Professor | Tianyan Zhou | Asia Growth Partners

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Name	Tianyan Zhou
Contact Information	tianyanzhou@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Tianyan Zhou

Contact Information

tianyanzhou@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1992 - Bachelor's Degree: Peking University School of Pharmaceutical Sciences 1998 - Master's Degree: Peking University School of Pharmaceutical Sciences 2006 - Doctorate: Peking University School of Pharmaceutical Sciences 2002.8-2004.9 - Visiting Researcher: Hong Kong Polytechnic University 2007.2-2008.8 - Visiting Researcher: Oklahoma State University Published over 120 papers Authored 6 textbooks and monographs Granted 5 Chinese patents
Work Experience	1998-present - Peking University School of Pharmaceutical Sciences - Professor, Doctoral Supervisor

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1992 - Bachelor's Degree: Peking University School of Pharmaceutical Sciences
1998 - Master's Degree: Peking University School of Pharmaceutical Sciences
2006 - Doctorate: Peking University School of Pharmaceutical Sciences
2002.8-2004.9 - Visiting Researcher: Hong Kong Polytechnic University
2007.2-2008.8 - Visiting Researcher: Oklahoma State University
Published over 120 papers
Authored 6 textbooks and monographs
Granted 5 Chinese patents

Work Experience

1998-present - Peking University School of Pharmaceutical Sciences - Professor, Doctoral Supervisor

