Upload Avatar (500 x 500)
Zhongbing Lu
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Cardiac Hypertrophy
Heart Failure
Animal Models
Cell Models
Metabolic Diseases
Mechanisms
Free Radicals
Detection
Analysis
Signal Pathways
Areas of Focus
- Cardiac Hypertrophy and Heart Failure
- Mechanisms of Metabolic Diseases
- Free Radical Biology
Work Experience
- 2012-02 to Present - University of Chinese Academy of Sciences - Professor, Doctoral Supervisor
- 2009-08 to 2012-01 - University of Minnesota Medical School - Research Associate
- 2006-09 to 2009-08 - University of Minnesota Medical School - Postdoctoral Fellow
Academic Background & Achievements
- 2003-09 to 2006-09 PhD in Science: Institute of Biophysics, Chinese Academy of Sciences
- 2000-09 to 2003-07 Master's in Engineering: Sichuan University
- 1996-09 to 2000-07 Bachelor's in Engineering: Sichuan University
Publications
- Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes., Yangxiao Hou, Dong Wei, Zhaoqi Zhang, Tong Lei, Sihong Li, Jiaming Bao, Han Guo, Liang Tan, Xubiao Xie, Yuan Zhuang, Zhongbing Lu, Yong Zhao, 2024
- DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis., Zhongbing Lu, 2024
- DDAH1 promotes neurogenesis and neural repair in cerebral ischemia., Qiming Gao, Pinfei Ni, Yilin Wang, Peiyun Huo, Xiaojie Zhang, Sihan Wang, Fuyao Xiao, Yixuan Li, Wei Feng, Juntao Yuan, Teng Zhang, Qiang Li, Boyu Fan, Yuhao Kan, Zhirui Li, Yimiao Qi, Junfei Xing, Zhenghong Yang, Haixiao Cheng, Xinran Gao, Xiaoyan Feng, Ming Xue, Yang Liu, Yumin Luo, Zhongbing Lu, Yuming Zhao, 2024
- DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis., Juntao Yuan, Zhuoran Yu, Ping Zhang, Kai Luo, Ying Xu, Ting Lan, Min Zhang, Yingjie Chen, Zhongbing Lu, 2024
- DDAH1 Protects against Cardiotoxin-Induced Muscle Injury and Regeneration., Fei Feng, Bingqing Cui, Li Fang, Ting Lan, Kai Luo, Xin Xu, Zhongbing Lu, 2023
- Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice: Involvement of reduced S100A11 expression., Shen Xiyue, Luo Kai, Yuan Juntao, Gao Junling, Cui Bingqing, Yu Zhuoran, Lu Zhongbing, 2023
- Genetic and Pharmacological Inhibition of GCN2 Ameliorates Hyperglycemia and Insulin Resistance in Type 2 Diabetic Mice., Juntao Yuan, Fang Li, Xiyue Shen, Junling Gao, Zhuoran Yu, Kai Luo, Bingqing Cui, Zhongbing Lu, 2022
- Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation., Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu, 2022
- Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression., Tong Lei, Jiayu Zhang, Qian Zhang, Xinran Ma, Yanan Xu, Yang Zhao, Zhang Lianfeng, Zhongbing Lu, Yong Zhao, 2022
- Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress., Gao, Junling, Lei, Tong, Wang, Hongyun, Luo, Kai, Wang, Yuanli, Cui, Bingqing, Yu, Zhuoran, Hu, Xiaoqi, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing, 2022
- Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative Stress., Yuan, Juntao, Li, Fang, Cui, Bingqing, Gao, Junling, Yu, Zhuoran, Lu, Zhongbing, 2022
- DDAH1 Protects against Acetaminophen-Induced Liver Hepatoxicity in Mice., Shen, Xiyue, Ishaq, Saddam Muhammad, Wang, Qiaoe, Yuan, Juntao, Gao, Junling, Lu, Zhongbing, 2022
- Adipose-derived stem cells therapy effectively attenuates PM2.5-induced lung injury., Gao, Junling, Yuan, Juntao, Liu, Qun, Wang, Yuanli, Wang, Huiwen, Chen, Yingjie, Ding, Wenjun, Ji, Guangju, Lu, Zhongbing, 2021
- Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction., Li, Tianhe, Zhang, Tingting, Gao, Huimin, Liu, Ruixia, Gu, Muqing, Yang, Yuxi, Cui, Tianyu, Lu, Zhongbing, Yin, Chenghong, 2021
- Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha 2., Gao, Junling, Yuan, Juntao, Wang, Qiaoe, Lei, Tong, Shen, Xiyue, Cui, Bingqing, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing, 2020
- The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis., Wang, Hongyun, Shen, Xiyue, Liu, Jingli, Wu, Chunyan, Gao, Junling, Zhang, Zezhong, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing, 2019
- Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy., Yue, Wenhui, Tong, Lei, Liu, Xiaohong, Weng, Xinyu, Chen, Xiaoyu, Wang, Dongzhi, Dudley, Samuel C, Weir, E Kenneth, Ding, Wenjun, Lu, Zhongbing, Xu, Yawei, Chen, Yingjie, 2019
- GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress., Feng, Wei, Lei, Tong, Wang, Yue, Feng, Run, Yuan, Juntao, Shen, Xiyue, Wu, Yongguang, Gao, Junling, Ding, Wenjun, Lu, Zhongbing, 2019
- The amino acid sensor general control nonderepressible 2 (GCN2) controls TH9 cells and allergic airway inflammation., Peng Wang PhD, Yana Xu BS, Jiayu Zhang BS, Lu Shi PhD, Tong Lei BS, Yangxiao Hou MS, Zhongbing Lu PhD, Yong Zhao MD PhD, 2019
- GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress., Wang, Yue, Lei, Tong, Yuan, Juntao, Wu, Yongguang, Shen, Xiyue, Gao, Junling, Feng, Wei, Lu, Zhongbing, 2018
- GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation., Guo, Yuting, Wang, Huiwen, Tang, Yinglong, Wang, Yue, Zhang, Mengqi, Yang, Zhiguang, Nyirimigabo, Eric, Wei, Bin, Lu, Zhongbing, Ji, Guangju, 2018
- GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice., Shasha Liu, Juntao Yuan, Wenhui Yue, Yanwei Bi, Xiyue Shen, Junling Gao, Xin Xu, Zhongbing Lu, 2018
- AMPK alpha 2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction., Wang, Hongyun, Shen, Xiyue, Tian, Guoxiong, Shi, Xili, Huang, Wei, Wu, Yongguang, Sun, Lei, Peng, Can, Liu, Shasha, Huang, Ying, Chen, Xiaoyu, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing, 2018
- YAP promotes breast cancer metastasis by repressing growth differentiation factor-15., Wang, Ting, Mao, Beibei, Cheng, Chi, Zou, Zhuangzhi, Gao, Junling, Yang, Yanglu, Lei, Tong, Qi, Xiaolong, Yuan, Zengqiang, Xu, Wentong, Lu, Zhongbing, 2018
- Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway., Xu, Jinxia, Zhang, Wei, Lu, Zhongbing, Zhang, Fang, Ding, Wenjun, 2017
- Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice., Shi, Linlin, Zhao, Chenyang, Wang, Hongyun, Lei, Tong, Liu, Shasha, Cao, Jianwei, Lu, Zhongbing, 2017
- Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice., Li, Tianhe, Feng, Run, Zhao, Chenyang, Wang, Yue, Wang, Jian, Liu, Shasha, Cao, Jianwei, Wang, Hongyun, Wang, Ting, Guo, Yuting, Lu, Zhongbing, 2017
- AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy., Guo Yuting, Meng Jin, Tang Yinglong, Wang Ting, Wei Bin, Feng Run, Gong Bing, Wang Huiwen, Ji Guangju, Lu Zhongbing, 2016
- DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells., Wang, Hongyun, Guo, Yuting, Liu, Limin, Guan, Longfei, Wang, Ting, Zhang, Luyao, Wang, Yue, Cao, Jianwei, Ding, Wenjun, Zhang, Fang, Lu, Zhongbing, 2016
- DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts., Zhao, Chenyang, Li, Tianhe, Han, Bingxing, Yue, Wenhui, Shi, Linlin, Wang, Hongyun, Guo, Yuting, Lu, Zhongbing, 2016
- hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation., Xing, Yingying, Chu, Qiaoyun, Feng, Run, Wang, Wei, Liu, Lixin, Lu, Zhongbing, 2015
- The protein arginine methyltransferase PRMT5 regulates A-induced toxicity in human cells and Caenor
