Professor | Guohong Li | Asia Growth Partners

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Name	Guohong Li
Contact Information	liguohong@sun5.ibp.ac.cn
Language ability	Chinese, English, German
Province	Beijing

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Name

Guohong Li

Contact Information

liguohong@sun5.ibp.ac.cn

Language ability

Chinese, English, German

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1991-1995: Bachelor's Degree in Virology, Wuhan University 1995-1998: Master's Degree in Biophysics, Peking University Health Science Center 1998-2003: Ph.D. in Biology, Max Planck Institute for Cell Biology/Heidelberg University
Work Experience	2003-2006: Postdoctoral Researcher, Department of Biochemistry, New Jersey Medical School/Howard Hughes Medical Institute, Danny Reinberg Lab 2006-2009: Postdoctoral Researcher, Department of Biochemistry, New York University School of Medicine/Howard Hughes Medical Institute, Danny Reinberg Lab 2009-current: Researcher, Institute of Biophysics, Chinese Academy of Sciences, Doctoral Supervisor

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1991-1995: Bachelor's Degree in Virology, Wuhan University
1995-1998: Master's Degree in Biophysics, Peking University Health Science Center
1998-2003: Ph.D. in Biology, Max Planck Institute for Cell Biology/Heidelberg University

Work Experience

2003-2006: Postdoctoral Researcher, Department of Biochemistry, New Jersey Medical School/Howard Hughes Medical Institute, Danny Reinberg Lab
2006-2009: Postdoctoral Researcher, Department of Biochemistry, New York University School of Medicine/Howard Hughes Medical Institute, Danny Reinberg Lab
2009-current: Researcher, Institute of Biophysics, Chinese Academy of Sciences, Doctoral Supervisor

