Professor | Aibin He | Asia Growth Partners

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Name	Aibin He
Contact Information	ahe@pku.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Aibin He

Contact Information

ahe@pku.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences / Medical / Biology
Academic Background & Achievements	2021-present: Professor at the Institute of Molecular Medicine, Academy for Advanced Interdisciplinary Studies, Peking University 2014-2021: Researcher at the Institute of Molecular Medicine, Peking University 2014-present: Researcher at the Peking-Tsinghua Center for Life Sciences 2012-2013: Lecturer at Harvard Medical School, Boston Children's Hospital 2007-2012: Postdoctoral Fellow at Harvard Medical School, Boston Children's Hospital 2004-2007: Ph.D. in Science from Peking Union Medical College 2003-2004: Assistant Researcher at Shenzhen National Biochemical Engineering Center 2000-2003: Master's degree from Chongqing Medical University 1995-1999: Bachelor's degree from Hubei University
Work Experience	2021-present: Professor at the Institute of Molecular Medicine, Academy for Advanced Interdisciplinary Studies, Peking University 2014-2021: Researcher at the Institute of Molecular Medicine, Peking University 2014-present: Researcher at the Peking-Tsinghua Center for Life Sciences 2012-2013: Lecturer at Harvard Medical School, Boston Children's Hospital 2007-2012: Postdoctoral Fellow at Harvard Medical School, Boston Children's Hospital 2003-2004: Assistant Researcher at Shenzhen National Biochemical Engineering Center
Awards	2020: National Natural Science Foundation of China, Outstanding Youth Fund 2020: Boehringer Ingelheim Research Award 2018: Bayer Scholar Award 2016: Peking University Green Leaf Biomedical Award 2014: Ministry of Organization 'Overseas High-Level Talent'

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences / Medical / Biology

Academic Background & Achievements

2021-present: Professor at the Institute of Molecular Medicine, Academy for Advanced Interdisciplinary Studies, Peking University
2014-2021: Researcher at the Institute of Molecular Medicine, Peking University
2014-present: Researcher at the Peking-Tsinghua Center for Life Sciences
2012-2013: Lecturer at Harvard Medical School, Boston Children's Hospital
2007-2012: Postdoctoral Fellow at Harvard Medical School, Boston Children's Hospital
2004-2007: Ph.D. in Science from Peking Union Medical College
2003-2004: Assistant Researcher at Shenzhen National Biochemical Engineering Center
2000-2003: Master's degree from Chongqing Medical University
1995-1999: Bachelor's degree from Hubei University

Work Experience

2021-present: Professor at the Institute of Molecular Medicine, Academy for Advanced Interdisciplinary Studies, Peking University
2014-2021: Researcher at the Institute of Molecular Medicine, Peking University
2014-present: Researcher at the Peking-Tsinghua Center for Life Sciences
2012-2013: Lecturer at Harvard Medical School, Boston Children's Hospital
2007-2012: Postdoctoral Fellow at Harvard Medical School, Boston Children's Hospital
2003-2004: Assistant Researcher at Shenzhen National Biochemical Engineering Center

Awards

2020: National Natural Science Foundation of China, Outstanding Youth Fund
2020: Boehringer Ingelheim Research Award
2018: Bayer Scholar Award
2016: Peking University Green Leaf Biomedical Award
2014: Ministry of Organization 'Overseas High-Level Talent'

Areas of Focus	Epigenetic regulation mechanisms of cell fate determination Development of novel single-cell multi-dimensional epigenetic techniques Integration of optical imaging, image processing, and machine learning Molecular and cellular mechanisms of organogenesis, regeneration, and disease Early diagnosis of diseases and clinical treatment of human cancers
Publications	Single-cell EpiChem jointly measures drug-chromatin binding and multimodal epigenome, Dong C, Meng X, Zhang T, Guo Z, Liu Y, Wu P, Chen S, Zhou F, Ma Y, Shu S# and He A#, 2024 Single-cell joint profiling of multiple epigenetic proteins and gene transcription, Xiong H, Wang Q, Li CC and He A, 2024 Genetic reporter for live tracing fluid flow forces during cell fate regulation in mouse blastocyst development, Zhang Y, Li X, Gao S, Liao Y, Luo Y, Liu M, Bian Y, Xiong H, Yue Y#., He A#, 2023 Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos, Li C C, Zhang G, Du J, Li Z, Ni Y, Zhou J, Li Y, Hou S, Zheng X, Lan Y#, Liu B#, He A#, 2022 Continuous live imaging reveals a subtle pathological alteration with cell behaviors in congenital heart malformation, Li X, Yue Y, Zhang Y, Liao Y, Wang Q, Bian Y, Na J, He A, 2022 Single-cell joint detection of chromatin occupancy and transcriptome enables higher-dimensional epigenomic reconstructions, Xiong H, Luo Y, Wang Q, Yu X and He, A, 2021 Long-term live imaging reconstructs in toto cardiomyocyte behaviors underlying mammalian heart chamber formation, Yue Y, Zong W, Li X, Li J, Zhang Y, Wu R, Liu Y, Cui J, Wang Q, Bian Y, Yu X, Liu Y, Tan G, Zhang Y, Zhao G, Zhou B, Chen L, Xiao W#, Cheng H#, and He, A#, 2020 Profiling chromatin state by single-cell itChIP-seq, Ai S, Xiong H, Li CC, Luo Y, Shi Q, Liu Y, Yu X, Li C and He A, 2019 CoBATCH for High-throughput Single-cell Epigenomic Profiling, Wang Q, Xiong H, Ai S, Yu X, Liu Y, Zhang J and He A, 2019 Single-Cell Transcriptomics Reveals Chemotaxis Mediated Intra-Organ Crosstalk During Cardiogenesis, Xiong H, Luo Y, Yue Y, Zhang J, Ai S, Li X, Wang X, Zhang YL, Wei Y, Li H, Hu X, Li C and He A, 2019 Replication-Independent Histone Turnover Underlines the Epigenetic Homeostasis in Adult Heart, Li Y, Ai S, Yu X, Li C, Li X, Yue Y, Wei Y, Li CY# and He A#, 2019 The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2, Han X, Zhang J, Liu Y, Fan X, Ai S, Luo Y, Li X, Jin H, Luo S, Zheng H, Yue Y, Chang Z, Yang Z, Tang F, He A# and Shen X#, 2019 Human exonization through differential nucleosome occupancy, Li Y, Ai S, Yu X, Li C, Li X, Yue Y, Wei Y, Li CY# and He A#, 2018 Divergent Requirements for EZH1 in Heart Development Versus Regeneration, Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C-Y, Pu WT and He A, 2017 EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent, Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang D-Z, Yu J, Pu WT# and He A#, 2017

