Upload Avatar (500 x 500)
Hong Zhang
Life Science
University of Chinese Academy of Sciences
Beijing
Language: English, Chinese
Autophagy
Multicellular Organisms
Regulation
Mechanisms
Neurodegenerative Diseases
Protein Degradation
Cell Biology
Genetics
Biochemistry
Molecular Biology
Areas of Focus
- Mechanisms and regulatory mechanisms of autophagy in multicellular organisms
- Mechanisms of neurodegenerative diseases
Work Experience
- 2012-02~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2004-07~2012-02 - Beijing Institute of Life Sciences - Senior Researcher
- 2001-03~2004-06 - Harvard Medical School, Massachusetts General Hospital Cancer Center - Postdoctoral Fellow
Academic Background & Achievements
- 1994-09--2001-03 PhD in Molecular Genetics: Albert Einstein College of Medicine, New York, USA
- 1991-09--1994-07 Master's in Oncology: Peking University Health Science Center, Beijing, China
- 1987-09--1991-07 Bachelor's in Biochemistry: Anhui University, Anhui, China
Publications
- Atg8 family proteins, LIR/AIM motifs and other interaction modes, Vladimir V Rogov, Ioannis P Nezis, Panagiotis Tsapras, Hong Zhang, Yasin Dagdas, Nobuo N Noda, Hitoshi Nakatogawa, Martina Wirth, Stephane Mouilleron, David G McEwan, Christian Behrends, Vojo Deretic, Zvulun Elazar, Sharon A Tooze, Ivan Dikic, Trond Lamark, Terje Johansen, 2023
- Frontiers in biomolecular condensate research, Mayr, Christine, Mittag, Tanja, Tang, T Y Dora, Wen, Wenyu, Zhang, Hong, Zhang, Huaiying, 2023
- Cellular proteins act as surfactants to modulate the interfacial behavior and function of biological condensates, Wang, Zheng, Yang, Chun, Guan, Dongshi, Li, Jiaqi, Zhang, Hong, 2023
- RNA recruitment switches the fate of protein condensates from autophagic degradation to accumulation, Hui Zheng, Hong Zhang, 2023
- Join the club: ORP8 is a lipophagy receptor, Zheng Wang, Hong Zhang, 2023
- Calcium transients on the ER surface, 张宏, 2022
- Material properties of phase-separated TFEB condensates regulate the autophagy-lysosome pathway, 王峥, 杨春, 关东石, 张宏, 2022
- The genetics of autophagy in multicellular organisms, Hong Zhang, 2022
- ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation, Miao, Guangyan, Zhao, Hongyu, Li, Yan, Ji, Mingming, Chen, Yong, Shi, Yi, Bi, Yuhai, Wang, Peihui, Zhang, Hong, 2021
- β-propeller proteins WDR45 and WDR45B control autophagosome maturation into autolysosomes in neural cells, Hong Zhang, 2021
- The ER membrane proteins Atlastin 2/3 regulate ER targeting of the ULK1 complex and formation of the ER-isolation membrane contact, Hong Zhang, 2021
- Entry, egress and vertical transmission of SARS-CoV-2, Zhang, Hui, Zhang, Hong, 2021
- ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress, Chen, Di, Zheng, Qiaoxia, Sun, Long, Ji, Mingming, Li, Yan, Deng, Hongyu, Zhang, Hong, 2021
- Machinery, regulation and pathophysiological implications of autophagosome maturation, Zhao, Yan G, Codogno, Patrice, Zhang, Hong, 2021
- Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases, Zhang, Hong, Ji, Xiong, Li, Pilong, Liu, Cong, Lou, Jizhong, Wang, Zheng, Wen, Wenyu, Xiao, Yue, Zhang, Mingjie, Zhu, Xueliang, 2020
- Role of Wdr45b in maintaining neural autophagy and cognitive function, Ji, Cuicui, Zhao, Hongyu, Li, Dongfang, Sun, Huayu, Hao, Junfeng, Chen, Ruiguo, Wang, Xiaoqun, Zhang, Hong, Zhao, Yan G, 2020
- Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates, Zhao, Yan G, Zhang, Hong, 2020
- The tissue- and developmental stage-specific involvement of autophagy genes in aggrephagy, Zheng, Hui, Yuan, Chongzhen, Zhang, Hui, Chen, Yingyu, Zhang, Hong, 2020
- Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity, Chen, Di, Wang, Zheng, Zhao, Yan G, Zheng, Hui, Zhao, Hongyu, Liu, Nan, Zhang, Hong, 2020
- Protocol for analyzing protein liquid–liquid phase separation, Zheng Wang, Gangming Zhang, Hong Zhang, 2019
- The ER-localized transmembrane protein TMEM39A/SUSR2 regulates autophagy by controlling the trafficking of the PtdIns(4)P phosphatase SAC1, Hong Zhang, 2019
- Phase Separation, Transition, and Autophagic Degradation of Proteins in Development and Pathogenesis, Zheng Wang, Hong Zhang, 2019
- Role of Wdr45b in maintaining neural autophagy and cognitive function, Hong Zhang, 2019
- TGF beta-like DAF-7 acts as a systemic signal for autophagy regulation in C. elegans, Zhang, Yujie, Qi, Linxiang, Zhang, Hong, 2019
- The ER-Localized Protein DFCP1 Modulates ERLipid, Hong Zhang, 2019
- MDT-28/PLIN-1 mediates lipid droplet-microtubule interaction via DLC-1 in Caenorhabditis elegans, Xie, Kang, Zhang, Peng, Na, Huimin, Liu, Yangli, Zhang, Hong, Liu, Pingsheng, 2019
- mTOR通过调节PGL颗粒的相变来控制它被自噬降解的新机制, Gangming, Zhang, Zheng, Wang, Zhuo, Du, 张宏, 2019
- Protocol for analyzing protein liquid–liquid phase separation, ZhengWang, GangmingZhang, HongZhang, 2019
- Autophagosome maturation: An epic journey from the ER to lysosomes, Zhao, Yan G, Zhang, Hong, 2019
- The RBG-1-RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans, Wang, Zhaoyu, Zhao, Hongyu, Yuan, Chongzhen, Zhao, Dongfeng, Sun, Yanan, Wang, Xiaochen, Zhang, Hong, 2019
- Core autophagy genes and human diseases, Zhao, Yan G, Zhang, Hong, 2019
- Sec61 beta facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules, Zhu, Yimeng
Awards
- Second National Innovation Award (2020): National Level
- National Natural Science Award, Second Prize (2019): National Level
- Outstanding Achievement Award, Chinese Society for Cell Biology (2019): Other
- Zhenxi Life Scholar (2018): Other
- Hundred Thousand Talents Project, First Prize (2017): National Level
- Beijing Science and Technology Award, Second Prize (2016): Provincial Level
- Second Batch of National 'Ten Thousand Talents Plan' Leading Talents, First Prize (2016): Ministerial Level
- Sixth Tan Jiazhen Life Science Award Innovation Award, First Prize (2014): Other
- Young and Middle-aged Science and Technology Innovation Leading Talent Award, First Prize (2013): Ministerial Level
- National Outstanding Youth Fund Award, First Prize (2012): National Level
- Howard Hughes Medical Institute (HHMI) International Young Scientist Award, First Prize (2012): Other
- Lilly Asia Outstanding Research Achievement Award, First Prize (2006): Other
- Burroughs Wellcome Fund Biomedical Achievement Award, First Prize (2005): Other
- Massachusetts General Hospital Medical Discovery Award, First Prize (2004): Other