Areas of Focus	Chromatin structure and epigenetic regulation
Publications	Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1, Guohong Li, 2023 Histone H1 facilitates restoration of H3K27me3 during DNA replication by chromatin compaction, Cuifang Liu, Juan Yu, Aoqun Song, Min Wang, Jiansen Hu, Ping Chen, Jicheng Zhao, Guohong Li, 2023 H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation, Anfeng Luo, Jingwei Kong, Jun Chen, Xue Xiao, Jie Lan, Xiaorong Li, Cuifang Liu, PengYe Wang, Guohong Li, Wei Li, Ping Chen, 2023 Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase, Weiran Ge, Cong Yu, Jingjing Li, Zhenyu Yu, Xiaorong Li, Yan Zhang, ChaoPei Liu, Yingfeng Li, Changlin Tian, Xinzheng Zhang, Guohong Li, Bing Zhu, RuiMing Xu, 2023 H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly, YiZhou Wang, Cuifang Liu, Jicheng Zhao, Juan Yu, Anfeng Luo, Xue Xiao, ShuoXing Dou, Lu Ma, PengYe Wang, Ming Li, Guohong Li, Jianbin Yan, Ping Chen, Wei Li, 2022 Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice, Yuting Liu, Kehui Wang, Li Huang, Jicheng Zhao, Xinpeng Chen, Qiang Wu, Zhouliang Yu, Guohong Li, 2022 Phase separation of RNA-binding protein promotes polymerase binding and transcription, Wen Shao, Xianju Bi, Yixuan Pan, Boyang Gao, Jun Wu, Yafei Yin, Zhimin Liu, Mengyuan Peng, Wenhao Zhang, Xu Jiang, Ren Wenlin, Yanhui Xu, Zhongyang Wu, Kaili Wang, Ge Zhan, J Yuyang Lu, Xue Han, Tong Li, Jianlong Wang, Guohong Li, Haiteng Deng, Bing Li, Xiaohua Shen, 2022 CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency, Dawei Huo, Zhaowei Yu, Rui Li, Meihan Gong, Simone Sidoli, Xukun Lu, Yuying Hou, Zhongye Dai, Yu Kong, Guifen Liu, Ole N Jensen, Wei Xie, Kristian Helin, Chaoyang Xiong, Guohong Li, Yong Zhang, Xudong Wu, 2022 The influence of high-order chromatin state in the regulation of stem cell fate, Xinpeng Chen, Haiyan Lin, Guohong Li, 2022 Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones, ChaoPei Liu, Wenxing Jin, Jie Hu, Mingzhu Wang, Jingjing Chen, Guohong Li, RuiMing Xu, 2021 Structures and Functions of Chromatin Fibers, Ping Chen, Wei Li, Guohong Li, KA Dill, 2021 单分子力谱研究组蛋白H2A泛素化修饰调控核小体的分子机制, 陈萍, 李国红, 李伟, 2021 Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle, Kehui Wang, Yuting Liu, Zhouliang Yu, Bo Gu, Jie Hu, Li Huang, Xiao Ge, Lingyi Xu, Mengyu Zhang, Jicheng Zhao, Mingli Hu, Rongrong Le, Qiang Wu, Sheng Ye, Shaorong Gao, Xiaodong Zhang, RuiMing Xu, Guohong Li, 2021 DNA polymerase Gp90 activities and regulations on strand displacement DNA synthesis revealed at single-molecule level, Shuming Zhang, Xue Xiao, Jingwei Kong, Ke Lu, ShuoXing Dou, PengYe Wang, Lu Ma, Yuru Liu, Guohong Li, Wei Li, Huidong Zhang, 2021 Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level, Ke Lu, Cuifang Liu, Yinuo Liu, Anfeng Luo, Jun Chen, Zhichao Lei, Jingwei Kong, Xue Xiao, Shuming Zhang, YiZhou Wang, Lu Ma, ShuoXing Dou, PengYe Wang, Ming Li, Guohong Li, Wei Li, Ping Chen, 2021 Analysis of Local Chromatin States Reveals Gene Transcription Potential during Mouse Neural Progenitor Cell Differentiation, Juan Yu, Chaoyang Xiong, Baowen Zhuo, Zengqi Wen, Jie Shen, Cuifang Liu, Luyuan Chang, Kehui Wang, Min Wang, Chenyi Wu, Xudong Wu, Xueqin Xu, Haihe Ruan, Guohong Li, 2020 RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division, Jicheng Zhao, Min Wang, Luyuan Chang, Juan Yu, Aoqun Song, Cuifang Liu, Wenjun Huang, Tiantian Zhang, Xudong Wu, Xiaohua Shen, Bing Zhu, Guohong Li, 2020 Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at the Single-Nucleosome Level, Xue Xiao, Cuifang Liu, Yingxin Pei, YiZhou Wang, Jingwei Kong, Ke Lu, Lu Ma, ShuoXing Dou, PengYe Wang, Guohong Li, Ping Chen, Wei Li, 2020 The 3D organization of genome in the nucleus: from the nucleosome to the 4D nucleome, Guohong Li, 2020 Structures and Functions of Chromatin Fibers, Guohong Li, 2020 Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells, Zengqi Wen, Liwei Zhang, Haihe Ruan, Guohong Li, 2020 H2A.Z facilitates licensing and activation of early replication origins, Haizhen Long, Liwei Zhang, Mengjie Lv, Zengqi Wen, Wenhao Zhang, Xiulan Chen, Peitao Zhang, Tongqing Li, Luyuan Chang, Caiwei Jin, Guozhao Wu, Xi Wang, Fuquan Yang, Jianfeng Pei, Ping Chen, Raphael Margueron, Haiteng Deng, Mingzhao Zhu, Guohong Li, 2020 Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin, Liang Wang, Mingli Hu, MeiQing Zuo, Jicheng Zhao, Di Wu, Li Huang, Yongxin Wen, Yunfan Li, Ping Chen, Xinhua Bao, MengQiu Dong, Guohong Li, Pilong Li, 2020 Structure and dynamics of the 30-nm chromatin fiber in gene regulation, Guohong Li, 2020 Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism, Liang Wang, Yifei Gao, Xiangdong Zheng, Cuifang Liu, Shuangshuang Dong, Ru Li, Guanwei Zhang, Yixuan Wei, Hongyuan Qu, Yuhan Li, C David Allis, Guohong Li, Haitao Li, Pilong Li, 2019 A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair, Weizhe Li, HongYan Wang, Xiaolu Zhao, Hongguo Duan, Binghua Cheng, Yafei Liu, Mengjie Zhao, Wenjie Shu, Yuchao Mei, Zengqi Wen, Mingliang Tang, Lin Guo, Guohong Li, Qiang Chen, Xiaoqi Liu, HaiNing Du, 2019 RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control, Xianju Bi, Yanhui Xu, Tong Li, Xinmin Li, Wenzhi Li, Wen Shao, Kaili Wang, Ge Zhan, Zhongyang Wu, Wei Liu, J Yuyang Lu, Liang Wang, Jicheng Zhao, Jiawei Wu, Jie Na, Guohong Li, Pilong Li, Xiaohua Shen, 2019 Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks, Sihao Zheng, Dan Li, Zhen Lu, Guangxue Liu, Meng Wang, Poyuan Xing, Min Wang, Yang Dong, Xuejie Wang, Jingyao Li, Simin Zhang, Haoyang Peng, Grzegorz Ira, Guohong Li, Xuefeng Chen, 2018 Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers, Xue Xiao, Liping Dong, YiZhou Wang, PengYe Wang, Ming Li, Guohong Li, Ping Chen, Wei Li, 2018 Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells, Yan Wang, Haizhen Long, Juan Yu, Liping Dong, Michel Wassef, Baowen Zhuo, Xia Li, Jicheng Zhao, Min Wang, Cuifang Liu, Zengqi Wen, Luyuan Chang, Ping Chen, Qianfei Wang, Xueqing Xu, Raphael Margueron, Guohong Li, 2018 UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis- regulatory elements of genes in mouse ES cells, Chaoyang Xiong, Zengqi Wen, Juan Yu, Jun Chen, ChaoPei Liu, Xiaodong Zhang, Ping Chen, RuiMing Xu, Guohong Li, 0201

