Professor | Wei Feng | Asia Growth Partners

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Name	Wei Feng
Contact Information	wfeng@ibp.ac.cn
Language ability	English, Chinese
Province	Beijing

Upload Avatar (500 x 500)

Name

Wei Feng

Contact Information

wfeng@ibp.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2001-09--2005-11 PhD in Biochemistry: Hong Kong University of Science and Technology 1997-09--2001-07 Bachelor's in Chemistry: Fudan University
Work Experience	2009-08~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher 2007-08~2009-08 - Department of Biochemistry, Hong Kong University of Science and Technology - Research Assistant Professor 2005-11~2007-08 - Department of Biochemistry, Hong Kong University of Science and Technology - Postdoctoral Research Assistant

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2001-09--2005-11 PhD in Biochemistry: Hong Kong University of Science and Technology
1997-09--2001-07 Bachelor's in Chemistry: Fudan University

Work Experience

2009-08~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2007-08~2009-08 - Department of Biochemistry, Hong Kong University of Science and Technology - Research Assistant Professor
2005-11~2007-08 - Department of Biochemistry, Hong Kong University of Science and Technology - Postdoctoral Research Assistant

Areas of Focus	Regulation of intracellular material transport by molecular motors Structure and function of protein complexes related to vesicle transport and autophagosome formation
Publications	A Plant Flavonol and Genetic Suppressors Rescues a Pathogenic Mutation Associated with Kinesin in Neurons, Chai, Yongping, Li, Dong, Gong, Weibin, Ke, Jingyi, Tian, Dianzhe, Chen, Zhe, Guo, Angel, Guo, Zhengyang, Li, Wei, Feng, Wei, Ou, Guangshuo, 2024 The HEAT repeat protein HPO-27 is a lysosome fission factor, Li, Letao, Liu, Xilu, Yang, Shanshan, Li, Meijiao, Wu, Yanwei, Hu, Siqi, Wang, Wenjuan, Jiang, Amin, Zhang, Qianqian, Zhang, Junbing, Ma, Xiaoli, Hu, Junyan, Zhang, Qiaohong, Liu, Yubing, Li, Dong, Hu, Junjie, Yang, Chonglin, Feng, Wei, Wang, Xiaochen, 2024 A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex, Li, Wei, Xing, Ying, Wang, Yue, Xu, Tao, Song, Eli, Feng, Wei, 2023 Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation, Ren, Jinqi, Li, Dong, Liu, Juyuan, Liu, Hao, Yan, Xiumin, Zhu, Xueliang, Feng, Wei, 2022 Characterization of a thermostable, protease-tolerant inhibitor of α-glycosidase from carrot: A potential oral additive for treatment of diabetes, Hao, Yang, Guo, Tao, Ren, Jinqi, Wang, Yaxin, Wang, Lei, Shi, Yawei, Feng, Wei, 2022 The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition, Wang, Wenjuan, Ren, Jinqi, Song, Weiye, Zhang, Yong, Feng, Wei, 2022 Crystal Structure of the Core Module of the Yeast Paf1 Complex, Chen, Feilong, Liu, Beibei, Zeng, Jianwei, Guo, Lu, Ge, Xuan, Feng, Wei, Li, DeFeng, Zhou, Hao, Long, Jiafu, 2022 Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A, Cong, Dezi, Ren, Jinqi, Zhou, Yurong, Wang, Shuang, Jingjing Liang, Ding, Mei, Feng, Wei, 2021 Metaxins are core components of mitochondrial transport adaptor complexes, Zhao, Yinsuo, Song, Eli, Wang, Wenjuan, Hsieh, ChungHan, Wang, Xinnan, Feng, Wei, Wang, Xiangming, Shen, Kang, 2021 Biochemical insights into Paf1 complex-induced stimulation of Rad6/Bre1-mediated H2B monoubiquitination, Chen, Feilong, Liu, Beibei, Guo, Lu, Ge, Xuan, Feng, Wei, Li, De-Feng, Zhou, Hao, Long, Jiafu, 2021 CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion, Zhang, Zhe, Li, Wei, Yang, Guang, Lu, Xuefeng, Qi, Xin, Wang, Shuting, Cao, Can, Zhang, Peng, Ren, Jinqi, Zhao, Jiaxu, Zhang, Junyi, Hong, Sheng, Tan, Yan, Burchfield, James, Yu, Yang, Xu, Tao, Yao, Xuebiao, James, David, Feng, Wei, Chen, Zhengjun, 