Professor | Xin Cheng | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Xin Cheng
Contact Information	xcheng@sibcb.ac.cn
Language ability	English, Chinese
Province	Shanghai

Upload Avatar (500 x 500)

Name

Xin Cheng

Contact Information

xcheng@sibcb.ac.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2002-08 to 2009-03 PhD: Mount Sinai School of Medicine, New York University 1997-09 to 2000-06 Master's: Beijing Normal University 1993-09 to 1997-06 Bachelor's: Beijing Normal University
Work Experience	2013-04 to Present - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Researcher 2009-03 to 2013-04 - University of Pennsylvania, Children's Hospital of Philadelphia, Molecular Cell Therapy Center - Postdoctoral/Assistant Researcher 2001-06 to 2002-07 - Mount Sinai School of Medicine, New York University - Research Assistant
Awards	2015: Outstanding Class, Science and Technology Activities Project for Returned Overseas Students, Ministry of Human Resources and Social Security of China 2014: Pujiang Talent, Shanghai 2014: S-Class Talent, Chinese Academy of Sciences

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2002-08 to 2009-03 PhD: Mount Sinai School of Medicine, New York University
1997-09 to 2000-06 Master's: Beijing Normal University
1993-09 to 1997-06 Bachelor's: Beijing Normal University

Work Experience

2013-04 to Present - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Researcher
2009-03 to 2013-04 - University of Pennsylvania, Children's Hospital of Philadelphia, Molecular Cell Therapy Center - Postdoctoral/Assistant Researcher
2001-06 to 2002-07 - Mount Sinai School of Medicine, New York University - Research Assistant

Awards

2015: Outstanding Class, Science and Technology Activities Project for Returned Overseas Students, Ministry of Human Resources and Social Security of China
2014: Pujiang Talent, Shanghai
2014: S-Class Talent, Chinese Academy of Sciences

