1996-02--1998-12 PhD: University of Science and Technology of China
1990-09--1993-06 Master's Degree: University of Science and Technology of China
2003-06~Present - Institute of Genetics and Developmental Biology, Chinese Academy of Sciences - Researcher
1999-09~2003-05 - MD Anderson Cancer Center, USA - Postdoctoral Fellow
1999-02~1999-08 - Purdue University, USA - Visiting Scholar
1993-07~1999-02 - University of Science and Technology of China - Lecturer
Research
Human and Animal Cell Biology Human and Animal Developmental Biology
PRMT5 determines the pattern of polyploidization and prevents liver from cirrhosis and carcinogenesis, Journal of Genetics and Genomics, 2023
Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63, J. Biol. Chem., 2023
Generation of GM130 Conditional Knockout Mouse, Methods in Molecular Biology, 2023
Shading Promoted Theanine Biosynthesis in the Roots and Allocation in the Shoots of the Tea Plant (Camellia sinensis L.) Cultivar Shuchazao, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021
PRMT5 regulates ovarian follicle development by facilitating Wt1 translation, ELIFE, 2021
The tea plant CsLHT1 and CsLHT6 transporters take up amino acids, as a nitrogen source, from the soil of organic tea plantations, HORTICULTURE RESEARCH, 2021
GM130 regulates pulmonary surfactant protein secretion in alveolar type II cells, SCIENCE CHINA-LIFE SCIENCES, 2021
PRMT7 targets of Foxm1 controls alveolar myofibroblast proliferation and differentiation during alveologenesis, CELL DEATH & DISEASE, 2021
A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19, NATURE METABOLISM, 2021
A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1, SCIENCE ADVANCES, 2020
PRMT7 is involved in regulation of germ cell proliferation during embryonic stage, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells, AUTOPHAGY, 2019
PRMT5-mediated H4R3sme2 Confers Cell Differentiation in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia, CLINICAL CANCER RESEARCH, 2019
Phosphorylation of serine/arginine-rich splicing factor 1 at tyrosine 19 promotes cell proliferation in pediatric acute lymphoblastic leukemia, CANCER SCIENCE, 2018
Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling, JOURNAL OF CELL SCIENCE, 2018
Expression of miR-652-3p and Effect on Apoptosis and Drug Sensitivity in Pediatric Acute Lymphoblastic Leukemia, BIOMED RESEARCH INTERNATIONAL, 2018
Nitric Oxide Regulates Protein Methylation during Stress Responses in Plants, MOLECULAR CELL, 2017
Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
Globozoospermia and Lack of Acrosome Formation in GM130-Deficient Mice, CELL DEATH & DISEASE, 2017
The Protein Arginine Methylase 5 (PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage, JOURNAL OF GENETICS AND GENOMICS, 2016
Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via Regulating Bcl6 Transcription, JOURNAL OF IMMUNOLOGY, 2015
Prmt5 Is Required for Germ Cell Survival During Spermatogenesis in Mice, SCIENTIFIC REPORTS, 2015
An advanced fragment analysis-based individualized subtype classification of pediatric acute lymphoblastic leukemia, SCIENTIFIC REPORTS, 2015
Protein Arginine Methyltransferase 5 (Prmt5) Is Required for Germ Cell Survival During Mouse Embryonic Development, BIOLOGY OF REPRODUCTION, 2015
Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
调控细胞内囊泡运输机器的发现者——2013年诺贝尔生理学或医学奖简介, 生物学通报, 2014
SKB1/PRMT5-mediated histone H4R3 dimethylation of Ib subgroup bHLH genes negatively regulates iron homeostasis in Arabidopsis thaliana, PLANT JOURNAL, 2014
NF-kappa B mediated Up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia, MOLECULAR CANCER, 2014
Histone H4R3 Methylation Catalyzed by SKB1/PRMT5 Is Required for Maintaining Shoot Apical Meristem, PLOS ONE, 2013
Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia, JOURNAL OF HEMATOLOGY & ONCOLOGY, 2012
miRNA mediated up-regulation of cochaperone p23 acts as an anti-apoptotic factor in childhood acute lymphoblastic leukemia, LEUKEMIA RESEARCH, 2012
Structural insights into protein arginine symmetric dimethylation by PRMT5, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011
LTP4基因超表达载体的构建及其遗传转化, 中南林业科技大学学报：自然科学版, 2011
Arabidopsis Floral Initiator SKB1 Confers High Salt Tolerance by Regulating Transcription and Pre-mRNA Splicing through Altering Histone H4R3 and Small Nuclear Ribonucleoprotein LSM4 Methylation, PLANTCELL, 2011
