Professor | Zhuo Huang | Asia Growth Partners

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Name	Zhuo Huang
Contact Information	huangz@hsc.pku.edu.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Zhuo Huang

Contact Information

huangz@hsc.pku.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1998-2002 Bachelor's Degree: School of Pharmaceutical Sciences, Peking University 2003-2008 PhD in Neuropharmacology: University College London Youth Top-notch Talent of the Central Organization Department New Century Talent of the Ministry of Education
Work Experience	2008-2013 - University College London - Postdoctoral Researcher in Neuropharmacology 2013-present - Peking University School of Pharmaceutical Sciences - Researcher
Awards	Youth Top-notch Talent of the Central Organization Department New Century Talent of the Ministry of Education

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1998-2002 Bachelor's Degree: School of Pharmaceutical Sciences, Peking University
2003-2008 PhD in Neuropharmacology: University College London
Youth Top-notch Talent of the Central Organization Department
New Century Talent of the Ministry of Education

Work Experience

2008-2013 - University College London - Postdoctoral Researcher in Neuropharmacology
2013-present - Peking University School of Pharmaceutical Sciences - Researcher

Awards

Youth Top-notch Talent of the Central Organization Department
New Century Talent of the Ministry of Education

Areas of Focus	Expression, distribution, regulation, and function of ion channels in neuronal microstructures Drug screening and preclinical research targeting ion channels Discovery and validation of new targets for neuropsychiatric diseases
Publications	Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3, Gao, Y., Xu, S., Cui, X., Xu H., Qiu Y., Wei Y., Dong Y., Zhu B., Peng C., Liu S., Zhang X., Sun J., Huang Z, Zhao Y., 2023 Identification of a novel frameshift mutation in the SCNN1B causing Liddle syndrome, Qu Y, Lu Y, Zhang D, Liu X, Fan P, Chen J, Zhang H, Yang K, Tian T, Zhou Y, Zhang Q, Zhang Y, Wang L, Huang Z, Liu Y, Hu A, Zhou X., 2023 Structure of human NaV1.6 channel reveals Na+ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin, Li Y., Yuan T., Huang B., Zhou F., Peng C., Li X., Qiu Y., Yang B., Zhao Y., Huang Z., and Jiang D., 2023 Structure, gating and pharmacology of human CaV3.3 channel, He L, Yu Z, Geng Z, Huang Z, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y., 2022 N-type fast inactivation of a eukaryotic voltage-gated sodium channel, Zhang J, Shi Y, Fan J, Chen H, Xia Z, Huang B, Jiang J, Gong J, Huang Z, Jiang D., 2022 Structural basis of ligand binding modes of human EAAT2, Zhang ZL, Chen HW, Geng Z, Yu ZY, Li H, Dong YL, Zhang HW, Huang Z, Jiang JQ, Zhao Y, 2022 JADE2 is essential for hippocampal synaptic plasticity and cognitive, Fan MH, Liu YQ, Shang YF, Xue YX, Liang J, Huang Z, 2022 Structural basis for NaV1.7 inhibition by pore blockers, Zhang JT#, Shi YQ#, Huang Z#, Li Y, Yang B, Gong JK, Jiang D, 2022 Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms, Ma Z, Eaton M, Liu Y, Zhang J, Chen X, Tu X, Shi Y, Que Z, Wettschurack K, Zhang Z, Shi R, Chen Y, Kimbrough A, Lanman NA, Schust L, Huang Z, Yang Y., 2022 Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation, Wang H#, Wu T#, Huang Z#, Huang J, Geng Z, Cui B, Yan