Areas of Focus	Quantitative Pharmacology: Mechanism-based Pharmacokinetics/Pharmacodynamics (PK/PD); Population Pharmacokinetics/Pharmacodynamics; Application of Quantitative Pharmacology in Cancer Treatment and New Drug Development
Publications	Semi-mechanism-based pharmacokinetic-pharmacodynamic model for characterizing time-dependent pharmacokinetics of dexamethasone and its efficacy in the treatment of breast cancer, Li, J; Chen, R; Yao, QY; Liu, SJ; Tian, XY; Lu, W; Zhou, TY, 2018 Pharmacokinetic/Pharmacodynamic Modeling of Schedule-Dependent Interaction between Docetaxel and Cabozantinib in Human Prostate Cancer Xenograft Models, Chen, WJ; Chen, R; Li, J; Fu, Y; Yang, L; Su, H; Yao, Y; Li, L; Zhou, TY; Lu, W, 2018 Pharmacokinetic-pharmacodynamic modeling of the anti-tumor effect of sunitinib combined with dopamine in the human non-small cell lung cancer xenograft, Hao, FR; Wang, SY; Zhu, X; Xue, JS; Li, JY; Wang, LJ; Li, J; Lu, W; Zhou, TY, 2017 Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer, Li, J; Yao, QY; Xue, JS; Wang, LJ; Yuan, Y; Tian, XY; Su, H; Wang, SY; Chen, WJ; Lu, W; Zhou, TY, 2017 A highly sensitive LC-MS/MS method for the determination of 21-hydroxy deflazacort in nude mice plasma and its application to a pharmacokinetic study, Yao, QY; Li, J; Yao, Y; Chen, R; Chen, WJ; Su, H, Yang, L; Xue, JS; Lu, W; Zhou, TY, 2017 Preclinical PK/PD model for combined administration of erlotinib and sunitinib in the treatment of A549 human NSCLC xenograft mice, Li, JY; Ren, YP; Yuan, Y; Ji SM; Zhou, SP; Wang, LJ; Mou Z; Li, L; Lu, W, Zhou, TY, 2016 Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen, Wang, LJ; Li, J; Hao, FR; Yuan, Y; Li, JY; Lu, W; Zhou, TY, 2016 Pharmacokinetic-pharmacodynamic modeling of the antitumor effect of TM208 and EGFR-TKI resistance in breast cancer, Ji, XW; Ji, SM; Li, RT; Wu, KH; Zhu, X; Lu, W; Zhou, TY, 2016 Pharmacokinetic/Pharmacodynamic Analysis of Metformin using Different in Diabetic Rats, Li, X; Chen Y; Zhao W; Lu, W; Zhou, TY, 2016 Cabozantinib enhances the response of NSCLC cells with wild-type EGFR to erlotinib and pharmacodynamic modeling of their sequential combinations, Mou, ZZ; Wang, SY; Su, QH; Yuan, Y; Li, JY; Wang, LJ; Yao, QY; Ji, SM; Lu, W; Zhou, TY, 2016 Pharmacokinetic-pharmacodynamic modeling of the anticancer effect of TM208 on non-small cell lung cancer xenograft, Hua, M; Ji, XW; Li, RT; Ji, SM; Li, J; Yao, QY; Wang, LJ; Hao, FR; Lu, W; Zhou, TY, 2016 A liquid chromatography-tandem mass spectrometric method for the determination of axitinib in nude mouse plasma: Development, validation and application to a pharmacokinetic study, Ma, YH; Li, J; Su, QH; Chen, WJ; Lu, W; Zhou, TY, 2016 Semi-Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for the Combination Use of Dexamethasone and Gemcitabine in Breast Cancer, Yuan, Y; Zhou, X; Ren, YP; Zhou, SP, Wang, LJ; Ji, SM; Hua, M; Li L; Lu, W; Zhou, TY, 2015 Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208, Ji, XW; Chen, GP; Song, Y; Hua, M; Wang, LJ; Li, L; Yuan, Y; Wang, SY; Zhou, TY; Lu, W, 2015 Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: involvement of eradicating cancer stem-like cells, Wang, SY; Mou, ZZ; Ma, YH; Li, J; Li, JY; Ji, XW; Wu, KH; Li, L; Lu, W; Zhou, TY, 2015 Breast cancer treatment and sulfotransferase, Ji, XW; Zhou, TY; Lu, Y; Wei, MJ, Lu; W; Cho, William Cs, 2015 A Simple LC/MS/MS Method for the Determination of Moxifloxacin N-Sulfate in Rat Plasma and Its Application in a Pharmacokinetic Study, Li, J; Yuan, Y; Fan, R; Su, QH; Wang, SY; Zhou, TY; Lu, W, 2015 Simultaneous determination of sunitinib and its active metabolites N-desethylsunitinib (SU12662) in nude mice plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study, Li, JY; Li, J; Wang, SY; Yuan, Y; Su, QH; Lu, W; Zhou, TY, 2015 Development and validation of a highly sensitive LC-MS/MS method for the determination of dexamethasone in nude mice plasma and its application to a pharmacokinetic study, Yuan, Y; Zhou, X; Li, J; Ye, S., Ji, XW; Li, L; Zhou, TY; and Lu, W, 2015 Exogenous dopamine induces dehydroepiandrosterone sulfotranferase (rSULT2A1) in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats, Shao, XY#; Li, J#; Wang, SY; Chen, GP; Xu, JJ; Ji, XW; Li, L; Lu, W; Zhou, TY, 2015 Pharmacokinetics, in vitro and in vivo correlation, and efficacy of exenatide microspheres in diabetic rats, Li, XG; Zhao, ZG; Li, L; Zhou, TY; and Lu, W, 2015 Comparison of dopamine with levodopa in the induction of aryl sulfotransferases and estrogen sulfotransferase in rat liver, Shao, XY; Li, J; Wang, SY; Chen, GP; Xu, JJ; Ji, XW; Li, L; Lu, W; Zhou, TY, 2014 Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells, Xu, JJ; Wang, SY; Chen, Y; Chen, GP; Li ZQ; Shao, XY; Li, L; Lu, W; Zhou, TY, 2014 Inhibition of autophosphorylation of EGFR plays an important role in the anti-breast cancer efficacy of a dithiocarbamate derivative TM208, Ji, XW; Li, RT; Li, ZQ; Li, L; Shao, XY; Wang, SY; Yuan, Y; Zhou, TY; Lu, W, 2014 Preclinical Pharmacokinetic/Pharmacodynamic Models to Predict Schedule-Dependent Interaction between Erlotinib and Gemcitabine, Li, MY; Li, HQ; Cheng, XL; Wang, XP; Li, L; Zhou, TY, and Lu, W, 2013 Methamphetamine Regulation of Sulfotransferase 1A1 and 2A1 Expression in Rat Brain Sections, Zhou, TY; Huang, CQ; Chen, Y; Xu, JJ; Shanbhag, PD; Chen, GP, 2013 Pharmacokinetic and pharmacodynamic study of erlotinib based upon phosphorylated epidermal growth factor receptor and tumor volume in human non-small cell lung cancer xenograft mouse mode, Wu, Q; Li, MY; Li, HQ; Deng, CH; Li, L; Zhou, TY, and Lu, W, 2013 A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study, Cheng, XL; Guo,LP; Li, ZQ; Li, L; Zhou, TY, Lu, W, 2013 Caffeine induction of sulfotransferases in rat liver and intestine, Zhou, TY; Chen, Y; Huang, CQ; Chen, GP, 2012 Modeling of Angiotensin II-Angiotensin-(1-7) Counterbalance in Disease Progression in Spontaneously Hypertensive Rats Treated With/Without Perindopril, Zhou, X; Shang, DW; Zhang, TL; Li, L; Zhou, TY; Lu, W, 0201

