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Shilai Bao
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Cell Biology
Developmental Biology
Human Biology
Animal Biology
Genetics
Epigenetics
Molecular Biology
Cancer Research
Stem Cells
Regenerative Medicine
Areas of Focus
- Human and Animal Cell Biology
- Human and Animal Developmental Biology
Work Experience
- 2003-06~Present - Institute of Genetics and Developmental Biology, Chinese Academy of Sciences - Researcher
- 1999-09~2003-05 - MD Anderson Cancer Center, USA - Postdoctoral Fellow
- 1999-02~1999-08 - Purdue University, USA - Visiting Scholar
- 1993-07~1999-02 - University of Science and Technology of China - Lecturer
Academic Background & Achievements
- 1996-02--1998-12 PhD: University of Science and Technology of China
- 1990-09--1993-06 Master's Degree: University of Science and Technology of China
Publications
- PRMT5 determines the pattern of polyploidization and prevents liver from cirrhosis and carcinogenesis, Journal of Genetics and Genomics, 2023
- Prmt5 promotes ciliated cell specification of airway epithelial progenitors via transcriptional inhibition of Tp63, J. Biol. Chem., 2023
- Generation of GM130 Conditional Knockout Mouse, Methods in Molecular Biology, 2023
- Shading Promoted Theanine Biosynthesis in the Roots and Allocation in the Shoots of the Tea Plant (Camellia sinensis L.) Cultivar Shuchazao, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021
- PRMT5 regulates ovarian follicle development by facilitating Wt1 translation, ELIFE, 2021
- The tea plant CsLHT1 and CsLHT6 transporters take up amino acids, as a nitrogen source, from the soil of organic tea plantations, HORTICULTURE RESEARCH, 2021
- GM130 regulates pulmonary surfactant protein secretion in alveolar type II cells, SCIENCE CHINA-LIFE SCIENCES, 2021
- PRMT7 targets of Foxm1 controls alveolar myofibroblast proliferation and differentiation during alveologenesis, CELL DEATH & DISEASE, 2021
- A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19, NATURE METABOLISM, 2021
- A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1, SCIENCE ADVANCES, 2020
- PRMT7 is involved in regulation of germ cell proliferation during embryonic stage, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020
- Theanine transporters identified in tea plants (Camellia sinensis L.), PLANT JOURNAL, 2020
- RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells, AUTOPHAGY, 2019
- PRMT5-mediated H4R3sme2 Confers Cell Differentiation in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia, CLINICAL CANCER RESEARCH, 2019
- Phosphorylation of serine/arginine-rich splicing factor 1 at tyrosine 19 promotes cell proliferation in pediatric acute lymphoblastic leukemia, CANCER SCIENCE, 2018
- Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling, JOURNAL OF CELL SCIENCE, 2018
- Expression of miR-652-3p and Effect on Apoptosis and Drug Sensitivity in Pediatric Acute Lymphoblastic Leukemia, BIOMED RESEARCH INTERNATIONAL, 2018
- Nitric Oxide Regulates Protein Methylation during Stress Responses in Plants, MOLECULAR CELL, 2017
- Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
- Globozoospermia and Lack of Acrosome Formation in GM130-Deficient Mice, CELL DEATH & DISEASE, 2017
- The Protein Arginine Methylase 5 (PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage, JOURNAL OF GENETICS AND GENOMICS, 2016
- Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via Regulating Bcl6 Transcription, JOURNAL OF IMMUNOLOGY, 2015
- Prmt5 Is Required for Germ Cell Survival During Spermatogenesis in Mice, SCIENTIFIC REPORTS, 2015
- An advanced fragment analysis-based individualized subtype classification of pediatric acute lymphoblastic leukemia, SCIENTIFIC REPORTS, 2015
- Protein Arginine Methyltransferase 5 (Prmt5) Is Required for Germ Cell Survival During Mouse Embryonic Development, BIOLOGY OF REPRODUCTION, 2015
- Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
- 调控细胞内囊泡运输机器的发现者——2013年诺贝尔生理学或医学奖简介, 生物学通报, 2014
- SKB1/PRMT5-mediated histone H4R3 dimethylation of Ib subgroup bHLH genes negatively regulates iron homeostasis in Arabidopsis thaliana, PLANT JOURNAL, 2014
- NF-kappa B mediated Up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia, MOLECULAR CANCER, 2014
- Histone H4R3 Methylation Catalyzed by SKB1/PRMT5 Is Required for Maintaining Shoot Apical Meristem, PLOS ONE, 2013
- Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia, JOURNAL OF HEMATOLOGY & ONCOLOGY, 2012
- miRNA mediated up-regulation of cochaperone p23 acts as an anti-apoptotic factor in childhood acute lymphoblastic leukemia, LEUKEMIA RESEARCH, 2012
- Structural insights into protein arginine symmetric dimethylation by PRMT5, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011
- LTP4基因超表达载体的构建及其遗传转化, 中南林业科技大学学报：自然科学版, 2011
- Arabidopsis Floral Initiator SKB1 Confers High Salt Tolerance by Regulating Transcription and Pre-mRNA Splicing through Altering Histone H4R3 and Small Nuclear Ribonucleoprotein LSM4 Methylation, PLANTCELL, 2011
- LTP4基因超表达载体的构建及其遗传转化, 中南林业科技大学学报：自然科学版, 2011
- BCL6、KLF5、NCL基因在儿童急性淋巴细胞白血病中异常表达的特点, 中国肿瘤生物治疗杂志, 2011
- Methylation of Ribosomal Protein S10 by Protein-arginine Methyltransferase 5 Regulates Ribosome Biogenesis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010
- srGAP2 Arginine Methylation Regulates Cell Migration and Cell Spreading through Promoting Dimerization, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010
- PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130, 细胞研究：英文版, 2010
- 蛋白质甲基转移酶的结合蛋白在肺癌组织中的表达, 中国热带医学, 2010
- 肺癌组织中蛋白质甲基转移酶的表达, 中国热带医学, 2010
- Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia, BLOOD, 2009
- PRMT1通过精氨酸甲基化作用修饰剪接因子SF2／ASF, 中国肿瘤生物治疗杂志, 2009
- Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009
- 对大肠杆菌中表达蛋白质精氨酸甲基转移酶5的几个缺失突变体的活性研究, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2008
- Skb1-mediated symmetric dimethylation of histone h4r3 controls flowering time in arabidopsis, EMBO JOURNAL, 2007
- Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans, JOURNAL OF STRUCTURAL BIOLOGY, 2007
- 高尔基体堆形成的分子机制, 生物学通报, 2006
- 高尔基体的结构与功能研究简介, 生物学通报, 2006
- 钩端螺旋体liprm