Areas of Focus	Directed differentiation of human pluripotent stem cells into mesoderm and endoderm
Publications	Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue, Jiaying Wu, Tuo Li, Meng Guo, Junsong Ji, Xiaoxi Meng, Tianlong Fu, Tengfei Nie, Tongkun Wei, Ying Zhou, Weihua Dong, Ming Zhang, Yongquan Shi, Xin Cheng, Hao Yin, 2024 Human Endoderm Stem Cells Reverse Inflammation-Related Acute Liver Failure through Cystatin SN-Mediated Inhibition of Interferon Signaling, Yilin Xu, Xin Cheng, Jinglin Wang, 2023 Dynamic network biomarker factors orchestrate cell-fate determination at tipping points during hESC differentiation, Xin Cheng, 2022 ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson's disease, Hongxia Cai, Xin Cheng, XiaoPing Wang, 2022 ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes, Qing Ma, Yini Xiao, Wenjun Xu, Menghan Wang, Sheng Li, Zhihao Yang, Minglu Xu, Tengjiao Zhang, ZhenNing Zhang, Rui Hu, Qiang Su, Fei Yuan, Tinghui Xiao, Xuan Wang, Qing He, Jiaxu Zhao, Zhengjun Chen, Zhejin Sheng, Mengyao Chai, Hong Wang, Weiyang Shi, Qiaolin Deng, Xin Cheng, Weida Li, 2022 Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells, Sisi Feng, Jiaying Wu, WeiLin Qiu, Li Yang, Xiaogang Deng, Ying Zhou, Yabin Chen, Xiao Li, Lei Yu, Hongsheng Li, ZiRan Xu, Yini Xiao, Xiongzhao Ren, Ludi Zhang, Chenhua Wang, Zhen Sun, Jinglin Wang, Xiaoyan Ding, Yuelei Chen, Paul Gadue, Guoyu Pan, Mina Ogawa, Shinichiro Ogawa, Jie Na, Peilin Zhang, Lijian Hui, Hao Yin, Luonan Chen, ChengRan Xu, Xin Cheng, 2020 m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance, Tengfei Zhou, Shichao Li, Daimin Xiang, Junyu Liu, Wen Sun, Xiuliang Cui, Beifang Ning, Xiao Li, Zhuo Cheng, Weiqi Jiang, Cheng Zhang, Xijun Liang, Liang Li, Xin Cheng, Liu Hui, Hongyang Wang, Jin Ding, 2020 多能干细胞来源的胰岛细胞及其在糖尿病治疗中的应用, Tianlong Fu, Tengfei Nie, Hao Yin, Xin Cheng, 2019 Single-cell transcriptomic analyses reveal distinct dorsal/ventral pancreatic programs, LinChen Li, WeiLin Qiu, YuWei Zhang, ZiRan Xu, YiNi Xiao, Caiying Hou, Lamaoqiezhong, Peng Yu, Xin Cheng, ChengRan Xu, 2018 In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity, Kun Zhang, Ludi Zhang, Wenming Liu, Xiaolong Ma, Jin Cen, Zhen Sun, Chenhua Wang, Sisi Feng, Zhengtao Zhang, Liyun Yue, Lulu Sun, Zhenfeng Zhu, Xiaotao Chen, Anqi Feng, Jiaying Wu, Zhiwu Jiang, Peng Li, Xin Cheng, Dong Gao, Luying Peng, Lijian Hui, 2018 Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target, Huan Zhao, Xueying Tian, Lingjuan He, Yan Li, Wenjuan Pu, Qiaozhen Liu, Juan Tang, Jiaying Wu, Xin Cheng, Yang Liu, Qingtong Zhou, Zhen Tan, Fei Xu, Nicola Smart, Bin Zhou, 2018 Graphene Sheet-Induced Global Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells, Jiaxian Wang, Chang Cui, Haiyan Nan, Yuanfang Yu, Yini Xiao, Ellen Poon, Gang Yang, Xijie Wang, Chenchen Wang, Lingsong Li, Kenneth Richard Bohelee, Xu Ma, Xin Cheng, Zhenhua Ni, Minglong Chen, 2017 Lineage conversion of mouse fibroblasts to pancreatic α-cells, Tianjin Liu, Liangliang Sun, Beige Jiang, Limei Li, Jin Cen, Xiaotao Chen, Zhaoyun Zhang, Qinghua Wang, Xin Cheng, Yongquan Shi, Lijian Hui, 2017 Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, Yimeng Gao, Xiaoran Zhang, Ludi Zhang, Jin Cen, Xuan Ni, Xiaoying Liao, Chenxi Yang, Ying Li, Xiaotao Chen, Zhao Zhang, Yajing Shu, Xin Cheng, David C Hay, Dongmei Lai, Guoyu Pan, Gang Wei, Lijian Hui, 2017 Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, XiaoLei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang, Xuan Ni, Ludi Zhang, Xin Zhao, Haozhen Ren, Dan Hu, Yan Zhou, Feng Tian, Yuan Ji, Xin Cheng, Guoyu Pan, YiTao Ding, Lijian Hui, 2016 Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages, Andrea Ditadi, Christopher M Sturgeon, Joanna Tober, Geneve Awong, Marion Kennedy, Amanda D Yzaguirre, Lisa Azzola, Elizabeth S Ng, Edouard G Stanley, Deborah L French, Xin Cheng, Paul Gadue, Nancy A Speck, Andrew G Elefanty, Gordon Keller, 2015 Direct reprogramming of human fibroblasts to functional and expandable hepatocyte-like cells, Xin Cheng, 2014 The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells, Prasuna Paluru, Kristin M Hudock, Xin Cheng, Jason A Mills, Lei Ying, Aline M Galvao, Lin Lu, Amita Tiyaboonchai, Xiuli Sim, Spencer K Sullivan, Deborah L French, Paul Gadue, 2014 Endodermal stem cell populations derived from pluripotent stem cells, Xin Cheng, Amita Tiyaboonchai, Paul Gadue, 2013 Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells, Xin Cheng, Lei Ying, Lin Lu, Aline M Galvao, Jason A Mills, Henry C Lin, Darrell N Kotton, Steven S Shen, M Cristina Nostro, John Kim Choi, Mitchell J Weiss, Deborah L French, Paul Gadue, 2012 A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells, Joel T Outten, Xin Cheng, Paul Gadue, Deborah L French, Scott L Diamond, 2011 Liver Regeneration From Induced Pluripotent Stem Cells, Xin Cheng, Paul Gadue, 2010 The Generation of Monoclonal Antibodies Specific for Cell Surface Molecules Expressed on Early Mouse Endoderm, Paul Gadue, Valerie Gouon-Evans, Xin Cheng, Ewa Wandzioch, Kenneth S Zaret, Markus Grompe, Philip R Streeter, Gordon M Keller, 2009 Wnt, Activin and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cell to blood, Xin Cheng, 2008 Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast, Xin Cheng, Tara L Huber, Vincent C Chen, Paul Gadue, Gordon M Keller, 2008 Notch signaling respecifies the hemangioblast to a cardiac fate, Vincent C Chen, Robert Stull, Daniel Joo, Xin Cheng, Gordon Keller, 2008

