Professor | Zhongbing Lu | Asia Growth Partners

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Name	Zhongbing Lu
Contact Information	luzhongbing@ucas.ac.cn
Language ability	Chinese, English
Province	Beijing

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Name

Zhongbing Lu

Contact Information

luzhongbing@ucas.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2003-09 to 2006-09 PhD in Science: Institute of Biophysics, Chinese Academy of Sciences 2000-09 to 2003-07 Master's in Engineering: Sichuan University 1996-09 to 2000-07 Bachelor's in Engineering: Sichuan University
Work Experience	2012-02 to Present - University of Chinese Academy of Sciences - Professor, Doctoral Supervisor 2009-08 to 2012-01 - University of Minnesota Medical School - Research Associate 2006-09 to 2009-08 - University of Minnesota Medical School - Postdoctoral Fellow

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2003-09 to 2006-09 PhD in Science: Institute of Biophysics, Chinese Academy of Sciences
2000-09 to 2003-07 Master's in Engineering: Sichuan University
1996-09 to 2000-07 Bachelor's in Engineering: Sichuan University

Work Experience

2012-02 to Present - University of Chinese Academy of Sciences - Professor, Doctoral Supervisor
2009-08 to 2012-01 - University of Minnesota Medical School - Research Associate
2006-09 to 2009-08 - University of Minnesota Medical School - Postdoctoral Fellow

