Upload Avatar (500 x 500)
He-Ping Cheng
Life Sciences / Medical / Biology
Peking University
Beijing
Language: Chinese, English
Calcium Spark
Calcium Signaling
Cell Biology
Physiology
Pathology
Mitochondria
Superoxide Generation
Energy Metabolism
Oxidative Stress
Biomedical Imaging
Areas of Focus
- Calcium Signaling
- Mitochondrial Function
- Biomedical Instrumentation
Work Experience
- 1987.7-1989.7 - Peking University, Department of Radio Electronics - Teaching Assistant
- 1995.8-1998.5 - National Institutes of Health, National Institute on Aging - Senior Research Assistant
- 1998.6-2004.11 - National Institutes of Health, National Institute on Aging - Researcher
- 2004.11-2006.1 - National Institutes of Health, National Institute on Aging - Senior Researcher
- 1998.6-2004.12 - Peking University, State Key Laboratory of Biomembrane and Membrane Biotechnology - Visiting Researcher
- 2005.1-present - Peking University, Institute of Molecular Medicine - Professor
- 2020.12-present - Peking University, National Biomedical Imaging Center - Director
Academic Background & Achievements
- 1980-1984 Bachelor in Fluid Mechanics: Peking University
- 1984-1987 Master in Biomechanics: Peking University
- 1984-1987 Bachelor in Physiology: Peking University
- 1989-1990 PhD Student: University of Puerto Rico School of Medicine
- 1990-1995 PhD in Physiology: University of Maryland School of Medicine
- 2013 Elected as Academician of the Chinese Academy of Sciences
- 1993 Discovered and named 'Calcium Spark'
Publications
- Miniature two-photon microscopy for enlarged field-of-view, multi-plane, and long-term brain imaging, W Zong, R Wu, S Chen, J Wu, H Wang, Z Zhao, G Chen, R Tu, D Wu, Y Hu, Y Xu, Y Wang, Z Duan, H Wu, Y Zhang, J Zhang, A Wang, L Chen, H Cheng, 2021
- BacFlash signals acid-resistance gene expression in bacteria, D Wu, W Qi, W Nie, Z Lu, Y Ye, J Li, T Sun, Y Zhu, H Cheng, X Wang, 2021
- Imaging sarcoplasmic reticulum Ca2+ signaling in intact cardiac myocytes, F Lu, Y Zhao, W Xie, Q Guo, S Wang, X Wang, H Cheng, 2020
- Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution, Y Yue, W Zong, X Li, J Li, Y Zhang, R Wu, Y Liu, J Cui, Q Wang, Y Bian, X Yu, Y Liu, G Tan, Y Zhang, G Zhao, B Zhou, L Chen, W Xiao, H Cheng, A He, 2020
- Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients, Y Lin, L Li, W Nie, X Liu, A Adler, C Xiao, F Lu, L Wang, H Han, X Wang, W-B Gan, H Cheng, 2019
- NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly, T Hou, R Zhang, C Jian, W Ding, Y Wang, S Ling, Q Ma, X Hu, H Cheng, X Wang, 2019
- Mitochondrial flashes regulate ATP homeostasis in the heart, X Wang, X Zhang, D Wu, Z Huang, T Hou, C Jian, P Yu, F Lu, R Zhang, T Sun, J Li, W Qi, Y Wang, F Gao, H Cheng, 2017
- Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice, W Zong, R Wu, M Li, Y Hu, Y Li, J Li, H Rong, H Wu, Y Xu, Y Lu, H Jia, M Fan, Z Zhou, Y Zhang, A Wang, L Chen, H Cheng, 2017
- Dendritic mitoflash as a putative signal for stabilizing long-term synaptic plasticity, Z Fu, X Tan, H Fang, P-M Lau, X Wang, H Cheng, G Bi, 2017
- Protons trigger mitochondrial flashes, XH Wang, X Zhang, ZL Huang, D Wu, BB Liu, RF Zhang, RK Yin, TT Hou, CS Jian, JJ Xu, Y Zhao, YR Wang, F Gao, H Cheng, 2016
- Imaging Ca2+ nanosparks in heart with a new targeted biosensor, W Shang, F Lu, T Sun, J Xu, L-L Li, Y Wang, G Wang, L Chen, X Wang, M B Cannell, S-Q Wang, H Cheng, 2014
- Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans, E-Z Shen, C-Q Song, Y Lin, W-H Zhang, P-F Su, W-Y Liu, P Zhang, J Xu, N Lin, C Zhan, X Wang, Y Shyr, H Cheng, M-Q Dong, 2014
- Calcium flickers steer cell migration, C Wei, X Wang, M Chen, K Ouyang, L-S Song, H Cheng, 2009
- Superoxide flashes in single mitochondria, W Wang, H Fang, L Groom, A Cheng, W Zhang, J Liu, X Wang, K Li, P Han, M Zheng, J Yin, W Wang, M P Mattson, J P Y Kao, E G Lakatta, S-S Sheu, K Ouyang, J Chen, R T Dirksen, H Cheng, 2008
- Calcium sparks, H Cheng, W J Lederer, 2008
- Ca2+ blinks: rapid nanoscopic store calcium signaling, D X P Brochet, D Yang, A D Maio, W J Lederer, C Franzini-Armstrong, H Cheng, 2005
- Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells, S Wang, L Song, E G Lakatta, H Cheng, 2001
- Two mechanisms of quantized calcium release in skeletal muscle, M G Klein, H Cheng, L F Santana, Y Jiang, W J Lederer, M F Schneider, 1996
- Models of calcium release channel adaptation, H Cheng, M Fill, H H Valdivia, W J Lederer, 1995
- Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle, H Cheng, W J Lederer, M B Cannell, 1993
Awards
- Research Achievement Award (2016): International Society for Heart Research