2020 Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy, Ren, Jinqi, Liang, Ruobing, Wang, Wenjuan, Zhang, Dachuan, Yu, Li, Feng, Wei, 2020 Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins, Liang, Ruobing, Ren, Jinqi, Zhang, Yong, Feng, Wei, 2019 YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization, Xu, Yang, Ren, Jinqi, He, Xiaolong, Chen, Han, Wei, Taotao, Feng, Wei, 2019 Structural conservation of the autoinhibitory domain in SUN proteins, Xu, Yang, Li, Wei, Ke, Huimin, Feng, Wei, 2018 Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement, Ren, Jinqi, Wang, Shuang, Chen, Han, Wang, Wenjuan, Huo, Lin, Feng, Wei, 2018 Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition, Ren, Jinqi, Wang, Shuang, Chen, Han, Wang, Wenjuan, Huo, Lin, Feng, Wei, 2018 BORC regulates the axonal transport of synaptic vesicle precursors by activating ARL-8, Niwa Shinsuke, Tao Li, Lu Sharon Y., Liew Gerald M., Feng Wei, Nachury Maxence V., Shen Kang, 2017 Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A, Ren, Jinqi, Huo, Lin, Wang, Wenjuan, Zhang, Yong, Li, Wei, Lou, Jizhong, Xu, Tao, Feng, Wei, 2016 HID-1 is required for homotypic fusion of immature secretory granules during maturation, Du, Wen, Zhou, Maoge, Zhao, Wei, Cheng, Dongwan, Wang, Lifen, Lu, Jingze, Song, Eli, Feng, Wei, Xue, Yanhong, Xu, Pingyong, Xu, Tao, 2016 Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators, Nie, Si, Ke, Huimin, Gao, Feng, Ren, Jinqi, Wang, Mingzhu, Huo, Lin, Gong, Weimin, Feng, Wei, 2016 Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism, Yi, Fengshuang, Kong, Ruirui, Ren, Jinqi, Zhu, Li, Lou, Jizhong, Wu, Jane Y, Feng, Wei, 2016 Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression, Kong, Ruirui, Yi, Fengshuang, Wen, Pushuai, Liu, Jianghong, Chen, Xiaoping, Ren, Jinqi, Li, Xiaofei, Shang, Yulong, Nie, Yongzhan, Wu, Kaichun, Fan, Daiming, Zhu, Li, Feng, Wei, Wu, Jane Y, 2015 Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule, Ren, Jinqi, Feng, Lei, Bai, Yujie, Pei, Haohong, Yuan, Zengqiang, Feng, Wei, 2015 Structural Insights into the Intrinsic Self-Assembly of Par-3 N-Terminal Domain, Zhang, Yan, Wang, Wenjuan, Chen, Jia, Zhang, Kai, Gao, Feng, Gao, Bingquan, Zhang, Shuai, Dong, Mingdong, Besenbacher, Flemming, Gong, Weimin, Zhang, Mingjie, Sun, Fei, Feng, Wei, 2013 Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase, Wang, Chao, Li, Wei, Ren, Jinqi, Fang, Jingqi, Ke, Huimin, Gong, Weimin, Feng, Wei, Wang, Chihchen, 2013 The Balance between Capture and Dissociation of Presynaptic Proteins Controls the Spatial Distribution of Synapses, Wu, Ye E, Huo, Lin, Maeder, Celine I, Feng, Wei, Shen, Kang, 2013 Membrane-induced Lever Arm Expansion Allows Myosin VI to Walk with Large and Variable Step Sizes, Cong Yu, Jizhong Lou, Jingjing Wu, Lifeng Pan, Wei Feng, Mingjie Zhang, 2012 The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A, Huo, Lin, Yue, Yang, Ren, Jinqi, Yu, Jiang, Liu, Junlin, Yu, Yong, Ye, Fei, Xu, Tao, Zhang, Mingjie, Feng, Wei, 2012 Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a ', Wang, Chao, Yu, Jiang, Huo, Lin, Wang, Lei, Feng, Wei, Wang, Chihchen, 2012 Cdc42-dependent formation of the ZO-1/MRCK beta complex at the leading edge controls cell migration, Huo, Lin, Wen, Wenyu, Wang, Rui, Kam, Chuen, Xia, Jun, Feng, Wei, Zhang, Mingjie, 2011 Organization and Dynamics of PDZ Domain-Related Supramodules in the Postsynaptic Density, Feng, Wei, Zhang, Mingjie, 2009 Myosin VI undergoes cargo-mediated dimerization, Yu, Cong, Feng, Wei, Miyanoiri, Yohei, Wen, Wenyu, Zhao, Yanxiang, Zhang, Mingjie, 2009 The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization, Feng, Wei, Wu, Hao, Chan, Ling-Nga, Zhang, Mingjie, 2007 PDZ domains of Par-3