Areas of Focus

Directed differentiation of human pluripotent stem cells into mesoderm and endoderm

Publications

Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue, Jiaying Wu, Tuo Li, Meng Guo, Junsong Ji, Xiaoxi Meng, Tianlong Fu, Tengfei Nie, Tongkun Wei, Ying Zhou, Weihua Dong, Ming Zhang, Yongquan Shi, Xin Cheng, Hao Yin, 2024
Human Endoderm Stem Cells Reverse Inflammation-Related Acute Liver Failure through Cystatin SN-Mediated Inhibition of Interferon Signaling, Yilin Xu, Xin Cheng, Jinglin Wang, 2023
Dynamic network biomarker factors orchestrate cell-fate determination at tipping points during hESC differentiation, Xin Cheng, 2022
ATP7B gene therapy of autologous reprogrammed hepatocytes alleviates copper accumulation in a mouse model of Wilson's disease, Hongxia Cai, Xin Cheng, XiaoPing Wang, 2022
ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes, Qing Ma, Yini Xiao, Wenjun Xu, Menghan Wang, Sheng Li, Zhihao Yang, Minglu Xu, Tengjiao Zhang, ZhenNing Zhang, Rui Hu, Qiang Su, Fei Yuan, Tinghui Xiao, Xuan Wang, Qing He, Jiaxu Zhao, Zhengjun Chen, Zhejin Sheng, Mengyao Chai, Hong Wang, Weiyang Shi, Qiaolin Deng, Xin Cheng, Weida Li, 2022
Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells, Sisi Feng, Jiaying Wu, WeiLin Qiu, Li Yang, Xiaogang Deng, Ying Zhou, Yabin Chen, Xiao Li, Lei Yu, Hongsheng Li, ZiRan Xu, Yini Xiao, Xiongzhao Ren, Ludi Zhang, Chenhua Wang, Zhen Sun, Jinglin Wang, Xiaoyan Ding, Yuelei Chen, Paul Gadue, Guoyu Pan, Mina Ogawa, Shinichiro Ogawa, Jie Na, Peilin Zhang, Lijian Hui, Hao Yin, Luonan Chen, ChengRan Xu, Xin Cheng, 2020
m6A RNA methylation-mediated HNF3γ reduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance, Tengfei Zhou, Shichao Li, Daimin Xiang, Junyu Liu, Wen Sun, Xiuliang Cui, Beifang Ning, Xiao Li, Zhuo Cheng, Weiqi Jiang, Cheng Zhang, Xijun Liang, Liang Li, Xin Cheng, Liu Hui, Hongyang Wang, Jin Ding, 2020
多能干细胞来源的胰岛细胞及其在糖尿病治疗中的应用, Tianlong Fu, Tengfei Nie, Hao Yin, Xin Cheng, 2019
Single-cell transcriptomic analyses reveal distinct dorsal/ventral pancreatic programs, LinChen Li, WeiLin Qiu, YuWei Zhang, ZiRan Xu, YiNi Xiao, Caiying Hou, Lamaoqiezhong, Peng Yu, Xin Cheng, ChengRan Xu, 2018
In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity, Kun Zhang, Ludi Zhang, Wenming Liu, Xiaolong Ma, Jin Cen, Zhen Sun, Chenhua Wang, Sisi Feng, Zhengtao Zhang, Liyun Yue, Lulu Sun, Zhenfeng Zhu, Xiaotao Chen, Anqi Feng, Jiaying Wu, Zhiwu Jiang, Peng Li, Xin Cheng, Dong Gao, Luying Peng, Lijian Hui, 2018
Apj(+) Vessels Drive Tumor Growth and Represent a Tractable Therapeutic Target, Huan Zhao, Xueying Tian, Lingjuan He, Yan Li, Wenjuan Pu, Qiaozhen Liu, Juan Tang, Jiaying Wu, Xin Cheng, Yang Liu, Qingtong Zhou, Zhen Tan, Fei Xu, Nicola Smart, Bin Zhou, 2018
Graphene Sheet-Induced Global Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells, Jiaxian Wang, Chang Cui, Haiyan Nan, Yuanfang Yu, Yini Xiao, Ellen Poon, Gang Yang, Xijie Wang, Chenchen Wang, Lingsong Li, Kenneth Richard Bohelee, Xu Ma, Xin Cheng, Zhenhua Ni, Minglong Chen, 2017
