2004-09 to 2007-07 PhD: Institute of Biophysics, Chinese Academy of Sciences
2001-09 to 2004-07 Master's: Dalian University of Technology
1997-09 to 2001-07 Bachelor's: Dalian Polytechnic University
2008-2010 - University of California, Berkeley - Postdoctoral Researcher
2010-2015 - Cornell University - Research Assistant
2015-2016 - Duke University - Senior Scientist
2016-09 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
National Innovation Research Group (2019): National Level
Youth Program by the Organization Department (2017): National Level
CAS Award (2016): Institute Level
Beijing Science and Technology Award First Prize (2014): Provincial Level
Research
Non-coding RNA and Cancer Cancer Metabolism Cancer Stem Cells
Fusobacterium nucleatum Promotes Colorectal Cancer Cell to Acquire Stem Cell-Like Features by Manipulating Lipid Droplet-Mediated Numb Degradation, Liu H, Du J, Chao S, Li S, Cai H, Zhang H, Chen G, Liu P, Bu P, 2022
Creatine promotes cancer metastasis through activation of Smad2/3, Zhang L, Zhu Z, Yan H, Wang W, Wu Z, Zhang F, Zhang Q, Shi G, Du J, Cai H, Zhang X, Hsu D, Gao P, Piao HL, Chen G, Bu P, 2021
Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling, Yan H, Wang Z, Sun Y, Hu L, Bu P, 2021
CD146 is a novel ANGPTL2 receptor that promotes obesity by manipulating lipid metabolism and energy expenditure, Wu Z, Liu J, Chen G, Du J, Cai H, Chen X, Ye G, Luo Y, Luo Y, Zhang L, Duan H, Liu Z, Yang S, Sun H, Cui Y, Sun L, Zhang H, Shi G, Wei T, Liu P, Yan Y, Feng J, Bu P, 2021
Advanced Science, Wang L, Wang E, Prado Balcazar J, Wu Z, Xiang K, Wang Y, Huang Q, Negrete M, Chen KY, Li W, Fu Y, Dohlman A, Mines R, Zhang L, Kobayashi Y, Chen T, Shi G, Shen JP, Kopetz S, Tata PR, Moreno V, Gersbach C, Crawford G, Hsu D, Huang E, Bu P, Shen X, 2021
N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles, Wang X, Liu C, Zhang S, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D, 2021
Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis, Bu P, Chen KY, Xiang K, Johnson C, Crown SB, Rakhilin N, Ai Y, Wang L, Xi R, Astapova I, Han Y, Li J, Barth BB, Lu M, Gao Z, Mines R, Zhang L, Herman M, Hsu D, Zhang GF, Shen X, 2018
miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis, Wang L, Wang E, Wang Y, Mines R, Xiang K, Sun Z, Zhou G, Chen KY, Rakhilin N, Chao S, Ye G, Wu Z, Yan H, Shen H, Everitt J, Bu P, Shen X, 2018
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal, Chen KY, Srinivasan T, Tung KL, Belmonte JM, Wang L, Murthy PKL, Choi J, Rakhilin N, King S, Varanko AK, Witherspoon M, Nishimura N, Glazier JA, Lipkin SM, Bu P, Shen X, 2017
miR-34a and Numb synergize for asymmetric cell fate determination to control stem cell proliferation, Bu P, Wang L, Chen KY, Srinivasan T, Murthy PK, Tung KL, Varanko AK, Chen HJ, Ai Y, King S, Lipkin SM, Shen X, 2016
A large non-coding RNA regulates colon cancer stem cell asymmetric division, Wang L, Bu P, Ai Y, Srinivasan T, Chen HJ, Xiang K, Lipkin SM, Shen X, 2016
A recellularized human colon model identifies cancer driver genes, Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML, 2016
Notch signaling regulates asymmetric cell fate of fast- and slow-cycling colon cancer initiating cells, Srinivasan T, Walters J, Bu P, Than EB, Tung KL, Chen KY, Panarelli N, Milsom J, Augenlicht L, Lipkin SM, Shen X, 2016
miR-1269 Promotes Metastasis through a Positive Feedback Loop with TGF-b, Bu P, Wang L, Chen KY, Rakhilin N, Sun J, Closa A, Tung KL, King S, Kristine Varanko A, Xu Y, Huan Chen J, Zessin AS, Shealy J, Cummings B, Hsu D, Lipkin SM, Moreno V, Gümü? ZH, Shen X, 2015
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation, Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L, 2015
Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles, Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu Q, Wun B, Roy S, Shen X, King MR, 2015
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal, Chen HJ, Sun J, Huang Z, Hou H Jr, Arcilla M, Rakhilin N, Joe DJ, Choi J, Gadamsetty P, Milsom J, Nandakumar G, Longman R, Zhou XK, Edwards R, Chen J, Chen KY, Bu P, Wang L, Xu Y, Munroe R, Abratte C, Miller AD, Gümü? ZH, Shuler M, Nishimura N, Edelmann W, Shen X, Lipkin SM, 2015
A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression, Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, He L, 2014
A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells, Bu P, Chen KY, Chen JH, Wang L, Walters J, Shin YJ, Goerger JP, Sun J, Witherspoon M, Rakhilin N, Li J, Yang H, Milsom J, Lee S, Zipfel W, Jin MM, Gümüş ZH, Lipkin SM, Shen X, 2013
The chemokine 25 and chemokine receptor 9 axis suppresses colon cancer invasion and metastasis, Chen HJ, Edwards R, Tucci S, Bu P, Milsom J, Lee S, Edelmann W, Gümüs ZH, Shen X, Lipkin S, 2012
miR-34a miRNAs provide a barrier for somatic cell reprogramming, Choi YJ, Lin CP, Ho JJ, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks GG, Hannon GJ, He L, 2011
Visualization of CD146 dimerization and its regulation in living cells, Bu P, Zhuang J, Feng J, Yang D, Shen X, Yan X, 2007
Anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis via suppression of NF-kB activation, Bu P, Gao L, Zhuang J, Feng J, Yang D, Yan X, 2006
