Q, 2012
Monitoring the transport of polymeric micelles across MDCK cell monolayer and exploring related mechanisms, Zhao S, Dai W, He B, Wang J, He Z, Zhang X*, Zhang Q*, 2012
Pharmacokinetics, tissue distribution and anti-tumour efficacy of paclitaxel delivered by polyvinylpyrrolidone solid dispersion, Liu X, Sun J, Chen X, Wang S, Scott H, Zhang X*, Zhang Q, 2012
Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel, Luo LM, Huang Y, Zhao BX, Zhao X, Duan Y, Du R, Yu KF, Song P, Zhao Y, Zhang X*, Zhang Q, 2013
Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings, Li D, Yang K, Li JS, Ke XY, Duan Y, Du R, Song P, Yu KF, Ren W, Huang D, Li XH, Hu X, Zhang X*, Zhang Q, 2012
Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation, Duan Y, Zhao X, Ren W, Wang X, Yu KF, Li D, Zhang X*, Zhang Q, 2013
The antitumor activity of a doxorubicin loaded, iRGD-modified sterically-stabilized liposome on B16-F10 melanoma cells: in vitro and in vivo evaluation, Yu KF, Zhang WQ, Luo LM, Song P, Li D, Du R, Ren W, Huang D, Lu WL, Zhang X*, Zhang Q, 2013
Antitumor effect of iRGD-modified liposomes containing conjugated linoleic acid-paclitaxel (CLA-PTX) on B16-F10 melanoma, Du R Zhong T, Zhang WQ, Song P, Song WD, Zhao Y, Wang C, Tang YQ, Zhang X*, Zhang Q, 2014
The antitumor activity of tumor-homing peptide-modified thermosensitive liposomes containing doxorubicin on MCF-7/ADR: in vitro and in vivo, Wang C, Wang X, Zhong T, Zhao Y, Zhang WQ, Ren W, Huang D, Zhang S, Guo Y, Yao X, Tang YQ, Zhang X*, Zhang Q, 2015
Does ligand-receptor mediated competitive effect or penetrating effect of iRGD peptide when co-administration with iRGD-modified SSL?, Zhang WQ, Yu KF, Zhong T, Luo LM, Du R, Ren W, Huang D, Song P, Li D, Zhao Y, Wang C, Zhang X*, 2015
Tumor-specific pH-responsive peptide-modified pH-sensitive liposomes containing doxorubicin for enhancing glioma targeting and anti-tumor activity, Zhao Y, Ren W, Zhong T, Zhang S, Huang D, Guo Y, Yao X, Wang C, Zhang WQ, Zhang X*, Zhang Q, 2016
Multi-targeting NGR-modified liposomes recognizing glioma tumor cells and vasculogenic mimicry for improving anti-glioma therapy, Huang D, Zhang S, Zhong T, Ren W, Yao X, Guo Y, Duan XC, Yin YF, Zhang SS, Zhang X*, 2016
The anti-tumor efficacy of 3-(2-Nitrophenyl) propionic acid-paclitaxel (NPPA-PTX): a novel paclitaxel bioreductive prodrug, Song P, Yao X, Zhong T, Zhang S, Guo Y, Ren W, Huang D, Duan XC, Yin YF, Zhang SS, Zhang X*, 2016
A self-assembling nanomedicine of conjugated linoleic acid-paclitaxel conjugate (CLA-PTX) with higher drug loading and carrier-free characteristic, Zhong T, Yao X, Zhang S, Guo Y, Duan XC, Ren W, Dan Huang, Yin YF, Zhang X*, 2016
Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix, Guo Y, Zhong T, Duan XC, Zhang S, Yao X, Yin YF, Huang D, Ren W, Zhang Q, Zhang X*, 2017
Improving Solubility and Oral Bioavailability of Febuxostat by Polymer-Coated Nanomatrix, Yin YF, Guo Y, Song WD, Duan XC, Zheng XC, Zhong T, Zhang S, Yao X, Xu MQ, Zhang Q, Zhang X*, 2017
The effect of XlogP and Hansen solubility parameters on small molecule modified paclitaxel anti-cancer drug conjugates self-assembled into nanoparticles, Zhong T, Hao YL, Yao X, Zhang S, Duan XC, Yin YF, Xu MQ, Guo Y, Li ZT, Zheng XC, Li H, Zhang X*, 2018

Drug Delivery Pharmaceutics Nanomedicine Liposomes Micelles Paclitaxel Glioma Anti-Tumor Bioavailability Pharmacokinetics

Jianping Qi - Fudan University

Jian Chen - Fudan University

Jing Qin - Fudan University

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