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Zhenguo Chen
Biomedical Sciences
Fudan University
Shanghai
Language: Chinese, English
Cryo-Electron Microscopy
Structural Biology
Pathogenic Microorganisms
Protein Complexes
Virus Structure
Infection Mechanisms
Transmission Mechanisms
Virus-Antibody Complexes
Virus-Inhibitor Complexes
Vaccine Development
Areas of Focus
- Structural biology of pathogenic microorganisms and related protein complexes using cryo-electron microscopy
Work Experience
- 2017.07-Present - Fudan University - Young Researcher, Adjunct Professor
- 2016.05-2017.06 - University of Texas Southwestern Medical Center - Assistant Research Professor
- 2010.10-2016.04 - Purdue University - Postdoctoral Researcher
Academic Background & Achievements
- 2006-2010 PhD: University of Groningen, Department of Physics
- 2001-2005 Master's: Tsinghua University, Department of Chemistry
- 1997-2001 Bachelor's: Tongji University, Department of Environmental Engineering
Publications
- An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope, Liu, Z. Xu, W. Chen, Z. Fu, W. Zhan, W. Gao, Y. Zhou, J. Zhou, Y. Wu, J. Wang, Q. Zhang, X. Hao, A. Wu, W. Zhang, Q. Li, Y. Fan, K. Chen, R. Jiang, Q. Mayer, C. Schoofs, T. Xie, Y. Jiang, S. Wen, Y. Yuan, Z. Wang, K. Lu, L. Sun, L. Wang, Q., 2023
- The molecular mechanism of cytoadherence to placenta or tumor cells through VAR2CSA from Plasmodium falciparum, Wang, W. Wang, Z. Yang, X. Gao, Y. Zhang, X. Wang, W. Zhao, L. Zhang, J. Jing, Q. Xu, Q. Cao, L. Tian, Y. Sun, J. Sun, L. Jiang, L. Chen, Z. Wang, L., 2023
- Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-Å resolution and its relevance to the assembly of icosahedral viruses, Chen, Z. Sun, L. Zhang, Z. Fokine, A. Padilla-Sanchez, V. Hanein, D. Jiang, W. Rossmann, M. Rao, V., 2017
- 3.8 Å Cryo-EM structure of Zika Virus, Sirohi, D. Chen, Z. Sun, L. Klose, T. Rossmann, M. Kuhn, R., 2016
- Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution, Sun, L. Zhang, X. Gao, S. Rao, P. Padilla-Sanchez, V. Chen, Z. Sun, S. Xiang, Y. Subramaniam, S. Rao, V. Rossmann, M., 2015