Areas of Focus	Cardiac Hypertrophy and Heart Failure Mechanisms of Metabolic Diseases Free Radical Biology
Publications	Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes., Yangxiao Hou, Dong Wei, Zhaoqi Zhang, Tong Lei, Sihong Li, Jiaming Bao, Han Guo, Liang Tan, Xubiao Xie, Yuan Zhuang, Zhongbing Lu, Yong Zhao, 2024 DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis., Zhongbing Lu, 2024 DDAH1 promotes neurogenesis and neural repair in cerebral ischemia., Qiming Gao, Pinfei Ni, Yilin Wang, Peiyun Huo, Xiaojie Zhang, Sihan Wang, Fuyao Xiao, Yixuan Li, Wei Feng, Juntao Yuan, Teng Zhang, Qiang Li, Boyu Fan, Yuhao Kan, Zhirui Li, Yimiao Qi, Junfei Xing, Zhenghong Yang, Haixiao Cheng, Xinran Gao, Xiaoyan Feng, Ming Xue, Yang Liu, Yumin Luo, Zhongbing Lu, Yuming Zhao, 2024 DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis., Juntao Yuan, Zhuoran Yu, Ping Zhang, Kai Luo, Ying Xu, Ting Lan, Min Zhang, Yingjie Chen, Zhongbing Lu, 2024 DDAH1 Protects against Cardiotoxin-Induced Muscle Injury and Regeneration., Fei Feng, Bingqing Cui, Li Fang, Ting Lan, Kai Luo, Xin Xu, Zhongbing Lu, 2023 Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice: Involvement of reduced S100A11 expression., Shen Xiyue, Luo Kai, Yuan Juntao, Gao Junling, Cui Bingqing, Yu Zhuoran, Lu Zhongbing, 2023 Genetic and Pharmacological Inhibition of GCN2 Ameliorates Hyperglycemia and Insulin Resistance in Type 2 Diabetic Mice., Juntao Yuan, Fang Li, Xiyue Shen, Junling Gao, Zhuoran Yu, Kai Luo, Bingqing Cui, Zhongbing Lu, 2022 Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation., Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu, 2022 Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression., Tong Lei, Jiayu Zhang, Qian Zhang, Xinran Ma, Yanan Xu, Yang Zhao, Zhang Lianfeng, Zhongbing Lu, Yong Zhao, 2022 Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress., Gao, Junling, Lei, Tong, Wang, Hongyun, Luo, Kai, Wang, Yuanli, Cui, Bingqing, Yu, Zhuoran, Hu, Xiaoqi, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing, 2022 Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative Stress., Yuan, Juntao, Li, Fang, Cui, Bingqing, Gao, Junling, Yu, Zhuoran, Lu, Zhongbing, 2022 DDAH1 Protects against Acetaminophen-Induced Liver Hepatoxicity in Mice., Shen, Xiyue, Ishaq, Saddam Muhammad, Wang, Qiaoe, Yuan, Juntao, Gao, Junling, Lu, Zhongbing, 2022 Adipose-derived stem cells therapy effectively attenuates PM2.5-induced lung injury., Gao, Junling, Yuan, Juntao, Liu, Qun, Wang, Yuanli, Wang, Huiwen, Chen, Yingjie, Ding, Wenjun, Ji, Guangju, Lu, Zhongbing, 2021 Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction., Li, Tianhe, Zhang, Tingting, Gao, Huimin, Liu, Ruixia, Gu, Muqing, Yang, Yuxi, Cui, Tianyu, Lu, Zhongbing, Yin, Chenghong, 2021 Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha 2., Gao, Junling, Yuan, Juntao, Wang, Qiaoe, Lei, Tong, Shen, Xiyue, Cui, Bingqing, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing, 2020 The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis., Wang, Hongyun, Shen, Xiyue, Liu, Jingli, Wu, Chunyan, Gao, Junling, Zhang, Zezhong, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing, 2019 Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy., Yue, Wenhui, Tong, Lei, Liu, Xiaohong, Weng, Xinyu, Chen, Xiaoyu, Wang, Dongzhi, Dudley, Samuel C, Weir, E Kenneth, Ding, Wenjun, Lu, Zhongbing, Xu, Yawei, Chen, Yingjie, 2019 GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress., Feng, Wei, Lei, Tong, Wang, Yue, Feng, Run, Yuan, Juntao, Shen, Xiyue, Wu, Yongguang, Gao, Junling, Ding, Wenjun, Lu, Zhongbing, 2019 The amino acid sensor general control nonderepressible 2 (GCN2) controls TH9 cells and allergic airway inflammation., Peng Wang PhD, Yana Xu BS, Jiayu Zhang BS, Lu Shi PhD, Tong Lei BS, Yangxiao Hou MS, Zhongbing Lu PhD, Yong Zhao MD PhD, 2019 GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress., Wang, Yue, Lei, Tong, Yuan, Juntao, Wu, Yongguang, Shen, Xiyue, Gao, Junling, Feng, Wei, Lu, Zhongbing, 2018 GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation., Guo, Yuting, Wang, Huiwen, Tang, Yinglong, Wang, Yue, Zhang, Mengqi, Yang, Zhiguang, Nyirimigabo, Eric, Wei, Bin, Lu, Zhongbing, Ji, Guangju, 2018 GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice., Shasha Liu, Juntao Yuan, Wenhui Yue, Yanwei Bi, Xiyue Shen, Junling Gao, Xin Xu, Zhongbing Lu, 2018 AMPK alpha 2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction., Wang, Hongyun, Shen, Xiyue, Tian, Guoxiong, Shi, Xili, Huang, Wei, Wu, Yongguang, Sun, Lei, Peng, Can, Liu, Shasha, Huang, Ying, Chen, Xiaoyu, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing, 2018 YAP promotes breast cancer metastasis by repressing growth differentiation factor-15., Wang, Ting, Mao, Beibei, Cheng, Chi, Zou, Zhuangzhi, Gao, Junling, Yang, Yanglu, Lei, Tong, Qi, Xiaolong, Yuan, Zengqiang, Xu, Wentong, Lu, Zhongbing, 2018 Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway., Xu, Jinxia, Zhang, Wei, Lu, Zhongbing, Zhang, Fang, Ding, Wenjun, 2017 Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice., Shi, Linlin, Zhao, Chenyang, Wang, Hongyun, Lei, Tong, Liu, Shasha, Cao, Jianwei, Lu, Zhongbing, 2017 Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice., Li, Tianhe, Feng, Run, Zhao, Chenyang, Wang, Yue, Wang, Jian, Liu, Shasha, Cao, Jianwei, Wang, Hongyun, Wang, Ting, Guo, Yuting, Lu, Zhongbing, 2017 AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy., Guo Yuting, Meng Jin, Tang Yinglong, Wang Ting, Wei Bin, Feng Run, Gong Bing, Wang Huiwen, Ji Guangju, Lu Zhongbing, 2016 DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells., Wang, Hongyun, Guo, Yuting, Liu, Limin, Guan, Longfei, Wang, Ting, Zhang, Luyao, Wang, Yue, Cao, Jianwei, Ding, Wenjun, Zhang, Fang, Lu, Zhongbing, 2016 DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts., Zhao, Chenyang, Li, Tianhe, Han, Bingxing, Yue, Wenhui, Shi, Linlin, Wang, Hongyun, Guo, Yuting, Lu, Zhongbing, 2016 hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation., Xing, Yingying, Chu, Qiaoyun, Feng, Run, Wang, Wei, Liu, Lixin, Lu, Zhongbing, 2015 The protein arginine methyltransferase PRMT5 regulates A-induced toxicity in human cells and Caenor

