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Aibin He
Life Sciences / Medical / Biology
Peking University
Beijing
Language: Chinese, English
Epigenetics
Cell Fate
Single-Cell Techniques
Optical Imaging
Image Processing
Machine Learning
Organogenesis
Regeneration
Disease Mechanisms
Early Diagnosis
Areas of Focus
- Epigenetic regulation mechanisms of cell fate determination
- Development of novel single-cell multi-dimensional epigenetic techniques
- Integration of optical imaging, image processing, and machine learning
- Molecular and cellular mechanisms of organogenesis, regeneration, and disease
- Early diagnosis of diseases and clinical treatment of human cancers
Work Experience
- 2021-present: Professor at the Institute of Molecular Medicine, Academy for Advanced Interdisciplinary Studies, Peking University
- 2014-2021: Researcher at the Institute of Molecular Medicine, Peking University
- 2014-present: Researcher at the Peking-Tsinghua Center for Life Sciences
- 2012-2013: Lecturer at Harvard Medical School, Boston Children's Hospital
- 2007-2012: Postdoctoral Fellow at Harvard Medical School, Boston Children's Hospital
- 2003-2004: Assistant Researcher at Shenzhen National Biochemical Engineering Center
Academic Background & Achievements
- 2021-present: Professor at the Institute of Molecular Medicine, Academy for Advanced Interdisciplinary Studies, Peking University
- 2014-2021: Researcher at the Institute of Molecular Medicine, Peking University
- 2014-present: Researcher at the Peking-Tsinghua Center for Life Sciences
- 2012-2013: Lecturer at Harvard Medical School, Boston Children's Hospital
- 2007-2012: Postdoctoral Fellow at Harvard Medical School, Boston Children's Hospital
- 2004-2007: Ph.D. in Science from Peking Union Medical College
- 2003-2004: Assistant Researcher at Shenzhen National Biochemical Engineering Center
- 2000-2003: Master's degree from Chongqing Medical University
- 1995-1999: Bachelor's degree from Hubei University
Publications
- Single-cell EpiChem jointly measures drug-chromatin binding and multimodal epigenome, Dong C, Meng X, Zhang T, Guo Z, Liu Y, Wu P, Chen S, Zhou F, Ma Y, Shu S# and He A#, 2024
- Single-cell joint profiling of multiple epigenetic proteins and gene transcription, Xiong H, Wang Q, Li CC and He A, 2024
- Genetic reporter for live tracing fluid flow forces during cell fate regulation in mouse blastocyst development, Zhang Y, Li X, Gao S, Liao Y, Luo Y, Liu M, Bian Y, Xiong H, Yue Y#., He A#, 2023
- Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos, Li C C, Zhang G, Du J, Li Z, Ni Y, Zhou J, Li Y, Hou S, Zheng X, Lan Y#, Liu B#, He A#, 2022
- Continuous live imaging reveals a subtle pathological alteration with cell behaviors in congenital heart malformation, Li X, Yue Y, Zhang Y, Liao Y, Wang Q, Bian Y, Na J, He A, 2022
- Single-cell joint detection of chromatin occupancy and transcriptome enables higher-dimensional epigenomic reconstructions, Xiong H, Luo Y, Wang Q, Yu X and He, A, 2021
- Long-term live imaging reconstructs in toto cardiomyocyte behaviors underlying mammalian heart chamber formation, Yue Y, Zong W, Li X, Li J, Zhang Y, Wu R, Liu Y, Cui J, Wang Q, Bian Y, Yu X, Liu Y, Tan G, Zhang Y, Zhao G, Zhou B, Chen L, Xiao W#, Cheng H#, and He, A#, 2020
- Profiling chromatin state by single-cell itChIP-seq, Ai S, Xiong H, Li CC, Luo Y, Shi Q, Liu Y, Yu X, Li C and He A, 2019
- CoBATCH for High-throughput Single-cell Epigenomic Profiling, Wang Q, Xiong H, Ai S, Yu X, Liu Y, Zhang J and He A, 2019
- Single-Cell Transcriptomics Reveals Chemotaxis Mediated Intra-Organ Crosstalk During Cardiogenesis, Xiong H, Luo Y, Yue Y, Zhang J, Ai S, Li X, Wang X, Zhang YL, Wei Y, Li H, Hu X, Li C and He A, 2019
- Replication-Independent Histone Turnover Underlines the Epigenetic Homeostasis in Adult Heart, Li Y, Ai S, Yu X, Li C, Li X, Yue Y, Wei Y, Li CY# and He A#, 2019
- The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2, Han X, Zhang J, Liu Y, Fan X, Ai S, Luo Y, Li X, Jin H, Luo S, Zheng H, Yue Y, Chang Z, Yang Z, Tang F, He A# and Shen X#, 2019
- Human exonization through differential nucleosome occupancy, Li Y, Ai S, Yu X, Li C, Li X, Yue Y, Wei Y, Li CY# and He A#, 2018
- Divergent Requirements for EZH1 in Heart Development Versus Regeneration, Ai S, Yu X, Li Y, Peng Y, Li C, Yue Y, Tao G, Li C-Y, Pu WT and He A, 2017
- EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent, Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, Wang D-Z, Yu J, Pu WT# and He A#, 2017
Awards
- 2020: National Natural Science Foundation of China, Outstanding Youth Fund
- 2020: Boehringer Ingelheim Research Award
- 2018: Bayer Scholar Award
- 2016: Peking University Green Leaf Biomedical Award
- 2014: Ministry of Organization 'Overseas High-Level Talent'
