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Zhihua Zhang
zhangzhihua@big.ac.cn
Chinese, English
Beijing
University of Chinese Academy of Sciences
Life Sciences
  • 2002-09--2006-05 PhD in Science: Institute of Biophysics, Chinese Academy of Sciences
  • 2011-10~Present - Chinese Academy of Sciences, Beijing Institute of Genomics - Researcher
  • 2010-03~2011-09 - University of Texas at Dallas - Postdoctoral Researcher
  • 2009-03~2010-03 - Cold Spring Harbor Laboratory - Postdoctoral Researcher
  • 2006-08~2009-03 - University of Michigan, Ann Arbor - Postdoctoral Researcher
Microevolution of Gene Regulatory Networks
Long-Range Interactions of Gene Regulatory Elements
Non-coding RNA in Gene Regulatory Networks
  • Delta.EPI: a probabilistic voting-based enhancer-promoter interaction prediction platform, Yuyang Zhang, Haoyu Wang, Jing Liu, Junlin Li, Qing Zhang, Bixia Tang, Zhihua Zhang, 2023
  • DeDoc2 Identifies and Characterizes the Hierarchy and Dynamics of Chromatin TAD-Like Domains in the Single Cells, Li, Angsheng, Zeng, Guangjie, Wang, Haoyu, Li, Xiao, Zhang, Zhihua, 2023
  • Decooc Deconvoluted Hi-C Map Characterizes the Chromatin Architecture of Cells in Physiologically Distinctive Tissues, Wang, Junmei, Lu, Lu, Zheng, Shiqi, Wang, Danyang, Jin, Long, Zhang, Qing, Li, Mingzhou, Zhang, Zhihua, 2023
  • Dynamic chromatin architecture of the porcine adipose tissues with weight gain and loss, Jin, Long, Wang, Danyang, Zhang, Jiaman, Liu, Pengliang, Wang, Yujie, Lin, Yu, Liu, Can, Han, Ziyin, Long, Keren, Li, Diyan, Jiang, Yu, Li, Guisen, Zhang, Yu, Bai, Jingyi, Li, Xiaokai, Li, Jing, Lu, Lu, Kong, Fanli, Wang, Xun, Li, Hua, Huang, Zhiqing, Ma, Jideng, Fan, Xiaolan, Shen, Linyuan, Zhu, Li, Jiang, Yanzhi, Tang, Guoqing, Feng, Bin, Zeng, Bo, Ge, Liangpeng, Li, Xuewei, Tang, Qianzi, Zhang, Zhihua, Li, Mingzhou, 2023
  • Cell cycle arrest explained the observed bulk 3D genomic alterations in response to long term heat shock in K562 cells, xu bingxiang, Xiaomeng Gao, xiaoli li, yan jia, Feifei li, Zhihua Zhang, 2022
  • Lattice simulation-based diffusion modelling of 3D chromatin structure, Yang, Qingzhu, Zhang, Zhihua, 2022
  • DeNOPA: decoding nucleosome positions sensitively with sparse ATAC-seq data, Xu, Bingxiang, Li, Xiaoli, Gao, Xiaomeng, Jia, Yan, Liu, Jing, Li, Feifei, Zhang, Zhihua, 2022
  • Comparative 3D genome architecture in vertebrates, Li, Diyan, He, Mengnan, Tang, Qianzi, Tian, Shilin, Zhang, Jiaman, Li, Yan, Wang, Danyang, Jin, Long, Ning, Chunyou, Zhu, Wei, Hu, Silu, Long, Keren, Ma, Jideng, Liu, Jing, Zhang, Zhihua, Li, Mingzhou, 2022
  • DeTOKI identifies and characterizes the dynamics of chromatin TAD-like domains in a single cell, Li, Xiao, Zeng, Guangjie, Li, Angsheng, Zhang, Zhihua, 2021
  • DNA transposons mediate duplications via transposition-independent and -dependent mechanisms in metazoans, Shengjun Tan, Huijing Ma, Jinbo Wang, Man Wang, Mengxia Wang, Haodong Yin, Yaqiong Zhang, Xinying Zhang, Jieyu Shen, Danyang Wang, Graham L Banes, Zhihua Zhang, Jianmin Wu, Xun Huang, Hua Chen, Siqin Ge, ChunLong Chen, Yong E Zhang, 2021
  • DeNOPA: decoding nucleosome positions sensitively with sparse ATAC-seq data, Zhang Zhihua, 2021
  • Exploring multiomics data in 3D genomic space using augmented reality based visualization platform Delta.AR, Bixia Tang, Xiaoxing Li, Guan Li, Dong Tian, Feifei Li, Zhihua Zhang, 2021
  • Episo: quantitative estimation of RNA 5-methylcytosine at isoform level by high-throughput sequencing of RNA treated with bisulfite, Liu, Junfeng, An, Ziyang, Luo, Jianjun, Li, Jing, Li, Feifei, Zhang, Zhihua, 2020
  • Comparison of computational methods for 3D genome analysis at single-cell Hi-C level, Li, Xiao, An, Ziyang, Zhang, Zhihua, 2020
