Professor | Jizhong Lou | Asia Growth Partners

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Name	Jizhong Lou
Contact Information	jlou@ibp.ac.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Jizhong Lou

Contact Information

jlou@ibp.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1997-09--2000-08 PhD: Institute of Theoretical Physics, Chinese Academy of Sciences 1994-09--1997-07 Master's: Peking University 1990-10--1994-07 Bachelor's: Jilin University
Work Experience	2009-10~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher, Group Leader 2005-08~2009-09 - Georgia Institute of Technology - Research Assistant Professor 2001-10~2005-07 - Georgia Institute of Technology - Postdoctoral Researcher 2000-10~2001-09 - University of Nevada, Las Vegas - Postdoctoral Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1997-09--2000-08 PhD: Institute of Theoretical Physics, Chinese Academy of Sciences
1994-09--1997-07 Master's: Peking University
1990-10--1994-07 Bachelor's: Jilin University

Work Experience

2009-10~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher, Group Leader
2005-08~2009-09 - Georgia Institute of Technology - Research Assistant Professor
2001-10~2005-07 - Georgia Institute of Technology - Postdoctoral Researcher
2000-10~2001-09 - University of Nevada, Las Vegas - Postdoctoral Researcher

Areas of Focus	Tumor immune recognition and regulation T cell functional modification Mechanobiology Transmembrane signal transduction Single-molecule biophysics Molecular dynamics simulation
Publications	GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3, Dong Li, Yihong Yang, Chenglin Lv, Yingjie Wang, Xiaoting Chao, Jiafeng Huang, Shashi P. Singh, Ye Yuan, Chengyu Zhang, Jizhong Lou, Pu Gao, Shanjin Huang, Bo Li, Huaqing Cai, 2023 Self-programmed dynamics of T cell receptor condensation, Chen, Hui, Xu, Xinyi, Hu, Wei, Wu, Songfang, Xiao, Jianhui, Wu, Peng, Wang, Xiaowen, Han, Xuling, Zhang, Yanruo, Zhang, Yong, Jiang, Ning, Liu, Wanli, Lou, Changjie, Chen, Wei, Xu, Chenqi, Lou, Jizhong, 2023 Catch bond models may explain how force amplifies TCR signaling and antigen discrimination, Choi, HyunKyu, Cong, Peiwen, Ge, Chenghao, Natarajan, Aswin, Liu, Baoyu, Zhang, Yong, Li, Kaitao, Rushdi, Muaz Nik, Chen, Wei, Lou, Jizhong, Krogsgaard, Michelle, Zhu, Cheng, 2023 Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH, Yu, Guimei, Hao, Jingfang, Pan, Xiaowei, Shi, Lifang, Zhang, Yong, Wang, Jifeng, Fan, Hongcheng, Xiao, Yang, Yang, Fuquan, Lou, Jizhong, Chang, Wenrui, Malnoe, Alizee, Li, Mei, 2022 Essence determines phenomenon: Assaying the material properties of biological condensates, Wang, Z., Lou, J., Zhang, H., 2022 CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma, Chen, Yiran, Li, Li, Lan, Jie, Cui, Yang, Rao, Xiaosong, Zhao, Jing, Xing, Tao, Ju, Gaoda, Song, Guangtao, jlou@ibp.ac.cn, Liang, Jun, 2022 NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes, Fan, Juan, Shi, Jiawei, Zhang, Yong, Liu, Junwei, An, Chenyi, Zhu, Huaying, Wu, Peng, Hu, Wei, Qin, Rui, Yao, Danmei, Shou, Xin, Xu, Yibing, Tong, Zhou, Wen, Xue, Xu, Jianpo, Zhang, Jin, Fang, Weijia, Lou, Jizhong, Yin, Weiwei, Chen, Wei, 2022 Mechanical activation of spike fosters SARS-CoV-2 infection (Aug, 10.1038/s41422-021-00576-9, 