Upload Avatar (500 x 500)
Mingzhao Zhu
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
T Cells
Immunity
Vaccines
Immune Response
Lymphoid Tissue
Microenvironment
Immunology
Cell Biology
Vaccine Development
Immune Regulation
Areas of Focus
- T cell immunity and vaccine immunity
- Lymphoid tissue microenvironment
Work Experience
- 2023-11~Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher
- 2009-10~2023-11 - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2009-01~2009-12 - University of Chicago - Research Assistant Professor
- 2004-01~2008-12 - University of Chicago - Postdoctoral Fellow
Academic Background & Achievements
- 1998-09--2003-07 PhD: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
- 1994-09--1998-07 Bachelor: School of Life Sciences, Peking University
Publications
- Research progress in mechanism of T cell senescence, Mingzhao Zhu, 2023
- Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells, Mingzhao Zhu, 2022
- Immunological perspectives on spatial and temporal vaccine delivery, Mingzhao Zhu, 2021
- Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates, Mingzhao Zhu, 2021
- Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice, Mingzhao Zhu, 2021
- CD146 bound to LCK promotes TCR signaling and anti-tumor immune response in mice, Mingzhao Zhu, 2021
- Thymic Egress Is Regulated by T Cell-Derived LTβR Signal and via Distinct Thymic Portal Endothelial Cells, Mingzhao Zhu, 2021
- Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LT beta R Pathway during Listeria Infection, Mingzhao Zhu, 2020
- RelB regulates the homeostatic proliferation but not the function of Tregs, Mingzhao Zhu, 2020
- TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway, Mingzhao Zhu, 2020
- H2A.Z facilitates licensing and activation of early replication origins, Mingzhao Zhu, 2020
- Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B, Mingzhao Zhu, 2020
- TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via MEK/ERK signaling pathway, Mingzhao Zhu, 2019
- Ferritin nanoparticle-based SpyTag/SpyCatcher-enabled click vaccine for tumor immunotherapy, Mingzhao Zhu, 2019
- Langerhans cells control lymphatic vessel function during inflammation via direct LIGHT-LTbR signaling, Mingzhao Zhu, 2019
- Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LT beta R Signaling, Mingzhao Zhu, 2019
- CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development, Mingzhao Zhu, 2019
- T cell-derived lymphotoxin limits Th1 response during HSV-1 infection, Mingzhao Zhu, 2018
- RelB intrinsically regulates the development and function of medullary thymic epithelial cells, Mingzhao Zhu, 2018
- Differential Roles of LT beta R in Endothelial Cell Subsets for Lymph Node Organogenesis and Maturation, Mingzhao Zhu, 2018
- T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response, Mingzhao Zhu, 2018
- Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-beta receptor, Mingzhao Zhu, 2018
- Differential roles of LTbR in endothelial cell subsets for lymph node organogenesis and maturation, Mingzhao Zhu, 2018
- Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor, Mingzhao Zhu, 2018
- RelB intrinsically regulates the development and function of medullary thymic epithelial cells, Mingzhao Zhu, 2018
- Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion, Mingzhao Zhu, 2018
- Immune cell trafficking and dynamic immunity, Mingzhao Zhu, 2018
- Dual targeting of innate and adaptive checkpoints on tumor cells limits immune evasion, Mingzhao Zhu, 2018
- Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine, Mingzhao Zhu, 2017
- Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy, Mingzhao Zhu, 2017
- The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation, Mingzhao Zhu, 2017
- LTbR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration, Mingzhao Zhu, 2016
- Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration, Mingzhao Zhu, 2016
- A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice, Mingzhao Zhu, 2016
- Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon, Mingzhao Zhu, 2015
- Epithelial lymphotoxin beta receptor regulates embryonic medullary thymic epithelial cell development for central tolerance, Mingzhao Zhu, 2014
- Recruitment of adult thymic progenitors is regulated by lymphotoxin beta receptor, Mingzhao Zhu, 2014
- A novel method for synthetic vaccine construction based on protein assembly, Mingzhao Zhu, 2014
- Lipopolysaccharide Increases the Incidence of Collagen-Induced Arthritis in Mice Through Induction of Protease HTRA-1 Expression, Mingzhao Zhu, 2013
- Medullary thymic epithelial cells, the indispensable player in central tolerance, Mingzhao Zhu, 2013
- Proinflammatory IL-17 induces iBALT development, Mingzhao Zhu, 2012
- Proinflammatory IL-17 induces iBALT development, Mingzhao Zhu, 2012
- LIGHT Regulates Inflamed Draining Lymph Node Hypertrophy, Mingzhao Zhu, 2011
- Deflating the Lymph Node, Mingzhao Zhu, 2011
- The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling, Mingzhao Zhu, 2011
- Direct and indirect roles of the LT beta R pathway in central tolerance induction, Mingzhao Zhu, 2010
- The complicated role of NF-kappa B in T-cell selection, Mingzhao Zhu, 2010
- The complicated role of NF-κB in T-cell selection, Mingzhao Zhu, 2010
- Promoting Immune Responses by LIGHT in the Face of Abundant Regulatory T Cell Inhibition, Mingzhao Zhu, 2010
- Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition, Mingzhao Zhu, 2009
- Immunoregulation by tumor necrosis factor superfamily member LIGHT, Mingzhao Zhu, 2009
- Coordinating Development of Medullary Thymic Epithelial Cells, Mingzhao Zhu, 2008
- Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla, Mingzhao Zhu, 2007
- NF-kappa B2 is required for the establishment of central tolerance through an Aire-dependent pathway, Mingzhao Zhu, 2006
- Enhancement of Herpes Simplex Virus-1 Glycoprotein-D DNA Vaccine Induced Specific Immune Responses by Coimmunization with Interleukin-2 Genetic Adjuvant, Mingzhao Zhu, 2005
- Modifid E6E7 gene of HPV increases immunogenicity of human papillomavirus 16
Awards
- National Science Fund for Distinguished Young Scholars (2020): National Level
- Chinese Academy of Sciences Award (2010): Ministerial Level