Areas of Focus

Quantitative Pharmacology: Mechanism-based Pharmacokinetics/Pharmacodynamics (PK/PD); Population Pharmacokinetics/Pharmacodynamics; Application of Quantitative Pharmacology in Cancer Treatment and New Drug Development

Publications

Semi-mechanism-based pharmacokinetic-pharmacodynamic model for characterizing time-dependent pharmacokinetics of dexamethasone and its efficacy in the treatment of breast cancer, Li, J; Chen, R; Yao, QY; Liu, SJ; Tian, XY; Lu, W*; Zhou, TY*, 2018
Pharmacokinetic/Pharmacodynamic Modeling of Schedule-Dependent Interaction between Docetaxel and Cabozantinib in Human Prostate Cancer Xenograft Models, Chen, WJ; Chen, R; Li, J; Fu, Y; Yang, L; Su, H; Yao, Y; Li, L; Zhou, TY*; Lu, W*, 2018
Pharmacokinetic-pharmacodynamic modeling of the anti-tumor effect of sunitinib combined with dopamine in the human non-small cell lung cancer xenograft, Hao, FR; Wang, SY; Zhu, X; Xue, JS; Li, JY; Wang, LJ; Li, J; Lu, W; Zhou, TY*, 2017
Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer, Li, J; Yao, QY; Xue, JS; Wang, LJ; Yuan, Y; Tian, XY; Su, H; Wang, SY; Chen, WJ; Lu, W*; Zhou, TY*, 2017
A highly sensitive LC-MS/MS method for the determination of 21-hydroxy deflazacort in nude mice plasma and its application to a pharmacokinetic study, Yao, QY; Li, J; Yao, Y; Chen, R; Chen, WJ; Su, H, Yang, L; Xue, JS; Lu, W; Zhou, TY*, 2017
Preclinical PK/PD model for combined administration of erlotinib and sunitinib in the treatment of A549 human NSCLC xenograft mice, Li, JY; Ren, YP; Yuan, Y; Ji SM; Zhou, SP; Wang, LJ; Mou Z; Li, L; Lu, W, Zhou, TY*, 2016
Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen, Wang, LJ; Li, J; Hao, FR; Yuan, Y; Li, JY; Lu, W; Zhou, TY*, 2016
Pharmacokinetic-pharmacodynamic modeling of the antitumor effect of TM208 and EGFR-TKI resistance in breast cancer, Ji, XW; Ji, SM; Li, RT; Wu, KH; Zhu, X; Lu, W*; Zhou, TY*, 2016
Pharmacokinetic/Pharmacodynamic Analysis of Metformin using Different in Diabetic Rats, Li, X; Chen Y; Zhao W; Lu, W*; Zhou, TY*, 2016
Cabozantinib enhances the response of NSCLC cells with wild-type EGFR to erlotinib and pharmacodynamic modeling of their sequential combinations, Mou, ZZ; Wang, SY; Su, QH; Yuan, Y; Li, JY; Wang, LJ; Yao, QY; Ji, SM; Lu, W*; Zhou, TY*, 2016
Pharmacokinetic-pharmacodynamic modeling of the anticancer effect of TM208 on non-small cell lung cancer xenograft, Hua, M; Ji, XW; Li, RT; Ji, SM; Li, J; Yao, QY; Wang, LJ; Hao, FR; Lu, W; Zhou, TY*, 2016
A liquid chromatography-tandem mass spectrometric method for the determination of axitinib in nude mouse plasma: Development, validation and application to a pharmacokinetic study, Ma, YH; Li, J; Su, QH; Chen, WJ; Lu, W*; Zhou, TY*, 2016
Semi-Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for the Combination Use of Dexamethasone and Gemcitabine in Breast Cancer, Yuan, Y; Zhou, X; Ren, YP; Zhou, SP, Wang, LJ; Ji, SM; Hua, M; Li L; Lu, W; Zhou, TY*, 2015
Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208, Ji, XW; Chen, GP; Song, Y; Hua, M; Wang, LJ; Li, L; Yuan, Y; Wang, SY; Zhou, TY*; Lu, W, 2015
Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: involvement of eradicating cancer stem-like cells, Wang, SY; Mou, ZZ; Ma, YH; Li, J; Li, JY; Ji, XW; Wu, KH; Li, L; Lu, W; Zhou, TY*, 2015