2021), Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, PeiHui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei, 2021 新冠病毒入侵与免疫防御的分子力学生物学研究进展, 胡炜, 秦瑞, 张勇, 武鹏, 费攀宇, 张同同, 安宸毅, 尹巍巍, 李振海, 娄继忠, 陈伟, 2021 机械力调控的PD-1信号通路, 陈辉, 崔蕾, 宋广涛, 娄继忠, 2021 神经突触后膜蛋白Neuroligin-1的力-电感知及其耦合调控分子机制的研究, 胡炜, 安辰毅, 张同同, 廖泰霖, 刘俊伟, 张勇, 欧阳波, 娄继忠, 许均瑜, 陈伟, 2021 CD8选择性利用生物力增强TCR抗原识别的灵敏度和鲁棒性, 秦瑞, 武鹏, 施佳未, 张勇, 娄继忠, 尹巍巍, 陈伟, 2021 Mechanical unfolding of a beta-barrel membrane protein by single-molecule force spectroscopy, Chen, Hui, Song, Guangtao, Zhang, Yong, Ni, Dongchun, Zhang, Xinwei, Huang, Yihua, Lou, Jizhong, 2021 Mechanical activation of spike fosters SARS-CoV-2 viral infection, Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, PeiHui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei, 2021 Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases, Zhang, Hong, Ji, Xiong, Li, Pilong, Liu, Cong, Lou, Jizhong, Wang, Zheng, Wen, Wenyu, Xiao, Yue, Zhang, Mingjie, Zhu, Xueliang, 2020 Protein Databases Related to Liquid-Liquid Phase Separation, Li, Qian, Wang, Xi, Dou, Zhihui, Yang, Weishan, Huang, Beifang, Lou, Jizhong, Zhang, Zhuqing, 2020 Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA, Chen, Hui, Cui, Yang, Han, Xuling, Hu, Wei, Sun, Min, Zhang, Yong, Wang, PeiHui, Song, Guangtao, Chen, Wei, Lou, Jizhong, 2020 Preparation of DNA Origami for Ordered Immobilization of Single Molecules on Diamond Surface, Wei YiCheng, Yu Pei, Chen Ming, Sun ZiTing, Zeng Yan, Lou JiZhong, Chen SanYou, Shi FaZhan, Du JiangFeng, 2020 Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF, Song, Guangtao, Xu, Benjin, Shi, Huigang, Zhang, Yong, Zhang, Dejiu, Cao, Xintao, Liu, Zengrui, Guo, Ran, Guan, YanZhong, Chu, Yanhui, Zhang, Xinzheng, Lou, Jizhong, Qin, Yan, 2020 用于金刚石表面单分子有序固定的DNA折纸制备, 魏一成, 余佩, 陈明, 孙梓庭, 曾俨, 娄继忠, 陈三友, 石发展, 杜江峰, 2020 Direct observation of the formation of a CRISPR-Cas12a R-loop complex at the single-molecule level, Cui, Yang, Tang, Yangchao, Liang, Meng, Ji, Qinghua, Zeng, Yan, Chen, Hui, Lan, Jie, Jin, Peng, Wang, Lei, Song, Guangtao, Lou, Jizhong, 2020 Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020 Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition, Wu, Peng, Zhang, Tongtong, Liu, Baoyu, Fei, Panyu, Cui, Lei, Qin, Rui, Zhu, Huaying, Yao, Danmei, Martinez, Ryan J, Hu, Wei, An, Chenyi, Zhang, Yong, Liu, Junwei, Shi, Jiawei, Fan, Juan, Yin, Weiwei, Sun, Jie, Zhou, Chun, Zeng, Xun, Xu, Chenqi, Wang, Jianan, Evavold, Brian D, Zhu, Cheng, Chen, Wei, Lou, Jizhong, 2019 Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains, Huang, Yuwei, Zucker, Ben, Zhang, Shaojin, Elias, Sharon, Zhu, Yun, Chen, Hui, Ding, Tianlun, Li, Ying, Sun, Yujie, Lou, Jizhong, Kozlov, Michael M, Yu, Li, 2019 Conformational Dynamics, Intramolecular Domain Conformation Signaling, and Activation of Apo-FimD Revealed by Single-Molecule Fluorescence Resonance Energy Transfer Studies, Liu, Yanqing, Sun, Chuanqi, Han, Long, Yu, Yuqi, Zhou, Haizhen, Shao, Qiang, Lou, Jizhong, Zhao, Yongfang, Huang, Yihua, 2019 Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States, Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli, 2019 Mechanosensing through immunoreceptors, Zhu, Cheng, Chen, Wei, Lou, Jizhong, Rittase, William, Li, Kaitao, 2019 A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3