Areas of Focus

Regulation of intracellular material transport by molecular motors
Structure and function of protein complexes related to vesicle transport and autophagosome formation

Publications

A Plant Flavonol and Genetic Suppressors Rescues a Pathogenic Mutation Associated with Kinesin in Neurons, Chai, Yongping, Li, Dong, Gong, Weibin, Ke, Jingyi, Tian, Dianzhe, Chen, Zhe, Guo, Angel, Guo, Zhengyang, Li, Wei, Feng, Wei, Ou, Guangshuo, 2024
The HEAT repeat protein HPO-27 is a lysosome fission factor, Li, Letao, Liu, Xilu, Yang, Shanshan, Li, Meijiao, Wu, Yanwei, Hu, Siqi, Wang, Wenjuan, Jiang, Amin, Zhang, Qianqian, Zhang, Junbing, Ma, Xiaoli, Hu, Junyan, Zhang, Qiaohong, Liu, Yubing, Li, Dong, Hu, Junjie, Yang, Chonglin, Feng, Wei, Wang, Xiaochen, 2024
A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex, Li, Wei, Xing, Ying, Wang, Yue, Xu, Tao, Song, Eli, Feng, Wei, 2023
Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation, Ren, Jinqi, Li, Dong, Liu, Juyuan, Liu, Hao, Yan, Xiumin, Zhu, Xueliang, Feng, Wei, 2022
Characterization of a thermostable, protease-tolerant inhibitor of α-glycosidase from carrot: A potential oral additive for treatment of diabetes, Hao, Yang, Guo, Tao, Ren, Jinqi, Wang, Yaxin, Wang, Lei, Shi, Yawei, Feng, Wei, 2022
The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition, Wang, Wenjuan, Ren, Jinqi, Song, Weiye, Zhang, Yong, Feng, Wei, 2022
Crystal Structure of the Core Module of the Yeast Paf1 Complex, Chen, Feilong, Liu, Beibei, Zeng, Jianwei, Guo, Lu, Ge, Xuan, Feng, Wei, Li, DeFeng, Zhou, Hao, Long, Jiafu, 2022
Motor domain-mediated autoinhibition dictates axonal transport by the kinesin UNC-104/KIF1A, Cong, Dezi, Ren, Jinqi, Zhou, Yurong, Wang, Shuang, Jingjing Liang, Ding, Mei, Feng, Wei, 2021
Metaxins are core components of mitochondrial transport adaptor complexes, Zhao, Yinsuo, Song, Eli, Wang, Wenjuan, Hsieh, ChungHan, Wang, Xinnan, Feng, Wei, Wang, Xiangming, Shen, Kang, 2021
Biochemical insights into Paf1 complex-induced stimulation of Rad6/Bre1-mediated H2B monoubiquitination, Chen, Feilong, Liu, Beibei, Guo, Lu, Ge, Xuan, Feng, Wei, Li, De-Feng, Zhou, Hao, Long, Jiafu, 2021
CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion, Zhang, Zhe, Li, Wei, Yang, Guang, Lu, Xuefeng, Qi, Xin, Wang, Shuting, Cao, Can, Zhang, Peng, Ren, Jinqi, Zhao, Jiaxu, Zhang, Junyi, Hong, Sheng, Tan, Yan, Burchfield, James, Yu, Yang, Xu, Tao, Yao, Xuebiao, James, David, Feng, Wei, Chen, Zhengjun, 2020
Multi-site-mediated entwining of the linear WIR-motif around WIPI beta-propellers for autophagy, Ren, Jinqi, Liang, Ruobing, Wang, Wenjuan, Zhang, Dachuan, Yu, Li, Feng, Wei, 2020
Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins, Liang, Ruobing, Ren, Jinqi, Zhang, Yong, Feng, Wei, 2019
YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization, Xu, Yang, Ren, Jinqi, He, Xiaolong, Chen, Han, Wei, Taotao, Feng, Wei, 2019
Structural conservation of the autoinhibitory domain in SUN proteins, Xu, Yang, Li, Wei, Ke, Huimin, Feng, Wei, 2018
Structural Delineation of the Neck Linker of Kinesin-3 for Processive Movement, Ren, Jinqi, Wang, Shuang, Chen, Han, Wang, Wenjuan, Huo, Lin, Feng, Wei, 2018
Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition, Ren, Jinqi, Wang, Shuang, Chen, Han, Wang, Wenjuan, Huo, Lin, Feng, Wei, 2018
