Professor | Hong Cheng | Asia Growth Partners

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Name	Hong Cheng
Contact Information	hcheng@sibcb.ac.cn
Language ability	Chinese, English, Japanese
Province	Shanghai

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Name

Hong Cheng

Contact Information

hcheng@sibcb.ac.cn

Language ability

Chinese, English, Japanese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1998-09--2003-06 PhD: Kobe University, Japan
Work Experience	2020-04~Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Researcher, Doctoral Supervisor 2008-07~2020-04 - Chinese Academy of Sciences, Shanghai Institute of Biochemistry and Cell Biology - Researcher, Doctoral Supervisor 2003-09~2008-07 - Harvard University - Postdoctoral Researcher
Awards	Second 'Zeng Ai·Chang Mu Academic Award' First Prize (2019): Other

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1998-09--2003-06 PhD: Kobe University, Japan

Work Experience

2020-04~Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Researcher, Doctoral Supervisor
2008-07~2020-04 - Chinese Academy of Sciences, Shanghai Institute of Biochemistry and Cell Biology - Researcher, Doctoral Supervisor
2003-09~2008-07 - Harvard University - Postdoctoral Researcher

Awards

Second 'Zeng Ai·Chang Mu Academic Award' First Prize (2019): Other

Areas of Focus	Mechanisms and functions of RNA transport and degradation
Publications	CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing, 11th Author, 2023 Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation, 7th Author, 2022 Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex, 11th Author, 2021 Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum, 5th Author, 2021 Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation, 5th Author, 2021 Technologies of studying RNA binding proteins, 11th Author, 2021 ZFC3H1 prevents RNA trafficking into nuclear speckles through condensation, 11th Author, 2021 Out or decay: fate determination of nuclear RNAs, 11th Author, 2020 The micropeptide LEMP plays an evolutionarily conserved role in myogenesis, 11th Author, 2020 A U2-snRNP-independent role of SF3b in promoting mRNA export, 11th Author, 2019 A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation, 23rd Author, 2019 The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export, 11th Author, 2019 ALYREF links 3' end processing to nuclear export of non-polyadenylated mRNAs, 11th Author, 2019 New means to an end: mRNA export activity impacts alternative polyadenylation, 11th Author, 2019 NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction, 11th Author, 2019 Structural insight into precursor tRNA processing by yeast ribonuclease P, 0th Author, 2018 Intronless mRNAs transit through nuclear speckles to gain export competence, 11th Author, 2018 mRNAs are sorted for export or degradation before passing through nuclear speckles, 11th Author, 2018 ALYREF mainly binds to the 5' and the 3' regions of the mRNA in vivo, 11th Author, 2017 Microinjection and fluorescence in situ hybridization assay for studying mRNA export in mammalian cells., 11th Author, 2017 Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export, 11th Author, 2017 The Effect of Codon Mismatch on the Protein Translation System, 11th Author, 2016 Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner, 13th Author, 2015 A Sub-Element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18, 11th Author, 2014 Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA, 11th Author, 2013 Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction, 10th Author, 2013 Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency Maintenance, 6th Author, 2012 mRNA出核转运及其偶联网络, 5th Author, 2010 Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction, 6th Author, 2010

Areas of Focus

Mechanisms and functions of RNA transport and degradation

Publications

CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing, 11th Author, 2023
Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation, 7th Author, 2022
Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex, 11th Author, 2021
Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum, 5th Author, 2021
Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation, 5th Author, 2021
Technologies of studying RNA binding proteins, 11th Author, 2021
ZFC3H1 prevents RNA trafficking into nuclear speckles through condensation, 11th Author, 2021
Out or decay: fate determination of nuclear RNAs, 11th Author, 2020
The micropeptide LEMP plays an evolutionarily conserved role in myogenesis, 11th Author, 2020
A U2-snRNP-independent role of SF3b in promoting mRNA export, 11th Author, 2019
A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation, 23rd Author, 2019
The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export, 11th Author, 2019
ALYREF links 3' end processing to nuclear export of non-polyadenylated mRNAs, 11th Author, 2019
New means to an end: mRNA export activity impacts alternative polyadenylation, 11th Author, 2019
NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction, 11th Author, 2019
Structural insight into precursor tRNA processing by yeast ribonuclease P, 0th Author, 2018
Intronless mRNAs transit through nuclear speckles to gain export competence, 11th Author, 2018
mRNAs are sorted for export or degradation before passing through nuclear speckles, 11th Author, 2018
ALYREF mainly binds to the 5' and the 3' regions of the mRNA in vivo, 11th Author, 2017
Microinjection and fluorescence in situ hybridization assay for studying mRNA export in mammalian cells., 11th Author, 2017
Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export, 11th Author, 2017
The Effect of Codon Mismatch on the Protein Translation System, 11th Author, 2016
Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner, 13th Author, 2015
A Sub-Element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18, 11th Author, 2014
Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA, 11th Author, 2013
Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction, 10th Author, 2013
Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency Maintenance, 6th Author, 2012
mRNA出核转运及其偶联网络, 5th Author, 2010
Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction, 6th Author, 2010

Rna Transport Rna Degradation Molecular Biology Biochemistry Cell Biology Gene Expression Rna Processing Rna Localization Rna Stability Rna Regulation

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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