Areas of Focus

Tumor immune recognition and regulation
T cell functional modification
Mechanobiology
Transmembrane signal transduction
Single-molecule biophysics
Molecular dynamics simulation

Publications

GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3, Dong Li, Yihong Yang, Chenglin Lv, Yingjie Wang, Xiaoting Chao, Jiafeng Huang, Shashi P. Singh, Ye Yuan, Chengyu Zhang, Jizhong Lou, Pu Gao, Shanjin Huang, Bo Li, Huaqing Cai, 2023
Self-programmed dynamics of T cell receptor condensation, Chen, Hui, Xu, Xinyi, Hu, Wei, Wu, Songfang, Xiao, Jianhui, Wu, Peng, Wang, Xiaowen, Han, Xuling, Zhang, Yanruo, Zhang, Yong, Jiang, Ning, Liu, Wanli, Lou, Changjie, Chen, Wei, Xu, Chenqi, Lou, Jizhong, 2023
Catch bond models may explain how force amplifies TCR signaling and antigen discrimination, Choi, HyunKyu, Cong, Peiwen, Ge, Chenghao, Natarajan, Aswin, Liu, Baoyu, Zhang, Yong, Li, Kaitao, Rushdi, Muaz Nik, Chen, Wei, Lou, Jizhong, Krogsgaard, Michelle, Zhu, Cheng, 2023
Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH, Yu, Guimei, Hao, Jingfang, Pan, Xiaowei, Shi, Lifang, Zhang, Yong, Wang, Jifeng, Fan, Hongcheng, Xiao, Yang, Yang, Fuquan, Lou, Jizhong, Chang, Wenrui, Malnoe, Alizee, Li, Mei, 2022
Essence determines phenomenon: Assaying the material properties of biological condensates, Wang, Z., Lou, J., Zhang, H., 2022
CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma, Chen, Yiran, Li, Li, Lan, Jie, Cui, Yang, Rao, Xiaosong, Zhao, Jing, Xing, Tao, Ju, Gaoda, Song, Guangtao, jlou@ibp.ac.cn, Liang, Jun, 2022
NKG2D discriminates diverse ligands through selectively mechano-regulated ligand conformational changes, Fan, Juan, Shi, Jiawei, Zhang, Yong, Liu, Junwei, An, Chenyi, Zhu, Huaying, Wu, Peng, Hu, Wei, Qin, Rui, Yao, Danmei, Shou, Xin, Xu, Yibing, Tong, Zhou, Wen, Xue, Xu, Jianpo, Zhang, Jin, Fang, Weijia, Lou, Jizhong, Yin, Weiwei, Chen, Wei, 2022
Mechanical activation of spike fosters SARS-CoV-2 infection (Aug, 10.1038/s41422-021-00576-9, 2021), Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, PeiHui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei, 2021
新冠病毒入侵与免疫防御的分子力学生物学研究进展, 胡炜, 秦瑞, 张勇, 武鹏, 费攀宇, 张同同, 安宸毅, 尹巍巍, 李振海, 娄继忠, 陈伟, 2021
机械力调控的PD-1信号通路, 陈辉, 崔蕾, 宋广涛, 娄继忠, 2021
神经突触后膜蛋白Neuroligin-1的力-电感知及其耦合调控分子机制的研究, 胡炜, 安辰毅, 张同同, 廖泰霖, 刘俊伟, 张勇, 欧阳波, 娄继忠, 许均瑜, 陈伟, 2021
CD8选择性利用生物力增强TCR抗原识别的灵敏度和鲁棒性, 秦瑞, 武鹏, 施佳未, 张勇, 娄继忠, 尹巍巍, 陈伟, 2021
Mechanical unfolding of a beta-barrel membrane protein by single-molecule force spectroscopy, Chen, Hui, Song, Guangtao, Zhang, Yong, Ni, Dongchun, Zhang, Xinwei, Huang, Yihua, Lou, Jizhong, 2021
Mechanical activation of spike fosters SARS-CoV-2 viral infection, Hu, Wei, Zhang, Yong, Fei, Panyu, Zhang, Tongtong, Yao, Danmei, Gao, Yufei, Liu, Jia, Chen, Hui, Lu, Qiao, Mudianto, Tenny, Zhang, Xinrui, Xiao, Chuxuan, Ye, Yang, Sun, Qiming, Zhang, Jing, Xie, Qi, Wang, PeiHui, Wang, Jun, Li, Zhenhai, Lou, Jizhong, Chen, Wei, 2021
