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Qiang Cheng
Life Sciences / Medical / Biology
Peking University
Beijing
Language: English, Chinese
Rna
Lipid Nanoparticles
Lnps
Mrna
Sirna
Cas-Sgrna
Genetic Diseases
Metabolic Diseases
Cancer
Precision Delivery
Areas of Focus
- Development of novel RNA lipid nanoparticle drugs
Work Experience
- 2017 - 2021 - University of Texas Southwestern Medical Center - Postdoctoral Researcher
Academic Background & Achievements
- 2011 - 2016 Ph.D.: Peking University
- 2007 - 2011 Bachelor's: Nanchang University
- Published around 40 academic papers in top journals
- Cited over 1800 times
- 8 international/domestic patents applied or granted
- Research highlighted in Nature Nanotechnology and Nature Materials
- PCT patents licensed to Recode Therapeutics for clinical translation
Publications
- Membrane destabilizing ionizable phospholipids for organ selective mRNA delivery and CRISPR/Cas gene editing, Liu S, Cheng Q, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ, 2021
- Selective ORgan Targeting (SORT) nanoparticles for tissue specific mRNA delivery and CRISPR/Cas gene editing, Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ, 2020
- Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue-specific genome editing, Wei T, Cheng Q, Min YL, Olson EN, Siegwart DJ, 2020
- Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I, Cheng Q, Wei T, Jia Y, Farbiak L, Zhou K, Zhang S, Wei Y, Zhu H, Siegwart DJ, 2018
- The pH-Triggered Triblock Nanocarrier Enabled Highly Efficient siRNA Delivery for Cancer Therapy, Du L, Zhou J, Meng L, Wang X, Wang C, Huang Y, Zheng S, Deng L, Cao H, Liang Z, Dong A, Cheng Q, 2017
- Balancing Biocompatibility, Internalization and Pharmacokinetics of Polycations/siRNA by Structuring the Weak Negative Charged Ternary Complexes with Hyaluronic Acid, Zhou J, Song X, Han S, Wei T, Wang X, Cao H, Liang X-J, Liang Z, Cheng Q, Deng L, Dong A, 2017
- The promising nanocarrier for doxorubicin and siRNA co-delivery by PDMAEMA based amphiphilic nanomicelles, Cheng Q, Du L, Meng L, Han S, Wei T, Wang X, Wu Y, Zhou J, Zheng S, Huang Y, Liang X-J, Cao H, Dong A, Liang Z, 2016
- Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery, Han S, Cheng Q, Wu Y, Zhou J, Long X, Wei T, Huang Y, Zheng S, Zhang J, Deng L, Wang X, Liang X-J, Cao H, Liang Z, Dong A, 2015
- Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA, Li Y, Cheng Q, Jiang Q, Huang Y, Liu H, Zhao Y, Cao W, Ma G, Dai F, Liang X-J, Liang Z, Zhang X, 2014
- The effect of guanidinylation of PEGylated poly (2-aminoethyl methacrylate) on the systemic delivery of siRNA, Cheng Q, Huang Y, Zheng H, Wei T, Zheng S, Huo S, Wang X, Du Q, Zhang X, Zhang HY, Liang X-J, Wang C, Tang R, Liang Z, 2013
- Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid, Zhang W, Cheng Q, Guo S, Lin D, Huang P, Liu J, Wei T, Deng L, Liang Z, Liang X-J, Dong A, 2013
- Intracellular cleavable poly (2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo, Lin D, Cheng Q, Jiang Q, Huang Y, Yang Z, Han S, Zhao Y, Guo S, Liang Z, Dong A, 2013