Breast cancer treatment and sulfotransferase, Ji, XW; Zhou, TY; Lu, Y; Wei, MJ, Lu; W; Cho, William Cs, 2015
A Simple LC/MS/MS Method for the Determination of Moxifloxacin N-Sulfate in Rat Plasma and Its Application in a Pharmacokinetic Study, Li, J; Yuan, Y; Fan, R; Su, QH; Wang, SY; Zhou, TY*; Lu, W, 2015
Simultaneous determination of sunitinib and its active metabolites N-desethylsunitinib (SU12662) in nude mice plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study, Li, JY; Li, J; Wang, SY; Yuan, Y; Su, QH; Lu, W; Zhou, TY*, 2015
Development and validation of a highly sensitive LC-MS/MS method for the determination of dexamethasone in nude mice plasma and its application to a pharmacokinetic study, Yuan, Y; Zhou, X; Li, J; Ye, S., Ji, XW; Li, L; Zhou, TY*; and Lu, W, 2015
Exogenous dopamine induces dehydroepiandrosterone sulfotranferase (rSULT2A1) in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats, Shao, XY#; Li, J#; Wang, SY; Chen, GP; Xu, JJ; Ji, XW; Li, L; Lu, W; Zhou, TY*, 2015
Pharmacokinetics, in vitro and in vivo correlation, and efficacy of exenatide microspheres in diabetic rats, Li, XG; Zhao, ZG; Li, L; Zhou, TY*; and Lu, W*, 2015
Comparison of dopamine with levodopa in the induction of aryl sulfotransferases and estrogen sulfotransferase in rat liver, Shao, XY; Li, J; Wang, SY; Chen, GP; Xu, JJ; Ji, XW; Li, L; Lu, W; Zhou, TY*, 2014
Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells, Xu, JJ; Wang, SY; Chen, Y; Chen, GP; Li ZQ; Shao, XY; Li, L; Lu, W; Zhou, TY*, 2014
Inhibition of autophosphorylation of EGFR plays an important role in the anti-breast cancer efficacy of a dithiocarbamate derivative TM208, Ji, XW; Li, RT; Li, ZQ; Li, L; Shao, XY; Wang, SY; Yuan, Y; Zhou, TY*; Lu, W*, 2014
Preclinical Pharmacokinetic/Pharmacodynamic Models to Predict Schedule-Dependent Interaction between Erlotinib and Gemcitabine, Li, MY; Li, HQ; Cheng, XL; Wang, XP; Li, L; Zhou, TY*, and Lu, W*, 2013
Methamphetamine Regulation of Sulfotransferase 1A1 and 2A1 Expression in Rat Brain Sections, Zhou, TY; Huang, CQ; Chen, Y; Xu, JJ; Shanbhag, PD; Chen, GP, 2013
Pharmacokinetic and pharmacodynamic study of erlotinib based upon phosphorylated epidermal growth factor receptor and tumor volume in human non-small cell lung cancer xenograft mouse mode, Wu, Q; Li, MY; Li, HQ; Deng, CH; Li, L; Zhou, TY*, and Lu, W*, 2013
A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study, Cheng, XL; Guo,LP; Li, ZQ; Li, L; Zhou, TY*, Lu, W*, 2013
Caffeine induction of sulfotransferases in rat liver and intestine, Zhou, TY; Chen, Y; Huang, CQ; Chen, GP, 2012
Modeling of Angiotensin II-Angiotensin-(1-7) Counterbalance in Disease Progression in Spontaneously Hypertensive Rats Treated With/Without Perindopril, Zhou, X; Shang, DW; Zhang, TL; Li, L; Zhou, TY*; Lu, W*, 0201

Pharmacokinetics Pharmacodynamics Quantitative Pharmacology Cancer Treatment New Drug Development Mechanism-Based Population Pharmacokinetics Population Pharmacodynamics Pk/Pd Drug Metabolism

Weimin Cai - Fudan University

Qingfeng He - Fudan University

Xiang Xiaoqiang - Fudan University

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