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Kuangshi Chen
Life Sciences / Medical / Biology
Peking University
Beijing
Language: English, Chinese
Live-Cell Imaging
Rna
Dna
Visualization
Technology
Virus
Assembly
Biology
Live-Fish
Single-Molecule
Areas of Focus
- Live-cell RNA/DNA visualization technology (Live-FISH)
- Virus assembly biology
Work Experience
- 2021.1-present - Peking University, School of Future Technology, Department of Biomedical Engineering - Researcher, Tenured Associate Professor
- 2019.8-2020.12 - Peking University, College of Engineering, Department of Biomedical Engineering - Researcher, Tenured Associate Professor
- 2013.4-2019.7 - Peking University, College of Engineering, Department of Biomedical Engineering - Special Researcher, Assistant Professor
- 2010.3-2013.3 - National Institutes of Health (NIH), Jennifer Lippincott-Schwartz Lab - Postdoctoral Fellow
- 2010.3-2012.3 - National Institute of Standards and Technology (NIST), Anne L. Plant Lab - Postdoctoral Fellow
- 2009.1-2010.1 - University of Pennsylvania, Andrew Tsourkas Lab - Postdoctoral Fellow
Academic Background & Achievements
- 2004-2008 PhD: University of Pennsylvania, Biomedical Engineering (Supervisor: Andrew Tsourkas)
- 2000-2002 Master's: UC San Diego, Biomedical Engineering
- 1996-2000 Bachelor's: UC San Diego, Biomedical Engineering
Publications
- Roles of RNA scaffolding in nanoscale Gag multimerization and selective protein sorting at HIV membranes, Ying Y., Yang Y., Chen A.K., 2024
- Rational design of self-assembled RNA nanostructures for HIV-1 virus assembly blockade, Qu, N., Ying, Y., Qin, J., and Chen, A.K., 2022
- A Background Assessable and Correctable Bimolecular Fluorescence Complementation System for Nanoscopic Single-Molecule Imaging of Intracellular Protein-Protein Interactions, Mao, S., Ying, Y., Zhao, M., Yang, Y., and Chen, A.K., 2021
- Recent advances in the molecular beacon technology for live-cell single-molecule imaging, Mao, S., Ying, Y., Wu, R., and Chen, A.K., 2020
- CRISPR/dual-FRET molecular beacon for sensitive live-cell imaging of non-repetitive genomic loci, Mao, S., Ying, Y., Wu, X., Krueger, C.J. and Chen, A.K., 2019
- The applications of nanopores in studies of proteins, Ding, T., Chen, A.K. and Lu, Z., 2019
- Progress and challenges for live-cell imaging of genomic loci using CRISPR-based platforms, Wu, X., Mao, S., Ying, Y., Krueger, C.J. and Chen, A.K., 2019
- A CRISPR/molecular beacon hybrid system for live-cell genomic imaging, Wu, X., Mao, S., Yang, Y., Rushdi, M.N., Krueger, C.J. and Chen, A.K., 2018
- Inhibition of retroviral Gag assembly by non-silencing miRNAs promotes autophagic viral degradation, Qu, N., Ma, Z., Zhang, M., Rushdi, M.N., Krueger, C.J. and Chen, A.K., 2018
- Single-molecule detection and tracking of RNA transcripts in living cells using phosphorothioate-optimized 2’-O-Methyl RNA molecular beacons, Zhao, D., Yang, Y., Qu, N., Chen, M., Ma, Z. Krueger, C.J., Behlke, M.A. and Chen, A.K., 2016
- MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production, Chen, A.K., Sengupta, P., Waki, K., Van Engelenburg, S., Ochiya, T., Ablan, S.D., Freed, E.O. and Lippincott-Schwartz, J., 2014
