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Hong Cheng
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English, Japanese
Rna Transport
Rna Degradation
Molecular Biology
Biochemistry
Cell Biology
Gene Expression
Rna Processing
Rna Localization
Rna Stability
Rna Regulation
Areas of Focus
- Mechanisms and functions of RNA transport and degradation
Work Experience
- 2020-04~Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Researcher, Doctoral Supervisor
- 2008-07~2020-04 - Chinese Academy of Sciences, Shanghai Institute of Biochemistry and Cell Biology - Researcher, Doctoral Supervisor
- 2003-09~2008-07 - Harvard University - Postdoctoral Researcher
Academic Background & Achievements
- 1998-09--2003-06 PhD: Kobe University, Japan
Publications
- CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing, 11th Author, 2023
- Myogenesis controlled by a long non-coding RNA 1700113A16RIK and post-transcriptional regulation, 7th Author, 2022
- Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex, 11th Author, 2021
- Alternative 3' UTRs play a widespread role in translation-independent mRNA association with the endoplasmic reticulum, 5th Author, 2021
- Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation, 5th Author, 2021
- Technologies of studying RNA binding proteins, 11th Author, 2021
- ZFC3H1 prevents RNA trafficking into nuclear speckles through condensation, 11th Author, 2021
- Out or decay: fate determination of nuclear RNAs, 11th Author, 2020
- The micropeptide LEMP plays an evolutionarily conserved role in myogenesis, 11th Author, 2020
- A U2-snRNP-independent role of SF3b in promoting mRNA export, 11th Author, 2019
- A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation, 23rd Author, 2019
- The mRNA export receptor NXF1 coordinates transcriptional dynamics, alternative polyadenylation and mRNA export, 11th Author, 2019
- ALYREF links 3' end processing to nuclear export of non-polyadenylated mRNAs, 11th Author, 2019
- New means to an end: mRNA export activity impacts alternative polyadenylation, 11th Author, 2019
- NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction, 11th Author, 2019
- Structural insight into precursor tRNA processing by yeast ribonuclease P, 0th Author, 2018
- Intronless mRNAs transit through nuclear speckles to gain export competence, 11th Author, 2018
- mRNAs are sorted for export or degradation before passing through nuclear speckles, 11th Author, 2018
- ALYREF mainly binds to the 5' and the 3' regions of the mRNA in vivo, 11th Author, 2017
- Microinjection and fluorescence in situ hybridization assay for studying mRNA export in mammalian cells., 11th Author, 2017
- Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export, 11th Author, 2017
- The Effect of Codon Mismatch on the Protein Translation System, 11th Author, 2016
- Premature termination codons are recognized in the nucleus in a reading-frame-dependent manner, 13th Author, 2015
- A Sub-Element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18, 11th Author, 2014
- Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA, 11th Author, 2013
- Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction, 10th Author, 2013
- Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency Maintenance, 6th Author, 2012
- mRNA出核转运及其偶联网络, 5th Author, 2010
- Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction, 6th Author, 2010
Awards
- Second 'Zeng Ai·Chang Mu Academic Award' First Prize (2019): Other