Areas of Focus

Chromatin structure and epigenetic regulation

Publications

Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1, Guohong Li, 2023
Histone H1 facilitates restoration of H3K27me3 during DNA replication by chromatin compaction, Cuifang Liu, Juan Yu, Aoqun Song, Min Wang, Jiansen Hu, Ping Chen, Jicheng Zhao, Guohong Li, 2023
H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation, Anfeng Luo, Jingwei Kong, Jun Chen, Xue Xiao, Jie Lan, Xiaorong Li, Cuifang Liu, PengYe Wang, Guohong Li, Wei Li, Ping Chen, 2023
Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase, Weiran Ge, Cong Yu, Jingjing Li, Zhenyu Yu, Xiaorong Li, Yan Zhang, ChaoPei Liu, Yingfeng Li, Changlin Tian, Xinzheng Zhang, Guohong Li, Bing Zhu, RuiMing Xu, 2023
H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly, YiZhou Wang, Cuifang Liu, Jicheng Zhao, Juan Yu, Anfeng Luo, Xue Xiao, ShuoXing Dou, Lu Ma, PengYe Wang, Ming Li, Guohong Li, Jianbin Yan, Ping Chen, Wei Li, 2022
Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice, Yuting Liu, Kehui Wang, Li Huang, Jicheng Zhao, Xinpeng Chen, Qiang Wu, Zhouliang Yu, Guohong Li, 2022
Phase separation of RNA-binding protein promotes polymerase binding and transcription, Wen Shao, Xianju Bi, Yixuan Pan, Boyang Gao, Jun Wu, Yafei Yin, Zhimin Liu, Mengyuan Peng, Wenhao Zhang, Xu Jiang, Ren Wenlin, Yanhui Xu, Zhongyang Wu, Kaili Wang, Ge Zhan, J Yuyang Lu, Xue Han, Tong Li, Jianlong Wang, Guohong Li, Haiteng Deng, Bing Li, Xiaohua Shen, 2022
CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency, Dawei Huo, Zhaowei Yu, Rui Li, Meihan Gong, Simone Sidoli, Xukun Lu, Yuying Hou, Zhongye Dai, Yu Kong, Guifen Liu, Ole N Jensen, Wei Xie, Kristian Helin, Chaoyang Xiong, Guohong Li, Yong Zhang, Xudong Wu, 2022
The influence of high-order chromatin state in the regulation of stem cell fate, Xinpeng Chen, Haiyan Lin, Guohong Li, 2022
Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones, ChaoPei Liu, Wenxing Jin, Jie Hu, Mingzhu Wang, Jingjing Chen, Guohong Li, RuiMing Xu, 2021
Structures and Functions of Chromatin Fibers, Ping Chen, Wei Li, Guohong Li, KA Dill, 2021
单分子力谱研究组蛋白H2A泛素化修饰调控核小体的分子机制, 陈萍, 李国红, 李伟, 2021
Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle, Kehui Wang, Yuting Liu, Zhouliang Yu, Bo Gu, Jie Hu, Li Huang, Xiao Ge, Lingyi Xu, Mengyu Zhang, Jicheng Zhao, Mingli Hu, Rongrong Le, Qiang Wu, Sheng Ye, Shaorong Gao, Xiaodong Zhang, RuiMing Xu, Guohong Li, 2021
DNA polymerase Gp90 activities and regulations on strand displacement DNA synthesis revealed at single-molecule level, Shuming Zhang, Xue Xiao, Jingwei Kong, Ke Lu, ShuoXing Dou, PengYe Wang, Lu Ma, Yuru Liu, Guohong Li, Wei Li, Huidong Zhang, 2021
Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level, Ke Lu, Cuifang Liu, Yinuo Liu, Anfeng Luo, Jun Chen, Zhichao Lei, Jingwei Kong, Xue Xiao, Shuming Zhang, YiZhou Wang, Lu Ma, ShuoXing Dou, PengYe Wang, Ming Li, Guohong Li, Wei Li, Ping Chen, 2021
Analysis of Local Chromatin States Reveals Gene Transcription Potential during Mouse Neural Progenitor Cell Differentiation, Juan Yu, Chaoyang Xiong, Baowen Zhuo, Zengqi Wen, Jie Shen, Cuifang Liu, Luyuan Chang, Kehui Wang, Min Wang, Chenyi Wu, Xudong Wu, Xueqin Xu, Haihe Ruan, Guohong Li, 2020
RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division, Jicheng Zhao, Min Wang, Luyuan Chang, Juan Yu, Aoqun Song, Cuifang Liu, Wenjun Huang, Tiantian Zhang, Xudong Wu, Xiaohua Shen, Bing Zhu, Guohong Li, 2020
Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at the Single-Nucleosome Level, Xue Xiao, Cuifang Liu, Yingxin Pei, YiZhou Wang, Jingwei Kong, Ke Lu, Lu Ma, ShuoXing Dou, PengYe Wang, Guohong Li, Ping Chen, Wei Li, 2020
The 3D organization of genome in the nucleus: from the nucleosome to the 4D nucleome, Guohong Li, 2020
Structures and Functions of Chromatin Fibers, Guohong Li, 2020
Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells, Zengqi Wen, Liwei Zhang, Haihe Ruan, Guohong Li, 2020
H2A.Z facilitates licensing and activation of early replication origins, Haizhen Long, Liwei Zhang, Mengjie Lv, Zengqi Wen, Wenhao Zhang, Xiulan Chen, Peitao Zhang, Tongqing Li, Luyuan Chang, Caiwei Jin, Guozhao Wu, Xi Wang, Fuquan Yang, Jianfeng Pei, Ping Chen, Raphael Margueron, Haiteng Deng, Mingzhao Zhu, Guohong Li, 2020
Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin, Liang Wang, Mingli Hu, MeiQing Zuo, Jicheng Zhao, Di Wu, Li Huang, Yongxin Wen, Yunfan Li, Ping Chen, Xinhua Bao, MengQiu Dong, Guohong Li, Pilong Li, 2020
Structure and dynamics of the 30-nm chromatin fiber in gene regulation, Guohong Li, 2020
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism, Liang Wang, Yifei Gao, Xiangdong Zheng, Cuifang Liu, Shuangshuang Dong, Ru Li, Guanwei Zhang, Yixuan Wei, Hongyuan Qu, Yuhan Li, C David Allis, Guohong Li, Haitao Li, Pilong Li, 2019
A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair, Weizhe Li, HongYan Wang, Xiaolu Zhao, Hongguo Duan, Binghua Cheng, Yafei Liu, Mengjie Zhao, Wenjie Shu, Yuchao Mei, Zengqi Wen, Mingliang Tang, Lin Guo, Guohong Li, Qiang Chen, Xiaoqi Liu, HaiNing Du, 2019
RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control, Xianju Bi, Yanhui Xu, Tong Li, Xinmin Li, Wenzhi Li, Wen Shao, Kaili Wang, Ge Zhan, Zhongyang Wu, Wei Liu, J Yuyang Lu, Liang Wang, Jicheng Zhao, Jiawei Wu, Jie Na, Guohong Li, Pilong Li, Xiaohua Shen, 2019
Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks, Sihao Zheng, Dan Li, Zhen Lu, Guangxue Liu, Meng Wang, Poyuan Xing, Min Wang, Yang Dong, Xuejie Wang, Jingyao Li, Simin Zhang, Haoyang Peng, Grzegorz Ira, Guohong Li, Xuefeng Chen, 2018
Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers, Xue Xiao, Liping Dong, YiZhou Wang, PengYe Wang, Ming Li, Guohong Li, Ping Chen, Wei Li, 2018
Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells, Yan Wang, Haizhen Long, Juan Yu, Liping Dong, Michel Wassef, Baowen Zhuo, Xia Li, Jicheng Zhao, Min Wang, Cuifang Liu, Zengqi Wen, Luyuan Chang, Ping Chen, Qianfei Wang, Xueqing Xu, Raphael Margueron, Guohong Li, 2018
UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis- regulatory elements of genes in mouse ES cells, Chaoyang Xiong, Zengqi Wen, Juan Yu, Jun Chen, ChaoPei Liu, Xiaodong Zhang, Ping Chen, RuiMing Xu, Guohong Li, 0201

Chromatin Epigenetics Gene Expression Histones Nucleosome Dna Replication Transcription Cell Cycle Molecular Biology Biophysics

Yuejin Hua - Zhejiang University

Li Chao - East China Normal University

Shangbang Gao - Huazhong University of Science and Technology

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