Y, Zhang Y, Wang Y., 2022 Multiple machine learning methods aided virtual screening of NaV1.5 inhibitors, Kong WK, Huang WR, Peng C, Zhang BW, Duan GF, Ma WN, Huang Z, 2022 Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2, Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D, Huang Z, Zhao Y., 2021 Discovery of Novel and Potent Methyl-d-aspartate Receptor Positive Allosteric Modulators with Antidepressant-like Activity in Rodent Models, Li Z, Cai G, Fang F, Li W, Fan M, Lian J, Qiu Y, Xu X, Lv X, Li Y, Zheng R, Wang Y, Li Z, Zhang G, Liu Z, Huang Z, Zhang L., 2021 PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice, Zhang J, Zhang C, Chen X, Wang B, Ma W, Yang Y, Zheng R, Huang Z, 2021 In vivo chemical reprogramming of astrocytes into neurons, Ma Y, Xie H, Du X, Wang L, Jin X, Zhang Q, Han Y, Sun S, Wang L, Li X, Zhang C, Wang M, Li C, Xu J, Huang Z, Wang X, Chai Z, Deng H., 2021 Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing, Kong W, Tu X, Huang W, Yang Y, Xie Z* & Huang Z , 2020 Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis, Gao M, Kong W, Huang Z & Xie Z, 2020 Prognostic model of patients with liver cancer based on tumor stem cell content and immune process, Kong W, Gao M, Jin Y, Huang W, Huang Z & Xie Z, 2020 Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence, Chi XM, Jin XQ, Chen Y, Lu XL, Tu XY, Li XR, Zhang YY, Lei JL, Huang J, Huang Z, Zhou Q* and Pan XJ, 2020 Dopamine D2 Receptors Regulate the Action Potential Threshold by Modulating T-type Calcium Channels in Stellate Cells of the Entorhinal Cortex, Jin XQ, Chen Q, Song Y, Zheng J, Xiao K, Shao S, Fu ZB, Yi M, Yang Y, and Huang Z, 2019 CDYL-mediated histone crotonylation regulates stress-induced depressive behaviors, Liu YQ, Li MH, Fan MH, Song Y, Yu HJ, Zhi XJ, Xiao K, Lai SR, Zhang JL, Jin XQ, Shang YF, Liang J, and Huang Z, 2019 Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL, Yang L, Liu Y, Fan M, Zhu G, Jin H, Liang J, Liu Z, Huang Z, Zhang L, 2019 Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice, Zhang J, Chen X, K？rb？ M, Zhao Y, An L, Wang R, Wang K, Huang Z, 2018 ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice, Xiao K, Sun Z, Jin X, Ma W, Song Y, Lai S, Chen Q, Fan M, Zhang J, Yue W, Huang Z, 2018 CDYL suppresses epileptogenesis through repression of axonal Nav1.6 sodium channel expression, Liu YQ, Lai SR, Ma WN, Ke W, Zhang C, Liu SM, Zhang Y, Pei F, Li SY, Yi M, Shu YS, Shang YF, Liang J, and Huang Z, 2017 HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals, Huang Z, Li G, Aguado C, Lujan R, Shah MM., 2016 Mg2+ block properties of NMDA receptors in neonatal rat substantia nigra pars compacta dopaminergic neurones, Huang Z* and Gibb A.J., 2014 Presynaptic HCN1 channels regulate Ca(V)3.2 activity and neurotransmission at select cortical synapses, Huang Z, Lujan R, Kadurin I, Uebele VN, Renger JJ, Dolphin AC, Shah MM., 2011 TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels, Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM., 2012 Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis, Huang Z, Walker MC, Shah MM., 2009 RP-HPLC Method for Determination of Propofol in Human Serum, Huang Z, Wang Q, Wang JY, 2003 Progress in Research of Hyperpolarization-activated Cation Non-selective Channels and Antiepileptic Drugs Targeting the Channels, Sun ZM and Huang Z, 2015

