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Ruiming Xu
Life Science
University of Chinese Academy of Sciences
Beijing
Language: English, Chinese
Epigenetics
Gene Transcription
Rna Processing
Chromatin
Histones
Methylation
Acetylation
Gene Regulation
Structural Biology
Protein-Dna Interaction
Areas of Focus
- Epigenetic Regulation of Gene Transcription and RNA Post-Transcriptional Processing
- Epigenetics, Structural Biology
Work Experience
- 2015-12~Present - Institute of Biophysics, Chinese Academy of Sciences - Deputy Director
- 2013-05~2015-12 - Bureau of Frontier Sciences and Education, Chinese Academy of Sciences - Director
- 2012-11~2013-05 - Bureau of Biological Sciences and Biotechnology, Chinese Academy of Sciences - Director
- 2010-01~2012-11 - Institute of Biophysics, Chinese Academy of Sciences - Deputy Director
- 2009-01~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2006-01~2008-12 - New York University School of Medicine - Professor (Tenured)
- 2005-01~2005-12 - Cold Spring Harbor Laboratory - Professor
- 2000-01~2004-12 - Cold Spring Harbor Laboratory - Associate Professor
- 1996-06~2000-01 - Cold Spring Harbor Laboratory - Assistant Professor
- 1993-03~1996-05 - Cold Spring Harbor Laboratory - Visiting Scholar, Research Assistant
- 1991-09~1993-03 - State University of New York at Stony Brook - Postdoctoral Fellow
- 1989-09~1991-09 - University of Texas at Austin - Postdoctoral Fellow
Academic Background & Achievements
- 1985-06--1989-08 Ph.D. in Physics: Brandeis University
- 1984-09--1985-05 M.S. in Physics: Brandeis University
- 1980-09--1984-07 B.S. in Physics: Zhejiang University
Publications
- Mechanism and design of allosteric activators of SIRT1, Liu, Fei, Pang, Ningning, Xu, RuiMing, Yang, Na, 2023
- Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1, Chao-Pei Liu, Zhenyu Yu, Jun Xiong, Jie Hu, Aoqun Song, Dongbo Ding, Cong Yu, Na Yang, Mingzhu Wang, Juan Yu, Peini Hou, Kangning Zeng, Zhenyu Li, Xinzheng Zhang, Wei Li, Zhiguo Zhang, Bing Zhu, Guohong Li, Ruiming Xu, 2023
- Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase, Ge, Weiran, Yu, Cong, Li, Jingjing, Yu, Zhenyu, Li, Xiaorong, Zhang, Yan, Liu, ChaoPei, Li, Yingfeng, Tian, Changlin, Zhang, Xinzheng, Li, Guohong, Zhu, Bing, Xu, RuiMing, 2023
- Topography of histone H3–H4 interaction with the Hat1–Hat2 acetyltransferase complex, 许瑞明, 2022
- Topography of histone H3-H4 interaction with the Hat1-Hat2 acetyltransferase complex, Yue, Ye, Yang, WenSi, Zhang, Lin, Liu, ChaoPei, Xu, RuiMing, 2022
- Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation, Jing Zhang, Yan Zhang, Qinglong You, Chang Huang, Tiantian Zhang, Mingzhu Wang, Tianwei Zhang, Xiaocheng Yang, Jun Xiong, Yingfeng Li, Chao-Pei Liu, Zhuqiang Zhang, rui-ming xu, Bing Zhu, 2022
- Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones, Liu, ChaoPei, Jin, Wenxing, Hu, Jie, Wang, Mingzhu, Chen, Jingjing, Li, Guohong, Xu, RuiMing, 2021
- Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones, 许瑞明, 2021
- Structure specific DNA recognition by the SLX1-SLX4 endonuclease complex, Xu, Xiang, Wang, Mingzhu, Sun, Jixue, Yu, Zhenyu, Li, Guohong, Yang, Na, Xu, RuiMing, 2021
- Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation, Gou, LanTao, Lim, DoHwan, Ma, Wubin, Aubol, Brandon E, Hao, Yajing, Wang, Xin, Zhao, Jun, Liang, Zhengyu, Shao, Changwei, Zhang, Xuan, Meng, Fan, Li, Hairi, Zhang, Xiaorong, Xu, Ruiming, Li, Dangsheng, Rosenfeld, Michael G, Mellon, Pamela L, Adams, Joseph A, Liu, MoFang, Fu, XiangDong, 2020
- Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha, Gao, Yujing, Chen, Lijia, Han, Yali, Wu, Fangrui, Yang, WenSi, Zhang, Zheng, Huo, Tong, Zhu, Yingmin, Yu, Chengtai, Kim, Hong, Lee, Mark, Tang, Zhen, Phillips, Kevin, He, Bin, Jung, Sung Yun, Song, Yongcheng, Zhu, Bokai, Xu, RuiMing, Feng, Qin, 2020
- DNA polymerase alpha interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands, Li, Zhiming, Hua, Xu, SerraCardona, Albert, Xu, Xiaowei, Gan, Songlin, Zhou, Hui, Yang, WenSi, Chen, Chunlong, Xu, RuiMing, Zhang, Zhiguo, 2020
- Structural Basis for pri-miRNA Recognition by Drosha, Jin, Wenxing, Wang, Jia, Liu, ChaoPei, Wang, HongWei, Xu, RuiMing, 2020
- Structural basis for nucleosome-mediated inhibition of cGAS activity, Cao, Duanfang, Han, Xiaonan, Fan, Xiaoyi, Xu, RuiMing, Zhang, Xinzheng, 2020
- Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding, Hou, Peini, Huang, Chang, Liu, ChaoPei, Yang, Na, Yu, Tianshu, Yin, Yuxin, Zhu, Bing, Xu, RuiMing, 2019
- Rtt109催化组蛋白H3K56的Asf1依赖性乙酰化中的多位点底物识别, 张林, Albert, SerraCardona, Hui, Zhou, Mingzhu, Wang, Na, Yang, 张志国, 许瑞明, 2019
- Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1, Du, Wenlong, Dong, Qiang, Zhang, Zhuqiang, Liu, Baodong, Zhou, Ting, Xu, Ruiming, Wang, Hailin, Zhu, Bing, Li, Yingfeng, 2019
- A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity, Song, Xiaosheng, Yang, Liuliu, Wang, Mingzhu, Gu, Yue, Ye, Buqing, Fan, Zusen, Xu, RuiMing, Yang, Na, 2019
- A mechanism for preventing asymmetric histone segregation onto replicating DNA strands, Yu, Chuanhe, Gan, Haiyun, SerraCardona, Albert, Zhang, Lin, Gan, Songlin, Sharma, Sushma, Johansson, Erik, Chabes, Andrei, Xu, RuiMing, Zhang, Zhiguo, 2018
- The road to a first-class research institute: creating an exceptional environment, recruiting outstanding scientists, producing high-impact work,and nurturing a culture of innovation-preface to the 60th anniversary special issue, RuimingXu, 2018
- UBN
Awards
- National Excellent Scientific and Technological Worker (2016): National Level
- Outstanding Graduate Student Supervisor Award (2012): Chinese Academy of Sciences
- Contribution Award for Overseas Chinese (2010): Other
- Chinese Academy of Sciences-Novo Nordisk Great Wall Professor Award (2009): Ministry Level
- National 'Outstanding Youth' Fund (2009): Ministry Level
- First Batch of Experts (2008): National Level
- CUSPEA Selected (1984): Other
- Outstanding Graduation Thesis Award of Zhejiang University (1984): Institute Level