Areas of Focus

Cardiac Hypertrophy and Heart Failure
Mechanisms of Metabolic Diseases
Free Radical Biology

Publications

Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes., Yangxiao Hou, Dong Wei, Zhaoqi Zhang, Tong Lei, Sihong Li, Jiaming Bao, Han Guo, Liang Tan, Xubiao Xie, Yuan Zhuang, Zhongbing Lu, Yong Zhao, 2024
DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis., Zhongbing Lu, 2024
DDAH1 promotes neurogenesis and neural repair in cerebral ischemia., Qiming Gao, Pinfei Ni, Yilin Wang, Peiyun Huo, Xiaojie Zhang, Sihan Wang, Fuyao Xiao, Yixuan Li, Wei Feng, Juntao Yuan, Teng Zhang, Qiang Li, Boyu Fan, Yuhao Kan, Zhirui Li, Yimiao Qi, Junfei Xing, Zhenghong Yang, Haixiao Cheng, Xinran Gao, Xiaoyan Feng, Ming Xue, Yang Liu, Yumin Luo, Zhongbing Lu, Yuming Zhao, 2024
DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis., Juntao Yuan, Zhuoran Yu, Ping Zhang, Kai Luo, Ying Xu, Ting Lan, Min Zhang, Yingjie Chen, Zhongbing Lu, 2024
DDAH1 Protects against Cardiotoxin-Induced Muscle Injury and Regeneration., Fei Feng, Bingqing Cui, Li Fang, Ting Lan, Kai Luo, Xin Xu, Zhongbing Lu, 2023
Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice: Involvement of reduced S100A11 expression., Shen Xiyue, Luo Kai, Yuan Juntao, Gao Junling, Cui Bingqing, Yu Zhuoran, Lu Zhongbing, 2023
Genetic and Pharmacological Inhibition of GCN2 Ameliorates Hyperglycemia and Insulin Resistance in Type 2 Diabetic Mice., Juntao Yuan, Fang Li, Xiyue Shen, Junling Gao, Zhuoran Yu, Kai Luo, Bingqing Cui, Zhongbing Lu, 2022
Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation., Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu, 2022
Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression., Tong Lei, Jiayu Zhang, Qian Zhang, Xinran Ma, Yanan Xu, Yang Zhao, Zhang Lianfeng, Zhongbing Lu, Yong Zhao, 2022
Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress., Gao, Junling, Lei, Tong, Wang, Hongyun, Luo, Kai, Wang, Yuanli, Cui, Bingqing, Yu, Zhuoran, Hu, Xiaoqi, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing, 2022
Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative Stress., Yuan, Juntao, Li, Fang, Cui, Bingqing, Gao, Junling, Yu, Zhuoran, Lu, Zhongbing, 2022
DDAH1 Protects against Acetaminophen-Induced Liver Hepatoxicity in Mice., Shen, Xiyue, Ishaq, Saddam Muhammad, Wang, Qiaoe, Yuan, Juntao, Gao, Junling, Lu, Zhongbing, 2022
Adipose-derived stem cells therapy effectively attenuates PM2.5-induced lung injury., Gao, Junling, Yuan, Juntao, Liu, Qun, Wang, Yuanli, Wang, Huiwen, Chen, Yingjie, Ding, Wenjun, Ji, Guangju, Lu, Zhongbing, 2021
Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction., Li, Tianhe, Zhang, Tingting, Gao, Huimin, Liu, Ruixia, Gu, Muqing, Yang, Yuxi, Cui, Tianyu, Lu, Zhongbing, Yin, Chenghong, 2021
Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha 2., Gao, Junling, Yuan, Juntao, Wang, Qiaoe, Lei, Tong, Shen, Xiyue, Cui, Bingqing, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing, 2020
The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis., Wang, Hongyun, Shen, Xiyue, Liu, Jingli, Wu, Chunyan, Gao, Junling, Zhang, Zezhong, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing, 2019
Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy., Yue, Wenhui, Tong, Lei, Liu, Xiaohong, Weng, Xinyu, Chen, Xiaoyu, Wang, Dongzhi, Dudley, Samuel C, Weir, E Kenneth, Ding, Wenjun, Lu, Zhongbing, Xu, Yawei, Chen, Yingjie, 2019
GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress., Feng, Wei, Lei, Tong, Wang, Yue, Feng, Run, Yuan, Juntao, Shen, Xiyue, Wu, Yongguang, Gao, Junling, Ding, Wenjun, Lu, Zhongbing, 2019
The amino acid sensor general control nonderepressible 2 (GCN2) controls TH9 cells and allergic airway inflammation., Peng Wang PhD, Yana Xu BS, Jiayu Zhang BS, Lu Shi PhD, Tong Lei BS, Yangxiao Hou MS, Zhongbing Lu PhD, Yong Zhao MD PhD, 2019
GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress., Wang, Yue, Lei, Tong, Yuan, Juntao, Wu, Yongguang, Shen, Xiyue, Gao, Junling, Feng, Wei, Lu, Zhongbing, 2018
GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation., Guo, Yuting, Wang, Huiwen, Tang, Yinglong, Wang, Yue, Zhang, Mengqi, Yang, Zhiguang, Nyirimigabo, Eric, Wei, Bin, Lu, Zhongbing, Ji, Guangju, 2018
GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice., Shasha Liu, Juntao Yuan, Wenhui Yue, Yanwei Bi, Xiyue Shen, Junling Gao, Xin Xu, Zhongbing Lu, 2018
AMPK alpha 2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction., Wang, Hongyun, Shen, Xiyue, Tian, Guoxiong, Shi, Xili, Huang, Wei, Wu, Yongguang, Sun, Lei, Peng, Can, Liu, Shasha, Huang, Ying, Chen, Xiaoyu, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing, 2018
YAP promotes breast cancer metastasis by repressing growth differentiation factor-15., Wang, Ting, Mao, Beibei, Cheng, Chi, Zou, Zhuangzhi, Gao, Junling, Yang, Yanglu, Lei, Tong, Qi, Xiaolong, Yuan, Zengqiang, Xu, Wentong, Lu, Zhongbing, 2018
Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway., Xu, Jinxia, Zhang, Wei, Lu, Zhongbing, Zhang, Fang, Ding, Wenjun, 2017
Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice., Shi, Linlin, Zhao, Chenyang, Wang, Hongyun, Lei, Tong, Liu, Shasha, Cao, Jianwei, Lu, Zhongbing, 2017
Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice., Li, Tianhe, Feng, Run, Zhao, Chenyang, Wang, Yue, Wang, Jian, Liu, Shasha, Cao, Jianwei, Wang, Hongyun, Wang, Ting, Guo, Yuting, Lu, Zhongbing, 2017
AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy., Guo Yuting, Meng Jin, Tang Yinglong, Wang Ting, Wei Bin, Feng Run, Gong Bing, Wang Huiwen, Ji Guangju, Lu Zhongbing, 2016
DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells., Wang, Hongyun, Guo, Yuting, Liu, Limin, Guan, Longfei, Wang, Ting, Zhang, Luyao, Wang, Yue, Cao, Jianwei, Ding, Wenjun, Zhang, Fang, Lu, Zhongbing, 2016
DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts., Zhao, Chenyang, Li, Tianhe, Han, Bingxing, Yue, Wenhui, Shi, Linlin, Wang, Hongyun, Guo, Yuting, Lu, Zhongbing, 2016
hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation., Xing, Yingying, Chu, Qiaoyun, Feng, Run, Wang, Wei, Liu, Lixin, Lu, Zhongbing, 2015
The protein arginine methyltransferase PRMT5 regulates A-induced toxicity in human cells and Caenor

Cardiac Hypertrophy Heart Failure Animal Models Cell Models Metabolic Diseases Mechanisms Free Radicals Detection Analysis Signal Pathways

Juan Zhang - Shanghai University

Juan Zhang - Shanghai University

Zhongbing Lu - University of Chinese Academy of Sciences

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