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases, Zhang, Hong, Ji, Xiong, Li, Pilong, Liu, Cong, Lou, Jizhong, Wang, Zheng, Wen, Wenyu, Xiao, Yue, Zhang, Mingjie, Zhu, Xueliang, 2020
Protein Databases Related to Liquid-Liquid Phase Separation, Li, Qian, Wang, Xi, Dou, Zhihui, Yang, Weishan, Huang, Beifang, Lou, Jizhong, Zhang, Zhuqing, 2020
Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA, Chen, Hui, Cui, Yang, Han, Xuling, Hu, Wei, Sun, Min, Zhang, Yong, Wang, PeiHui, Song, Guangtao, Chen, Wei, Lou, Jizhong, 2020
Preparation of DNA Origami for Ordered Immobilization of Single Molecules on Diamond Surface, Wei YiCheng, Yu Pei, Chen Ming, Sun ZiTing, Zeng Yan, Lou JiZhong, Chen SanYou, Shi FaZhan, Du JiangFeng, 2020
Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF, Song, Guangtao, Xu, Benjin, Shi, Huigang, Zhang, Yong, Zhang, Dejiu, Cao, Xintao, Liu, Zengrui, Guo, Ran, Guan, YanZhong, Chu, Yanhui, Zhang, Xinzheng, Lou, Jizhong, Qin, Yan, 2020
用于金刚石表面单分子有序固定的DNA折纸制备, 魏一成, 余佩, 陈明, 孙梓庭, 曾俨, 娄继忠, 陈三友, 石发展, 杜江峰, 2020
Direct observation of the formation of a CRISPR-Cas12a R-loop complex at the single-molecule level, Cui, Yang, Tang, Yangchao, Liang, Meng, Ji, Qinghua, Zeng, Yan, Chen, Hui, Lan, Jie, Jin, Peng, Wang, Lei, Song, Guangtao, Lou, Jizhong, 2020
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020
Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition, Wu, Peng, Zhang, Tongtong, Liu, Baoyu, Fei, Panyu, Cui, Lei, Qin, Rui, Zhu, Huaying, Yao, Danmei, Martinez, Ryan J, Hu, Wei, An, Chenyi, Zhang, Yong, Liu, Junwei, Shi, Jiawei, Fan, Juan, Yin, Weiwei, Sun, Jie, Zhou, Chun, Zeng, Xun, Xu, Chenqi, Wang, Jianan, Evavold, Brian D, Zhu, Cheng, Chen, Wei, Lou, Jizhong, 2019
Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains, Huang, Yuwei, Zucker, Ben, Zhang, Shaojin, Elias, Sharon, Zhu, Yun, Chen, Hui, Ding, Tianlun, Li, Ying, Sun, Yujie, Lou, Jizhong, Kozlov, Michael M, Yu, Li, 2019
Conformational Dynamics, Intramolecular Domain Conformation Signaling, and Activation of Apo-FimD Revealed by Single-Molecule Fluorescence Resonance Energy Transfer Studies, Liu, Yanqing, Sun, Chuanqi, Han, Long, Yu, Yuqi, Zhou, Haizhen, Shao, Qiang, Lou, Jizhong, Zhao, Yongfang, Huang, Yihua, 2019
Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States, Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli, 2019
Mechanosensing through immunoreceptors, Zhu, Cheng, Chen, Wei, Lou, Jizhong, Rittase, William, Li, Kaitao, 2019
A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3

Tumor Immune Recognition Regulation T Cell Functional Modification Mechanobiology Signal Transduction

Yule Liu - Tsinghua University

Biwu Liu - Xi'an Jiaotong University

Sheng He - University of Chinese Academy of Sciences

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