  • The asynchronous establishment of chromatin 3D architecture between in vitro fertilized and uniparental preimplantation pig embryos, Li, Feifei, Wang, Danyang, Song, Ruigao, Cao, Chunwei, Zhang, Zhihua, Wang, Yu, Li, Xiaoli, Huang, Jiaojiao, Liu, Qiang, Hou, Naipeng, Xu, Bingxiang, Li, Xiao, Gao, Xiaomeng, Jia, Yan, Zhao, Jianguo, Wang, Yanfang, 2020
  • Evidence of constraint in the 3D genome for trans-splicing in human cells, Liu, Cong, Zhang, Yiqun, Li, Xiaoli, Jia, Yan, Li, Feifei, Li, Jing, Zhang, Zhihua, 2020
  • 基于Hi-C技术识别基因组结构变异及其在肿瘤研究中的应用, 刘聪, 张治华, 2020
  • 生物大分子“液–液相分离”调控染色质三维空间结构和功能, 高晓萌, 张治华, 2020
  • The Dynamic 3D Genome in Gametogenesis and Early Embryonic Development, Li, Feifei, An, Ziyang, Zhang, Zhihua, 2019
  • Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy, Angsheng Li, Xianchen Yin, Bingxiang Xu, Danyang Wang, Jimin Han, Yi Wei, Yun Deng, Ying Xiong, Zhihua Zhang, 2018
  • Delta: a new Web-based 3D genome visualiza-tion and analysis platform, Zhang Zhihua, 2017
  • An efficient and assumption-free method to approximate protein level distribution in the two-states gene expression model, Xu, Bingxiang, Ge, Hao, Zhang, Zhihua, 2017
  • Characteristic arrangement of nucleosomes is predictive of chromatin interactions at kilobase resolution, Zhang, Hui, Li, Feifei, Jia, Yan, Xu, Bingxiang, Zhang, Yiqun, Li, Xiaoli, Zhang, Zhihua, 2017
  • 3CDB: a manually curated database of chromosome conformation capture data, Yun, Xiaoxiao, Xia, Lili, Tang, Bixia, Zhang, Hui, Li, Feifei, Zhang, Zhihua, 2016
  • Computational inference of physical spatial organization of eukaryotic genomes, Xu Bingxiang, Zhang Zhihua, 2016
  • ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling, Sheng, Zhentao, Yu, Lijia, Zhang, Tianyi, Pei, Xun, Li, Xuan, Zhang, Zhihua, Du, Wei, 2016
  • Functional diversity of CTCFs is encoded in their binding motifs, Fang, Rongxin, Wang, Chengqi, Skogerbo, Geir, Zhang, Zhihua, 2015
  • The Evolution of Heterogeneities Altered by Mutational Robustness, Gene Expression Noise and Bottlenecks in Gene Regulatory Networks, Zhang, Zhihua, 2014
  • Computational Identification of Active Enhancers in Model Organisms, Wang Chengqi, Zhang Michael Q, Zhang Zhihua, 2013
  • Prediction of novel long non-coding RNAs based on RNA-Seq data of mouse Klf1 knockout study, Sun, Lei, Zhang, Zhihua, Bailey, Timothy L, Perkins, Andrew C, Tallack, Michael R, Xu, Zhao, Liu, Hui, 2012
  • Bivalent-Like Chromatin Markers Are Predictive for Transcription Start Site Distribution in Human, Zhang, Zhihua, Ma, Xiaotu, Zhang, Michael Q, 2012
  • Histone modification profiles are predictive for tissue/cell-type specific expression of both protein-coding and microRNA genes, Zhang, Zhihua, Zhang, Michael Q, 2011
  • Positive selection for elevated gene expression noise in yeast, Zhang, Zhihua, Qian, Wenfeng, Zhang, Jianzhi, 2009
  • A Big World Inside Small-World Networks, Zhang, Zhihua, Zhang, Jianzhi, 2009
  • Accuracy and application of the motif expression decomposition method in dissecting transcriptional regulation, Zhang, Zhihua, Zhang, Jianzhi, 2008
  • Dynamic changes in subgraph preference profiles of crucial transcription factors, 陈润生, 2006
  • A hypothetical model of trans-acting R-loops-mediated promoter-enhancer interactions by Alu elements, Xue Bai, Feifei Li, Zhihua Zhang, 2021
  • Delta.EPI: a probabilistic voting-based enhancer-promoter interaction prediction platform, Yuyang Zhang, Haoyu Wang, Jing Liu, Junlin Li, Qing Zhang, Bixia Tang, Zhihua Zhang, 2023
Gene Regulation Microevolution Tumor Heterogeneity Network Dynamics Mutations Epigenetics Chromatin Ncrna Enhancers

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