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Liang Chen
Life Science
University of Chinese Academy of Sciences
Guangdong
Language: Chinese, English
Tumor
Cell
Survival
Apoptosis
Signaling
Pathways
Detection
Treatment
Cancer
Research
Areas of Focus
- Tumor Cell Survival and Apoptosis
- Tumor Cell Signaling Pathways
- Tumor Detection and Treatment
Work Experience
- 2018-07 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Associate Researcher
- 2014-08 to 2018-06 - University of Pennsylvania - Postdoctoral Researcher
Academic Background & Achievements
- 2008-09 to 2014-07 PhD: Peking University
- 2004-09 to 2008-06 Bachelor's: Hebei University
Publications
- TRIM28 attenuates Bortezomib sensitivity of hepatocellular carcinoma cells through enhanced proteasome expression., Zhang, Jianchao, Fan, Xiaokai, Liao, Lijuan, Zhu, Yan, Wan, Xiaochun, Rao, Hai, Chen, Liang., 2022
- Inhibition of AMPK activity by TRIM11 facilitates cell survival of hepatocellular carcinoma under metabolic stress., Liu, Yanfeng, Xu, Yingying, Wang, Fan, Tong, Yu, Li, Hongchang, Wan, Xiaochun, Yang, Xiaolu, Chen, Liang., 2021
- Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins., Zhang, Litian, Afolabi, Lukman O, Wan, Xiaochun, Li, Yang, Chen, Liang., 2020
- TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway., Yanfeng Liu, Shishi Tao, Lijuan Liao, Yang Li, Hongchang Li, Zhihuan Li, Lilong Lin, Xiaochun Wan, Xiaolu Yang, Liang Chen., 2020
- TRIM11 cooperates with HSF1 to suppress the anti-tumor effect of proteotoxic stress drugs., Chen, Liang, Yang, Xiaolu., 2019
- TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14., Liang Chen, Guixin Zhu, Eleanor M Johns, Xiaolu Yang., 2018
- Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis., Chen, Liang, Brewer, Michael D, Guo, Lili, Wang, Ruoxing, Jiang, Peng, Yang, Xiaolu., 2017
- Cab45S promotes cell proliferation through SERCA2b inhibition and Ca2+ signaling., Chen, L, Xu, S, Xu, Y, Lu, W, Liu, L, Yue, D, Teng, J, Chen, J., 2016
Awards
- Patent (2019): TRIM11 gene and protein target and inhibitor in breast cancer, First Author, Patent No: 201910686481.9