Areas of Focus

Epigenetic regulation mechanisms of cell fate determination
Development of novel single-cell multi-dimensional epigenetic techniques
Integration of optical imaging, image processing, and machine learning
Molecular and cellular mechanisms of organogenesis, regeneration, and disease
Early diagnosis of diseases and clinical treatment of human cancers

Publications

Single-cell EpiChem jointly measures drug-chromatin binding and multimodal epigenome, Dong C, Meng X, Zhang T, Guo Z, Liu Y, Wu P, Chen S, Zhou F, Ma Y, Shu S# and He A#, 2024
Single-cell joint profiling of multiple epigenetic proteins and gene transcription, Xiong H, Wang Q, Li CC and He A, 2024
Genetic reporter for live tracing fluid flow forces during cell fate regulation in mouse blastocyst development, Zhang Y, Li X, Gao S, Liao Y, Luo Y, Liu M, Bian Y, Xiong H, Yue Y#., He A#, 2023
Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos, Li C C, Zhang G, Du J, Li Z, Ni Y, Zhou J, Li Y, Hou S, Zheng X, Lan Y#, Liu B#, He A#, 2022
Continuous live imaging reveals a subtle pathological alteration with cell behaviors in congenital heart malformation, Li X, Yue Y, Zhang Y, Liao Y, Wang Q, Bian Y, Na J, He A, 2022
Single-cell joint detection of chromatin occupancy and transcriptome enables higher-dimensional epigenomic reconstructions, Xiong H, Luo Y, Wang Q, Yu X and He, A, 2021
Long-term live imaging reconstructs in toto cardiomyocyte behaviors underlying mammalian heart chamber formation, Yue Y, Zong W, Li X, Li J, Zhang Y, Wu R, Liu Y, Cui J, Wang Q, Bian Y, Yu X, Liu Y, Tan G, Zhang Y, Zhao G, Zhou B, Chen L, Xiao W#, Cheng H#, and He, A#, 2020
Profiling chromatin state by single-cell itChIP-seq, Ai S, Xiong H, Li CC, Luo Y, Shi Q, Liu Y, Yu X, Li C and He A, 2019
CoBATCH for High-throughput Single-cell Epigenomic Profiling, Wang Q, Xiong H, Ai S, Yu X, Liu Y, Zhang J and He A, 2019
Single-Cell Transcriptomics Reveals Chemotaxis Mediated Intra-Organ Crosstalk During Cardiogenesis, Xiong H, Luo Y, Yue Y, Zhang J, Ai S, Li X, Wang X, Zhang YL, Wei Y, Li H, Hu X, Li C and He A, 2019
Replication-Independent Histone Turnover Underlines the Epigenetic Homeostasis in Adult Heart, Li Y, Ai S, Yu X, Li C, Li X, Yue Y, Wei Y, Li CY# and He A#, 2019
The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2, Han X, Zhang J, Liu Y, Fan X, Ai S, Luo Y, Li X, Jin H, Luo S, Zheng H, Yue Y, Chang Z, Yang Z, Tang F, He A# and Shen X#, 2019
Human exonization through differential nucleosome occupancy, Li Y, Ai S, Yu X, Li C, Li X, Yue Y, Wei Y, Li CY# and He A#, 2018
Divergent Requirements for EZH1 in Heart Development Versus Regeneration, Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C-Y, Pu WT and He A, 2017
EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent, Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang D-Z, Yu J, Pu WT# and He A#, 2017

Epigenetics Cell Fate Single-Cell Techniques Optical Imaging Image Processing Machine Learning Organogenesis Regeneration Disease Mechanisms Early Diagnosis

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