Lineage conversion of mouse fibroblasts to pancreatic α-cells, Tianjin Liu, Liangliang Sun, Beige Jiang, Limei Li, Jin Cen, Xiaotao Chen, Zhaoyun Zhang, Qinghua Wang, Xin Cheng, Yongquan Shi, Lijian Hui, 2017
Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, Yimeng Gao, Xiaoran Zhang, Ludi Zhang, Jin Cen, Xuan Ni, Xiaoying Liao, Chenxi Yang, Ying Li, Xiaotao Chen, Zhao Zhang, Yajing Shu, Xin Cheng, David C Hay, Dongmei Lai, Guoyu Pan, Gang Wei, Lijian Hui, 2017
Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, XiaoLei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang, Xuan Ni, Ludi Zhang, Xin Zhao, Haozhen Ren, Dan Hu, Yan Zhou, Feng Tian, Yuan Ji, Xin Cheng, Guoyu Pan, YiTao Ding, Lijian Hui, 2016
Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages, Andrea Ditadi, Christopher M Sturgeon, Joanna Tober, Geneve Awong, Marion Kennedy, Amanda D Yzaguirre, Lisa Azzola, Elizabeth S Ng, Edouard G Stanley, Deborah L French, Xin Cheng, Paul Gadue, Nancy A Speck, Andrew G Elefanty, Gordon Keller, 2015
Direct reprogramming of human fibroblasts to functional and expandable hepatocyte-like cells, Xin Cheng, 2014
The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells, Prasuna Paluru, Kristin M Hudock, Xin Cheng, Jason A Mills, Lei Ying, Aline M Galvao, Lin Lu, Amita Tiyaboonchai, Xiuli Sim, Spencer K Sullivan, Deborah L French, Paul Gadue, 2014
Endodermal stem cell populations derived from pluripotent stem cells, Xin Cheng, Amita Tiyaboonchai, Paul Gadue, 2013
Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells, Xin Cheng, Lei Ying, Lin Lu, Aline M Galvao, Jason A Mills, Henry C Lin, Darrell N Kotton, Steven S Shen, M Cristina Nostro, John Kim Choi, Mitchell J Weiss, Deborah L French, Paul Gadue, 2012
A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells, Joel T Outten, Xin Cheng, Paul Gadue, Deborah L French, Scott L Diamond, 2011
Liver Regeneration From Induced Pluripotent Stem Cells, Xin Cheng, Paul Gadue, 2010
The Generation of Monoclonal Antibodies Specific for Cell Surface Molecules Expressed on Early Mouse Endoderm, Paul Gadue, Valerie Gouon-Evans, Xin Cheng, Ewa Wandzioch, Kenneth S Zaret, Markus Grompe, Philip R Streeter, Gordon M Keller, 2009
Wnt, Activin and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cell to blood, Xin Cheng, 2008
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast, Xin Cheng, Tara L Huber, Vincent C Chen, Paul Gadue, Gordon M Keller, 2008
Notch signaling respecifies the hemangioblast to a cardiac fate, Vincent C Chen, Robert Stull, Daniel Joo, Xin Cheng, Gordon Keller, 2008

Stem Cells Pluripotent Mesoderm Endoderm Differentiation Human Directed Cell Lines Regeneration Transplantation

Jun Chen - Zhejiang University

Xudong Guo - Tongji University

Jiuhong Kang - Tongji University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us