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Haiwei Chen
Biomedical Sciences
Fudan University
Shanghai
Language: English, Chinese
Human Physiology
Pathology
Technological Innovation
Next-Generation Sequencing
High-Throughput Screening
Human Metabolites
Microbial Metabolites
Orphan Gpcrs
Modern Traditional Chinese Medicine
Systematic Engineering
Areas of Focus
- Systematic study of human physiology and pathology through technological innovation
Work Experience
- 2022.09-Present - Fudan University, Institute of Biomedical Sciences - Young Researcher
- 2018.11-2022.07 - Yale University, Department of Immunology - Associate Researcher
- 2016.04-2018.10 - Yale University, Department of Immunology - Postdoctoral Fellow
Academic Background & Achievements
- 2010.09-2016.01 PhD: Peking University, School of Life Sciences
- 2006.09-2010.07 Bachelor: Sun Yat-sen University, School of Life Sciences
Publications
- Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions, Chen H, Rosen CE, Gonzalez-Hernandez JA, Ring AM, Palm NW, 2023
- Within-host evolution of a gut pathobiont facilitates liver translocation, Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Martin AK, Palm NW, 2022
- Characterization of autoinducer-3 structure and biosynthesis in E.Coli, Kim CS, Gatsios A, Guesta S, Lam YC, Wei Z, Chen H, Russell RM, Shine EE, Wang R, Wyche TP, Piizzi G, Flavell RA, Palm NW, Sperandio V, Crawford JM, 2020
- An Ugi-like biosynthetic pathway encodes bombesin receptor subtype-3 agonists, Oh J, Kin NY, Chen H, Palm NW, Crawford JM, 2019
- A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology, Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW, 2019
- Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells, Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA, 2017
- Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1, Li M, Di W, Xu H, Yang Y, Chen H, Zhang F, Zhai Z, Chen D, 2013
- Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms, Yang Z, Liang H, Zhou Q, Li Y, Chen H, Ye W, Chen D, Fleming J, Shu H, Liu Y, 2012
- ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner, Yang Y, Qu H, Gao D, Di W, Chen H, Guo X, Zhai Z, Chen D, 2011
- Ring finger protein 166 potentiates RNA virus-induced interferon production via enhancing the ubiquitination of TRAF3 and TRAF6, Chen H, Yang Y, Xu H, Yang W, Zhai Z, Chen DY, 2015
Awards
- The Trudeau Trainee Research Fellowship (2018): Yale University, Department of Immunology