Areas of Focus

Expression, distribution, regulation, and function of ion channels in neuronal microstructures
Drug screening and preclinical research targeting ion channels
Discovery and validation of new targets for neuropsychiatric diseases

Publications

Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3, Gao, Y., Xu, S., Cui, X., Xu H., Qiu Y., Wei Y., Dong Y., Zhu B., Peng C., Liu S., Zhang X., Sun J., Huang Z*, Zhao Y., 2023
Identification of a novel frameshift mutation in the SCNN1B causing Liddle syndrome, Qu Y, Lu Y, Zhang D, Liu X, Fan P, Chen J, Zhang H, Yang K, Tian T, Zhou Y, Zhang Q, Zhang Y, Wang L, Huang Z*, Liu Y*, Hu A*, Zhou X*., 2023
Structure of human NaV1.6 channel reveals Na+ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin, Li Y., Yuan T., Huang B., Zhou F., Peng C., Li X., Qiu Y., Yang B., Zhao Y., Huang Z.*, and Jiang D.*, 2023
Structure, gating and pharmacology of human CaV3.3 channel, He L, Yu Z, Geng Z, Huang Z*, Zhang C, Dong Y, Gao Y, Wang Y, Chen Q, Sun L, Ma X, Huang B, Wang X, Zhao Y., 2022
N-type fast inactivation of a eukaryotic voltage-gated sodium channel, Zhang J, Shi Y, Fan J, Chen H, Xia Z, Huang B, Jiang J, Gong J, Huang Z*, Jiang D*., 2022
Structural basis of ligand binding modes of human EAAT2, Zhang ZL, Chen HW, Geng Z, Yu ZY, Li H, Dong YL, Zhang HW, Huang Z*, Jiang JQ*, Zhao Y*, 2022
JADE2 is essential for hippocampal synaptic plasticity and cognitive, Fan MH, Liu YQ, Shang YF, Xue YX, Liang J, Huang Z*, 2022
Structural basis for NaV1.7 inhibition by pore blockers, Zhang JT#, Shi YQ#, Huang Z#, Li Y, Yang B, Gong JK, Jiang D*, 2022
Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms, Ma Z, Eaton M, Liu Y, Zhang J, Chen X, Tu X, Shi Y, Que Z, Wettschurack K, Zhang Z, Shi R, Chen Y, Kimbrough A, Lanman NA, Schust L, Huang Z*, Yang Y*., 2022
Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation, Wang H#, Wu T#, Huang Z#, Huang J, Geng Z, Cui B, Yan Y, Zhang Y, Wang Y., 2022
Multiple machine learning methods aided virtual screening of NaV1.5 inhibitors, Kong WK, Huang WR, Peng C, Zhang BW, Duan GF, Ma WN*, Huang Z*, 2022
Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2, Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D*, Huang Z*, Zhao Y*., 2021
Discovery of Novel and Potent Methyl-d-aspartate Receptor Positive Allosteric Modulators with Antidepressant-like Activity in Rodent Models, Li Z, Cai G, Fang F, Li W, Fan M, Lian J, Qiu Y, Xu X, Lv X, Li Y, Zheng R, Wang Y, Li Z, Zhang G, Liu Z, Huang Z*, Zhang L*., 2021
PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice, Zhang J, Zhang C, Chen X, Wang B, Ma W, Yang Y, Zheng R*, Huang Z*, 2021
In vivo chemical reprogramming of astrocytes into neurons, Ma Y, Xie H, Du X, Wang L, Jin X, Zhang Q, Han Y, Sun S, Wang L, Li X, Zhang C, Wang M, Li C, Xu J, Huang Z*, Wang X*, Chai Z*, Deng H*., 2021
Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing, Kong W, Tu X, Huang W, Yang Y, Xie Z* & Huang Z *, 2020
Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis, Gao M, Kong W, Huang Z* & Xie Z*, 2020
Prognostic model of patients with liver cancer based on tumor stem cell content and immune process, Kong W, Gao M, Jin Y, Huang W, Huang Z* & Xie Z*, 2020
Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence, Chi XM, Jin XQ, Chen Y, Lu XL, Tu XY, Li XR, Zhang YY, Lei JL, Huang J, Huang Z*, Zhou Q* and Pan XJ*, 2020
Dopamine D2 Receptors Regulate the Action Potential Threshold by Modulating T-type Calcium Channels in Stellate Cells of the Entorhinal Cortex, Jin XQ, Chen Q, Song Y, Zheng J, Xiao K, Shao S, Fu ZB, Yi M, Yang Y, and Huang Z*, 2019
CDYL-mediated histone crotonylation regulates stress-induced depressive behaviors, Liu YQ, Li MH, Fan MH, Song Y, Yu HJ, Zhi XJ, Xiao K, Lai SR, Zhang JL, Jin XQ, Shang YF, Liang J*, and Huang Z*, 2019
Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL, Yang L, Liu Y, Fan M, Zhu G, Jin H, Liang J, Liu Z, Huang Z*, Zhang L*, 2019
Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice, Zhang J, Chen X, K？rb？ M, Zhao Y, An L, Wang R, Wang K, Huang Z*, 2018
ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice, Xiao K, Sun Z, Jin X, Ma W, Song Y, Lai S, Chen Q, Fan M, Zhang J, Yue W, Huang Z*, 2018
CDYL suppresses epileptogenesis through repression of axonal Nav1.6 sodium channel expression, Liu YQ, Lai SR, Ma WN, Ke W, Zhang C, Liu SM, Zhang Y, Pei F, Li SY, Yi M, Shu YS, Shang YF, Liang J*, and Huang Z*, 2017
HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals, Huang Z, Li G, Aguado C, Lujan R, Shah MM., 2016
Mg2+ block properties of NMDA receptors in neonatal rat substantia nigra pars compacta dopaminergic neurones, Huang Z* and Gibb A.J.*, 2014
Presynaptic HCN1 channels regulate Ca(V)3.2 activity and neurotransmission at select cortical synapses, Huang Z, Lujan R, Kadurin I, Uebele VN, Renger JJ, Dolphin AC, Shah MM., 2011
TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels, Huang Z, Lujan R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM., 2012
Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis, Huang Z, Walker MC, Shah MM., 2009
RP-HPLC Method for Determination of Propofol in Human Serum, Huang Z, Wang Q, Wang JY, 2003
Progress in Research of Hyperpolarization-activated Cation Non-selective Channels and Antiepileptic Drugs Targeting the Channels, Sun ZM and Huang Z*, 2015

Ion Channels Neuronal Microstructures Drug Screening Preclinical Research Neuropsychiatric Diseases Target Discovery Target Validation Electrophysiology Calcium Imaging Glutamate Uncaging

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