BORC regulates the axonal transport of synaptic vesicle precursors by activating ARL-8, Niwa Shinsuke, Tao Li, Lu Sharon Y., Liew Gerald M., Feng Wei, Nachury Maxence V., Shen Kang, 2017
Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A, Ren, Jinqi, Huo, Lin, Wang, Wenjuan, Zhang, Yong, Li, Wei, Lou, Jizhong, Xu, Tao, Feng, Wei, 2016
HID-1 is required for homotypic fusion of immature secretory granules during maturation, Du, Wen, Zhou, Maoge, Zhao, Wei, Cheng, Dongwan, Wang, Lifen, Lu, Jingze, Song, Eli, Feng, Wei, Xue, Yanhong, Xu, Pingyong, Xu, Tao, 2016
Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators, Nie, Si, Ke, Huimin, Gao, Feng, Ren, Jinqi, Wang, Mingzhu, Huo, Lin, Gong, Weimin, Feng, Wei, 2016
Noncanonical Myo9b-RhoGAP Accelerates RhoA GTP Hydrolysis by a Dual-Arginine-Finger Mechanism, Yi, Fengshuang, Kong, Ruirui, Ren, Jinqi, Zhu, Li, Lou, Jizhong, Wu, Jane Y, Feng, Wei, 2016
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression, Kong, Ruirui, Yi, Fengshuang, Wen, Pushuai, Liu, Jianghong, Chen, Xiaoping, Ren, Jinqi, Li, Xiaofei, Shang, Yulong, Nie, Yongzhan, Wu, Kaichun, Fan, Daiming, Zhu, Li, Feng, Wei, Wu, Jane Y, 2015
Interdomain interface-mediated target recognition by the Scribble PDZ34 supramodule, Ren, Jinqi, Feng, Lei, Bai, Yujie, Pei, Haohong, Yuan, Zengqiang, Feng, Wei, 2015
Structural Insights into the Intrinsic Self-Assembly of Par-3 N-Terminal Domain, Zhang, Yan, Wang, Wenjuan, Chen, Jia, Zhang, Kai, Gao, Feng, Gao, Bingquan, Zhang, Shuai, Dong, Mingdong, Besenbacher, Flemming, Gong, Weimin, Zhang, Mingjie, Sun, Fei, Feng, Wei, 2013
Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase, Wang, Chao, Li, Wei, Ren, Jinqi, Fang, Jingqi, Ke, Huimin, Gong, Weimin, Feng, Wei, Wang, Chihchen, 2013
The Balance between Capture and Dissociation of Presynaptic Proteins Controls the Spatial Distribution of Synapses, Wu, Ye E, Huo, Lin, Maeder, Celine I, Feng, Wei, Shen, Kang, 2013
Membrane-induced Lever Arm Expansion Allows Myosin VI to Walk with Large and Variable Step Sizes, Cong Yu, Jizhong Lou, Jingjing Wu, Lifeng Pan, Wei Feng, Mingjie Zhang, 2012
The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A, Huo, Lin, Yue, Yang, Ren, Jinqi, Yu, Jiang, Liu, Junlin, Yu, Yong, Ye, Fei, Xu, Tao, Zhang, Mingjie, Feng, Wei, 2012
Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a ', Wang, Chao, Yu, Jiang, Huo, Lin, Wang, Lei, Feng, Wei, Wang, Chihchen, 2012
Cdc42-dependent formation of the ZO-1/MRCK beta complex at the leading edge controls cell migration, Huo, Lin, Wen, Wenyu, Wang, Rui, Kam, Chuen, Xia, Jun, Feng, Wei, Zhang, Mingjie, 2011
Organization and Dynamics of PDZ Domain-Related Supramodules in the Postsynaptic Density, Feng, Wei, Zhang, Mingjie, 2009
Myosin VI undergoes cargo-mediated dimerization, Yu, Cong, Feng, Wei, Miyanoiri, Yohei, Wen, Wenyu, Zhao, Yanxiang, Zhang, Mingjie, 2009
The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization, Feng, Wei, Wu, Hao, Chan, Ling-Nga, Zhang, Mingjie, 2007
PDZ domains of Par-3

Molecular Motors Intracellular Transport Vesicle Transport Autophagosome Protein Complexes Structure Function Regulation Biochemistry Cell Biology

Shaojun Dai - Shanghai Normal University

Yonglan Cui - Shanghai Normal University

Jiaohong Zhao - Shanghai Normal University

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